Murcko scaffold
Ring system with 4 rings and 27 atoms
121 chemicals on CompoundList share this ring system.
- Rings
- 4
- Scaffold atoms
- 27
- Chemicals
- 121
- With full pages
- 9
Scaffold SMILES
O=C(Nc1cc2c(s1)CNCC2)c1ccc(S(=O)(=O)N2CCCCC2)cc1
A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.
Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.
Chemicals with this scaffold
Open one to see its structure, properties and suppliers.
Showing 1 to 48 of 121 chemicals
![Ethyl 6-isopropyl-2-(4-(piperidin-1-ylsulfonyl)benzamido)-4,5,6,7-tetrahydrothieno[2,3-c]pyridine-3-carboxylate chemical structure, C25H33N3O5S2, CAS 449768-23-4](/s/MBTZEKHYNWUVBW-UHFFFAOYSA-N.svg)
Ethyl 6-isopropyl-2-(4-(piperidin-1-ylsulfonyl)benzamido)-4,5,6,7-tetrahydrothieno[2,3-c]pyridine-3-carboxylate
CAS 449768-23-4C25H33N3O5S2
![Ethyl 6-isopropyl-2-(4-((2-methylpiperidin-1-yl)sulfonyl)benzamido)-4,5,6,7-tetrahydrothieno[2,3-c]pyridine-3-carboxylate chemical structure, C26H35N3O5S2, CAS 449768-25-6](/s/WRBDCTWSMOWFED-UHFFFAOYSA-N.svg)
Ethyl 6-isopropyl-2-(4-((2-methylpiperidin-1-yl)sulfonyl)benzamido)-4,5,6,7-tetrahydrothieno[2,3-c]pyridine-3-carboxylate
CAS 449768-25-6C26H35N3O5S2
![Ethyl 6-isopropyl-2-(4-((3-methylpiperidin-1-yl)sulfonyl)benzamido)-4,5,6,7-tetrahydrothieno[2,3-c]pyridine-3-carboxylate chemical structure, C26H35N3O5S2, CAS 449768-27-8](/s/YPVDQAZIKVYBHE-UHFFFAOYSA-N.svg)
Ethyl 6-isopropyl-2-(4-((3-methylpiperidin-1-yl)sulfonyl)benzamido)-4,5,6,7-tetrahydrothieno[2,3-c]pyridine-3-carboxylate
CAS 449768-27-8C26H35N3O5S2
![Ethyl 6-isopropyl-2-(4-((4-methylpiperidin-1-yl)sulfonyl)benzamido)-4,5,6,7-tetrahydrothieno[2,3-c]pyridine-3-carboxylate chemical structure, C26H35N3O5S2, CAS 449768-29-0](/s/SDHVJRFXDZVEHM-UHFFFAOYSA-N.svg)
Ethyl 6-isopropyl-2-(4-((4-methylpiperidin-1-yl)sulfonyl)benzamido)-4,5,6,7-tetrahydrothieno[2,3-c]pyridine-3-carboxylate
CAS 449768-29-0C26H35N3O5S2
![6-Ethyl-2-(4-(piperidin-1-ylsulfonyl)benzamido)-4,5,6,7-tetrahydrothieno[2,3-c]pyridine-3-carboxamide chemical structure, C22H28N4O4S2, CAS 449767-79-7](/s/JVQMYZYUHNAIHW-UHFFFAOYSA-N.svg)
6-Ethyl-2-(4-(piperidin-1-ylsulfonyl)benzamido)-4,5,6,7-tetrahydrothieno[2,3-c]pyridine-3-carboxamide
