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Murcko scaffold

Rhodblock 1a scaffold

68 chemicals on CompoundList share this ring system.

Rings
4
Scaffold atoms
24
Chemicals
68
With full pages
10
Scaffold SMILES

O=C(c1ccco1)N1N=C(c2ccccc2)CC1c1ccccc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffoldOpen the Rhodblock 1a page
Murcko scaffold O=C(c1ccco1)N1N=C(c2ccccc2)CC1c1ccccc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 48 of 68 chemicals

(5-Bromofuran-2-yl)(3-(4-methoxyphenyl)-5-(p-tolyl)-4,5-dihydro-1H-pyrazol-1-yl)methanone chemical structure, C22H19BrN2O3, CAS 361480-31-1
(5-Bromofuran-2-yl)(3-(4-methoxyphenyl)-5-(p-tolyl)-4,5-dihydro-1H-pyrazol-1-yl)methanone
CAS 361480-31-1C22H19BrN2O3
(3,5-Bis(3,4-dimethoxyphenyl)-4,5-dihydro-1H-pyrazol-1-yl)(5-bromofuran-2-yl)methanone chemical structure, C24H23BrN2O6, CAS 370852-34-9
(3,5-Bis(3,4-dimethoxyphenyl)-4,5-dihydro-1H-pyrazol-1-yl)(5-bromofuran-2-yl)methanone
CAS 370852-34-9C24H23BrN2O6
Rhodblock 1a chemical structure, C20H16N2O2, CAS 701226-08-6
Rhodblock 1a
CAS 701226-08-6C20H16N2O2
[3,5-Bis(4-methylphenyl)-3,4-dihydropyrazol-2-yl]-(5-bromofuran-2-yl)methanone chemical structure, C22H19BrN2O2, CAS 361480-32-2
[3,5-Bis(4-methylphenyl)-3,4-dihydropyrazol-2-yl]-(5-bromofuran-2-yl)methanone
CAS 361480-32-2C22H19BrN2O2
(5-Bromofuran-2-yl)(3-(3,4-dimethoxyphenyl)-5-(2-methoxyphenyl)-4,5-dihydro-1H-pyrazol-1-yl)methanone chemical structure, C23H21BrN2O5, CAS 402950-75-8
(5-Bromofuran-2-yl)(3-(3,4-dimethoxyphenyl)-5-(2-methoxyphenyl)-4,5-dihydro-1H-pyrazol-1-yl)methanone
CAS 402950-75-8C23H21BrN2O5
(5-Bromofuran-2-yl)(3-(3,4-dimethoxyphenyl)-5-(3-nitrophenyl)-4,5-dihydro-1H-pyrazol-1-yl)methanone chemical structure, C22H18BrN3O6, CAS 383902-59-8
(5-Bromofuran-2-yl)(3-(3,4-dimethoxyphenyl)-5-(3-nitrophenyl)-4,5-dihydro-1H-pyrazol-1-yl)methanone
CAS 383902-59-8C22H18BrN3O6
N-(4-(1-(Furan-2-carbonyl)-5-(p-tolyl)-4,5-dihydro-1H-pyrazol-3-yl)phenyl)ethanesulfonamide chemical structure, C23H23N3O4S, CAS 710986-41-7
N-(4-(1-(Furan-2-carbonyl)-5-(p-tolyl)-4,5-dihydro-1H-pyrazol-3-yl)phenyl)ethanesulfonamide
CAS 710986-41-7C23H23N3O4S
N-{3-[5-(2-Fluorophenyl)-1-(furan-2-carbonyl)-4,5-dihydro-1H-pyrazol-3-yl]phenyl}methanesulfonamide chemical structure, C21H18FN3O4S, CAS 714263-35-1
N-{3-[5-(2-Fluorophenyl)-1-(furan-2-carbonyl)-4,5-dihydro-1H-pyrazol-3-yl]phenyl}methanesulfonamide
CAS 714263-35-1C21H18FN3O4S
2-[1-(Furan-2-carbonyl)-3-phenyl-4,5-dihydro-1H-pyrazol-5-yl]phenol chemical structure, C20H16N2O3, CAS 364737-73-5
2-[1-(Furan-2-carbonyl)-3-phenyl-4,5-dihydro-1H-pyrazol-5-yl]phenol
CAS 364737-73-5C20H16N2O3
Ethyl 2-{2-[1-(furan-2-carbonyl)-3-phenyl-4,5-dihydro-1H-pyrazol-5-yl]phenoxy}acetate chemical structure, C24H22N2O5, CAS 831194-63-9
Ethyl 2-{2-[1-(furan-2-carbonyl)-3-phenyl-4,5-dihydro-1H-pyrazol-5-yl]phenoxy}acetate
CAS 831194-63-9C24H22N2O5
(5-(2-Chloro-6-fluorophenyl)-3-(3,4-dimethoxyphenyl)-4,5-dihydro-1H-pyrazol-1-yl)(furan-2-yl)methanone chemical structure, C22H18ClFN2O4, CAS 831243-55-1
(5-(2-Chloro-6-fluorophenyl)-3-(3,4-dimethoxyphenyl)-4,5-dihydro-1H-pyrazol-1-yl)(furan-2-yl)methanone
CAS 831243-55-1C22H18ClFN2O4
N-{3-[5-(3-Fluorophenyl)-1-(furan-2-carbonyl)-4,5-dihydro-1H-pyrazol-3-yl]phenyl}methanesulfonamide chemical structure, C21H18FN3O4S, CAS 835887-23-5
