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Murcko scaffold

1,3-Dihydro-1-[1-(phenylmethyl)-4-piperidinyl]-2H-benzimidazol-2-one scaffold

113 chemicals on CompoundList share this ring system.

Rings
4
Scaffold atoms
23
Chemicals
113
With full pages
2
Scaffold SMILES

O=c1[nH]c2ccccc2n1C1CCN(Cc2ccccc2)CC1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffoldOpen the 1,3-Dihydro-1-[1-(phenylmethyl)-4-piperidinyl]-2H-benzimidazol-2-one page
Murcko scaffold O=c1[nH]c2ccccc2n1C1CCN(Cc2ccccc2)CC1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 49 to 96 of 113 chemicals

4-((4-(2-Oxo-2,3-dihydro-1H-benzo[d]imidazol-1-yl)piperidin-1-yl)methyl)benzoic acid chemical structure, C20H21N3O3, CAS 1940471-03-3
4-((4-(2-Oxo-2,3-dihydro-1H-benzo[d]imidazol-1-yl)piperidin-1-yl)methyl)benzoic acid
CAS 1940471-03-3C20H21N3O3
3-((4-(2-Oxo-2,3-dihydro-1H-benzo[d]imidazol-1-yl)piperidin-1-yl)methyl)benzoic acid chemical structure, C20H21N3O3, CAS 1941117-03-8
3-((4-(2-Oxo-2,3-dihydro-1H-benzo[d]imidazol-1-yl)piperidin-1-yl)methyl)benzoic acid
CAS 1941117-03-8C20H21N3O3
1-{1-[(2-Chloro-4-fluorophenyl)methyl]piperidin-4-yl}-2,3-dihydro-1H-1,3-benzodiazol-2-one hydrochloride chemical structure, C19H20Cl2FN3O, CAS 1955531-60-8
1-{1-[(2-Chloro-4-fluorophenyl)methyl]piperidin-4-yl}-2,3-dihydro-1H-1,3-benzodiazol-2-one hydrochloride
CAS 1955531-60-8C19H20Cl2FN3O
1-(1-(4-Bromo-2-fluorobenzyl)piperidin-4-yl)-5,6-dichloro-1H-benzo[d]imidazol-2(3H)-one chemical structure, C19H17BrCl2FN3O, CAS 2133455-38-4
1-(1-(4-Bromo-2-fluorobenzyl)piperidin-4-yl)-5,6-dichloro-1H-benzo[d]imidazol-2(3H)-one
CAS 2133455-38-4C19H17BrCl2FN3O
1-(1-(1-(4-Bromophenyl)ethyl)piperidin-4-yl)-5,6-dichloro-1H-benzo[d]imidazol-2(3H)-one chemical structure, C20H20BrCl2N3O, CAS 2133455-40-8
1-(1-(1-(4-Bromophenyl)ethyl)piperidin-4-yl)-5,6-dichloro-1H-benzo[d]imidazol-2(3H)-one
CAS 2133455-40-8C20H20BrCl2N3O
RefChem:185193 chemical structure, C19H18Cl3N3O, CAS 2134602-45-0
RefChem:185193
CAS 2134602-45-0C19H18Cl3N3O
1-(1-(2-Chlorobenzyl)piperidin-4-yl)-5-methyl-1H-benzo[d]imidazol-2(3H)-one chemical structure, C20H22ClN3O, CAS 2133455-53-3
1-(1-(2-Chlorobenzyl)piperidin-4-yl)-5-methyl-1H-benzo[d]imidazol-2(3H)-one
CAS 2133455-53-3C20H22ClN3O
3-(1-(4-(2-Oxo-2,3-dihydro-1H-benzo[d]imidazol-1-yl)piperidin-1-yl)ethyl)benzonitrile chemical structure, C21H22N4O, CAS 2261240-65-5
3-(1-(4-(2-Oxo-2,3-dihydro-1H-benzo[d]imidazol-1-yl)piperidin-1-yl)ethyl)benzonitrile
CAS 2261240-65-5C21H22N4O
1-(1-Benzylpiperidin-4-yl)-6-fluoro-1H-benzo[d]imidazol-2(3H)-one chemical structure, C19H20FN3O, CAS 219325-17-4
1-(1-Benzylpiperidin-4-yl)-6-fluoro-1H-benzo[d]imidazol-2(3H)-one
CAS 219325-17-4C19H20FN3O
Methyl 2,3-dihydro-2-oxo-1-[1-(benzyl)piperidin-4-yl]-1H-benzo[d]imidazol-5-carboxylate chemical structure, C21H23N3O3, CAS 219325-19-6
Methyl 2,3-dihydro-2-oxo-1-[1-(benzyl)piperidin-4-yl]-1H-benzo[d]imidazol-5-carboxylate
CAS 219325-19-6C21H23N3O3
