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Murcko scaffold

Ring system with 4 rings and 22 atoms

13 chemicals on CompoundList share this ring system.

Rings
4
Scaffold atoms
22
Chemicals
13
With full pages
4
Scaffold SMILES

O=c1c(=Cc2ccccc2)sc2nc(-c3ccncc3)nn12

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=c1c(=Cc2ccccc2)sc2nc(-c3ccncc3)nn12

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 13 of 13 chemicals

(Z)-5-Benzylidene-2-(pyridin-4-yl)thiazolo[3,2-b][1,2,4]triazol-6(5H)-one chemical structure, C16H10N4OS, CAS 324568-66-3
(Z)-5-Benzylidene-2-(pyridin-4-yl)thiazolo[3,2-b][1,2,4]triazol-6(5H)-one
CAS 324568-66-3C16H10N4OS
(5Z)-5-(4-Chlorobenzylidene)-2-(pyridin-4-yl)[1,3]thiazolo[3,2-b][1,2,4]triazol-6(5H)-one chemical structure, C16H9ClN4OS, CAS 342785-37-9
(5Z)-5-(4-Chlorobenzylidene)-2-(pyridin-4-yl)[1,3]thiazolo[3,2-b][1,2,4]triazol-6(5H)-one
CAS 342785-37-9C16H9ClN4OS
(Z)-5-(4-Methoxybenzylidene)-2-(pyridin-4-yl)thiazolo[3,2-b][1,2,4]triazol-6(5H)-one chemical structure, C17H12N4O2S, CAS 606954-10-3
(Z)-5-(4-Methoxybenzylidene)-2-(pyridin-4-yl)thiazolo[3,2-b][1,2,4]triazol-6(5H)-one
CAS 606954-10-3C17H12N4O2S
(5Z)-5-[(2,4-Dichlorophenyl)methylidene]-2-pyridin-4-yl-[1,3]thiazolo[3,2-b][1,2,4]triazol-6-one chemical structure, C16H8Cl2N4OS, CAS 606959-08-4
(5Z)-5-[(2,4-Dichlorophenyl)methylidene]-2-pyridin-4-yl-[1,3]thiazolo[3,2-b][1,2,4]triazol-6-one
CAS 606959-08-4C16H8Cl2N4OS
(Z)-5-(3-Nitrobenzylidene)-2-(pyridin-4-yl)thiazolo[3,2-b][1,2,4]triazol-6(5H)-one chemical structure, C16H9N5O3S, CAS 606958-57-0
(Z)-5-(3-Nitrobenzylidene)-2-(pyridin-4-yl)thiazolo[3,2-b][1,2,4]triazol-6(5H)-one
CAS 606958-57-0C16H9N5O3S
4-{(Z)-[6-Oxo-2-(pyridin-4-yl)[1,3]thiazolo[3,2-b][1,2,4]triazol-5(6H)-ylidene]methyl}phenyl acetate chemical structure, C18H12N4O3S, CAS 606960-63-8
4-{(Z)-[6-Oxo-2-(pyridin-4-yl)[1,3]thiazolo[3,2-b][1,2,4]triazol-5(6H)-ylidene]methyl}phenyl acetate
CAS 606960-63-8C18H12N4O3S
(5E)-5-(3,4-Dimethoxybenzylidene)-2-(4-pyridinyl)[1,3]thiazolo[3,2-B][1,2,4]triazol-6(5H)-one chemical structure, C18H14N4O3S, CAS 606949-63-7
(5E)-5-(3,4-Dimethoxybenzylidene)-2-(4-pyridinyl)[1,3]thiazolo[3,2-B][1,2,4]triazol-6(5H)-one
CAS 606949-63-7C18H14N4O3S
(5Z)-5-(3-Methoxy-4-(octyloxy)benzylidene)-2-(4-pyridinyl)(1,3)thiazolo(3,2-B)(1,2,4)triazol-6(5H)-one chemical structure, C25H28N4O3S, CAS 617694-27-6
(5Z)-5-(3-Methoxy-4-(octyloxy)benzylidene)-2-(4-pyridinyl)(1,3)thiazolo(3,2-B)(1,2,4)triazol-6(5H)-one
CAS 617694-27-6C25H28N4O3S
(5Z)-5-(3-Ethoxy-4-propoxybenzylidene)-2-pyridin-4-yl[1,3]thiazolo[3,2-b][1,2,4]triazol-6(5H)-one chemical structure, C21H20N4O3S, CAS 617694-44-7
(5Z)-5-(3-Ethoxy-4-propoxybenzylidene)-2-pyridin-4-yl[1,3]thiazolo[3,2-b][1,2,4]triazol-6(5H)-one
CAS 617694-44-7C21H20N4O3S
(5Z)-5-(2-Propoxybenzylidene)-2-pyridin-4-yl[1,3]thiazolo[3,2-b][1,2,4]triazol-6(5H)-one chemical structure, C19H16N4O2S, CAS 608120-07-6
(5Z)-5-(2-Propoxybenzylidene)-2-pyridin-4-yl[1,3]thiazolo[3,2-b][1,2,4]triazol-6(5H)-one
CAS 608120-07-6C19H16N4O2S
(5E)-5-(2-(Hexyloxy)benzylidene)-2-(4-pyridinyl)(1,3)thiazolo(3,2-B)(1,2,4)triazol-6(5H)-one chemical structure, C22H22N4O2S, CAS 617695-17-7
(5E)-5-(2-(Hexyloxy)benzylidene)-2-(4-pyridinyl)(1,3)thiazolo(3,2-B)(1,2,4)triazol-6(5H)-one
CAS 617695-17-7C22H22N4O2S
5-[[3-Methoxy-4-(3-methylbutoxy)phenyl]methylene]-2-(4-pyridinyl)thiazolo[3,2-b][1,2,4]triazol-6(5H)-one chemical structure, C22H22N4O3S, CAS 378208-17-4
5-[[3-Methoxy-4-(3-methylbutoxy)phenyl]methylene]-2-(4-pyridinyl)thiazolo[3,2-b][1,2,4]triazol-6(5H)-one
CAS 378208-17-4C22H22N4O3S
(5E)-5-(2-(Pentyloxy)benzylidene)-2-(4-pyridinyl)(1,3)thiazolo(3,2-B)(1,2,4)triazol-6(5H)-one chemical structure, C21H20N4O2S, CAS 617694-61-8
(5E)-5-(2-(Pentyloxy)benzylidene)-2-(4-pyridinyl)(1,3)thiazolo(3,2-B)(1,2,4)triazol-6(5H)-one
CAS 617694-61-8C21H20N4O2S