CAS 449767-79-7C22H28N4O4S2
![6-Ethyl-2-(4-((3-methylpiperidin-1-yl)sulfonyl)benzamido)-4,5,6,7-tetrahydrothieno[2,3-c]pyridine-3-carboxamide chemical structure, C23H30N4O4S2, CAS 489470-18-0](/s/JZKWYPSXWNYZNP-UHFFFAOYSA-N.svg)
6-Ethyl-2-(4-((3-methylpiperidin-1-yl)sulfonyl)benzamido)-4,5,6,7-tetrahydrothieno[2,3-c]pyridine-3-carboxamide
CAS 489470-18-0C23H30N4O4S2
![6-Ethyl-2-[[4-(4-methylpiperidin-1-yl)sulfonylbenzoyl]amino]-5,7-dihydro-4H-thieno[2,3-c]pyridine-3-carboxamide chemical structure, C23H30N4O4S2, CAS 449767-81-1](/s/MFFBXWMPUZIICF-UHFFFAOYSA-N.svg)
6-Ethyl-2-[[4-(4-methylpiperidin-1-yl)sulfonylbenzoyl]amino]-5,7-dihydro-4H-thieno[2,3-c]pyridine-3-carboxamide
CAS 449767-81-1C23H30N4O4S2
![2-(4-((3,5-Dimethylpiperidin-1-yl)sulfonyl)benzamido)-6-ethyl-4,5,6,7-tetrahydrothieno[2,3-c]pyridine-3-carboxamide chemical structure, C24H32N4O4S2, CAS 489470-20-4](/s/SHSCKCJBUJSNRV-UHFFFAOYSA-N.svg)
2-(4-((3,5-Dimethylpiperidin-1-yl)sulfonyl)benzamido)-6-ethyl-4,5,6,7-tetrahydrothieno[2,3-c]pyridine-3-carboxamide
CAS 489470-20-4C24H32N4O4S2
![Ethyl 6-acetyl-2-(4-((3-methylpiperidin-1-yl)sulfonyl)benzamido)-4,5,6,7-tetrahydrothieno[2,3-c]pyridine-3-carboxylate chemical structure, C25H31N3O6S2, CAS 449769-55-5](/s/VQEMKZMPXBNYKJ-UHFFFAOYSA-N.svg)
Ethyl 6-acetyl-2-(4-((3-methylpiperidin-1-yl)sulfonyl)benzamido)-4,5,6,7-tetrahydrothieno[2,3-c]pyridine-3-carboxylate
CAS 449769-55-5C25H31N3O6S2
![6-Isopropyl-2-(4-((2-methylpiperidin-1-yl)sulfonyl)benzamido)-4,5,6,7-tetrahydrothieno[2,3-c]pyridine-3-carboxamide chemical structure, C24H32N4O4S2, CAS 449768-63-2](/s/CMCQKRDKHMULBX-UHFFFAOYSA-N.svg)
6-Isopropyl-2-(4-((2-methylpiperidin-1-yl)sulfonyl)benzamido)-4,5,6,7-tetrahydrothieno[2,3-c]pyridine-3-carboxamide
CAS 449768-63-2C24H32N4O4S2
![6-Acetyl-2-(4-((3-methylpiperidin-1-yl)sulfonyl)benzamido)-4,5,6,7-tetrahydrothieno[2,3-c]pyridine-3-carboxamide chemical structure, C23H28N4O5S2, CAS 449769-97-5](/s/ZBBZWLCXMYVKGS-UHFFFAOYSA-N.svg)
6-Acetyl-2-(4-((3-methylpiperidin-1-yl)sulfonyl)benzamido)-4,5,6,7-tetrahydrothieno[2,3-c]pyridine-3-carboxamide
CAS 449769-97-5C23H28N4O5S2
