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Murcko scaffold

Ring system with 4 rings and 30 atoms

15 chemicals on CompoundList share this ring system.

Rings
4
Scaffold atoms
30
Chemicals
15
With full pages
1
Scaffold SMILES

O=C(CSc1nnc(-c2ccccc2)n1-c1ccccc1)NN=Cc1cccnc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=C(CSc1nnc(-c2ccccc2)n1-c1ccccc1)NN=Cc1cccnc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 15 of 15 chemicals

2-[[4-Phenyl-5-(3,4,5-trimethoxyphenyl)-1,2,4-triazol-3-yl]sulfanyl]-N-[(E)-pyridin-3-ylmethylideneamino]acetamide chemical structure, C25H24N6O4S, CAS 315183-51-8
2-[[4-Phenyl-5-(3,4,5-trimethoxyphenyl)-1,2,4-triazol-3-yl]sulfanyl]-N-[(E)-pyridin-3-ylmethylideneamino]acetamide
CAS 315183-51-8C25H24N6O4S
2-[[4-(4-Chlorophenyl)-5-(4-methylphenyl)-1,2,4-triazol-3-yl]sulfanyl]-N-[(Z)-1-pyridin-3-ylethylideneamino]acetamide chemical structure, C24H21ClN6OS, CAS 380474-09-9
2-[[4-(4-Chlorophenyl)-5-(4-methylphenyl)-1,2,4-triazol-3-yl]sulfanyl]-N-[(Z)-1-pyridin-3-ylethylideneamino]acetamide
CAS 380474-09-9C24H21ClN6OS
2-[[4-(4-Ethoxyphenyl)-5-phenyl-1,2,4-triazol-3-yl]sulfanyl]-N-[(Z)-1-pyridin-3-ylethylideneamino]acetamide chemical structure, C25H24N6O2S, CAS 496775-11-2
2-[[4-(4-Ethoxyphenyl)-5-phenyl-1,2,4-triazol-3-yl]sulfanyl]-N-[(Z)-1-pyridin-3-ylethylideneamino]acetamide
CAS 496775-11-2C25H24N6O2S
2-[[5-(4-Chlorophenyl)-4-(4-ethoxyphenyl)-1,2,4-triazol-3-yl]sulfanyl]-N-[(Z)-1-pyridin-3-ylethylideneamino]acetamide chemical structure, C25H23ClN6O2S, CAS 488096-88-4
2-[[5-(4-Chlorophenyl)-4-(4-ethoxyphenyl)-1,2,4-triazol-3-yl]sulfanyl]-N-[(Z)-1-pyridin-3-ylethylideneamino]acetamide
CAS 488096-88-4C25H23ClN6O2S
2-[[5-(4-Chlorophenyl)-4-(4-methylphenyl)-1,2,4-triazol-3-yl]sulfanyl]-N-[(Z)-1-pyridin-3-ylethylideneamino]acetamide chemical structure, C24H21ClN6OS, CAS 315231-88-0
2-[[5-(4-Chlorophenyl)-4-(4-methylphenyl)-1,2,4-triazol-3-yl]sulfanyl]-N-[(Z)-1-pyridin-3-ylethylideneamino]acetamide
CAS 315231-88-0C24H21ClN6OS
2-[[5-(4-Methylphenyl)-4-phenyl-1,2,4-triazol-3-yl]sulfanyl]-N-[(Z)-pyridin-3-ylmethylideneamino]acetamide chemical structure, C23H20N6OS, CAS 314287-26-8
2-[[5-(4-Methylphenyl)-4-phenyl-1,2,4-triazol-3-yl]sulfanyl]-N-[(Z)-pyridin-3-ylmethylideneamino]acetamide
CAS 314287-26-8C23H20N6OS
2-[[5-(4-tert-Butylphenyl)-4-(4-methylphenyl)-1,2,4-triazol-3-yl]sulfanyl]-N-[(E)-pyridin-3-ylmethylideneamino]acetamide chemical structure, C27H28N6OS, CAS 489396-17-0
