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Murcko scaffold

Ring system with 4 rings and 25 atoms

12 chemicals on CompoundList share this ring system.

Rings
4
Scaffold atoms
25
Chemicals
12
With full pages
1
Scaffold SMILES

O=C(Cc1ccccc1)Nc1cccc(-c2nc3cccnc3s2)c1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=C(Cc1ccccc1)Nc1cccc(-c2nc3cccnc3s2)c1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 12 of 12 chemicals

N-(2-Methyl-3-{[1,3]thiazolo[5,4-B]pyridin-2-YL}phenyl)-2-phenylbutanamide chemical structure, C23H21N3OS, CAS 863593-51-5
N-(2-Methyl-3-{[1,3]thiazolo[5,4-B]pyridin-2-YL}phenyl)-2-phenylbutanamide
CAS 863593-51-5C23H21N3OS
N-(2-Methyl-3-{[1,3]thiazolo[5,4-b]pyridin-2-yl}phenyl)-2-phenylacetamide chemical structure, C21H17N3OS, CAS 863593-24-2
N-(2-Methyl-3-{[1,3]thiazolo[5,4-b]pyridin-2-yl}phenyl)-2-phenylacetamide
CAS 863593-24-2C21H17N3OS
2-(4-Chlorophenyl)-N-(2-methyl-3-{[1,3]thiazolo[5,4-B]pyridin-2-YL}phenyl)acetamide chemical structure, C21H16ClN3OS, CAS 863593-82-2
2-(4-Chlorophenyl)-N-(2-methyl-3-{[1,3]thiazolo[5,4-B]pyridin-2-YL}phenyl)acetamide
CAS 863593-82-2C21H16ClN3OS
2-Phenyl-N-(3-(thiazolo[5,4-b]pyridin-2-yl)phenyl)butanamide chemical structure, C22H19N3OS, CAS 863589-43-9
2-Phenyl-N-(3-(thiazolo[5,4-b]pyridin-2-yl)phenyl)butanamide
CAS 863589-43-9C22H19N3OS
2-(4-Chlorophenyl)-N-(3-(thiazolo[5,4-b]pyridin-2-yl)phenyl)acetamide chemical structure, C20H14ClN3OS, CAS 863592-60-3
2-(4-Chlorophenyl)-N-(3-(thiazolo[5,4-b]pyridin-2-yl)phenyl)acetamide
CAS 863592-60-3C20H14ClN3OS
2-(4-Fluorophenyl)-N-(2-methyl-5-(thiazolo[5,4-b]pyridin-2-yl)phenyl)acetamide chemical structure, C21H16FN3OS, CAS 896678-68-5
2-(4-Fluorophenyl)-N-(2-methyl-5-(thiazolo[5,4-b]pyridin-2-yl)phenyl)acetamide
CAS 896678-68-5C21H16FN3OS
N-(3-(Thiazolo[5,4-b]pyridin-2-yl)phenyl)-2-(m-tolyl)acetamide chemical structure, C21H17N3OS, CAS 863592-46-5
N-(3-(Thiazolo[5,4-b]pyridin-2-yl)phenyl)-2-(m-tolyl)acetamide
CAS 863592-46-5C21H17N3OS
2-(4-Fluorophenyl)-N-(2-methyl-3-(thiazolo[5,4-b]pyridin-2-yl)phenyl)acetamide chemical structure, C21H16FN3OS, CAS 863593-40-2
2-(4-Fluorophenyl)-N-(2-methyl-3-(thiazolo[5,4-b]pyridin-2-yl)phenyl)acetamide
CAS 863593-40-2C21H16FN3OS
2-(4-Bromophenyl)-N-(2-methyl-3-(thiazolo[5,4-b]pyridin-2-yl)phenyl)acetamide chemical structure, C21H16BrN3OS, CAS 941991-65-7
2-(4-Bromophenyl)-N-(2-methyl-3-(thiazolo[5,4-b]pyridin-2-yl)phenyl)acetamide
CAS 941991-65-7C21H16BrN3OS
2-(3,4-Dimethoxyphenyl)-N-(3-(thiazolo[5,4-b]pyridin-2-yl)phenyl)acetamide chemical structure, C22H19N3O3S, CAS 887207-18-3
2-(3,4-Dimethoxyphenyl)-N-(3-(thiazolo[5,4-b]pyridin-2-yl)phenyl)acetamide
CAS 887207-18-3C22H19N3O3S
2-(3,4-Dimethoxyphenyl)-N-(2-methyl-3-{[1,3]thiazolo[5,4-B]pyridin-2-YL}phenyl)acetamide chemical structure, C23H21N3O3S, CAS 887207-26-3
2-(3,4-Dimethoxyphenyl)-N-(2-methyl-3-{[1,3]thiazolo[5,4-B]pyridin-2-YL}phenyl)acetamide
CAS 887207-26-3C23H21N3O3S
2-(3,4-Dimethoxyphenyl)-N-(2-methyl-5-{[1,3]thiazolo[5,4-B]pyridin-2-YL}phenyl)acetamide chemical structure, C23H21N3O3S, CAS 887207-29-6
2-(3,4-Dimethoxyphenyl)-N-(2-methyl-5-{[1,3]thiazolo[5,4-B]pyridin-2-YL}phenyl)acetamide
CAS 887207-29-6C23H21N3O3S