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Murcko scaffold

Ring system with 3 rings and 18 atoms

55 chemicals on CompoundList share this ring system.

Rings
3
Scaffold atoms
18
Chemicals
55
With full pages
10
Scaffold SMILES

O=c1[nH]c(=O)c2nc(-c3ccccc3)nnc2[nH]1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=c1[nH]c(=O)c2nc(-c3ccccc3)nnc2[nH]1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 48 of 55 chemicals

Pyrimido(5,4-e)-1,2,4-triazine-5,7(1H,6H)-dione,3-(3,4-dichlorophenyl)-1,6-dimethyl-, 4-oxide chemical structure, C13H9Cl2N5O3, CAS 32496-16-5
Pyrimido(5,4-e)-1,2,4-triazine-5,7(1H,6H)-dione,3-(3,4-dichlorophenyl)-1,6-dimethyl-, 4-oxide
CAS 32496-16-5C13H9Cl2N5O3
Pyrimido(5,4-e)-1,2,4-triazine-5,7(6H,8H)-dione, 6,8-dimethyl-3-phenyl- chemical structure, C13H11N5O2, CAS 25696-85-9
Pyrimido(5,4-e)-1,2,4-triazine-5,7(6H,8H)-dione, 6,8-dimethyl-3-phenyl-
CAS 25696-85-9C13H11N5O2
8-Ethyl-6-methyl-3-phenylpyrimido[5,4-e][1,2,4]triazine-5,7(6H,8H)-dione chemical structure, C14H13N5O2, CAS 42285-85-8
8-Ethyl-6-methyl-3-phenylpyrimido[5,4-e][1,2,4]triazine-5,7(6H,8H)-dione
CAS 42285-85-8C14H13N5O2
Pyrimido(5,4-e)-1,2,4-triazine-5,7(6H,8H)-dione, 8-(2-hydroxyethyl)-6-methyl-3-phenyl- chemical structure, C14H13N5O3, CAS 42285-89-2
Pyrimido(5,4-e)-1,2,4-triazine-5,7(6H,8H)-dione, 8-(2-hydroxyethyl)-6-methyl-3-phenyl-
CAS 42285-89-2C14H13N5O3
6,8-Dimethyl-3-(4-nitrophenyl)pyrimido[5,4-e][1,2,4]triazine-5,7-dione chemical structure, C13H10N6O4, CAS 25775-01-3
6,8-Dimethyl-3-(4-nitrophenyl)pyrimido[5,4-e][1,2,4]triazine-5,7-dione
CAS 25775-01-3C13H10N6O4
Pyrimido(5,4-e)-1,2,4-triazine-5,7-(1H,6H)-dione, 3-(3,4-dichlorophenyl)-1,6-dimethyl- chemical structure, C13H9Cl2N5O2, CAS 42285-69-8
Pyrimido(5,4-e)-1,2,4-triazine-5,7-(1H,6H)-dione, 3-(3,4-dichlorophenyl)-1,6-dimethyl-
CAS 42285-69-8C13H9Cl2N5O2
Pyrimido(5,4-e)-1,2,4-triazine-5,7(1H,6H)-dione, 3-(3,4-dimethoxyphenyl)-1,6-dimethyl- chemical structure, C15H15N5O4, CAS 32502-16-2
Pyrimido(5,4-e)-1,2,4-triazine-5,7(1H,6H)-dione, 3-(3,4-dimethoxyphenyl)-1,6-dimethyl-
CAS 32502-16-2C15H15N5O4
Pyrimido(5,4-e)-1,2,4-triazine-5,7(1H,6H)-dione, 3-(4-chlorophenyl)-1,6-dimethyl-, 4-oxide chemical structure, C13H10ClN5O3, CAS 32496-15-4
Pyrimido(5,4-e)-1,2,4-triazine-5,7(1H,6H)-dione, 3-(4-chlorophenyl)-1,6-dimethyl-, 4-oxide
CAS 32496-15-4C13H10ClN5O3
Pyrimido(5,4-e)-1,2,4-triazine-5,7(1H,6H)-dione, 3-(4-(dimethylamino)phenyl)-1,6-dimethyl-, 4-oxide chemical structure, C15H16N6O3, CAS 60026-35-9
Pyrimido(5,4-e)-1,2,4-triazine-5,7(1H,6H)-dione, 3-(4-(dimethylamino)phenyl)-1,6-dimethyl-, 4-oxide
CAS 60026-35-9C15H16N6O3
3-(4-(Dimethylamino)phenyl)-1,6-dimethylpyrimido[5,4-e][1,2,4]triazine-5,7(1H,6H)-dione chemical structure, C15H16N6O2, CAS 52199-06-1
3-(4-(Dimethylamino)phenyl)-1,6-dimethylpyrimido[5,4-e][1,2,4]triazine-5,7(1H,6H)-dione
CAS 52199-06-1C15H16N6O2
