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Murcko scaffold

Ring system with 4 rings and 30 atoms

451 chemicals on CompoundList share this ring system.

Rings: 4
Scaffold atoms: 30
Chemicals: 451
With full pages: 55

Scaffold SMILES

O=C(CSc1nnc(-c2ccccc2)n1-c1ccccc1)NN=Cc1ccccc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold

Murcko scaffold O=C(CSc1nnc(-c2ccccc2)n1-c1ccccc1)NN=Cc1ccccc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 48 of 451 chemicals

2-((4,5-Diphenyl-4H-1,2,4-triazol-3-yl)thio)-N'-(2,4,6-trimethoxybenzylidene)acetohydrazide chemical structure, C26H25N5O4S, CAS 315215-19-1

2-((4,5-Diphenyl-4H-1,2,4-triazol-3-yl)thio)-N'-(2,4,6-trimethoxybenzylidene)acetohydrazide

CAS 315215-19-1C₂₆H₂₅N₅O₄S

2-((5-(4-Chlorophenyl)-4-phenyl-4H-1,2,4-triazol-3-yl)thio)-N'-(2,4-dihydroxybenzylidene)acetohydrazide chemical structure, C23H18ClN5O3S

2-((5-(4-Chlorophenyl)-4-phenyl-4H-1,2,4-triazol-3-yl)thio)-N'-(2,4-dihydroxybenzylidene)acetohydrazide

C₂₃H₁₈ClN₅O₃S

2-((4,5-Diphenyl-4H-1,2,4-triazol-3-yl)thio)-N'-(2-methoxybenzylidene)acetohydrazide chemical structure, C24H21N5O2S

2-((4,5-Diphenyl-4H-1,2,4-triazol-3-yl)thio)-N'-(2-methoxybenzylidene)acetohydrazide

C₂₄H₂₁N₅O₂S

N'-Benzylidene-2-((4-(4-methoxyphenyl)-5-(p-tolyl)-4H-1,2,4-triazol-3-yl)thio)acetohydrazide chemical structure, C25H23N5O2S, CAS 406465-34-7

N'-Benzylidene-2-((4-(4-methoxyphenyl)-5-(p-tolyl)-4H-1,2,4-triazol-3-yl)thio)acetohydrazide

CAS 406465-34-7C₂₅H₂₃N₅O₂S

2-((4,5-Bis(4-methoxyphenyl)-4H-1,2,4-triazol-3-yl)thio)-N'-(4-(dimethylamino)benzylidene)acetohydrazide chemical structure, C27H28N6O3S, CAS 406203-22-3

2-((4,5-Bis(4-methoxyphenyl)-4H-1,2,4-triazol-3-yl)thio)-N'-(4-(dimethylamino)benzylidene)acetohydrazide

CAS 406203-22-3C₂₇H₂₈N₆O₃S

N'-Benzylidene-2-((5-(4-methoxyphenyl)-4-phenyl-4H-1,2,4-triazol-3-yl)thio)acetohydrazide chemical structure, C24H21N5O2S, CAS 303206-23-7

N'-Benzylidene-2-((5-(4-methoxyphenyl)-4-phenyl-4H-1,2,4-triazol-3-yl)thio)acetohydrazide

CAS 303206-23-7C₂₄H₂₁N₅O₂S

2-((4-(4-Ethoxyphenyl)-5-phenyl-4H-1,2,4-triazol-3-yl)thio)-N'-(4-hydroxy-3,5-dimethoxybenzylidene)acetohydrazide chemical structure, C27H27N5O5S, CAS 497941-83-0

2-((4-(4-Ethoxyphenyl)-5-phenyl-4H-1,2,4-triazol-3-yl)thio)-N'-(4-hydroxy-3,5-dimethoxybenzylidene)acetohydrazide

CAS 497941-83-0C₂₇H₂₇N₅O₅S

2-((4-(4-Chlorophenyl)-5-(4-methoxyphenyl)-4H-1,2,4-triazol-3-yl)thio)-N'-(2,4-dihydroxybenzylidene)acetohydrazide chemical structure, C24H20ClN5O4S, CAS 406466-64-6

2-((4-(4-Chlorophenyl)-5-(4-methoxyphenyl)-4H-1,2,4-triazol-3-yl)thio)-N'-(2,4-dihydroxybenzylidene)acetohydrazide

