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Murcko scaffold

Ring system with 2 rings and 17 atoms

38 chemicals on CompoundList share this ring system.

Rings
2
Scaffold atoms
17
Chemicals
38
With full pages
15
Scaffold SMILES

O=C(CSc1nccc(=O)[nH]1)c1ccccc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=C(CSc1nccc(=O)[nH]1)c1ccccc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 38 of 38 chemicals

2-[2-(4-Methoxyphenyl)-2-oxoethyl]sulfanyl-1H-pyrimidin-6-one chemical structure, C13H12N2O3S, CAS 119730-23-3
2-[2-(4-Methoxyphenyl)-2-oxoethyl]sulfanyl-1H-pyrimidin-6-one
CAS 119730-23-3C13H12N2O3S
N-[4-[2-[(4-Hydroxy-6-oxo-1H-pyrimidin-2-yl)sulfanyl]acetyl]phenyl]acetamide chemical structure, C14H13N3O4S, CAS 420821-52-9
N-[4-[2-[(4-Hydroxy-6-oxo-1H-pyrimidin-2-yl)sulfanyl]acetyl]phenyl]acetamide
CAS 420821-52-9C14H13N3O4S
2-{[2-(4-Bromophenyl)-2-oxoethyl]sulfanyl}-3-ethyl-6-(trifluoromethyl)-4(3H)-pyrimidinone chemical structure, C15H12BrF3N2O2S, CAS 866049-81-2
2-{[2-(4-Bromophenyl)-2-oxoethyl]sulfanyl}-3-ethyl-6-(trifluoromethyl)-4(3H)-pyrimidinone
CAS 866049-81-2C15H12BrF3N2O2S
3-Ethyl-2-{[2-(4-methylphenyl)-2-oxoethyl]sulfanyl}-6-(trifluoromethyl)-4(3H)-pyrimidinone chemical structure, C16H15F3N2O2S, CAS 692287-60-8
3-Ethyl-2-{[2-(4-methylphenyl)-2-oxoethyl]sulfanyl}-6-(trifluoromethyl)-4(3H)-pyrimidinone
CAS 692287-60-8C16H15F3N2O2S
2-{[2-(4-Chlorophenyl)-2-oxoethyl]sulfanyl}-3-ethyl-6-(trifluoromethyl)-4(3H)-pyrimidinone chemical structure, C15H12ClF3N2O2S, CAS 692287-62-0
2-{[2-(4-Chlorophenyl)-2-oxoethyl]sulfanyl}-3-ethyl-6-(trifluoromethyl)-4(3H)-pyrimidinone
CAS 692287-62-0C15H12ClF3N2O2S
1-(4-Bromophenyl)-2-((4-hydroxypyrimidin-2-yl)thio)ethanone chemical structure, C12H9BrN2O2S, CAS 74195-45-2
1-(4-Bromophenyl)-2-((4-hydroxypyrimidin-2-yl)thio)ethanone
CAS 74195-45-2C12H9BrN2O2S
2-[2-(3,4-Dimethoxyphenyl)-2-oxoethyl]sulfanyl-1H-pyrimidin-6-one chemical structure, C14H14N2O4S, CAS 825656-97-1
2-[2-(3,4-Dimethoxyphenyl)-2-oxoethyl]sulfanyl-1H-pyrimidin-6-one
CAS 825656-97-1C14H14N2O4S
2-[2-(3,4-Dihydroxyphenyl)-2-oxoethyl]sulfanyl-1H-pyrimidin-6-one chemical structure, C12H10N2O4S, CAS 401583-87-7
2-[2-(3,4-Dihydroxyphenyl)-2-oxoethyl]sulfanyl-1H-pyrimidin-6-one
CAS 401583-87-7C12H10N2O4S
N-[4-[2-[(6-Oxo-1H-pyrimidin-2-yl)sulfanyl]acetyl]phenyl]acetamide chemical structure, C14H13N3O3S, CAS 826998-84-9
N-[4-[2-[(6-Oxo-1H-pyrimidin-2-yl)sulfanyl]acetyl]phenyl]acetamide
CAS 826998-84-9C14H13N3O3S
2-Phenacylsulfanyl-1H-pyrimidin-6-one, hydrobromide chemical structure, C12H11BrN2O2S, CAS 17649-38-6
2-Phenacylsulfanyl-1H-pyrimidin-6-one, hydrobromide
CAS 17649-38-6C12H11BrN2O2S
1-(4-Bromophenyl)-2-[(4-hydroxy-5-propylpyrimidin-2-yl)sulfanyl]ethan-1-one chemical structure, C15H15BrN2O2S, CAS 2308074-25-9
1-(4-Bromophenyl)-2-[(4-hydroxy-5-propylpyrimidin-2-yl)sulfanyl]ethan-1-one
CAS 2308074-25-9C15H15BrN2O2S
