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Murcko scaffold

3-Phenyl-1-(piperazin-1-yl)propan-1-one scaffold

65 chemicals on CompoundList share this ring system.

Rings
2
Scaffold atoms
16
Chemicals
65
With full pages
7
Scaffold SMILES

O=C(CCc1ccccc1)N1CCNCC1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffoldOpen the 3-Phenyl-1-(piperazin-1-yl)propan-1-one page
Murcko scaffold O=C(CCc1ccccc1)N1CCNCC1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 49 to 65 of 65 chemicals

N-[1-(2,4-Difluorophenyl)-3-oxo-3-(4-prop-2-ynylpiperazin-1-yl)propyl]acetamide chemical structure, C18H21F2N3O2, CAS 1436108-74-5
N-[1-(2,4-Difluorophenyl)-3-oxo-3-(4-prop-2-ynylpiperazin-1-yl)propyl]acetamide
CAS 1436108-74-5C18H21F2N3O2
3-(2-Bromo-4-methylphenyl)-1-(piperazin-1-yl)propan-1-one chemical structure, C14H19BrN2O, CAS 1478765-73-9
3-(2-Bromo-4-methylphenyl)-1-(piperazin-1-yl)propan-1-one
CAS 1478765-73-9C14H19BrN2O
3-(3-Chlorophenyl)-1-(4-methylpiperazin-1-yl)propan-1-one chemical structure, C14H19ClN2O, CAS 1328522-31-1
3-(3-Chlorophenyl)-1-(4-methylpiperazin-1-yl)propan-1-one
CAS 1328522-31-1C14H19ClN2O
tert-Butyl 4-(3-(4-bromophenyl)propanoyl)piperazine-1-carboxylate chemical structure, C18H25BrN2O3, CAS 1704065-10-0
tert-Butyl 4-(3-(4-bromophenyl)propanoyl)piperazine-1-carboxylate
CAS 1704065-10-0C18H25BrN2O3
1-(3-Methylpiperazin-1-yl)-3-phenylpropan-1-one hydrochloride chemical structure, C14H21ClN2O, CAS 1833260-17-5
1-(3-Methylpiperazin-1-yl)-3-phenylpropan-1-one hydrochloride
CAS 1833260-17-5C14H21ClN2O
3-(3-Chlorophenyl)-1-[4-(2-fluoroethyl)piperazin-1-yl]propan-1-one chemical structure, C15H20ClFN2O, CAS 2034561-75-4
3-(3-Chlorophenyl)-1-[4-(2-fluoroethyl)piperazin-1-yl]propan-1-one
CAS 2034561-75-4C15H20ClFN2O
3-(4-Iodophenyl)-1-(4-methylpiperazin-1-yl)-propan-1-one chemical structure, C14H19IN2O, CAS 2374758-37-7
3-(4-Iodophenyl)-1-(4-methylpiperazin-1-yl)-propan-1-one
CAS 2374758-37-7C14H19IN2O
Methyl (E)-4-oxo-4-[4-(3-phenylbutanoyl)piperazin-1-yl]but-2-enoate chemical structure, C19H24N2O4, CAS 2411327-19-8
Methyl (E)-4-oxo-4-[4-(3-phenylbutanoyl)piperazin-1-yl]but-2-enoate
CAS 2411327-19-8C19H24N2O4
(R)-N-(3-(4-Amino-3-fluorophenyl)-1-(4-methylpiperazin-1-yl)-1-oxopropan-2-yl)propionamide chemical structure, C17H25FN4O2, CAS 2467738-43-6
(R)-N-(3-(4-Amino-3-fluorophenyl)-1-(4-methylpiperazin-1-yl)-1-oxopropan-2-yl)propionamide
CAS 2467738-43-6C17H25FN4O2
N-((2R,3S)-3-(4-Amino-3-fluorophenyl)-1-(4-methylpiperazin-1-yl)-1-oxobutan-2-yl)propionamide chemical structure, C18H27FN4O2, CAS 2467738-92-5
N-((2R,3S)-3-(4-Amino-3-fluorophenyl)-1-(4-methylpiperazin-1-yl)-1-oxobutan-2-yl)propionamide
CAS 2467738-92-5C18H27FN4O2
N-[3-(3-Fluoro-4-nitrophenyl)-1-(4-methylpiperazin-1-yl)-1-oxobutan-2-yl]propanamide chemical structure, C18H25FN4O4, CAS 2467738-90-3
N-[3-(3-Fluoro-4-nitrophenyl)-1-(4-methylpiperazin-1-yl)-1-oxobutan-2-yl]propanamide
CAS 2467738-90-3C18H25FN4O4
3-(4-Aminophenyl)-1-(4-(2,2,2-trifluoroethyl)piperazin-1-yl)propan-1-one chemical structure, C15H20F3N3O, CAS 3078325-73-9
3-(4-Aminophenyl)-1-(4-(2,2,2-trifluoroethyl)piperazin-1-yl)propan-1-one
CAS 3078325-73-9C15H20F3N3O
tert-Butyl 4-(3-(4-aminophenyl)propanoyl)-2-methylpiperazine-1-carboxylate chemical structure, C19H29N3O3, CAS 3078327-76-8
tert-Butyl 4-(3-(4-aminophenyl)propanoyl)-2-methylpiperazine-1-carboxylate
CAS 3078327-76-8C19H29N3O3
3-(3-Aminophenyl)-1-(4-(2,2,2-trifluoroethyl)piperazin-1-yl)propan-1-one chemical structure, C15H20F3N3O, CAS 1580100-26-0
3-(3-Aminophenyl)-1-(4-(2,2,2-trifluoroethyl)piperazin-1-yl)propan-1-one
CAS 1580100-26-0C15H20F3N3O
Lrat-IN-1 chemical structure, C27H47N5O5S2, CAS 2820064-05-7
Lrat-IN-1
CAS 2820064-05-7C27H47N5O5S2
tert-Butyl N-[2-[4-(2-amino-3-phenylpropanoyl)piperazin-1-yl]ethyl]carbamate chemical structure, C20H32N4O3, CAS 3078589-91-7
tert-Butyl N-[2-[4-(2-amino-3-phenylpropanoyl)piperazin-1-yl]ethyl]carbamate
CAS 3078589-91-7C20H32N4O3
3-(3-Chlorophenyl)-1-(4-isopropylpiperazin-1-yl)propan-1-one chemical structure, C16H23ClN2O, CAS 2327405-68-3
3-(3-Chlorophenyl)-1-(4-isopropylpiperazin-1-yl)propan-1-one
CAS 2327405-68-3C16H23ClN2O