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Murcko scaffold

Ring system with 3 rings and 16 atoms

119 chemicals on CompoundList share this ring system.

Rings
3
Scaffold atoms
16
Chemicals
119
With full pages
18
Scaffold SMILES

c1ccc(Nc2ncnc3[nH]ncc23)cc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold c1ccc(Nc2ncnc3[nH]ncc23)cc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 48 of 119 chemicals

N-(4-Chlorophenyl)-1-methyl-1H-pyrazolo[3,4-d]pyrimidin-4-amine chemical structure, C12H10ClN5, CAS 5334-66-7
N-(4-Chlorophenyl)-1-methyl-1H-pyrazolo[3,4-d]pyrimidin-4-amine
CAS 5334-66-7C12H10ClN5
4-[(M-Chlorophenyl)amino]-1-methyl-1H-pyrazolo[3,4-D]pyrimidine chemical structure, C12H10ClN5, CAS 5334-67-8
4-[(M-Chlorophenyl)amino]-1-methyl-1H-pyrazolo[3,4-D]pyrimidine
CAS 5334-67-8C12H10ClN5
N-(2-Chlorophenyl)-1-methyl-1H-pyrazolo(3,4-d)pyrimidin-4-amine chemical structure, C12H10ClN5, CAS 5334-68-9
N-(2-Chlorophenyl)-1-methyl-1H-pyrazolo(3,4-d)pyrimidin-4-amine
CAS 5334-68-9C12H10ClN5
N-(2,6-Diethylphenyl)-1-methyl-1H-pyrazolo[3,4-d]pyrimidin-4-amine chemical structure, C16H19N5, CAS 5334-69-0
N-(2,6-Diethylphenyl)-1-methyl-1H-pyrazolo[3,4-d]pyrimidin-4-amine
CAS 5334-69-0C16H19N5
N-(2,5-Dichlorophenyl)-1-methyl-1H-pyrazolo[3,4-d]pyrimidin-4-amine chemical structure, C12H9Cl2N5, CAS 5334-70-3
N-(2,5-Dichlorophenyl)-1-methyl-1H-pyrazolo[3,4-d]pyrimidin-4-amine
CAS 5334-70-3C12H9Cl2N5
1,6-Dimethyl-N-(4-methylphenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine chemical structure, C14H15N5, CAS 5346-55-4
1,6-Dimethyl-N-(4-methylphenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine
CAS 5346-55-4C14H15N5
N-(2,6-Diethylphenyl)-1,6-dimethyl-1H-pyrazolo(3,4-d)pyrimidin-4-amine chemical structure, C17H21N5, CAS 5346-59-8
N-(2,6-Diethylphenyl)-1,6-dimethyl-1H-pyrazolo(3,4-d)pyrimidin-4-amine
CAS 5346-59-8C17H21N5
1,6-Dimethyl-4-[(2-methylphenyl)amino]-1H-pyrazolo[3,4-D]pyrimidine chemical structure, C14H15N5, CAS 5401-53-6
1,6-Dimethyl-4-[(2-methylphenyl)amino]-1H-pyrazolo[3,4-D]pyrimidine
CAS 5401-53-6C14H15N5
6-Chloro-N-(2-chlorophenyl)-1-methyl-1H-pyrazolo[3,4-d]pyrimidin-4-amine chemical structure, C12H9Cl2N5, CAS 5413-95-6
6-Chloro-N-(2-chlorophenyl)-1-methyl-1H-pyrazolo[3,4-d]pyrimidin-4-amine
CAS 5413-95-6C12H9Cl2N5
6-Chloro-N-(2,4-dimethylphenyl)-1-methyl-1H-pyrazolo[3,4-d]pyrimidin-4-amine chemical structure, C14H14ClN5, CAS 5413-97-8
6-Chloro-N-(2,4-dimethylphenyl)-1-methyl-1H-pyrazolo[3,4-d]pyrimidin-4-amine
CAS 5413-97-8C14H14ClN5
6-Chloro-N-(2,5-dimethylphenyl)-1-methyl-1H-pyrazolo[3,4-d]pyrimidin-4-amine chemical structure, C14H14ClN5, CAS 5413-99-0
6-Chloro-N-(2,5-dimethylphenyl)-1-methyl-1H-pyrazolo[3,4-d]pyrimidin-4-amine
CAS 5413-99-0C14H14ClN5