1,6-Dimethyl-3-phenylpyrimido[5,4-E][1,2,4]triazine-5,7(1H,6H)-dione chemical structure, C13H11N5O2, CAS 32502-63-9
1,6-Dimethyl-3-phenylpyrimido[5,4-E][1,2,4]triazine-5,7(1H,6H)-dione
CAS 32502-63-9C13H11N5O2
3-(4-Chloro-phenyl)-1,6-dimethyl-1H-pyrimido[5,4-e][1,2,4]triazine-5,7-dione chemical structure, C13H10ClN5O2, CAS 42285-61-0
3-(4-Chloro-phenyl)-1,6-dimethyl-1H-pyrimido[5,4-e][1,2,4]triazine-5,7-dione
CAS 42285-61-0C13H10ClN5O2
Pyrimido(5,4-e)-1,2,4-triazine-5,7(6H,8H)-dione, 6,8-dimethyl-3-phenyl-, 4-oxide chemical structure, C13H11N5O3, CAS 41661-91-0
Pyrimido(5,4-e)-1,2,4-triazine-5,7(6H,8H)-dione, 6,8-dimethyl-3-phenyl-, 4-oxide
CAS 41661-91-0C13H11N5O3
Pyrimido(5,4-e)-1,2,4-triazine-5,7(6H,8H)-dione, 3-(4-(dimethylamino)phenyl)-6,8-dimethyl-, 4-oxide chemical structure, C15H16N6O3, CAS 60026-38-2
Pyrimido(5,4-e)-1,2,4-triazine-5,7(6H,8H)-dione, 3-(4-(dimethylamino)phenyl)-6,8-dimethyl-, 4-oxide
CAS 60026-38-2C15H16N6O3
1-Ethyl-6-methyl-3-phenyl-1H-pyrimido[5,4-e][1,2,4]triazine-5,7-dione chemical structure, C14H13N5O2, CAS 164520-05-2
1-Ethyl-6-methyl-3-phenyl-1H-pyrimido[5,4-e][1,2,4]triazine-5,7-dione
CAS 164520-05-2C14H13N5O2
Kdm4C-IN-1 chemical structure, C14H13N5O3, CAS 52348-60-4
Kdm4C-IN-1
CAS 52348-60-4C14H13N5O3
1-Ethyl-3-(4-methoxyphenyl)-6-methylpyrimido[5,4-e][1,2,4]triazine-5,7(1H,6H)-dione chemical structure, C15H15N5O3, CAS 144294-65-5
1-Ethyl-3-(4-methoxyphenyl)-6-methylpyrimido[5,4-e][1,2,4]triazine-5,7(1H,6H)-dione
CAS 144294-65-5C15H15N5O3
3-(4-Fluorophenyl)-1,6-dimethylpyrimido[5,4-e][1,2,4]triazine-5,7(1H,6H)-dione chemical structure, C13H10FN5O2, CAS 878419-28-4
3-(4-Fluorophenyl)-1,6-dimethylpyrimido[5,4-e][1,2,4]triazine-5,7(1H,6H)-dione
CAS 878419-28-4C13H10FN5O2
1,6-Dimethyl-3-(o-tolyl)pyrimido[5,4-e][1,2,4]triazine-5,7(1H,6H)-dione chemical structure, C14H13N5O2, CAS 878419-58-0
1,6-Dimethyl-3-(o-tolyl)pyrimido[5,4-e][1,2,4]triazine-5,7(1H,6H)-dione
CAS 878419-58-0C14H13N5O2
Walrycin B chemical structure, C14H10F3N5O2, CAS 878419-78-4
Walrycin B
CAS 878419-78-4C14H10F3N5O2
1,6-Dimethyl-3-(4-nitrophenyl)pyrimido[5,4-e][1,2,4]triazine-5,7(1H,6H)-dione chemical structure, C13H10N6O4, CAS 891030-19-6
1,6-Dimethyl-3-(4-nitrophenyl)pyrimido[5,4-e][1,2,4]triazine-5,7(1H,6H)-dione
CAS 891030-19-6C13H10N6O4
3-(2-Bromophenyl)-1,6-dimethylpyrimido[5,4-e][1,2,4]triazine-5,7(1H,6H)-dione chemical structure, C13H10BrN5O2, CAS 1023459-90-6
3-(2-Bromophenyl)-1,6-dimethylpyrimido[5,4-e][1,2,4]triazine-5,7(1H,6H)-dione
CAS 1023459-90-6C13H10BrN5O2
3-(3-Bromophenyl)-1,6-dimethylpyrimido[5,4-e][1,2,4]triazine-5,7(1H,6H)-dione chemical structure, C13H10BrN5O2, CAS 1023846-10-7
3-(3-Bromophenyl)-1,6-dimethylpyrimido[5,4-e][1,2,4]triazine-5,7(1H,6H)-dione
CAS 1023846-10-7C13H10BrN5O2
1-Ethyl-6-methyl-3-(o-tolyl)pyrimido[5,4-e][1,2,4]triazine-5,7(1H,6H)-dione chemical structure, C15H15N5O2, CAS 878419-93-3
1-Ethyl-6-methyl-3-(o-tolyl)pyrimido[5,4-e][1,2,4]triazine-5,7(1H,6H)-dione
CAS 878419-93-3C15H15N5O2