![Ethyl 6-ethyl-2-[(4-piperidin-1-ylsulfonylbenzoyl)amino]-5,7-dihydro-4H-thieno[2,3-c]pyridine-3-carboxylate chemical structure, C24H31N3O5S2, CAS 449767-56-0](/s/SVHWMMGXCVIUTC-UHFFFAOYSA-N.svg)
Ethyl 6-ethyl-2-[(4-piperidin-1-ylsulfonylbenzoyl)amino]-5,7-dihydro-4H-thieno[2,3-c]pyridine-3-carboxylate
CAS 449767-56-0C24H31N3O5S2
![6-Methyl-2-(4-(piperidin-1-ylsulfonyl)benzamido)-4,5,6,7-tetrahydrothieno[2,3-c]pyridine-3-carboxamide chemical structure, C21H26N4O4S2, CAS 449767-15-1](/s/GAIJOPBHCZAFBG-UHFFFAOYSA-N.svg)
6-Methyl-2-(4-(piperidin-1-ylsulfonyl)benzamido)-4,5,6,7-tetrahydrothieno[2,3-c]pyridine-3-carboxamide
CAS 449767-15-1C21H26N4O4S2
![6-Isopropyl-2-(4-((4-methylpiperidin-1-yl)sulfonyl)benzamido)-4,5,6,7-tetrahydrothieno[2,3-c]pyridine-3-carboxamide chemical structure, C24H32N4O4S2, CAS 489470-93-1](/s/DPUSWQAHRLUMKG-UHFFFAOYSA-N.svg)
6-Isopropyl-2-(4-((4-methylpiperidin-1-yl)sulfonyl)benzamido)-4,5,6,7-tetrahydrothieno[2,3-c]pyridine-3-carboxamide
CAS 489470-93-1C24H32N4O4S2
![Diethyl 2-(4-((2-methylpiperidin-1-yl)sulfonyl)benzamido)-4,5-dihydrothieno[2,3-c]pyridine-3,6(7H)-dicarboxylate chemical structure, C26H33N3O7S2, CAS 449781-68-4](/s/LYMDNDHRXJGOMC-UHFFFAOYSA-N.svg)
Diethyl 2-(4-((2-methylpiperidin-1-yl)sulfonyl)benzamido)-4,5-dihydrothieno[2,3-c]pyridine-3,6(7H)-dicarboxylate
CAS 449781-68-4C26H33N3O7S2
![2-(4-((2-Ethylpiperidin-1-yl)sulfonyl)benzamido)-N,6-dimethyl-4,5,6,7-tetrahydrothieno[2,3-c]pyridine-3-carboxamide chemical structure, C24H32N4O4S2, CAS 533891-20-2](/s/TYLRBSPBMYNQJU-UHFFFAOYSA-N.svg)
2-(4-((2-Ethylpiperidin-1-yl)sulfonyl)benzamido)-N,6-dimethyl-4,5,6,7-tetrahydrothieno[2,3-c]pyridine-3-carboxamide
CAS 533891-20-2C24H32N4O4S2
![Methyl 6-acetyl-2-(4-((2-methylpiperidin-1-yl)sulfonyl)benzamido)-4,5,6,7-tetrahydrothieno[2,3-c]pyridine-3-carboxylate chemical structure, C24H29N3O6S2, CAS 449769-09-9](/s/IARRKEZHUKBLFR-UHFFFAOYSA-N.svg)
Methyl 6-acetyl-2-(4-((2-methylpiperidin-1-yl)sulfonyl)benzamido)-4,5,6,7-tetrahydrothieno[2,3-c]pyridine-3-carboxylate
CAS 449769-09-9C24H29N3O6S2
![2-(4-((3,5-Dimethylpiperidin-1-yl)sulfonyl)benzamido)-N,6-dimethyl-4,5,6,7-tetrahydrothieno[2,3-c]pyridine-3-carboxamide chemical structure, C24H32N4O4S2, CAS 533890-55-0](/s/FYJDTLQRZWHORC-UHFFFAOYSA-N.svg)
