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Murcko scaffold

(3,5-Diphenyl-3,4-dihydropyrazol-2-yl)-thiophen-2-ylmethanone scaffold

65 chemicals on CompoundList share this ring system.

Rings
4
Scaffold atoms
24
Chemicals
65
With full pages
8
Scaffold SMILES

O=C(c1cccs1)N1N=C(c2ccccc2)CC1c1ccccc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffoldOpen the (3,5-Diphenyl-3,4-dihydropyrazol-2-yl)-thiophen-2-ylmethanone page
Murcko scaffold O=C(c1cccs1)N1N=C(c2ccccc2)CC1c1ccccc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 48 of 65 chemicals

(3,5-Diphenyl-3,4-dihydropyrazol-2-yl)-thiophen-2-ylmethanone chemical structure, C20H16N2OS, CAS 312620-57-8
(3,5-Diphenyl-3,4-dihydropyrazol-2-yl)-thiophen-2-ylmethanone
CAS 312620-57-8C20H16N2OS
[3-(4-Methoxyphenyl)-5-phenyl-3,4-dihydropyrazol-2-yl]-thiophen-2-ylmethanone chemical structure, C21H18N2O2S, CAS 303787-34-0
[3-(4-Methoxyphenyl)-5-phenyl-3,4-dihydropyrazol-2-yl]-thiophen-2-ylmethanone
CAS 303787-34-0C21H18N2O2S
N-(3-(5-(2-Methoxyphenyl)-1-(thiophene-2-carbonyl)-4,5-dihydro-1H-pyrazol-3-yl)phenyl)methanesulfonamide chemical structure, C22H21N3O4S2, CAS 710986-16-6
N-(3-(5-(2-Methoxyphenyl)-1-(thiophene-2-carbonyl)-4,5-dihydro-1H-pyrazol-3-yl)phenyl)methanesulfonamide
CAS 710986-16-6C22H21N3O4S2
N-(4-(5-(2-Chloro-6-fluorophenyl)-1-(thiophene-2-carbonyl)-4,5-dihydro-1H-pyrazol-3-yl)phenyl)methanesulfonamide chemical structure, C21H17ClFN3O3S2, CAS 710986-35-9
N-(4-(5-(2-Chloro-6-fluorophenyl)-1-(thiophene-2-carbonyl)-4,5-dihydro-1H-pyrazol-3-yl)phenyl)methanesulfonamide
CAS 710986-35-9C21H17ClFN3O3S2
N-(4-(1-(Thiophene-2-carbonyl)-5-(p-tolyl)-4,5-dihydro-1H-pyrazol-3-yl)phenyl)methanesulfonamide chemical structure, C22H21N3O3S2, CAS 710986-38-2
N-(4-(1-(Thiophene-2-carbonyl)-5-(p-tolyl)-4,5-dihydro-1H-pyrazol-3-yl)phenyl)methanesulfonamide
CAS 710986-38-2C22H21N3O3S2
(3-(3,4-Dimethoxyphenyl)-5-(2-methoxyphenyl)-4,5-dihydro-1H-pyrazol-1-yl)(thiophen-2-yl)methanone chemical structure, C23H22N2O4S, CAS 402950-84-9
(3-(3,4-Dimethoxyphenyl)-5-(2-methoxyphenyl)-4,5-dihydro-1H-pyrazol-1-yl)(thiophen-2-yl)methanone
CAS 402950-84-9C23H22N2O4S
Ethyl 2-[2-[5-phenyl-2-(thiophene-2-carbonyl)-3,4-dihydropyrazol-3-yl]phenoxy]acetate chemical structure, C24H22N2O4S, CAS 830344-94-0
Ethyl 2-[2-[5-phenyl-2-(thiophene-2-carbonyl)-3,4-dihydropyrazol-3-yl]phenoxy]acetate