N-{3-[5-(3-Fluorophenyl)-1-(furan-2-carbonyl)-4,5-dihydro-1H-pyrazol-3-yl]phenyl}methanesulfonamide
CAS 835887-23-5C21H18FN3O4S
Furan-2-yl-[3-(2-hydroxyphenyl)-5-(4-methylphenyl)-3,4-dihydropyrazol-2-yl]methanone chemical structure, C21H18N2O3, CAS 868155-47-9
Furan-2-yl-[3-(2-hydroxyphenyl)-5-(4-methylphenyl)-3,4-dihydropyrazol-2-yl]methanone
CAS 868155-47-9C21H18N2O3
(3,5-Bis(4-bromophenyl)-4,5-dihydro-1H-pyrazol-1-yl)(5-bromofuran-2-yl)methanone chemical structure, C20H13Br3N2O2, CAS 331841-27-1
(3,5-Bis(4-bromophenyl)-4,5-dihydro-1H-pyrazol-1-yl)(5-bromofuran-2-yl)methanone
CAS 331841-27-1C20H13Br3N2O2
(5-Bromofuran-2-yl)(5-(4-methoxyphenyl)-3-phenyl-4,5-dihydro-1H-pyrazol-1-yl)methanone chemical structure, C21H17BrN2O3, CAS 313967-97-4
(5-Bromofuran-2-yl)(5-(4-methoxyphenyl)-3-phenyl-4,5-dihydro-1H-pyrazol-1-yl)methanone
CAS 313967-97-4C21H17BrN2O3
[5-(3,4-Dimethoxyphenyl)-3-(2-hydroxyphenyl)-3,4-dihydropyrazol-2-yl]-(furan-2-yl)methanone chemical structure, C22H20N2O5, CAS 871307-93-6
[5-(3,4-Dimethoxyphenyl)-3-(2-hydroxyphenyl)-3,4-dihydropyrazol-2-yl]-(furan-2-yl)methanone
CAS 871307-93-6C22H20N2O5
N-{4-[1-(Furan-2-carbonyl)-5-(4-methoxyphenyl)-4,5-dihydro-1H-pyrazol-3-yl]phenyl}methanesulfonamide chemical structure, C22H21N3O5S, CAS 851717-68-5
N-{4-[1-(Furan-2-carbonyl)-5-(4-methoxyphenyl)-4,5-dihydro-1H-pyrazol-3-yl]phenyl}methanesulfonamide
CAS 851717-68-5C22H21N3O5S
N-[3-[2-(Furan-2-carbonyl)-3-(4-methylphenyl)-3,4-dihydropyrazol-5-yl]phenyl]methanesulfonamide chemical structure, C22H21N3O4S, CAS 851718-53-1
N-[3-[2-(Furan-2-carbonyl)-3-(4-methylphenyl)-3,4-dihydropyrazol-5-yl]phenyl]methanesulfonamide
CAS 851718-53-1C22H21N3O4S
(5-Bromofuran-2-yl)-[3-(4-chlorophenyl)-5-(3,4-dimethoxyphenyl)-3,4-dihydropyrazol-2-yl]methanone chemical structure, C22H18BrClN2O4, CAS 402950-78-1
(5-Bromofuran-2-yl)-[3-(4-chlorophenyl)-5-(3,4-dimethoxyphenyl)-3,4-dihydropyrazol-2-yl]methanone
CAS 402950-78-1C22H18BrClN2O4
(5-Bromofuran-2-yl)(5-(2-chlorophenyl)-3-(3,4-dimethoxyphenyl)-4,5-dihydro-1H-pyrazol-1-yl)methanone chemical structure, C22H18BrClN2O4, CAS 384350-73-6
(5-Bromofuran-2-yl)(5-(2-chlorophenyl)-3-(3,4-dimethoxyphenyl)-4,5-dihydro-1H-pyrazol-1-yl)methanone
CAS 384350-73-6C22H18BrClN2O4
N-(3-(1-(Furan-2-carbonyl)-5-(o-tolyl)-4,5-dihydro-1H-pyrazol-3-yl)phenyl)methanesulfonamide chemical structure, C22H21N3O4S, CAS 851719-28-3
N-(3-(1-(Furan-2-carbonyl)-5-(o-tolyl)-4,5-dihydro-1H-pyrazol-3-yl)phenyl)methanesulfonamide
CAS 851719-28-3C22H21N3O4S
(5-Bromofuran-2-yl)(3-(3,4-dimethoxyphenyl)-5-(p-tolyl)-4,5-dihydro-1H-pyrazol-1-yl)methanone chemical structure, C23H21BrN2O4, CAS 369396-69-0
(5-Bromofuran-2-yl)(3-(3,4-dimethoxyphenyl)-5-(p-tolyl)-4,5-dihydro-1H-pyrazol-1-yl)methanone
CAS 369396-69-0C23H21BrN2O4
N-(3-(1-(Furan-2-carbonyl)-5-(4-methoxyphenyl)-4,5-dihydro-1H-pyrazol-3-yl)phenyl)methanesulfonamide chemical structure, C22H21N3O5S, CAS 851718-73-5
N-(3-(1-(Furan-2-carbonyl)-5-(4-methoxyphenyl)-4,5-dihydro-1H-pyrazol-3-yl)phenyl)methanesulfonamide
CAS 851718-73-5C22H21N3O5S
(5-Bromofuran-2-yl)(3-(3,4-dimethoxyphenyl)-5-phenyl-4,5-dihydro-1H-pyrazol-1-yl)methanone chemical structure, C22H19BrN2O4, CAS 370846-92-7
(5-Bromofuran-2-yl)(3-(3,4-dimethoxyphenyl)-5-phenyl-4,5-dihydro-1H-pyrazol-1-yl)methanone
CAS 370846-92-7C22H19BrN2O4