2-(4-((3,5-Dimethylpiperidin-1-yl)sulfonyl)benzamido)-N,6-dimethyl-4,5,6,7-tetrahydrothieno[2,3-c]pyridine-3-carboxamide
CAS 533890-55-0C24H32N4O4S2
![Methyl 5,5,7,7-tetramethyl-2-[[4-(4-methylpiperidin-1-yl)sulfonylbenzoyl]amino]-4,6-dihydrothieno[2,3-c]pyridine-3-carboxylate chemical structure, C26H35N3O5S2, CAS 449782-59-6](/s/CPXUEBDNGNORCQ-UHFFFAOYSA-N.svg)
Methyl 5,5,7,7-tetramethyl-2-[[4-(4-methylpiperidin-1-yl)sulfonylbenzoyl]amino]-4,6-dihydrothieno[2,3-c]pyridine-3-carboxylate
CAS 449782-59-6C26H35N3O5S2
![Ethyl 6-methyl-2-(4-((3-methylpiperidin-1-yl)sulfonyl)benzamido)-4,5,6,7-tetrahydrothieno[2,3-c]pyridine-3-carboxylate chemical structure, C24H31N3O5S2, CAS 449766-96-5](/s/FWEXGWOGEUZDQC-UHFFFAOYSA-N.svg)
Ethyl 6-methyl-2-(4-((3-methylpiperidin-1-yl)sulfonyl)benzamido)-4,5,6,7-tetrahydrothieno[2,3-c]pyridine-3-carboxylate
CAS 449766-96-5C24H31N3O5S2
![6-Methyl-2-(4-((2-methylpiperidin-1-yl)sulfonyl)benzamido)-4,5,6,7-tetrahydrothieno[2,3-c]pyridine-3-carboxamide chemical structure, C22H28N4O4S2, CAS 449767-16-2](/s/XFQRGHCGFKKSOH-UHFFFAOYSA-N.svg)
6-Methyl-2-(4-((2-methylpiperidin-1-yl)sulfonyl)benzamido)-4,5,6,7-tetrahydrothieno[2,3-c]pyridine-3-carboxamide
CAS 449767-16-2C22H28N4O4S2
![6-Methyl-2-[[4-(4-methylpiperidin-1-yl)sulfonylbenzoyl]amino]-5,7-dihydro-4H-thieno[2,3-c]pyridine-3-carboxamide chemical structure, C22H28N4O4S2, CAS 449767-18-4](/s/UGRRWFRETRXUPS-UHFFFAOYSA-N.svg)
6-Methyl-2-[[4-(4-methylpiperidin-1-yl)sulfonylbenzoyl]amino]-5,7-dihydro-4H-thieno[2,3-c]pyridine-3-carboxamide
CAS 449767-18-4C22H28N4O4S2
![2-[[4-(3,5-Dimethylpiperidin-1-yl)sulfonylbenzoyl]amino]-6-methyl-5,7-dihydro-4H-thieno[2,3-c]pyridine-3-carboxamide chemical structure, C23H30N4O4S2, CAS 449767-19-5](/s/YTNLUWVYOJUYGW-UHFFFAOYSA-N.svg)
2-[[4-(3,5-Dimethylpiperidin-1-yl)sulfonylbenzoyl]amino]-6-methyl-5,7-dihydro-4H-thieno[2,3-c]pyridine-3-carboxamide
CAS 449767-19-5C23H30N4O4S2
![Ethyl 6-ethyl-2-[[4-(2-methylpiperidin-1-yl)sulfonylbenzoyl]amino]-5,7-dihydro-4H-thieno[2,3-c]pyridine-3-carboxylate chemical structure, C25H33N3O5S2, CAS 449767-57-1](/s/FKNBQDZGNNHLSA-UHFFFAOYSA-N.svg)
