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Murcko scaffold

Ring system with 3 rings and 26 atoms

9 chemicals on CompoundList share this ring system.

Rings
3
Scaffold atoms
26
Chemicals
9
With full pages
7
Scaffold SMILES

O=C(CC1C(=O)NCCN1C(=O)Nc1ccccc1)Nc1ccccc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=C(CC1C(=O)NCCN1C(=O)Nc1ccccc1)Nc1ccccc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 9 of 9 chemicals

N-(3,4-Dichlorophenyl)-2-{2-[(2-methoxyphenyl)amino]-2-oxoethyl}-3-oxo-1-piperazinecarboxamide chemical structure, C20H20Cl2N4O4, CAS 1008016-50-9
N-(3,4-Dichlorophenyl)-2-{2-[(2-methoxyphenyl)amino]-2-oxoethyl}-3-oxo-1-piperazinecarboxamide
CAS 1008016-50-9C20H20Cl2N4O4
3-Oxo-2-(2-oxo-2-{[3-(trifluoromethyl)phenyl]amino}ethyl)-N-phenylpiperazine-1-carboxamide chemical structure, C20H19F3N4O3, CAS 1009163-19-2
3-Oxo-2-(2-oxo-2-{[3-(trifluoromethyl)phenyl]amino}ethyl)-N-phenylpiperazine-1-carboxamide
CAS 1009163-19-2C20H19F3N4O3
N-(4-Chlorophenyl)-2-{2-[(3-methylphenyl)amino]-2-oxoethyl}-3-oxopiperazine-1-carboxamide chemical structure, C20H21ClN4O3, CAS 1008924-98-8
N-(4-Chlorophenyl)-2-{2-[(3-methylphenyl)amino]-2-oxoethyl}-3-oxopiperazine-1-carboxamide
CAS 1008924-98-8C20H21ClN4O3
2-{2-[(4-Ethoxyphenyl)amino]-2-oxoethyl}-3-oxo-N-phenylpiperazine-1-carboxamide chemical structure, C21H24N4O4, CAS 1007886-56-7
2-{2-[(4-Ethoxyphenyl)amino]-2-oxoethyl}-3-oxo-N-phenylpiperazine-1-carboxamide
CAS 1007886-56-7C21H24N4O4
N-(4-Chlorophenyl)-2-{2-[(4-fluorophenyl)amino]-2-oxoethyl}-3-oxopiperazine-1-carboxamide chemical structure, C19H18ClFN4O3, CAS 1009245-92-4
N-(4-Chlorophenyl)-2-{2-[(4-fluorophenyl)amino]-2-oxoethyl}-3-oxopiperazine-1-carboxamide
CAS 1009245-92-4C19H18ClFN4O3
2-{2-[(3,5-Dichlorophenyl)amino]-2-oxoethyl}-3-oxo-N-phenylpiperazine-1-carboxamide chemical structure, C19H18Cl2N4O3, CAS 1022918-35-9
2-{2-[(3,5-Dichlorophenyl)amino]-2-oxoethyl}-3-oxo-N-phenylpiperazine-1-carboxamide
CAS 1022918-35-9C19H18Cl2N4O3
N-(4-Chlorophenyl)-2-(2-((4-ethylphenyl)amino)-2-oxoethyl)-3-oxopiperazine-1-carboxamide chemical structure, C21H23ClN4O3, CAS 1008010-20-5
N-(4-Chlorophenyl)-2-(2-((4-ethylphenyl)amino)-2-oxoethyl)-3-oxopiperazine-1-carboxamide
CAS 1008010-20-5C21H23ClN4O3
N-(3-Chlorophenyl)-2-{2-[(2,5-dimethoxyphenyl)amino]-2-oxoethyl}-3-oxopiperazine-1-carboxamide chemical structure, C21H23ClN4O5, CAS 1025062-94-5
N-(3-Chlorophenyl)-2-{2-[(2,5-dimethoxyphenyl)amino]-2-oxoethyl}-3-oxopiperazine-1-carboxamide
CAS 1025062-94-5C21H23ClN4O5
2-{2-[(2-Methoxyphenyl)amino]-2-oxoethyl}-3-oxo-N-phenylpiperazine-1-carboxamide chemical structure, C20H22N4O4, CAS 1008924-87-5
2-{2-[(2-Methoxyphenyl)amino]-2-oxoethyl}-3-oxo-N-phenylpiperazine-1-carboxamide
CAS 1008924-87-5C20H22N4O4