CAS 406466-64-6C₂₄H₂₀ClN₅O₄S

N'-(1-(4-Hydroxy-3-methoxyphenyl)ethylidene)-2-((4-(4-methoxyphenyl)-5-(p-tolyl)-4H-1,2,4-triazol-3-yl)thio)acetohydrazide chemical structure, C27H27N5O4S, CAS 406465-79-0

N'-(1-(4-Hydroxy-3-methoxyphenyl)ethylidene)-2-((4-(4-methoxyphenyl)-5-(p-tolyl)-4H-1,2,4-triazol-3-yl)thio)acetohydrazide

CAS 406465-79-0C₂₇H₂₇N₅O₄S

2-[[4-(4-Methoxyphenyl)-5-(4-methylphenyl)-1,2,4-triazol-3-yl]sulfanyl]-N-[(3-nitrophenyl)methylideneamino]acetamide chemical structure, C25H22N6O4S, CAS 5687-54-7

2-[[4-(4-Methoxyphenyl)-5-(4-methylphenyl)-1,2,4-triazol-3-yl]sulfanyl]-N-[(3-nitrophenyl)methylideneamino]acetamide

CAS 5687-54-7C₂₅H₂₂N₆O₄S

2-((4,5-Bis(4-methoxyphenyl)-4H-1,2,4-triazol-3-yl)thio)-N'-(2-hydroxybenzylidene)acetohydrazide chemical structure, C25H23N5O4S, CAS 406203-20-1

2-((4,5-Bis(4-methoxyphenyl)-4H-1,2,4-triazol-3-yl)thio)-N'-(2-hydroxybenzylidene)acetohydrazide

CAS 406203-20-1C₂₅H₂₃N₅O₄S

2-((5-(3,4-Dimethoxyphenyl)-4-phenyl-4H-1,2,4-triazol-3-yl)thio)-N'-(3-methoxybenzylidene)acetohydrazide chemical structure, C26H25N5O4S, CAS 315217-15-3

2-((5-(3,4-Dimethoxyphenyl)-4-phenyl-4H-1,2,4-triazol-3-yl)thio)-N'-(3-methoxybenzylidene)acetohydrazide

CAS 315217-15-3C₂₆H₂₅N₅O₄S

2-((4,5-Diphenyl-4H-1,2,4-triazol-3-yl)thio)-N'-(2-fluorobenzylidene)acetohydrazide chemical structure, C23H18FN5OS, CAS 306756-03-6

2-((4,5-Diphenyl-4H-1,2,4-triazol-3-yl)thio)-N'-(2-fluorobenzylidene)acetohydrazide

CAS 306756-03-6C₂₃H₁₈FN₅OS

N'-Benzylidene-2-((4-(4-methoxyphenyl)-5-phenyl-4H-1,2,4-triazol-3-yl)thio)acetohydrazide chemical structure, C24H21N5O2S, CAS 612826-96-7

N'-Benzylidene-2-((4-(4-methoxyphenyl)-5-phenyl-4H-1,2,4-triazol-3-yl)thio)acetohydrazide

CAS 612826-96-7C₂₄H₂₁N₅O₂S

2-((4-(4-Methoxyphenyl)-5-phenyl-4H-1,2,4-triazol-3-yl)thio)-N'-(2,4,6-trimethoxybenzylidene)acetohydrazide chemical structure, C27H27N5O5S, CAS 612827-64-2

2-((4-(4-Methoxyphenyl)-5-phenyl-4H-1,2,4-triazol-3-yl)thio)-N'-(2,4,6-trimethoxybenzylidene)acetohydrazide

CAS 612827-64-2C₂₇H₂₇N₅O₅S

2-((4-(4-Ethoxyphenyl)-5-phenyl-4H-1,2,4-triazol-3-yl)thio)-N'-(2-methylbenzylidene)acetohydrazide chemical structure, C26H25N5O2S, CAS 496798-72-2

2-((4-(4-Ethoxyphenyl)-5-phenyl-4H-1,2,4-triazol-3-yl)thio)-N'-(2-methylbenzylidene)acetohydrazide

