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Murcko scaffold

Ring system with 2 rings and 19 atoms

323 chemicals on CompoundList share this ring system.

Rings: 2
Scaffold atoms: 19
Chemicals: 323
With full pages: 12

Scaffold SMILES

O=C(COC(=O)c1cccnc1)Nc1ccccc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold

Murcko scaffold O=C(COC(=O)c1cccnc1)Nc1ccccc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 48 of 323 chemicals

{[4-(Dimethylamino)phenyl]carbamoyl}methyl 5,6-dichloropyridine-3-carboxylate chemical structure, C16H15Cl2N3O3, CAS 391652-34-9

{[4-(Dimethylamino)phenyl]carbamoyl}methyl 5,6-dichloropyridine-3-carboxylate

CAS 391652-34-9C₁₆H₁₅Cl₂N₃O₃

2-((4-(Methoxycarbonyl)phenyl)amino)-2-oxoethyl 5-bromonicotinate chemical structure, C16H13BrN2O5, CAS 745788-57-2

2-((4-(Methoxycarbonyl)phenyl)amino)-2-oxoethyl 5-bromonicotinate

CAS 745788-57-2C₁₆H₁₃BrN₂O₅

[(4-Chloro-2-methoxy-5-methylphenyl)carbamoyl]methyl 5,6-dichloropyridine-3-carboxylate chemical structure, C16H13Cl3N2O4, CAS 391652-23-6

[(4-Chloro-2-methoxy-5-methylphenyl)carbamoyl]methyl 5,6-dichloropyridine-3-carboxylate

CAS 391652-23-6C₁₆H₁₃Cl₃N₂O₄

1,3-Dimethyl 5-[2-(2-chloropyridine-3-carbonyloxy)acetamido]benzene-1,3-dicarboxylate chemical structure, C18H15ClN2O7, CAS 572895-80-8

1,3-Dimethyl 5-[2-(2-chloropyridine-3-carbonyloxy)acetamido]benzene-1,3-dicarboxylate

CAS 572895-80-8C₁₈H₁₅ClN₂O₇

2-((2-Cyanoethyl)(phenyl)amino)-2-oxoethyl 2-(methylthio)nicotinate chemical structure, C18H17N3O3S, CAS 474499-36-0

2-((2-Cyanoethyl)(phenyl)amino)-2-oxoethyl 2-(methylthio)nicotinate

CAS 474499-36-0C₁₈H₁₇N₃O₃S

[(2-Cyanoethyl)(phenyl)carbamoyl]methyl 5,6-dichloropyridine-3-carboxylate chemical structure, C17H13Cl2N3O3, CAS 391652-20-3

[(2-Cyanoethyl)(phenyl)carbamoyl]methyl 5,6-dichloropyridine-3-carboxylate

CAS 391652-20-3C₁₇H₁₃Cl₂N₃O₃

2-((4-Cyanophenyl)amino)-2-oxoethyl 2-(methylthio)nicotinate chemical structure, C16H13N3O3S, CAS 474259-10-4

2-((4-Cyanophenyl)amino)-2-oxoethyl 2-(methylthio)nicotinate

CAS 474259-10-4C₁₆H₁₃N₃O₃S

[(2,6-Dichloro-3-methylphenyl)carbamoyl]methyl 5,6-dichloropyridine-3-carboxylate chemical structure, C15H10Cl4N2O3, CAS 391653-33-1

[(2,6-Dichloro-3-methylphenyl)carbamoyl]methyl 5,6-dichloropyridine-3-carboxylate

CAS 391653-33-1C₁₅H₁₀Cl₄N₂O₃

2-((4-((Difluoromethyl)thio)phenyl)amino)-2-oxoethyl 2-(methylthio)nicotinate chemical structure, C16H14F2N2O3S2, CAS 502554-84-9

2-((4-((Difluoromethyl)thio)phenyl)amino)-2-oxoethyl 2-(methylthio)nicotinate

CAS 502554-84-9C₁₆H₁₄F₂N₂O₃S₂

[(5-Chloro-2-methoxyphenyl)carbamoyl]methyl 5,6-dichloropyridine-3-carboxylate chemical structure, C15H11Cl3N2O4, CAS 478940-89-5

[(5-Chloro-2-methoxyphenyl)carbamoyl]methyl 5,6-dichloropyridine-3-carboxylate

CAS 478940-89-5C₁₅H₁₁Cl₃N₂O₄

[(5-tert-Butyl-2-methoxyphenyl)carbamoyl]methyl 5,6-dichloropyridine-3-carboxylate chemical structure, C19H20Cl2N2O4, CAS 391653-42-2

[(5-tert-Butyl-2-methoxyphenyl)carbamoyl]methyl 5,6-dichloropyridine-3-carboxylate

CAS 391653-42-2C₁₉H₂₀Cl₂N₂O₄

[(2-Chloro-5-methanesulfonylphenyl)carbamoyl]methyl 2-chloropyridine-3-carboxylate chemical structure, C15H12Cl2N2O5S, CAS 753477-18-8