Ethyl 6-ethyl-2-[[4-(2-methylpiperidin-1-yl)sulfonylbenzoyl]amino]-5,7-dihydro-4H-thieno[2,3-c]pyridine-3-carboxylate
CAS 449767-57-1C25H33N3O5S2
- Ethyl 6-ethyl-2-(4-((3-methylpiperidin-1-yl)sulfonyl)benzamido)-4,5,6,7-tetrahydrothieno[2,3-c]pyridine-3-carboxylate449767-58-2C25H33N3O5S2
- Ethyl 2-[[4-(3,5-dimethylpiperidin-1-yl)sulfonylbenzoyl]amino]-6-ethyl-5,7-dihydro-4H-thieno[2,3-c]pyridine-3-carboxylate449767-60-6C26H35N3O5S2
- Methyl 6-ethyl-2-(4-((2-methylpiperidin-1-yl)sulfonyl)benzamido)-4,5,6,7-tetrahydrothieno[2,3-c]pyridine-3-carboxylate449767-37-7C24H31N3O5S2
- 6-Ethyl 3-methyl 2-(4-((3-methylpiperidin-1-yl)sulfonyl)benzamido)-4,5-dihydrothieno[2,3-c]pyridine-3,6(7H)-dicarboxylate449770-73-4C25H31N3O7S2
- Ethyl 6-acetyl-2-(4-((3,5-dimethylpiperidin-1-yl)sulfonyl)benzamido)-4,5,6,7-tetrahydrothieno[2,3-c]pyridine-3-carboxylate449769-59-9C26H33N3O6S2
- Methyl 5,5,7,7-tetramethyl-2-[[4-(3-methylpiperidin-1-yl)sulfonylbenzoyl]amino]-4,6-dihydrothieno[2,3-c]pyridine-3-carboxylate449782-57-4C26H35N3O5S2
- 6-Isopropyl-N-methyl-2-(4-(piperidin-1-ylsulfonyl)benzamido)-4,5,6,7-tetrahydrothieno[2,3-c]pyridine-3-carboxamide533907-27-6C24H32N4O4S2
- Diethyl 2-(4-(piperidin-1-ylsulfonyl)benzamido)-4,5-dihydrothieno[2,3-c]pyridine-3,6(7H)-dicarboxylate449781-66-2C25H31N3O7S2
- Ethyl 6-acetyl-2-(4-((2-methylpiperidin-1-yl)sulfonyl)benzamido)-4,5,6,7-tetrahydrothieno[2,3-c]pyridine-3-carboxylate449769-53-3C25H31N3O6S2
- Ethyl 2-(4-((3,5-dimethylpiperidin-1-yl)sulfonyl)benzamido)-6-methyl-4,5,6,7-tetrahydrothieno[2,3-c]pyridine-3-carboxylate449766-98-7C25H33N3O5S2
- Ethyl 6-acetyl-2-[[4-(4-methylpiperidin-1-yl)sulfonylbenzoyl]amino]-5,7-dihydro-4H-thieno[2,3-c]pyridine-3-carboxylate449769-57-7C25H31N3O6S2
- 6-Isopropyl-2-(4-((3-methylpiperidin-1-yl)sulfonyl)benzamido)-4,5,6,7-tetrahydrothieno[2,3-c]pyridine-3-carboxamide449768-65-4C24H32N4O4S2
- Ethyl 3-cyano-2-(4-((2-methylpiperidin-1-yl)sulfonyl)benzamido)-4,5-dihydrothieno[2,3-c]pyridine-6(7H)-carboxylate681437-43-4C24H28N4O5S2
- Diethyl 2-(4-((3,5-dimethylpiperidin-1-yl)sulfonyl)benzamido)-4,5-dihydrothieno[2,3-c]pyridine-3,6(7H)-dicarboxylate449781-74-2C27H35N3O7S2
- Methyl 6-acetyl-2-(4-((3-methylpiperidin-1-yl)sulfonyl)benzamido)-4,5,6,7-tetrahydrothieno[2,3-c]pyridine-3-carboxylate681435-79-0C24H29N3O6S2