CAS 496798-72-2C₂₆H₂₅N₅O₂S

2-((4-(4-Chlorophenyl)-5-(4-methoxyphenyl)-4H-1,2,4-triazol-3-yl)thio)-N'-(2,3-dichlorobenzylidene)acetohydrazide chemical structure, C24H18Cl3N5O2S, CAS 406466-32-8

2-((4-(4-Chlorophenyl)-5-(4-methoxyphenyl)-4H-1,2,4-triazol-3-yl)thio)-N'-(2,3-dichlorobenzylidene)acetohydrazide

CAS 406466-32-8C₂₄H₁₈Cl₃N₅O₂S

2-((4-(4-Bromophenyl)-5-phenyl-4H-1,2,4-triazol-3-yl)thio)-N'-(2-ethoxybenzylidene)acetohydrazide chemical structure, C25H22BrN5O2S, CAS 487025-86-5

2-((4-(4-Bromophenyl)-5-phenyl-4H-1,2,4-triazol-3-yl)thio)-N'-(2-ethoxybenzylidene)acetohydrazide

CAS 487025-86-5C₂₅H₂₂BrN₅O₂S

(2-{[2-({[5-(4-tert-Butylphenyl)-4-(4-methylphenyl)-4H-1,2,4-triazol-3-yl]sulfanyl}acetyl)hydrazinylidene]methyl}phenoxy)acetate chemical structure, C30H30N5O4S-, CAS 6848-48-2

(2-{[2-({[5-(4-tert-Butylphenyl)-4-(4-methylphenyl)-4H-1,2,4-triazol-3-yl]sulfanyl}acetyl)hydrazinylidene]methyl}phenoxy)acetate

CAS 6848-48-2C₃₀H₃₀N₅O₄S-

2-((4-(4-Chlorophenyl)-5-(4-methoxyphenyl)-4H-1,2,4-triazol-3-yl)thio)-N'-(4-methoxybenzylidene)acetohydrazide chemical structure, C25H22ClN5O3S, CAS 406466-63-5

2-((4-(4-Chlorophenyl)-5-(4-methoxyphenyl)-4H-1,2,4-triazol-3-yl)thio)-N'-(4-methoxybenzylidene)acetohydrazide

CAS 406466-63-5C₂₅H₂₂ClN₅O₃S

2-((5-(4-(tert-Butyl)phenyl)-4-(p-tolyl)-4H-1,2,4-triazol-3-yl)thio)-N'-(3-nitrobenzylidene)acetohydrazide chemical structure, C28H28N6O3S, CAS 497921-42-3

2-((5-(4-(tert-Butyl)phenyl)-4-(p-tolyl)-4H-1,2,4-triazol-3-yl)thio)-N'-(3-nitrobenzylidene)acetohydrazide

CAS 497921-42-3C₂₈H₂₈N₆O₃S

2-((5-(4-(tert-Butyl)phenyl)-4-(4-methoxyphenyl)-4H-1,2,4-triazol-3-yl)thio)-N'-(4-nitrobenzylidene)acetohydrazide chemical structure, C28H28N6O4S, CAS 487019-65-8

2-((5-(4-(tert-Butyl)phenyl)-4-(4-methoxyphenyl)-4H-1,2,4-triazol-3-yl)thio)-N'-(4-nitrobenzylidene)acetohydrazide

CAS 487019-65-8C₂₈H₂₈N₆O₄S

2-((5-(4-(tert-Butyl)phenyl)-4-(p-tolyl)-4H-1,2,4-triazol-3-yl)thio)-N'-(3-methylbenzylidene)acetohydrazide chemical structure, C29H31N5OS, CAS 488706-71-4

2-((5-(4-(tert-Butyl)phenyl)-4-(p-tolyl)-4H-1,2,4-triazol-3-yl)thio)-N'-(3-methylbenzylidene)acetohydrazide

CAS 488706-71-4C₂₉H₃₁N₅OS

N'-(4-Bromobenzylidene)-2-((4-(4-methoxyphenyl)-5-(p-tolyl)-4H-1,2,4-triazol-3-yl)thio)acetohydrazide chemical structure, C25H22BrN5O2S, CAS 406465-44-9

N'-(4-Bromobenzylidene)-2-((4-(4-methoxyphenyl)-5-(p-tolyl)-4H-1,2,4-triazol-3-yl)thio)acetohydrazide

CAS 406465-44-9C₂₅H₂₂BrN₅O₂S