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Murcko scaffold

Ring system with 4 rings and 30 atoms

20 chemicals on CompoundList share this ring system.

Rings
4
Scaffold atoms
30
Chemicals
20
With full pages
2
Scaffold SMILES

O=C(CSc1nnc(-c2ccccc2)n1-c1ccccc1)NN=Cc1ccncc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=C(CSc1nnc(-c2ccccc2)n1-c1ccccc1)NN=Cc1ccncc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 20 of 20 chemicals

2-[[4-Phenyl-5-(3,4,5-trimethoxyphenyl)-1,2,4-triazol-3-yl]sulfanyl]-N-[(E)-pyridin-4-ylmethylideneamino]acetamide chemical structure, C25H24N6O4S, CAS 5751-63-3
2-[[4-Phenyl-5-(3,4,5-trimethoxyphenyl)-1,2,4-triazol-3-yl]sulfanyl]-N-[(E)-pyridin-4-ylmethylideneamino]acetamide
CAS 5751-63-3C25H24N6O4S
2-[[5-(4-Chlorophenyl)-4-(4-ethoxyphenyl)-1,2,4-triazol-3-yl]sulfanyl]-N-[(Z)-1-pyridin-4-ylethylideneamino]acetamide chemical structure, C25H23ClN6O2S, CAS 488096-15-7
2-[[5-(4-Chlorophenyl)-4-(4-ethoxyphenyl)-1,2,4-triazol-3-yl]sulfanyl]-N-[(Z)-1-pyridin-4-ylethylideneamino]acetamide
CAS 488096-15-7C25H23ClN6O2S
2-[[5-(4-Methoxyphenyl)-4-(4-methylphenyl)-1,2,4-triazol-3-yl]sulfanyl]-N-[(Z)-1-pyridin-4-ylethylideneamino]acetamide chemical structure, C25H24N6O2S, CAS 497077-08-4
2-[[5-(4-Methoxyphenyl)-4-(4-methylphenyl)-1,2,4-triazol-3-yl]sulfanyl]-N-[(Z)-1-pyridin-4-ylethylideneamino]acetamide
CAS 497077-08-4C25H24N6O2S
2-[[4-(4-Chlorophenyl)-5-(4-methylphenyl)-1,2,4-triazol-3-yl]sulfanyl]-N-[(Z)-1-pyridin-4-ylethylideneamino]acetamide chemical structure, C24H21ClN6OS, CAS 488810-39-5
2-[[4-(4-Chlorophenyl)-5-(4-methylphenyl)-1,2,4-triazol-3-yl]sulfanyl]-N-[(Z)-1-pyridin-4-ylethylideneamino]acetamide
CAS 488810-39-5C24H21ClN6OS
2-[[4,5-Bis(4-methylphenyl)-1,2,4-triazol-3-yl]sulfanyl]-N-[(Z)-1-pyridin-4-ylethylideneamino]acetamide chemical structure, C25H24N6OS, CAS 488726-04-1
2-[[4,5-Bis(4-methylphenyl)-1,2,4-triazol-3-yl]sulfanyl]-N-[(Z)-1-pyridin-4-ylethylideneamino]acetamide
CAS 488726-04-1C25H24N6OS
2-[[5-(4-Chlorophenyl)-4-(4-methylphenyl)-1,2,4-triazol-3-yl]sulfanyl]-N-[(Z)-1-pyridin-4-ylethylideneamino]acetamide chemical structure, C24H21ClN6OS, CAS 315231-89-1
2-[[5-(4-Chlorophenyl)-4-(4-methylphenyl)-1,2,4-triazol-3-yl]sulfanyl]-N-[(Z)-1-pyridin-4-ylethylideneamino]acetamide
CAS 315231-89-1C24H21ClN6OS
2-[[5-(4-Methoxyphenyl)-4-phenyl-1,2,4-triazol-3-yl]sulfanyl]-N-[(Z)-pyridin-4-ylmethylideneamino]acetamide chemical structure, C23H20N6O2S, CAS 314288-79-4
2-[[5-(4-Methoxyphenyl)-4-phenyl-1,2,4-triazol-3-yl]sulfanyl]-N-[(Z)-pyridin-4-ylmethylideneamino]acetamide
CAS 314288-79-4C23H20N6O2S
2-[[5-(4-Methylphenyl)-4-phenyl-1,2,4-triazol-3-yl]sulfanyl]-N-[(Z)-pyridin-4-ylmethylideneamino]acetamide chemical structure, C23H20N6OS, CAS 306750-80-1
2-[[5-(4-Methylphenyl)-4-phenyl-1,2,4-triazol-3-yl]sulfanyl]-N-[(Z)-pyridin-4-ylmethylideneamino]acetamide
CAS 306750-80-1C23H20N6OS
2-[[5-(4-tert-Butylphenyl)-4-(4-methylphenyl)-1,2,4-triazol-3-yl]sulfanyl]-N-[(E)-pyridin-4-ylmethylideneamino]acetamide chemical structure, C27H28N6OS, CAS 488841-66-3
2-[[5-(4-tert-Butylphenyl)-4-(4-methylphenyl)-1,2,4-triazol-3-yl]sulfanyl]-N-[(E)-pyridin-4-ylmethylideneamino]acetamide
CAS 488841-66-3C27H28N6OS