- N,6-dimethyl-2-(4-(piperidin-1-ylsulfonyl)benzamido)-4,5,6,7-tetrahydrothieno[2,3-c]pyridine-3-carboxamide533890-81-2C22H28N4O4S2
- Ethyl 3-carbamoyl-2-(4-((3-methylpiperidin-1-yl)sulfonyl)benzamido)-4,5-dihydrothieno[2,3-c]pyridine-6(7H)-carboxylate449782-15-4C24H30N4O6S2
- 6-Acetyl-2-(4-(piperidin-1-ylsulfonyl)benzamido)-4,5,6,7-tetrahydrothieno[2,3-c]pyridine-3-carboxamide449769-93-1C22H26N4O5S2
- N,6-dimethyl-2-[[[4-[(2-methyl-1-piperidinyl)sulfonyl]phenyl]-oxomethyl]amino]-5,7-dihydro-4H-thieno[2,3-c]pyridine-3-carboxamide533891-07-5C23H30N4O4S2
- Ethyl 3-cyano-2-(4-(piperidin-1-ylsulfonyl)benzamido)-4,5-dihydrothieno[2,3-c]pyridine-6(7H)-carboxylate681437-42-3C23H26N4O5S2
- Methyl 2-(4-((4-methylpiperidin-1-yl)sulfonyl)benzamido)-6-propyl-4,5,6,7-tetrahydrothieno[2,3-c]pyridine-3-carboxylate681178-01-8C25H33N3O5S2
- 6-O-Ethyl 3-O-methyl 2-[[4-(4-methylpiperidin-1-yl)sulfonylbenzoyl]amino]-5,7-dihydro-4H-thieno[2,3-c]pyridine-3,6-dicarboxylate449770-75-6C25H31N3O7S2
- Methyl 6-methyl-2-(4-((2-methylpiperidin-1-yl)sulfonyl)benzamido)-4,5,6,7-tetrahydrothieno[2,3-c]pyridine-3-carboxylate486453-08-1C23H29N3O5S2
- N-(3-Cyano-5,5,7,7-tetramethyl-4,5,6,7-tetrahydrothieno[2,3-c]pyridin-2-yl)-4-(piperidin-1-ylsulfonyl)benzamide681438-92-6C24H30N4O3S2
Related scaffolds
Same ring framework with different atoms or bond orders
O=C(Nc1nc2ccccc2s1)c1ccc(S(=O)(=O)N2CCOCC2)cc110 chemicals
O=C(Nc1cc2c(s1)CNCC2)c1ccc(S(=O)(=O)N2CCOCC2)cc18 chemicals
O=C(Nc1cc2c(s1)CNCC2)c1ccc(C(=O)c2ccccc2)cc16 chemicals
O=C(Nc1nc2ccccc2s1)c1ccc(C(=O)c2ccccc2)cc16 chemicals
O=C(Nc1nc2ccccc2s1)c1ccc(S(=O)(=O)N2CCCCC2)cc15 chemicals
O=C(Nc1ccc(S(=O)(=O)N2CCCCC2)cc1)c1cc2ccccc2o13 chemicals
O=C(Nc1nc2ccccc2s1)C1CCN(S(=O)(=O)c2ccccc2)CC11 chemical
O=C(Nc1cc2ccccc2s1)N1CCN(Cc2ccccc2)CC11 chemical
O=C1c2ccccc2C(=O)N1CCC1CCN(Cc2ccccc2)CC11 chemical![Scaffold O=S(=O)(c1ccc(C=Cc2nc3ccccc3[nH]2)cc1)N1CCCCC1](/scaffold/GCMDSFDPHLEEQV-UHFFFAOYSA-N/structure.svg)
O=S(=O)(c1ccc(C=Cc2nc3ccccc3[nH]2)cc1)N1CCCCC11 chemical
O=C(Nc1ccc(CN2CCCCC2)cc1)c1cc2ccccc2s11 chemical
O=C(CN1C(=O)c2ccccc2C1=O)N1CCN(Cc2ccccc2)CC11 chemical