6-Chloro-N-(2,6-dimethylphenyl)-1-methyl-1H-pyrazolo[3,4-d]pyrimidin-4-amine chemical structure, C14H14ClN5, CAS 5414-00-6
6-Chloro-N-(2,6-dimethylphenyl)-1-methyl-1H-pyrazolo[3,4-d]pyrimidin-4-amine
CAS 5414-00-6C14H14ClN5
1-Methyl-N-(4-nitrophenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine chemical structure, C12H10N6O2, CAS 5417-92-5
1-Methyl-N-(4-nitrophenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine
CAS 5417-92-5C12H10N6O2
N-(2,5-Dichlorophenyl)-1,6-dimethyl-1H-pyrazolo[3,4-d]pyrimidin-4-amine chemical structure, C13H11Cl2N5, CAS 6289-07-2
N-(2,5-Dichlorophenyl)-1,6-dimethyl-1H-pyrazolo[3,4-d]pyrimidin-4-amine
CAS 6289-07-2C13H11Cl2N5
1-Methyl-N-(3-methylphenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine chemical structure, C13H13N5, CAS 6289-08-3
1-Methyl-N-(3-methylphenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine
CAS 6289-08-3C13H13N5
N-(2,4-Dimethylphenyl)-1-methyl-1H-pyrazolo[3,4-d]pyrimidin-4-amine chemical structure, C14H15N5, CAS 6289-10-7
N-(2,4-Dimethylphenyl)-1-methyl-1H-pyrazolo[3,4-d]pyrimidin-4-amine
CAS 6289-10-7C14H15N5
N-(2,5-Dimethylphenyl)-1-methyl-1H-pyrazolo[3,4-d]pyrimidin-4-amine chemical structure, C14H15N5, CAS 6289-11-8
N-(2,5-Dimethylphenyl)-1-methyl-1H-pyrazolo[3,4-d]pyrimidin-4-amine
CAS 6289-11-8C14H15N5
N-(2,6-Dimethylphenyl)-1-methyl-1H-pyrazolo[3,4-d]pyrimidin-4-amine chemical structure, C14H15N5, CAS 5418-01-9
N-(2,6-Dimethylphenyl)-1-methyl-1H-pyrazolo[3,4-d]pyrimidin-4-amine
CAS 5418-01-9C14H15N5
6-Chloro-1-methyl-N-(4-nitrophenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine chemical structure, C12H9ClN6O2, CAS 5444-57-5
6-Chloro-1-methyl-N-(4-nitrophenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine
CAS 5444-57-5C12H9ClN6O2
4-[(6-Chloro-1-methyl-1H-pyrazolo[3,4-d]pyrimidin-4-yl)amino]phenol chemical structure, C12H10ClN5O, CAS 5444-59-7
4-[(6-Chloro-1-methyl-1H-pyrazolo[3,4-d]pyrimidin-4-yl)amino]phenol
CAS 5444-59-7C12H10ClN5O
N-(4-Chlorophenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine chemical structure, C11H8ClN5, CAS 120765-47-1
N-(4-Chlorophenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine
CAS 120765-47-1C11H8ClN5
(4-Methylphenyl)(1-methylpyrazolo[4,5-e]pyrimidin-4-yl)amine chemical structure, C13H13N5, CAS 105945-90-2
(4-Methylphenyl)(1-methylpyrazolo[4,5-e]pyrimidin-4-yl)amine
CAS 105945-90-2C13H13N5
4-((1-Methyl-1H-pyrazolo[3,4-d]pyrimidin-4-yl)amino)benzoic acid chemical structure, C13H11N5O2, CAS 361986-42-7
4-((1-Methyl-1H-pyrazolo[3,4-d]pyrimidin-4-yl)amino)benzoic acid
CAS 361986-42-7C13H11N5O2
N-(4-Methoxyphenyl)-1-methyl-1H-pyrazolo[3,4-d]pyrimidin-4-amine chemical structure, C13H13N5O, CAS 361984-85-2
N-(4-Methoxyphenyl)-1-methyl-1H-pyrazolo[3,4-d]pyrimidin-4-amine
CAS 361984-85-2C13H13N5O