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Murcko scaffold

1-(3-Pyridinylcarbonyl)piperazine scaffold

102 chemicals on CompoundList share this ring system.

Rings
2
Scaffold atoms
14
Chemicals
102
With full pages
6
Scaffold SMILES

O=C(c1cccnc1)N1CCNCC1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffoldOpen the 1-(3-Pyridinylcarbonyl)piperazine page
Murcko scaffold O=C(c1cccnc1)N1CCNCC1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 48 of 102 chemicals

(4-Ethylsulfonylpiperazin-1-yl)-pyridin-3-ylmethanone chemical structure, C12H17N3O3S, CAS 428838-07-7
(4-Ethylsulfonylpiperazin-1-yl)-pyridin-3-ylmethanone
CAS 428838-07-7C12H17N3O3S
(4-Propylsulfonylpiperazin-1-yl)-pyridin-3-ylmethanone chemical structure, C13H19N3O3S, CAS 428842-89-1
(4-Propylsulfonylpiperazin-1-yl)-pyridin-3-ylmethanone
CAS 428842-89-1C13H19N3O3S
1-(3-Pyridinylcarbonyl)piperazine chemical structure, C10H13N3O, CAS 39640-08-9
1-(3-Pyridinylcarbonyl)piperazine
CAS 39640-08-9C10H13N3O
(4-Propan-2-ylpiperazin-1-yl)-pyridin-3-ylmethanone chemical structure, C13H19N3O, CAS 504432-24-0
(4-Propan-2-ylpiperazin-1-yl)-pyridin-3-ylmethanone
CAS 504432-24-0C13H19N3O
(2-Chloro-3-pyridinyl)[4-(2-hydroxyethyl)-1-piperazinyl]methanone chemical structure, C12H16ClN3O2, CAS 444791-56-4
(2-Chloro-3-pyridinyl)[4-(2-hydroxyethyl)-1-piperazinyl]methanone
CAS 444791-56-4C12H16ClN3O2
1-(6-Chloropyridine-3-carbonyl)-4-methylpiperazine chemical structure, C11H14ClN3O, CAS 64614-50-2
1-(6-Chloropyridine-3-carbonyl)-4-methylpiperazine
CAS 64614-50-2C11H14ClN3O
(2-Chloropyridin-3-yl)(4-methylpiperazin-1-yl)methanone chemical structure, C11H14ClN3O, CAS 60597-69-5
(2-Chloropyridin-3-yl)(4-methylpiperazin-1-yl)methanone
CAS 60597-69-5C11H14ClN3O
Ethyl 4-(6-chloropyridine-3-carbonyl)piperazine-1-carboxylate chemical structure, C13H16ClN3O3, CAS 385407-89-6
Ethyl 4-(6-chloropyridine-3-carbonyl)piperazine-1-carboxylate
CAS 385407-89-6C13H16ClN3O3
1-(4-(5-Bromonicotinoyl)piperazin-1-yl)ethan-1-one chemical structure, C12H14BrN3O2, CAS 721434-29-3
1-(4-(5-Bromonicotinoyl)piperazin-1-yl)ethan-1-one
CAS 721434-29-3C12H14BrN3O2
tert-Butyl 4-(2-chloronicotinoyl)piperazine-1-carboxylate chemical structure, C15H20ClN3O3, CAS 551921-02-9
tert-Butyl 4-(2-chloronicotinoyl)piperazine-1-carboxylate
CAS 551921-02-9C15H20ClN3O3
1-(6-Chloropyridine-3-carbonyl)-4-ethylpiperazine chemical structure, C12H16ClN3O, CAS 325734-82-5
1-(6-Chloropyridine-3-carbonyl)-4-ethylpiperazine
CAS 325734-82-5C12H16ClN3O
(4-Ethyl-1-piperazinyl)(3-pyridinyl)methanone chemical structure, C12H17N3O, CAS 545372-87-0
(4-Ethyl-1-piperazinyl)(3-pyridinyl)methanone
CAS 545372-87-0C12H17N3O
1-Piperazinecarboxaldehyde, 4-[(6-methyl-3-pyridinyl)carbonyl]- chemical structure, C12H15N3O2, CAS 613660-64-3
1-Piperazinecarboxaldehyde, 4-[(6-methyl-3-pyridinyl)carbonyl]-
CAS 613660-64-3C12H15N3O2
Piperazine, 1-methyl-4-[(6-methyl-3-pyridinyl)carbonyl]- chemical structure, C12H17N3O, CAS 613660-62-1
Piperazine, 1-methyl-4-[(6-methyl-3-pyridinyl)carbonyl]-
CAS 613660-62-1C12H17N3O
tert-Butyl 4-(6-chloronicotinoyl)piperazine-1-carboxylate chemical structure, C15H20ClN3O3, CAS 220359-66-0
tert-Butyl 4-(6-chloronicotinoyl)piperazine-1-carboxylate
CAS 220359-66-0C15H20ClN3O3
1-[(6-Methylpyridin-3-yl)carbonyl]piperazine chemical structure, C11H15N3O, CAS 953720-70-2
1-[(6-Methylpyridin-3-yl)carbonyl]piperazine
CAS 953720-70-2C11H15N3O
3-Methyl-1-(pyridine-3-carbonyl)piperazine chemical structure, C11H15N3O, CAS 1240564-98-0
3-Methyl-1-(pyridine-3-carbonyl)piperazine
CAS 1240564-98-0C11H15N3O
1-(Pyridine-3-carbonyl)piperazine dihydrochloride chemical structure, C10H15Cl2N3O, CAS 32422-95-0
1-(Pyridine-3-carbonyl)piperazine dihydrochloride
CAS 32422-95-0C10H15Cl2N3O
1-(5,6-Dichloropyridine-3-carbonyl)-4-methylpiperazine chemical structure, C11H13Cl2N3O, CAS 1016763-11-3
1-(5,6-Dichloropyridine-3-carbonyl)-4-methylpiperazine
CAS 1016763-11-3C11H13Cl2N3O
(5,6-Dichloropyridin-3-yl)(4-ethylpiperazin-1-yl)methanone chemical structure, C12H15Cl2N3O, CAS 1016528-51-0
(5,6-Dichloropyridin-3-yl)(4-ethylpiperazin-1-yl)methanone
CAS 1016528-51-0C12H15Cl2N3O
(5-Bromopyridin-3-yl)(4-methylpiperazin-1-yl)methanone chemical structure, C11H14BrN3O, CAS 342013-83-6
(5-Bromopyridin-3-yl)(4-methylpiperazin-1-yl)methanone
CAS 342013-83-6C11H14BrN3O
tert-Butyl 4-(5-bromopyridine-3-carbonyl)piperazine-1-carboxylate chemical structure, C15H20BrN3O3, CAS 1017782-72-7
tert-Butyl 4-(5-bromopyridine-3-carbonyl)piperazine-1-carboxylate
CAS 1017782-72-7C15H20BrN3O3
(5-Bromo-3-pyridinyl)(piperazino)methanone chemical structure, C10H12BrN3O, CAS 1017782-91-0
(5-Bromo-3-pyridinyl)(piperazino)methanone
CAS 1017782-91-0C10H12BrN3O
(4-Methylpiperazino)[6-(trifluoromethyl)-3-pyridinyl]methanone chemical structure, C12H14F3N3O, CAS 1092346-41-2
(4-Methylpiperazino)[6-(trifluoromethyl)-3-pyridinyl]methanone
CAS 1092346-41-2C12H14F3N3O