CompoundList
Sign in
Murcko scaffold

Ring system with 5 rings and 28 atoms

65 chemicals on CompoundList share this ring system.

Rings
5
Scaffold atoms
28
Chemicals
65
With full pages
3
Scaffold SMILES

c1ccc(CN2CCN(c3ccnc4c(-c5ccccc5)cnn34)CC2)cc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold c1ccc(CN2CCN(c3ccnc4c(-c5ccccc5)cnn34)CC2)cc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 48 of 65 chemicals

7-[4-(2,4-Dimethylbenzyl)piperazin-1-yl]-2-methyl-3-phenyl-5-(propan-2-yl)pyrazolo[1,5-a]pyrimidine chemical structure, C29H35N5, CAS 896594-54-0
7-[4-(2,4-Dimethylbenzyl)piperazin-1-yl]-2-methyl-3-phenyl-5-(propan-2-yl)pyrazolo[1,5-a]pyrimidine
CAS 896594-54-0C29H35N5
3-(4-Chlorophenyl)-7-[4-(2,4-dimethylbenzyl)piperazin-1-yl]-5-methylpyrazolo[1,5-a]pyrimidine chemical structure, C26H28ClN5, CAS 896807-08-2
3-(4-Chlorophenyl)-7-[4-(2,4-dimethylbenzyl)piperazin-1-yl]-5-methylpyrazolo[1,5-a]pyrimidine
CAS 896807-08-2C26H28ClN5
5-tert-Butyl-7-[4-(4-chlorobenzyl)piperazin-1-yl]-3-(4-chlorophenyl)pyrazolo[1,5-a]pyrimidine chemical structure, C27H29Cl2N5, CAS 896813-59-5
5-tert-Butyl-7-[4-(4-chlorobenzyl)piperazin-1-yl]-3-(4-chlorophenyl)pyrazolo[1,5-a]pyrimidine
CAS 896813-59-5C27H29Cl2N5
7-(4-(4-Chlorobenzyl)piperazin-1-yl)-3-(4-chlorophenyl)-5-methylpyrazolo[1,5-a]pyrimidine chemical structure, C24H23Cl2N5, CAS 896833-38-8
7-(4-(4-Chlorobenzyl)piperazin-1-yl)-3-(4-chlorophenyl)-5-methylpyrazolo[1,5-a]pyrimidine
CAS 896833-38-8C24H23Cl2N5
5-tert-Butyl-7-[4-(4-chlorobenzyl)piperazin-1-yl]-3-phenylpyrazolo[1,5-a]pyrimidine chemical structure, C27H30ClN5, CAS 896834-98-3
5-tert-Butyl-7-[4-(4-chlorobenzyl)piperazin-1-yl]-3-phenylpyrazolo[1,5-a]pyrimidine
CAS 896834-98-3C27H30ClN5
5-tert-Butyl-7-[4-(5-chloro-2-methoxybenzyl)piperazin-1-yl]-3-phenylpyrazolo[1,5-a]pyrimidine chemical structure, C28H32ClN5O, CAS 896841-85-3
5-tert-Butyl-7-[4-(5-chloro-2-methoxybenzyl)piperazin-1-yl]-3-phenylpyrazolo[1,5-a]pyrimidine
CAS 896841-85-3C28H32ClN5O
7-[4-(4-Chlorobenzyl)piperazin-1-yl]-2-methyl-3-phenyl-5-propylpyrazolo[1,5-a]pyrimidine chemical structure, C27H30ClN5, CAS 896847-21-5
7-[4-(4-Chlorobenzyl)piperazin-1-yl]-2-methyl-3-phenyl-5-propylpyrazolo[1,5-a]pyrimidine
CAS 896847-21-5C27H30ClN5
5-tert-Butyl-7-[4-(3-fluoro-4-methoxybenzyl)piperazin-1-yl]-3-phenylpyrazolo[1,5-a]pyrimidine chemical structure, C28H32FN5O, CAS 896848-32-1
5-tert-Butyl-7-[4-(3-fluoro-4-methoxybenzyl)piperazin-1-yl]-3-phenylpyrazolo[1,5-a]pyrimidine
CAS 896848-32-1C28H32FN5O
7-(4-(4-Chlorobenzyl)piperazin-1-yl)-5-methyl-3-phenylpyrazolo[1,5-a]pyrimidine chemical structure, C24H24ClN5, CAS 850190-99-7
7-(4-(4-Chlorobenzyl)piperazin-1-yl)-5-methyl-3-phenylpyrazolo[1,5-a]pyrimidine
CAS 850190-99-7C24H24ClN5
5-tert-Butyl-7-[4-(2,4-dimethylbenzyl)piperazin-1-yl]-3-phenylpyrazolo[1,5-a]pyrimidine chemical structure, C29H35N5, CAS 899392-86-0
5-tert-Butyl-7-[4-(2,4-dimethylbenzyl)piperazin-1-yl]-3-phenylpyrazolo[1,5-a]pyrimidine
CAS 899392-86-0C29H35N5
7-(4-Benzylpiperazin-1-yl)-5-tert-butyl-3-(4-chlorophenyl)-2-methylpyrazolo[1,5-a]pyrimidine chemical structure, C28H32ClN5, CAS 850235-78-8
7-(4-Benzylpiperazin-1-yl)-5-tert-butyl-3-(4-chlorophenyl)-2-methylpyrazolo[1,5-a]pyrimidine
