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Murcko scaffold

Ring system with 3 rings and 21 atoms

9 chemicals on CompoundList share this ring system.

Rings: 3
Scaffold atoms: 21
Chemicals: 9
With full pages: 4

Scaffold SMILES

O=C(Nc1ccccc1)C1CC(=O)N(Cc2ccco2)C1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold

Murcko scaffold O=C(Nc1ccccc1)C1CC(=O)N(Cc2ccco2)C1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 9 of 9 chemicals

1-(Furan-2-ylmethyl)-N-(4-methylphenyl)-5-oxopyrrolidine-3-carboxamide chemical structure, C17H18N2O3, CAS 720664-02-8

1-(Furan-2-ylmethyl)-N-(4-methylphenyl)-5-oxopyrrolidine-3-carboxamide

CAS 720664-02-8C₁₇H₁₈N₂O₃

N-(4-Acetamidophenyl)-1-(furan-2-ylmethyl)-5-oxopyrrolidine-3-carboxamide chemical structure, C18H19N3O4, CAS 847734-53-6

N-(4-Acetamidophenyl)-1-(furan-2-ylmethyl)-5-oxopyrrolidine-3-carboxamide

CAS 847734-53-6C₁₈H₁₉N₃O₄

1-(Furan-2-ylmethyl)-5-oxo-N-[3-(trifluoromethyl)phenyl]pyrrolidine-3-carboxamide chemical structure, C17H15F3N2O3, CAS 851452-74-9

1-(Furan-2-ylmethyl)-5-oxo-N-[3-(trifluoromethyl)phenyl]pyrrolidine-3-carboxamide

CAS 851452-74-9C₁₇H₁₅F₃N₂O₃

1-(Furan-2-ylmethyl)-5-oxo-N-(2-propoxy-5-(trifluoromethyl)phenyl)pyrrolidine-3-carboxamide chemical structure, C20H21F3N2O4, CAS 870760-17-1

1-(Furan-2-ylmethyl)-5-oxo-N-(2-propoxy-5-(trifluoromethyl)phenyl)pyrrolidine-3-carboxamide

CAS 870760-17-1C₂₀H₂₁F₃N₂O₄

N-(3-Acetylphenyl)-1-(furan-2-ylmethyl)-5-oxopyrrolidine-3-carboxamide chemical structure, C18H18N2O4, CAS 1061909-02-1

N-(3-Acetylphenyl)-1-(furan-2-ylmethyl)-5-oxopyrrolidine-3-carboxamide

CAS 1061909-02-1C₁₈H₁₈N₂O₄

N-[4-(Acetylsulfamoyl)phenyl]-1-(furan-2-ylmethyl)-5-oxopyrrolidine-3-carboxamide chemical structure, C18H19N3O6S, CAS 1144471-85-1

N-[4-(Acetylsulfamoyl)phenyl]-1-(furan-2-ylmethyl)-5-oxopyrrolidine-3-carboxamide

CAS 1144471-85-1C₁₈H₁₉N₃O₆S

1-(Furan-2-ylmethyl)-N-(4-hydroxyphenyl)-5-oxopyrrolidine-3-carboxamide chemical structure, C16H16N2O4, CAS 1144431-81-1

1-(Furan-2-ylmethyl)-N-(4-hydroxyphenyl)-5-oxopyrrolidine-3-carboxamide

CAS 1144431-81-1C₁₆H₁₆N₂O₄

Methyl 4-({[1-(furan-2-ylmethyl)-5-oxopyrrolidin-3-yl]carbonyl}amino)benzoate chemical structure, C18H18N2O5, CAS 1144473-85-7

Methyl 4-({[1-(furan-2-ylmethyl)-5-oxopyrrolidin-3-yl]carbonyl}amino)benzoate

CAS 1144473-85-7C₁₈H₁₈N₂O₅

1-(Furan-2-ylmethyl)-5-oxo-N-(3,4,5-trimethoxyphenyl)pyrrolidine-3-carboxamide chemical structure, C19H22N2O6, CAS 1144473-57-3

1-(Furan-2-ylmethyl)-5-oxo-N-(3,4,5-trimethoxyphenyl)pyrrolidine-3-carboxamide

CAS 1144473-57-3C₁₉H₂₂N₂O₆