CAS 830344-94-0C24H22N2O4S
2-[3-Phenyl-1-(thiophene-2-carbonyl)-4,5-dihydro-1H-pyrazol-5-yl]phenol chemical structure, C20H16N2O2S, CAS 831206-39-4
2-[3-Phenyl-1-(thiophene-2-carbonyl)-4,5-dihydro-1H-pyrazol-5-yl]phenol
CAS 831206-39-4C20H16N2O2S
N-{4-[5-(2-Fluorophenyl)-1-(thiophene-2-carbonyl)-4,5-dihydro-1H-pyrazol-3-yl]phenyl}methanesulfonamide chemical structure, C21H18FN3O3S2, CAS 833439-47-7
N-{4-[5-(2-Fluorophenyl)-1-(thiophene-2-carbonyl)-4,5-dihydro-1H-pyrazol-3-yl]phenyl}methanesulfonamide
CAS 833439-47-7C21H18FN3O3S2
N-[3-[3-(2-Methylphenyl)-2-(thiophene-2-carbonyl)-3,4-dihydropyrazol-5-yl]phenyl]methanesulfonamide chemical structure, C22H21N3O3S2, CAS 833442-05-0
N-[3-[3-(2-Methylphenyl)-2-(thiophene-2-carbonyl)-3,4-dihydropyrazol-5-yl]phenyl]methanesulfonamide
CAS 833442-05-0C22H21N3O3S2
N-{3-[5-(2-Chloro-6-fluorophenyl)-1-(thiophene-2-carbonyl)-4,5-dihydro-1H-pyrazol-3-yl]phenyl}methanesulfonamide chemical structure, C21H17ClFN3O3S2, CAS 838394-42-6
N-{3-[5-(2-Chloro-6-fluorophenyl)-1-(thiophene-2-carbonyl)-4,5-dihydro-1H-pyrazol-3-yl]phenyl}methanesulfonamide
CAS 838394-42-6C21H17ClFN3O3S2
[3-(2-Hydroxyphenyl)-5-(4-methylphenyl)-3,4-dihydropyrazol-2-yl]-thiophen-2-ylmethanone chemical structure, C21H18N2O2S, CAS 868155-48-0
[3-(2-Hydroxyphenyl)-5-(4-methylphenyl)-3,4-dihydropyrazol-2-yl]-thiophen-2-ylmethanone
CAS 868155-48-0C21H18N2O2S
(5-(2,3-Dimethoxyphenyl)-3-(3,4-dimethoxyphenyl)-4,5-dihydro-1H-pyrazol-1-yl)(thiophen-2-yl)methanone chemical structure, C24H24N2O5S, CAS 402950-87-2
(5-(2,3-Dimethoxyphenyl)-3-(3,4-dimethoxyphenyl)-4,5-dihydro-1H-pyrazol-1-yl)(thiophen-2-yl)methanone
CAS 402950-87-2C24H24N2O5S
[3,5-Bis(4-methoxyphenyl)-3,4-dihydropyrazol-2-yl]-thiophen-2-ylmethanone chemical structure, C22H20N2O3S, CAS 361171-48-4
[3,5-Bis(4-methoxyphenyl)-3,4-dihydropyrazol-2-yl]-thiophen-2-ylmethanone
CAS 361171-48-4C22H20N2O3S
N-{4-[5-(3-Fluorophenyl)-1-(thiophene-2-carbonyl)-4,5-dihydro-1H-pyrazol-3-yl]phenyl}methanesulfonamide chemical structure, C21H18FN3O3S2, CAS 851718-03-1
N-{4-[5-(3-Fluorophenyl)-1-(thiophene-2-carbonyl)-4,5-dihydro-1H-pyrazol-3-yl]phenyl}methanesulfonamide
CAS 851718-03-1C21H18FN3O3S2
(3-(4-Bromophenyl)-5-(4-methoxyphenyl)-4,5-dihydro-1H-pyrazol-1-yl)(thiophen-2-yl)methanone chemical structure, C21H17BrN2O2S, CAS 394230-86-5