1-(1-(1-(4-Methoxyphenyl)ethyl)piperidin-4-yl)-1H-benzo[d]imidazol-2(3H)-one chemical structure, C21H25N3O2, CAS 2244737-99-1
1-(1-(1-(4-Methoxyphenyl)ethyl)piperidin-4-yl)-1H-benzo[d]imidazol-2(3H)-one
CAS 2244737-99-1C21H25N3O2
Fluorphine chemical structure, C20H22FN3O, CAS 6440-42-2
Fluorphine
CAS 6440-42-2C20H22FN3O
1-(1-(2-Chlorobenzyl)piperidin-4-yl)-5-fluoro-1H-benzo[d]imidazol-2(3H)-one chemical structure, C19H19ClFN3O, CAS 2244738-09-6
1-(1-(2-Chlorobenzyl)piperidin-4-yl)-5-fluoro-1H-benzo[d]imidazol-2(3H)-one
CAS 2244738-09-6C19H19ClFN3O
1-(1-(1-(4-Chlorophenyl)propyl)piperidin-4-yl)-1H-benzo[d]imidazol-2(3H)-one chemical structure, C21H24ClN3O, CAS 6440-25-1
1-(1-(1-(4-Chlorophenyl)propyl)piperidin-4-yl)-1H-benzo[d]imidazol-2(3H)-one
CAS 6440-25-1C21H24ClN3O
1-(1-(2-Chlorobenzyl)piperidin-4-yl)-2-oxo-2,3-dihydro-1H-benzo[d]imidazole-5-carbonitrile chemical structure, C20H19ClN4O, CAS 2244738-13-2
1-(1-(2-Chlorobenzyl)piperidin-4-yl)-2-oxo-2,3-dihydro-1H-benzo[d]imidazole-5-carbonitrile
CAS 2244738-13-2C20H19ClN4O
1-(1-(1-(4-Ethoxyphenyl)ethyl)piperidin-4-yl)-1H-benzo[d]imidazol-2(3H)-one chemical structure, C22H27N3O2, CAS 2244738-00-7
1-(1-(1-(4-Ethoxyphenyl)ethyl)piperidin-4-yl)-1H-benzo[d]imidazol-2(3H)-one
CAS 2244738-00-7C22H27N3O2
1-(1-(4-Chloro-2-methylbenzyl)piperidin-4-yl)-1H-benzo[d]imidazol-2(3H)-one chemical structure, C20H22ClN3O, CAS 2244737-97-9
1-(1-(4-Chloro-2-methylbenzyl)piperidin-4-yl)-1H-benzo[d]imidazol-2(3H)-one
CAS 2244737-97-9C20H22ClN3O
1-(1-(3-Chlorobenzyl)piperidin-4-yl)-1H-benzo[d]imidazol-2(3H)-one chemical structure, C19H20ClN3O, CAS 2244737-90-2
1-(1-(3-Chlorobenzyl)piperidin-4-yl)-1H-benzo[d]imidazol-2(3H)-one
CAS 2244737-90-2C19H20ClN3O
Brorphine chemical structure, C20H22BrN3O, CAS 2244737-98-0
Brorphine
CAS 2244737-98-0C20H22BrN3O
N-(4-((4-(2-Oxo-2,3-dihydro-1H-benzo[d]imidazol-1-yl)piperidin-1-yl)methyl)phenyl)acetamide chemical structure, C21H24N4O2, CAS 2244737-93-5
N-(4-((4-(2-Oxo-2,3-dihydro-1H-benzo[d]imidazol-1-yl)piperidin-1-yl)methyl)phenyl)acetamide
CAS 2244737-93-5C21H24N4O2
4-((4-(2-Oxo-2,3-dihydro-1H-benzo[d]imidazol-1-yl)piperidin-1-yl)methyl)benzamide chemical structure, C20H22N4O2, CAS 2244737-95-7
4-((4-(2-Oxo-2,3-dihydro-1H-benzo[d]imidazol-1-yl)piperidin-1-yl)methyl)benzamide
CAS 2244737-95-7C20H22N4O2
1-(1-(4-Butylbenzyl)piperidin-4-yl)-1H-benzo[d]imidazol-2(3H)-one chemical structure, C23H29N3O, CAS 521176-14-7
1-(1-(4-Butylbenzyl)piperidin-4-yl)-1H-benzo[d]imidazol-2(3H)-one
CAS 521176-14-7C23H29N3O
2,3-Dihydro-2-oxo-3-[1-(benzyl)piperidin-4-yl]-1H-benzo[d]imidazol-1-propanenitrile chemical structure, C22H24N4O, CAS 53786-62-2
2,3-Dihydro-2-oxo-3-[1-(benzyl)piperidin-4-yl]-1H-benzo[d]imidazol-1-propanenitrile
CAS 53786-62-2C22H24N4O
1-(1-Benzylpiperidin-4-yl)-3-methyl-1H-benzo[d]imidazol-2(3H)-one hydrochloride chemical structure, C20H24ClN3O, CAS 6440-41-1
1-(1-Benzylpiperidin-4-yl)-3-methyl-1H-benzo[d]imidazol-2(3H)-one hydrochloride
CAS 6440-41-1C20H24ClN3O