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Murcko scaffold

Ring system with 4 rings and 22 atoms

261 chemicals on CompoundList share this ring system.

Rings
4
Scaffold atoms
22
Chemicals
261
With full pages
9
Scaffold SMILES

c1ccc(Nc2ccnc3c(-c4ccccc4)cnn23)cc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold c1ccc(Nc2ccnc3c(-c4ccccc4)cnn23)cc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 48 of 261 chemicals

5-tert-Butyl-N-(4-ethylphenyl)-2-methyl-3-phenylpyrazolo[1,5-a]pyrimidin-7-amine chemical structure, C25H28N4, CAS 849913-25-3
5-tert-Butyl-N-(4-ethylphenyl)-2-methyl-3-phenylpyrazolo[1,5-a]pyrimidin-7-amine
CAS 849913-25-3C25H28N4
N-(3,5-Dichlorophenyl)-2-methyl-3-phenyl-5-(propan-2-yl)pyrazolo[1,5-a]pyrimidin-7-amine chemical structure, C22H20Cl2N4, CAS 896804-84-5
N-(3,5-Dichlorophenyl)-2-methyl-3-phenyl-5-(propan-2-yl)pyrazolo[1,5-a]pyrimidin-7-amine
CAS 896804-84-5C22H20Cl2N4
N-(4-Chlorophenyl)-2-methyl-3-phenyl-5-(propan-2-yl)pyrazolo[1,5-a]pyrimidin-7-amine chemical structure, C22H21ClN4, CAS 896805-82-6
N-(4-Chlorophenyl)-2-methyl-3-phenyl-5-(propan-2-yl)pyrazolo[1,5-a]pyrimidin-7-amine
CAS 896805-82-6C22H21ClN4
N-(3-Methoxyphenyl)-2-methyl-3-phenyl-5-(propan-2-yl)pyrazolo[1,5-a]pyrimidin-7-amine chemical structure, C23H24N4O, CAS 896809-30-6
N-(3-Methoxyphenyl)-2-methyl-3-phenyl-5-(propan-2-yl)pyrazolo[1,5-a]pyrimidin-7-amine
CAS 896809-30-6C23H24N4O
N'-(5-tert-Butyl-3-phenylpyrazolo[1,5-a]pyrimidin-7-yl)-N,N-dimethylbenzene-1,4-diamine chemical structure, C24H27N5, CAS 896811-14-6
N'-(5-tert-Butyl-3-phenylpyrazolo[1,5-a]pyrimidin-7-yl)-N,N-dimethylbenzene-1,4-diamine
CAS 896811-14-6C24H27N5
N-(4-Chlorophenyl)-6-ethyl-2,5-dimethyl-3-phenylpyrazolo[1,5-a]pyrimidin-7-amine chemical structure, C22H21ClN4, CAS 896814-76-9
N-(4-Chlorophenyl)-6-ethyl-2,5-dimethyl-3-phenylpyrazolo[1,5-a]pyrimidin-7-amine
CAS 896814-76-9C22H21ClN4
5-tert-Butyl-3-(4-chlorophenyl)-N-(4-methoxyphenyl)pyrazolo[1,5-a]pyrimidin-7-amine chemical structure, C23H23ClN4O, CAS 896817-15-5
5-tert-Butyl-3-(4-chlorophenyl)-N-(4-methoxyphenyl)pyrazolo[1,5-a]pyrimidin-7-amine
CAS 896817-15-5C23H23ClN4O
2,5-Dimethyl-N,3-diphenylpyrazolo[1,5-a]pyrimidin-7-amine chemical structure, C20H18N4, CAS 849922-42-5
2,5-Dimethyl-N,3-diphenylpyrazolo[1,5-a]pyrimidin-7-amine
CAS 849922-42-5C20H18N4
N-(3,4-Dichlorophenyl)-2-methyl-3-phenyl-5-(propan-2-yl)pyrazolo[1,5-a]pyrimidin-7-amine chemical structure, C22H20Cl2N4, CAS 896820-08-9
N-(3,4-Dichlorophenyl)-2-methyl-3-phenyl-5-(propan-2-yl)pyrazolo[1,5-a]pyrimidin-7-amine
CAS 896820-08-9C22H20Cl2N4
N-[4-({2-Methyl-3-phenyl-5-propylpyrazolo[1,5-A]pyrimidin-7-YL}amino)phenyl]acetamide chemical structure, C24H25N5O, CAS 896820-81-8
N-[4-({2-Methyl-3-phenyl-5-propylpyrazolo[1,5-A]pyrimidin-7-YL}amino)phenyl]acetamide
CAS 896820-81-8C24H25N5O
3-(4-Chlorophenyl)-2,5-dimethyl-N-phenylpyrazolo[1,5-a]pyrimidin-7-amine chemical structure, C20H17ClN4, CAS 849923-11-1
3-(4-Chlorophenyl)-2,5-dimethyl-N-phenylpyrazolo[1,5-a]pyrimidin-7-amine
CAS 849923-11-1C20H17ClN4