(3-(4-Bromophenyl)-5-(4-methoxyphenyl)-4,5-dihydro-1H-pyrazol-1-yl)(thiophen-2-yl)methanone
CAS 394230-86-5C21H17BrN2O2S
N-{4-[5-(3-Nitrophenyl)-1-(thiophene-2-carbonyl)-4,5-dihydro-1H-pyrazol-3-yl]phenyl}methanesulfonamide chemical structure, C21H18N4O5S2, CAS 851717-90-3
N-{4-[5-(3-Nitrophenyl)-1-(thiophene-2-carbonyl)-4,5-dihydro-1H-pyrazol-3-yl]phenyl}methanesulfonamide
CAS 851717-90-3C21H18N4O5S2
4-[5-Phenyl-1-(thiophene-2-carbonyl)-4,5-dihydro-1H-pyrazol-3-yl]phenol chemical structure, C20H16N2O2S, CAS 868146-46-7
4-[5-Phenyl-1-(thiophene-2-carbonyl)-4,5-dihydro-1H-pyrazol-3-yl]phenol
CAS 868146-46-7C20H16N2O2S
N-[3-[3-(4-Methylphenyl)-2-(thiophene-2-carbonyl)-3,4-dihydropyrazol-5-yl]phenyl]methanesulfonamide chemical structure, C22H21N3O3S2, CAS 851718-48-4
N-[3-[3-(4-Methylphenyl)-2-(thiophene-2-carbonyl)-3,4-dihydropyrazol-5-yl]phenyl]methanesulfonamide
CAS 851718-48-4C22H21N3O3S2
N-[4-[3-(2-Methylphenyl)-2-(thiophene-2-carbonyl)-3,4-dihydropyrazol-5-yl]phenyl]methanesulfonamide chemical structure, C22H21N3O3S2, CAS 851718-11-1
N-[4-[3-(2-Methylphenyl)-2-(thiophene-2-carbonyl)-3,4-dihydropyrazol-5-yl]phenyl]methanesulfonamide
CAS 851718-11-1C22H21N3O3S2
(3-(4-Bromophenyl)-5-(3-nitrophenyl)-4,5-dihydro-1H-pyrazol-1-yl)(thiophen-2-yl)methanone chemical structure, C20H14BrN3O3S, CAS 385395-21-1
(3-(4-Bromophenyl)-5-(3-nitrophenyl)-4,5-dihydro-1H-pyrazol-1-yl)(thiophen-2-yl)methanone
CAS 385395-21-1C20H14BrN3O3S
Ethyl 2-[2-[5-(4-methoxyphenyl)-2-(thiophene-2-carbonyl)-3,4-dihydropyrazol-3-yl]phenoxy]acetate chemical structure, C25H24N2O5S, CAS 868212-14-0
Ethyl 2-[2-[5-(4-methoxyphenyl)-2-(thiophene-2-carbonyl)-3,4-dihydropyrazol-3-yl]phenoxy]acetate
CAS 868212-14-0C25H24N2O5S
N-[4-[3-(2-Chloro-6-fluorophenyl)-2-(thiophene-2-carbonyl)-3,4-dihydropyrazol-5-yl]phenyl]ethanesulfonamide chemical structure, C22H19ClFN3O3S2, CAS 865615-69-6
N-[4-[3-(2-Chloro-6-fluorophenyl)-2-(thiophene-2-carbonyl)-3,4-dihydropyrazol-5-yl]phenyl]ethanesulfonamide
CAS 865615-69-6C22H19ClFN3O3S2
N-(4-(5-(4-Methoxyphenyl)-1-(thiophene-2-carbonyl)-4,5-dihydro-1H-pyrazol-3-yl)phenyl)methanesulfonamide chemical structure, C22H21N3O4S2, CAS 851717-66-3
N-(4-(5-(4-Methoxyphenyl)-1-(thiophene-2-carbonyl)-4,5-dihydro-1H-pyrazol-3-yl)phenyl)methanesulfonamide
CAS 851717-66-3C22H21N3O4S2