CAS 850235-78-8C28H32ClN5
5-tert-Butyl-3-(4-chlorophenyl)-7-[4-(2,4-dimethylbenzyl)piperazin-1-yl]pyrazolo[1,5-a]pyrimidine chemical structure, C29H34ClN5, CAS 900268-94-2
5-tert-Butyl-3-(4-chlorophenyl)-7-[4-(2,4-dimethylbenzyl)piperazin-1-yl]pyrazolo[1,5-a]pyrimidine
CAS 900268-94-2C29H34ClN5
7-[4-(2,4-Dimethylbenzyl)piperazin-1-yl]-2-methyl-3-phenyl-5-propylpyrazolo[1,5-a]pyrimidine chemical structure, C29H35N5, CAS 900297-29-2
7-[4-(2,4-Dimethylbenzyl)piperazin-1-yl]-2-methyl-3-phenyl-5-propylpyrazolo[1,5-a]pyrimidine
CAS 900297-29-2C29H35N5
7-(4-Benzylpiperazin-1-yl)-5-tert-butyl-3-phenylpyrazolo[1,5-a]pyrimidine chemical structure, C27H31N5, CAS 900281-46-1
7-(4-Benzylpiperazin-1-yl)-5-tert-butyl-3-phenylpyrazolo[1,5-a]pyrimidine
CAS 900281-46-1C27H31N5
7-(4-Benzylpiperazin-1-yl)-5-tert-butyl-2-methyl-3-phenylpyrazolo[1,5-a]pyrimidine chemical structure, C28H33N5, CAS 850237-78-4
7-(4-Benzylpiperazin-1-yl)-5-tert-butyl-2-methyl-3-phenylpyrazolo[1,5-a]pyrimidine
CAS 850237-78-4C28H33N5
5-tert-Butyl-3-(4-chlorophenyl)-7-[4-(3,4-dichlorobenzyl)piperazin-1-yl]-2-methylpyrazolo[1,5-a]pyrimidine chemical structure, C28H30Cl3N5, CAS 850729-03-2
5-tert-Butyl-3-(4-chlorophenyl)-7-[4-(3,4-dichlorobenzyl)piperazin-1-yl]-2-methylpyrazolo[1,5-a]pyrimidine
CAS 850729-03-2C28H30Cl3N5
7-(4-Benzylpiperazin-1-yl)-5-methyl-3-phenylpyrazolo[1,5-a]pyrimidine chemical structure, C24H25N5, CAS 850730-35-7
7-(4-Benzylpiperazin-1-yl)-5-methyl-3-phenylpyrazolo[1,5-a]pyrimidine
CAS 850730-35-7C24H25N5
5-(tert-Butyl)-7-{4-[(2,4-dimethylphenyl)methyl]piperazinyl}-2-methyl-3-phenyl-8-hydropyrazolo[1,5-a]pyrimidine chemical structure, C30H37N5, CAS 850735-87-4
5-(tert-Butyl)-7-{4-[(2,4-dimethylphenyl)methyl]piperazinyl}-2-methyl-3-phenyl-8-hydropyrazolo[1,5-a]pyrimidine
CAS 850735-87-4C30H37N5
7-(4-Benzylpiperazin-1-yl)-2,5-dimethyl-3-phenylpyrazolo[1,5-a]pyrimidine chemical structure, C25H27N5, CAS 850751-32-5
7-(4-Benzylpiperazin-1-yl)-2,5-dimethyl-3-phenylpyrazolo[1,5-a]pyrimidine
CAS 850751-32-5C25H27N5
7-(4-Benzylpiperazin-1-yl)-5-tert-butyl-3-(4-chlorophenyl)pyrazolo[1,5-a]pyrimidine chemical structure, C27H30ClN5, CAS 896066-22-1
7-(4-Benzylpiperazin-1-yl)-5-tert-butyl-3-(4-chlorophenyl)pyrazolo[1,5-a]pyrimidine
CAS 896066-22-1C27H30ClN5
7-(4-Benzylpiperazin-1-yl)-2-methyl-3-phenyl-5-propylpyrazolo[1,5-a]pyrimidine chemical structure, C27H31N5, CAS 896071-60-6
7-(4-Benzylpiperazin-1-yl)-2-methyl-3-phenyl-5-propylpyrazolo[1,5-a]pyrimidine
CAS 896071-60-6C27H31N5
7-(4-Benzylpiperazin-1-yl)-3-(4-chlorophenyl)-5-methylpyrazolo[1,5-a]pyrimidine chemical structure, C24H24ClN5, CAS 896075-79-9
7-(4-Benzylpiperazin-1-yl)-3-(4-chlorophenyl)-5-methylpyrazolo[1,5-a]pyrimidine
CAS 896075-79-9C24H24ClN5
7-[4-(4-Chlorobenzyl)piperazin-1-yl]-2-methyl-3-phenyl-5-(propan-2-yl)pyrazolo[1,5-a]pyrimidine chemical structure, C27H30ClN5, CAS 896595-94-1
7-[4-(4-Chlorobenzyl)piperazin-1-yl]-2-methyl-3-phenyl-5-(propan-2-yl)pyrazolo[1,5-a]pyrimidine
CAS 896595-94-1C27H30ClN5
7-(4-Benzylpiperazin-1-yl)-5-isopropyl-2-methyl-3-phenylpyrazolo[1,5-a]pyrimidine chemical structure, C27H31N5, CAS 896068-58-9
7-(4-Benzylpiperazin-1-yl)-5-isopropyl-2-methyl-3-phenylpyrazolo[1,5-a]pyrimidine
CAS 896068-58-9C27H31N5