6-Methyl-2-[2-oxo-2-(4-propan-2-ylphenyl)ethyl]sulfanyl-1H-pyrimidin-4-one chemical structure, C16H18N2O2S, CAS 429652-88-0
6-Methyl-2-[2-oxo-2-(4-propan-2-ylphenyl)ethyl]sulfanyl-1H-pyrimidin-4-one
CAS 429652-88-0C16H18N2O2S
2-((4-Hydroxy-6-methylpyrimidin-2-yl)thio)-1-phenylethanone chemical structure, C13H12N2O2S, CAS 17649-31-9
2-((4-Hydroxy-6-methylpyrimidin-2-yl)thio)-1-phenylethanone
CAS 17649-31-9C13H12N2O2S
2-((2-(4-Bromophenyl)-2-oxoethyl)thio)-6-methylpyrimidin-4(1H)-one chemical structure, C13H11BrN2O2S, CAS 119730-09-5
2-((2-(4-Bromophenyl)-2-oxoethyl)thio)-6-methylpyrimidin-4(1H)-one
CAS 119730-09-5C13H11BrN2O2S
1-(3,4-Dimethoxyphenyl)-2-[(4-hydroxy-6-methylpyrimidin-2-yl)sulfanyl]ethanone chemical structure, C15H16N2O4S, CAS 324577-88-0
1-(3,4-Dimethoxyphenyl)-2-[(4-hydroxy-6-methylpyrimidin-2-yl)sulfanyl]ethanone
CAS 324577-88-0C15H16N2O4S
2-((1-(4-Ethoxyphenyl)-1-oxopropan-2-yl)thio)-6-methylpyrimidin-4(1H)-one chemical structure, C16H18N2O3S, CAS 324578-50-9
2-((1-(4-Ethoxyphenyl)-1-oxopropan-2-yl)thio)-6-methylpyrimidin-4(1H)-one
CAS 324578-50-9C16H18N2O3S
2-[2-(4-Chlorophenyl)-2-oxoethyl]sulfanyl-6-methyl-1H-pyrimidin-4-one chemical structure, C13H11ClN2O2S, CAS 119730-10-8
2-[2-(4-Chlorophenyl)-2-oxoethyl]sulfanyl-6-methyl-1H-pyrimidin-4-one
CAS 119730-10-8C13H11ClN2O2S
6-Hydroxy-3-methyl-2-[(2-oxo-2-phenylethyl)sulfanyl]pyrimidin-4(3H)-one chemical structure, C13H12N2O3S, CAS 376603-75-7
6-Hydroxy-3-methyl-2-[(2-oxo-2-phenylethyl)sulfanyl]pyrimidin-4(3H)-one
CAS 376603-75-7C13H12N2O3S
1-(3,4-Dihydroxyphenyl)-2-((4-hydroxy-6-methyl-2-pyrimidinyl)sulfanyl)ethanone chemical structure, C13H12N2O4S, CAS 429649-34-3
1-(3,4-Dihydroxyphenyl)-2-((4-hydroxy-6-methyl-2-pyrimidinyl)sulfanyl)ethanone
CAS 429649-34-3C13H12N2O4S
N-[4-[2-[(6-Methyl-4-oxo-1H-pyrimidin-2-yl)sulfanyl]acetyl]phenyl]acetamide chemical structure, C15H15N3O3S, CAS 353781-42-7
N-[4-[2-[(6-Methyl-4-oxo-1H-pyrimidin-2-yl)sulfanyl]acetyl]phenyl]acetamide
CAS 353781-42-7C15H15N3O3S
6-Amino-2-[2-(4-methoxy-3-methylphenyl)-2-oxoethyl]sulfanyl-1H-pyrimidin-4-one chemical structure, C14H15N3O3S, CAS 429637-83-2
6-Amino-2-[2-(4-methoxy-3-methylphenyl)-2-oxoethyl]sulfanyl-1H-pyrimidin-4-one
CAS 429637-83-2C14H15N3O3S
6-Amino-2-[2-(4-fluorophenyl)-2-oxoethyl]sulfanyl-1H-pyrimidin-4-one chemical structure, C12H10FN3O2S, CAS 119730-34-6
6-Amino-2-[2-(4-fluorophenyl)-2-oxoethyl]sulfanyl-1H-pyrimidin-4-one
CAS 119730-34-6C12H10FN3O2S
2-[2-(4-Methoxy-3-methylphenyl)-2-oxoethyl]sulfanyl-6-methyl-1H-pyrimidin-4-one chemical structure, C15H16N2O3S, CAS 429651-81-0
2-[2-(4-Methoxy-3-methylphenyl)-2-oxoethyl]sulfanyl-6-methyl-1H-pyrimidin-4-one
CAS 429651-81-0C15H16N2O3S
2-((2-Oxo-2-phenylethyl)thio)-6-propylpyrimidin-4(3H)-one chemical structure, C15H16N2O2S, CAS 353266-34-9
2-((2-Oxo-2-phenylethyl)thio)-6-propylpyrimidin-4(3H)-one
CAS 353266-34-9C15H16N2O2S