N-(4-Ethylphenyl)-5-methyl-3-phenylpyrazolo[1,5-a]pyrimidin-7-amine chemical structure, C21H20N4, CAS 849923-94-0
N-(4-Ethylphenyl)-5-methyl-3-phenylpyrazolo[1,5-a]pyrimidin-7-amine
CAS 849923-94-0C21H20N4
N-(4-Ethoxyphenyl)-2-methyl-3-phenyl-5-(propan-2-yl)pyrazolo[1,5-a]pyrimidin-7-amine chemical structure, C24H26N4O, CAS 896829-94-0
N-(4-Ethoxyphenyl)-2-methyl-3-phenyl-5-(propan-2-yl)pyrazolo[1,5-a]pyrimidin-7-amine
CAS 896829-94-0C24H26N4O
N-(4-{[2-Methyl-3-phenyl-5-(propan-2-yl)pyrazolo[1,5-a]pyrimidin-7-yl]amino}phenyl)acetamide chemical structure, C24H25N5O, CAS 896830-11-8
N-(4-{[2-Methyl-3-phenyl-5-(propan-2-yl)pyrazolo[1,5-a]pyrimidin-7-yl]amino}phenyl)acetamide
CAS 896830-11-8C24H25N5O
N-(4-Methoxyphenyl)-2-methyl-3-phenyl-5-(propan-2-yl)pyrazolo[1,5-a]pyrimidin-7-amine chemical structure, C23H24N4O, CAS 896830-52-7
N-(4-Methoxyphenyl)-2-methyl-3-phenyl-5-(propan-2-yl)pyrazolo[1,5-a]pyrimidin-7-amine
CAS 896830-52-7C23H24N4O
3-(4-Chlorophenyl)-N-(4-fluorophenyl)-5-methylpyrazolo[1,5-a]pyrimidin-7-amine chemical structure, C19H14ClFN4, CAS 896834-37-0
3-(4-Chlorophenyl)-N-(4-fluorophenyl)-5-methylpyrazolo[1,5-a]pyrimidin-7-amine
CAS 896834-37-0C19H14ClFN4
N-(4-Fluorophenyl)-2-methyl-3-phenyl-5-(propan-2-yl)pyrazolo[1,5-a]pyrimidin-7-amine chemical structure, C22H21FN4, CAS 896834-78-9
N-(4-Fluorophenyl)-2-methyl-3-phenyl-5-(propan-2-yl)pyrazolo[1,5-a]pyrimidin-7-amine
CAS 896834-78-9C22H21FN4
N-(4-Chlorophenyl)-2-methyl-3-phenyl-5-propylpyrazolo[1,5-a]pyrimidin-7-amine chemical structure, C22H21ClN4, CAS 896831-08-6
N-(4-Chlorophenyl)-2-methyl-3-phenyl-5-propylpyrazolo[1,5-a]pyrimidin-7-amine
CAS 896831-08-6C22H21ClN4
N-(4-Bromophenyl)-2-methyl-3-phenyl-5-(propan-2-yl)pyrazolo[1,5-a]pyrimidin-7-amine chemical structure, C22H21BrN4, CAS 896833-59-3
N-(4-Bromophenyl)-2-methyl-3-phenyl-5-(propan-2-yl)pyrazolo[1,5-a]pyrimidin-7-amine
CAS 896833-59-3C22H21BrN4
5-tert-Butyl-3-(4-chlorophenyl)-N-(3-methoxyphenyl)pyrazolo[1,5-a]pyrimidin-7-amine chemical structure, C23H23ClN4O, CAS 896835-47-5
5-tert-Butyl-3-(4-chlorophenyl)-N-(3-methoxyphenyl)pyrazolo[1,5-a]pyrimidin-7-amine
CAS 896835-47-5C23H23ClN4O
N-(3,4-Dichlorophenyl)-2-methyl-3-phenyl-5-propylpyrazolo[1,5-a]pyrimidin-7-amine chemical structure, C22H20Cl2N4, CAS 896838-25-8
N-(3,4-Dichlorophenyl)-2-methyl-3-phenyl-5-propylpyrazolo[1,5-a]pyrimidin-7-amine
CAS 896838-25-8C22H20Cl2N4
N-(4-Ethylphenyl)-2,5-dimethyl-3-phenylpyrazolo[1,5-a]pyrimidin-7-amine chemical structure, C22H22N4, CAS 850188-83-9
N-(4-Ethylphenyl)-2,5-dimethyl-3-phenylpyrazolo[1,5-a]pyrimidin-7-amine
CAS 850188-83-9C22H22N4
N-(3-Chloro-4-methylphenyl)-2-methyl-3-phenyl-5-(propan-2-yl)pyrazolo[1,5-a]pyrimidin-7-amine chemical structure, C23H23ClN4, CAS 896845-26-4
N-(3-Chloro-4-methylphenyl)-2-methyl-3-phenyl-5-(propan-2-yl)pyrazolo[1,5-a]pyrimidin-7-amine
CAS 896845-26-4C23H23ClN4
3-(4-Chlorophenyl)-5-methyl-N-[4-(propan-2-yl)phenyl]pyrazolo[1,5-a]pyrimidin-7-amine chemical structure, C22H21ClN4, CAS 896850-38-7
3-(4-Chlorophenyl)-5-methyl-N-[4-(propan-2-yl)phenyl]pyrazolo[1,5-a]pyrimidin-7-amine
CAS 896850-38-7C22H21ClN4