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Murcko scaffold

3-Benzyl-3,6-dihydropyrazine-2,5-diol scaffold

63 chemicals on CompoundList share this ring system.

Rings
2
Scaffold atoms
15
Chemicals
63
With full pages
15
Scaffold SMILES

O=C1CNC(=O)C(Cc2ccccc2)N1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffoldOpen the 3-Benzyl-3,6-dihydropyrazine-2,5-diol page
Murcko scaffold O=C1CNC(=O)C(Cc2ccccc2)N1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 48 of 63 chemicals

Cyclo(tyrosylarginyl) chemical structure, C15H21N5O3, CAS 81205-31-4
Cyclo(tyrosylarginyl)
CAS 81205-31-4C15H21N5O3
(2S,5S)-3,6-Dioxo-5-(phenylmethyl)-2-piperazineacetic acid chemical structure, C13H14N2O4, CAS 5262-10-2
(2S,5S)-3,6-Dioxo-5-(phenylmethyl)-2-piperazineacetic acid
CAS 5262-10-2C13H14N2O4
3-Carboxymethyl-6-benzyl-2,5-diketopiperazine chemical structure, C13H14N2O4, CAS 55102-13-1
3-Carboxymethyl-6-benzyl-2,5-diketopiperazine
CAS 55102-13-1C13H14N2O4
1-Methyl-3-(2,4,5-trimethoxy-3-methylphenylmethyl)-2,5-piperazinedione chemical structure, C16H22N2O5, CAS 120040-38-2
1-Methyl-3-(2,4,5-trimethoxy-3-methylphenylmethyl)-2,5-piperazinedione
CAS 120040-38-2C16H22N2O5
Cyclo(N-methyltyrosylarginyl) chemical structure, C16H23N5O3, CAS 83481-39-4
Cyclo(N-methyltyrosylarginyl)
CAS 83481-39-4C16H23N5O3
Cyclo(ethyltyrosylhomoarginyl) chemical structure, C18H27N5O3, CAS 85676-05-7
Cyclo(ethyltyrosylhomoarginyl)
CAS 85676-05-7C18H27N5O3
3-Benzyl-3,6-dihydropyrazine-2,5-diol chemical structure, C11H12N2O2, CAS 5037-75-2
3-Benzyl-3,6-dihydropyrazine-2,5-diol
CAS 5037-75-2C11H12N2O2
3-[(4-Hydroxyphenyl)methyl]piperazine-2,5-dione chemical structure, C11H12N2O3, CAS 5625-49-0
3-[(4-Hydroxyphenyl)methyl]piperazine-2,5-dione
CAS 5625-49-0C11H12N2O3
3-Benzyl-6-isopropyl-2,5-piperazinedione chemical structure, C14H18N2O2, CAS 14474-71-6
3-Benzyl-6-isopropyl-2,5-piperazinedione
CAS 14474-71-6C14H18N2O2
3-Benzyl-6-methyl-2,5-piperazinedione chemical structure, C12H14N2O2, CAS 14474-78-3
3-Benzyl-6-methyl-2,5-piperazinedione
CAS 14474-78-3C12H14N2O2
2,5-Piperazinedione, 3-(hydroxymethyl)-6-((4-((3-methyl-2-butenyl)oxy)phenyl)methyl)-, (3S,6S)- chemical structure, C17H22N2O4, CAS 74347-50-5
2,5-Piperazinedione, 3-(hydroxymethyl)-6-((4-((3-methyl-2-butenyl)oxy)phenyl)methyl)-, (3S,6S)-
CAS 74347-50-5C17H22N2O4
2-Benzyl-1,4-dimethyl-5-hydroxymethyl 2,5-bis(methylthio)-3,6-diketopiperazine chemical structure, C16H22N2O3S2, CAS 50655-20-4
2-Benzyl-1,4-dimethyl-5-hydroxymethyl 2,5-bis(methylthio)-3,6-diketopiperazine
CAS 50655-20-4C16H22N2O3S2
N-(3-{3,6-Dihydroxy-5-[(4-hydroxyphenyl)methyl]-2,5-dihydropyrazin-2-yl}propyl)guanidine chemical structure, C15H21N5O3, CAS 81205-34-7
N-(3-{3,6-Dihydroxy-5-[(4-hydroxyphenyl)methyl]-2,5-dihydropyrazin-2-yl}propyl)guanidine
CAS 81205-34-7C15H21N5O3
Cyclo(Phe-Leu) chemical structure, C15H20N2O2, CAS 3354-31-2
Cyclo(Phe-Leu)
CAS 3354-31-2C15H20N2O2
2,5-Piperazinedione, 3-(hydroxymethyl)-6-(phenylmethyl)- chemical structure, C12H14N2O3, CAS 57287-86-2
2,5-Piperazinedione, 3-(hydroxymethyl)-6-(phenylmethyl)-
CAS 57287-86-2C12H14N2O3
Cyclo(Ala-Tyr) chemical structure, C12H14N2O3, CAS 21754-26-7
Cyclo(Ala-Tyr)
CAS 21754-26-7C12H14N2O3
Cyclo(Tyr-Leu) chemical structure, C15H20N2O3, CAS 82863-65-8
Cyclo(Tyr-Leu)
CAS 82863-65-8C15H20N2O3
Rel-2-((2R,5S)-5-benzyl-3,6-dioxopiperazin-2-yl)acetic acid chemical structure, C13H14N2O4, CAS 130856-97-2
Rel-2-((2R,5S)-5-benzyl-3,6-dioxopiperazin-2-yl)acetic acid
CAS 130856-97-2C13H14N2O4
2-((2R,5R)-5-Benzyl-3,6-dioxopiperazin-2-yl)acetic acid chemical structure, C13H14N2O4, CAS 130856-96-1
2-((2R,5R)-5-Benzyl-3,6-dioxopiperazin-2-yl)acetic acid
CAS 130856-96-1C13H14N2O4
(3R)-3-Benzylpiperazine-2,5-dione chemical structure, C11H12N2O2, CAS 23927-19-7
(3R)-3-Benzylpiperazine-2,5-dione
CAS 23927-19-7C11H12N2O2
Cyclo(seryltyrosyl) chemical structure, C12H14N2O4, CAS 21754-31-4
Cyclo(seryltyrosyl)
CAS 21754-31-4C12H14N2O4
(3S,6S)-3-Benzyl-6-(hydroxymethyl)piperazine-2,5-dione chemical structure, C12H14N2O3, CAS 35591-00-5
(3S,6S)-3-Benzyl-6-(hydroxymethyl)piperazine-2,5-dione
CAS 35591-00-5C12H14N2O3
Cyclo(L-leucyl-L-phenylalanyl) chemical structure, C15H20N2O2, CAS 7280-77-5
Cyclo(L-leucyl-L-phenylalanyl)
CAS 7280-77-5C15H20N2O2
Cyclo(-Gly-Phe) chemical structure, C11H12N2O2, CAS 10125-07-2
Cyclo(-Gly-Phe)
CAS 10125-07-2C11H12N2O2