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Murcko scaffold

Thiophene, 2-(phenylmethyl)- scaffold

336 chemicals on CompoundList share this ring system.

Rings
2
Scaffold atoms
12
Chemicals
336
With full pages
25
Scaffold SMILES

c1ccc(Cc2cccs2)cc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffoldOpen the Thiophene, 2-(phenylmethyl)- page
Murcko scaffold c1ccc(Cc2cccs2)cc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 48 of 336 chemicals

3-Hydroxy-N,N,N-trimethyl-3-phenyl-3-(thiophen-2-yl)propan-1-aminium iodide chemical structure, C16H22INOS, CAS 357-76-6
3-Hydroxy-N,N,N-trimethyl-3-phenyl-3-(thiophen-2-yl)propan-1-aminium iodide
CAS 357-76-6C16H22INOS
Ammonium, (2-(alpha-hydroxy-N-methyl-alpha-phenyl-2-thiopheneacetamido)ethyl)trimethyl-, bromide chemical structure, C18H25BrN2O2S, CAS 26058-53-7
Ammonium, (2-(alpha-hydroxy-N-methyl-alpha-phenyl-2-thiopheneacetamido)ethyl)trimethyl-, bromide
CAS 26058-53-7C18H25BrN2O2S
Ammonium, diethyl(2-(alpha-hydroxy-N-methyl-alpha-phenyl-2-thiopheneacetamido)ethyl)methyl-, bromide chemical structure, C20H29BrN2O2S, CAS 26058-54-8
Ammonium, diethyl(2-(alpha-hydroxy-N-methyl-alpha-phenyl-2-thiopheneacetamido)ethyl)methyl-, bromide
CAS 26058-54-8C20H29BrN2O2S
Ammonium, diethyl(2-(alpha-hydroxy-alpha-phenyl-2-thiopheneacetamido)ethyl)methyl-, bromide chemical structure, C19H27BrN2O2S, CAS 26058-58-2
Ammonium, diethyl(2-(alpha-hydroxy-alpha-phenyl-2-thiopheneacetamido)ethyl)methyl-, bromide
CAS 26058-58-2C19H27BrN2O2S
Acetic acid, (2,3-dichloro-4-((2-thienyl)hydroxymethyl)phenoxy)- chemical structure, C13H10Cl2O4S, CAS 55901-78-5
Acetic acid, (2,3-dichloro-4-((2-thienyl)hydroxymethyl)phenoxy)-
CAS 55901-78-5C13H10Cl2O4S
Acetic acid, (2,3-dichloro-4-(2-thienylmethyl)phenoxy)- chemical structure, C13H10Cl2O3S, CAS 55901-79-6
Acetic acid, (2,3-dichloro-4-(2-thienylmethyl)phenoxy)-
CAS 55901-79-6C13H10Cl2O3S
Ethylamine, N,N-dimethyl-2-(phenyl-(2'-thienyl)methoxy)-, hydrochloride chemical structure, C15H20ClNOS, CAS 63918-16-1
Ethylamine, N,N-dimethyl-2-(phenyl-(2'-thienyl)methoxy)-, hydrochloride
CAS 63918-16-1C15H20ClNOS
Ethanaminium, N,N-diethyl-2-((2-hydroxy-2-phenyl-2-(2-thienyl)acetyl)oxy)-N-methyl-, bromide (1:1) chemical structure, C19H26BrNO3S, CAS 17692-63-6
Ethanaminium, N,N-diethyl-2-((2-hydroxy-2-phenyl-2-(2-thienyl)acetyl)oxy)-N-methyl-, bromide (1:1)
CAS 17692-63-6C19H26BrNO3S
Oxitefonium chemical structure, C19H26NO3S+, CAS 17989-37-6
Oxitefonium
CAS 17989-37-6C19H26NO3S+
2-Thiophenemethanol, alpha-(3-(diethylamino)-1-propynyl)-alpha-phenyl-, hydrochloride chemical structure, C18H22ClNOS, CAS 965-75-3