[(2-Chloro-5-methanesulfonylphenyl)carbamoyl]methyl 2-chloropyridine-3-carboxylate

CAS 753477-18-8C₁₅H₁₂Cl₂N₂O₅S

[2-(5-tert-Butyl-2-methoxyanilino)-2-oxoethyl] 2-ethoxypyridine-3-carboxylate chemical structure, C21H26N2O5, CAS 380161-87-5

[2-(5-tert-Butyl-2-methoxyanilino)-2-oxoethyl] 2-ethoxypyridine-3-carboxylate

CAS 380161-87-5C₂₁H₂₆N₂O₅

[(2,6-Dimethylphenyl)carbamoyl]methyl 2-chloropyridine-3-carboxylate chemical structure, C16H15ClN2O3, CAS 380167-46-4

[(2,6-Dimethylphenyl)carbamoyl]methyl 2-chloropyridine-3-carboxylate

CAS 380167-46-4C₁₆H₁₅ClN₂O₃

[(2,6-Dimethylphenyl)carbamoyl]methyl 6-chloropyridine-3-carboxylate chemical structure, C16H15ClN2O3, CAS 380167-58-8

[(2,6-Dimethylphenyl)carbamoyl]methyl 6-chloropyridine-3-carboxylate

CAS 380167-58-8C₁₆H₁₅ClN₂O₃

({4-[Ethyl(propan-2-yl)amino]phenyl}carbamoyl)methyl 2-chloropyridine-3-carboxylate chemical structure, C19H22ClN3O3, CAS 380185-84-2

({4-[Ethyl(propan-2-yl)amino]phenyl}carbamoyl)methyl 2-chloropyridine-3-carboxylate

CAS 380185-84-2C₁₉H₂₂ClN₃O₃

[(2,5-Dichlorophenyl)carbamoyl]methyl 2-aminopyridine-3-carboxylate chemical structure, C14H11Cl2N3O3, CAS 721416-46-2

[(2,5-Dichlorophenyl)carbamoyl]methyl 2-aminopyridine-3-carboxylate

CAS 721416-46-2C₁₄H₁₁Cl₂N₃O₃

2-((2,5-Dimethylphenyl)amino)-2-oxoethyl 2-(methylthio)nicotinate chemical structure, C17H18N2O3S, CAS 380436-67-9

2-((2,5-Dimethylphenyl)amino)-2-oxoethyl 2-(methylthio)nicotinate

CAS 380436-67-9C₁₇H₁₈N₂O₃S

[(3,5-Dichlorophenyl)carbamoyl]methyl 5,6-dichloropyridine-3-carboxylate chemical structure, C14H8Cl4N2O3, CAS 380438-19-7

[(3,5-Dichlorophenyl)carbamoyl]methyl 5,6-dichloropyridine-3-carboxylate

CAS 380438-19-7C₁₄H₈Cl₄N₂O₃

[(2,4-Difluorophenyl)carbamoyl]methyl 5,6-dichloropyridine-3-carboxylate chemical structure, C14H8Cl2F2N2O3, CAS 380438-23-3

[(2,4-Difluorophenyl)carbamoyl]methyl 5,6-dichloropyridine-3-carboxylate

CAS 380438-23-3C₁₄H₈Cl₂F₂N₂O₃

{[2-Chloro-5-(trifluoromethyl)phenyl]carbamoyl}methyl 2-chloropyridine-3-carboxylate chemical structure, C15H9Cl2F3N2O3, CAS 438592-37-1

{[2-Chloro-5-(trifluoromethyl)phenyl]carbamoyl}methyl 2-chloropyridine-3-carboxylate

CAS 438592-37-1C₁₅H₉Cl₂F₃N₂O₃

[(4-Chloro-2-fluorophenyl)carbamoyl]methyl 5,6-dichloropyridine-3-carboxylate chemical structure, C14H8Cl3FN2O3, CAS 380330-36-9

[(4-Chloro-2-fluorophenyl)carbamoyl]methyl 5,6-dichloropyridine-3-carboxylate

CAS 380330-36-9C₁₄H₈Cl₃FN₂O₃

[(2,6-Dichlorophenyl)carbamoyl]methyl 2-chloropyridine-3-carboxylate chemical structure, C14H9Cl3N2O3, CAS 380330-39-2

[(2,6-Dichlorophenyl)carbamoyl]methyl 2-chloropyridine-3-carboxylate

CAS 380330-39-2C₁₄H₉Cl₃N₂O₃

[(3,4-Dichlorophenyl)carbamoyl]methyl 5,6-dichloropyridine-3-carboxylate chemical structure, C14H8Cl4N2O3, CAS 380331-85-1

[(3,4-Dichlorophenyl)carbamoyl]methyl 5,6-dichloropyridine-3-carboxylate

CAS 380331-85-1C₁₄H₈Cl₄N₂O₃