2-[[4-(4-Methylphenyl)-5-phenyl-1,2,4-triazol-3-yl]sulfanyl]-N-[(E)-pyridin-4-ylmethylideneamino]acetamide chemical structure, C23H20N6OS, CAS 314071-61-9
2-[[4-(4-Methylphenyl)-5-phenyl-1,2,4-triazol-3-yl]sulfanyl]-N-[(E)-pyridin-4-ylmethylideneamino]acetamide
CAS 314071-61-9C23H20N6OS
2-{[5-(4-tert-Butylphenyl)-4-phenyl-4H-1,2,4-triazol-3-yl]sulfanyl}-N'-[(E)-1-(4-pyridinyl)ethylidene]acetohydrazide chemical structure, C27H28N6OS, CAS 303107-36-0
2-{[5-(4-tert-Butylphenyl)-4-phenyl-4H-1,2,4-triazol-3-yl]sulfanyl}-N'-[(E)-1-(4-pyridinyl)ethylidene]acetohydrazide
CAS 303107-36-0C27H28N6OS
2-[[5-(4-tert-Butylphenyl)-4-(4-methoxyphenyl)-1,2,4-triazol-3-yl]sulfanyl]-N-[(Z)-1-pyridin-4-ylethylideneamino]acetamide chemical structure, C28H30N6O2S, CAS 488121-56-8
2-[[5-(4-tert-Butylphenyl)-4-(4-methoxyphenyl)-1,2,4-triazol-3-yl]sulfanyl]-N-[(Z)-1-pyridin-4-ylethylideneamino]acetamide
CAS 488121-56-8C28H30N6O2S
2-[[4,5-Bis(4-methoxyphenyl)-1,2,4-triazol-3-yl]sulfanyl]-N-[(Z)-1-pyridin-4-ylethylideneamino]acetamide chemical structure, C25H24N6O3S, CAS 406464-59-3
2-[[4,5-Bis(4-methoxyphenyl)-1,2,4-triazol-3-yl]sulfanyl]-N-[(Z)-1-pyridin-4-ylethylideneamino]acetamide
CAS 406464-59-3C25H24N6O3S
2-[[4-(4-Chlorophenyl)-5-(4-methoxyphenyl)-1,2,4-triazol-3-yl]sulfanyl]-N-[(Z)-1-pyridin-4-ylethylideneamino]acetamide chemical structure, C24H21ClN6O2S, CAS 406467-13-8
2-[[4-(4-Chlorophenyl)-5-(4-methoxyphenyl)-1,2,4-triazol-3-yl]sulfanyl]-N-[(Z)-1-pyridin-4-ylethylideneamino]acetamide
CAS 406467-13-8C24H21ClN6O2S
2-[[5-(3,4-Dimethoxyphenyl)-4-phenyl-1,2,4-triazol-3-yl]sulfanyl]-N-[(Z)-pyridin-4-ylmethylideneamino]acetamide chemical structure, C24H22N6O3S, CAS 306756-82-1
2-[[5-(3,4-Dimethoxyphenyl)-4-phenyl-1,2,4-triazol-3-yl]sulfanyl]-N-[(Z)-pyridin-4-ylmethylideneamino]acetamide
CAS 306756-82-1C24H22N6O3S
2-[[5-(4-Chlorophenyl)-4-phenyl-1,2,4-triazol-3-yl]sulfanyl]-N-[(E)-pyridin-4-ylmethylideneamino]acetamide chemical structure, C22H17ClN6OS, CAS 306757-57-3
2-[[5-(4-Chlorophenyl)-4-phenyl-1,2,4-triazol-3-yl]sulfanyl]-N-[(E)-pyridin-4-ylmethylideneamino]acetamide
CAS 306757-57-3C22H17ClN6OS
2-[(4,5-Diphenyl-1,2,4-triazol-3-yl)sulfanyl]-N-[(E)-pyridin-4-ylmethylideneamino]acetamide chemical structure, C22H18N6OS, CAS 306756-17-2
2-[(4,5-Diphenyl-1,2,4-triazol-3-yl)sulfanyl]-N-[(E)-pyridin-4-ylmethylideneamino]acetamide
CAS 306756-17-2C22H18N6OS
2-((5-(4-Bromophenyl)-4-phenyl-4H-1,2,4-triazol-3-yl)sulfanyl)-N'-((E)-4-pyridinylmethylidene)acetohydrazide chemical structure, C22H17BrN6OS, CAS 303103-34-6
2-((5-(4-Bromophenyl)-4-phenyl-4H-1,2,4-triazol-3-yl)sulfanyl)-N'-((E)-4-pyridinylmethylidene)acetohydrazide
CAS 303103-34-6C22H17BrN6OS
2-[[4-(4-Bromophenyl)-5-phenyl-1,2,4-triazol-3-yl]sulfanyl]-N-[(Z)-1-pyridin-4-ylethylideneamino]acetamide chemical structure, C23H19BrN6OS, CAS 497083-34-8
2-[[4-(4-Bromophenyl)-5-phenyl-1,2,4-triazol-3-yl]sulfanyl]-N-[(Z)-1-pyridin-4-ylethylideneamino]acetamide
CAS 497083-34-8C23H19BrN6OS
2-[[4,5-Bis(4-chlorophenyl)-1,2,4-triazol-3-yl]sulfanyl]-N-[(Z)-1-pyridin-4-ylethylideneamino]acetamide chemical structure, C23H18Cl2N6OS, CAS 489397-13-9
2-[[4,5-Bis(4-chlorophenyl)-1,2,4-triazol-3-yl]sulfanyl]-N-[(Z)-1-pyridin-4-ylethylideneamino]acetamide
CAS 489397-13-9C23H18Cl2N6OS