2-Thiophenemethanol, alpha-(3-(diethylamino)-1-propynyl)-alpha-phenyl-, hydrochloride
CAS 965-75-3C18H22ClNOS
4-(Diethylamino)-1-phenyl-1-(thiophen-2-yl)but-2-yn-1-ol chemical structure, C18H21NOS, CAS 1156-12-3
4-(Diethylamino)-1-phenyl-1-(thiophen-2-yl)but-2-yn-1-ol
CAS 1156-12-3C18H21NOS
Thiophene, 2-(phenylmethyl)- chemical structure, C11H10S, CAS 13132-15-5
Thiophene, 2-(phenylmethyl)-
CAS 13132-15-5C11H10S
2-Thiopheneglycolic acid, alpha-phenyl-, 4-(diethylamino)-2-butynyl ester, hydrochloride chemical structure, C20H24ClNO3S, CAS 3512-32-1
2-Thiopheneglycolic acid, alpha-phenyl-, 4-(diethylamino)-2-butynyl ester, hydrochloride
CAS 3512-32-1C20H24ClNO3S
2-Thiopheneacetamide, N-(2-dimethylaminoethyl)-alpha-hydroxy-N-methyl-alpha-phenyl-, hydrochloride chemical structure, C17H23ClN2O2S, CAS 37109-10-7
2-Thiopheneacetamide, N-(2-dimethylaminoethyl)-alpha-hydroxy-N-methyl-alpha-phenyl-, hydrochloride
CAS 37109-10-7C17H23ClN2O2S
2-Thiopheneacetamide, N-(2-diethylaminoethyl)-alpha-hydroxy-N-methyl-alpha-phenyl-, hydrochloride chemical structure, C19H27ClN2O2S, CAS 37109-14-1
2-Thiopheneacetamide, N-(2-diethylaminoethyl)-alpha-hydroxy-N-methyl-alpha-phenyl-, hydrochloride
CAS 37109-14-1C19H27ClN2O2S
2-Thiopheneacetamide, N-(2-diethylaminoethyl)-alpha-hydroxy-alpha-phenyl-, hydrochloride chemical structure, C18H25ClN2O2S, CAS 37109-17-4
2-Thiopheneacetamide, N-(2-diethylaminoethyl)-alpha-hydroxy-alpha-phenyl-, hydrochloride
CAS 37109-17-4C18H25ClN2O2S
2,6-Ditert-butyl-4-(thiophen-2-ylmethyl)phenol chemical structure, C19H26OS, CAS 5429-76-5
2,6-Ditert-butyl-4-(thiophen-2-ylmethyl)phenol
CAS 5429-76-5C19H26OS
Phenyl(thiophen-2-yl)acetic acid chemical structure, C12H10O2S, CAS 6343-63-1
Phenyl(thiophen-2-yl)acetic acid
CAS 6343-63-1C12H10O2S
2-(2-Chlorobenzyl)thiophene chemical structure, C11H9ClS, CAS 91064-17-4
2-(2-Chlorobenzyl)thiophene
CAS 91064-17-4C11H9ClS
2-Thiophen-2-ylmethyl-benzoic acid chemical structure, C12H10O2S, CAS 62636-87-7
2-Thiophen-2-ylmethyl-benzoic acid
CAS 62636-87-7C12H10O2S
Phenyl(thiophen-2-yl)methanamine chemical structure, C11H11NS, CAS 5693-42-5
Phenyl(thiophen-2-yl)methanamine
CAS 5693-42-5C11H11NS
2-Benzyl-5-tert-butoxythiophene chemical structure, C15H18OS, CAS 55059-20-6
2-Benzyl-5-tert-butoxythiophene
CAS 55059-20-6C15H18OS
4-[(Thiophen-2-yl)methyl]phenol chemical structure, C11H10OS, CAS 91680-55-6
4-[(Thiophen-2-yl)methyl]phenol
CAS 91680-55-6C11H10OS
Methyl 2-amino-5-benzyl-4-methyl-3-thiophenecarboxylate chemical structure, C14H15NO2S, CAS 304478-66-8
Methyl 2-amino-5-benzyl-4-methyl-3-thiophenecarboxylate
CAS 304478-66-8C14H15NO2S