2-[[5-(4-tert-Butylphenyl)-4-(4-methylphenyl)-1,2,4-triazol-3-yl]sulfanyl]-N-[(E)-pyridin-3-ylmethylideneamino]acetamide
CAS 489396-17-0C27H28N6OS
2-{[4,5-Bis(4-chlorophenyl)-4H-1,2,4-triazol-3-yl]sulfanyl}-N'-[(E)-3-pyridinylmethylidene]acetohydrazide chemical structure, C22H16Cl2N6OS, CAS 488803-01-6
2-{[4,5-Bis(4-chlorophenyl)-4H-1,2,4-triazol-3-yl]sulfanyl}-N'-[(E)-3-pyridinylmethylidene]acetohydrazide
CAS 488803-01-6C22H16Cl2N6OS
2-((5-(4-Bromophenyl)-4-phenyl-4H-1,2,4-triazol-3-yl)sulfanyl)-N'-((E)-3-pyridinylmethylidene)acetohydrazide chemical structure, C22H17BrN6OS, CAS 303103-58-4
2-((5-(4-Bromophenyl)-4-phenyl-4H-1,2,4-triazol-3-yl)sulfanyl)-N'-((E)-3-pyridinylmethylidene)acetohydrazide
CAS 303103-58-4C22H17BrN6OS
2-[(4,5-Diphenyl-1,2,4-triazol-3-yl)sulfanyl]-N-[(E)-pyridin-3-ylmethylideneamino]acetamide chemical structure, C22H18N6OS, CAS 304450-21-3
2-[(4,5-Diphenyl-1,2,4-triazol-3-yl)sulfanyl]-N-[(E)-pyridin-3-ylmethylideneamino]acetamide
CAS 304450-21-3C22H18N6OS
2-[[4,5-Bis(4-chlorophenyl)-1,2,4-triazol-3-yl]sulfanyl]-N-[(Z)-1-pyridin-3-ylethylideneamino]acetamide chemical structure, C23H18Cl2N6OS, CAS 498544-10-8
2-[[4,5-Bis(4-chlorophenyl)-1,2,4-triazol-3-yl]sulfanyl]-N-[(Z)-1-pyridin-3-ylethylideneamino]acetamide
CAS 498544-10-8C23H18Cl2N6OS
2-[[4-(4-Bromophenyl)-5-phenyl-1,2,4-triazol-3-yl]sulfanyl]-N-[(Z)-1-pyridin-3-ylethylideneamino]acetamide chemical structure, C23H19BrN6OS, CAS 488724-93-2
2-[[4-(4-Bromophenyl)-5-phenyl-1,2,4-triazol-3-yl]sulfanyl]-N-[(Z)-1-pyridin-3-ylethylideneamino]acetamide
CAS 488724-93-2C23H19BrN6OS
2-[[4-(4-Chlorophenyl)-5-(4-methoxyphenyl)-1,2,4-triazol-3-yl]sulfanyl]-N-[(Z)-1-pyridin-3-ylethylideneamino]acetamide chemical structure, C24H21ClN6O2S, CAS 406467-12-7
2-[[4-(4-Chlorophenyl)-5-(4-methoxyphenyl)-1,2,4-triazol-3-yl]sulfanyl]-N-[(Z)-1-pyridin-3-ylethylideneamino]acetamide
CAS 406467-12-7C24H21ClN6O2S
2-[[4-(4-Chlorophenyl)-5-phenyl-1,2,4-triazol-3-yl]sulfanyl]-N-[(Z)-1-pyridin-3-ylethylideneamino]acetamide chemical structure, C23H19ClN6OS, CAS 315200-24-9
2-[[4-(4-Chlorophenyl)-5-phenyl-1,2,4-triazol-3-yl]sulfanyl]-N-[(Z)-1-pyridin-3-ylethylideneamino]acetamide
CAS 315200-24-9C23H19ClN6OS
2-[[5-(4-tert-Butylphenyl)-4-(4-methoxyphenyl)-1,2,4-triazol-3-yl]sulfanyl]-N-[(Z)-1-pyridin-3-ylethylideneamino]acetamide chemical structure, C28H30N6O2S, CAS 488852-49-9
2-[[5-(4-tert-Butylphenyl)-4-(4-methoxyphenyl)-1,2,4-triazol-3-yl]sulfanyl]-N-[(Z)-1-pyridin-3-ylethylideneamino]acetamide
CAS 488852-49-9C28H30N6O2S