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Murcko scaffold

1,3-Dihydro-1-[1-(phenylmethyl)-4-piperidinyl]-2H-benzimidazol-2-one scaffold

113 chemicals on CompoundList share this ring system.

Rings
4
Scaffold atoms
23
Chemicals
113
With full pages
2
Scaffold SMILES

O=c1[nH]c2ccccc2n1C1CCN(Cc2ccccc2)CC1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffoldOpen the 1,3-Dihydro-1-[1-(phenylmethyl)-4-piperidinyl]-2H-benzimidazol-2-one page
Murcko scaffold O=c1[nH]c2ccccc2n1C1CCN(Cc2ccccc2)CC1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 48 of 113 chemicals

Benzimidazoline-1-propionitrile, 3-(1-(p-chloro-alpha-methylbenzyl)4-piperidyl)-2-oxo-, hydrochloride chemical structure, C23H26Cl2N4O, CAS 6511-82-6
Benzimidazoline-1-propionitrile, 3-(1-(p-chloro-alpha-methylbenzyl)4-piperidyl)-2-oxo-, hydrochloride
CAS 6511-82-6C23H26Cl2N4O
Cychlorphine chemical structure, C23H25ClN4O, CAS 6449-60-1
Cychlorphine
CAS 6449-60-1C23H25ClN4O
1,3-Dihydro-1-[1-(phenylmethyl)-4-piperidinyl]-2H-benzimidazol-2-one chemical structure, C19H21N3O, CAS 16148-06-4
1,3-Dihydro-1-[1-(phenylmethyl)-4-piperidinyl]-2H-benzimidazol-2-one
CAS 16148-06-4C19H21N3O
1-(1-(4-Fluorobenzyl)piperidin-4-yl)-1H-benzo[d]imidazol-2(3H)-one chemical structure, C19H20FN3O, CAS 6441-55-0
1-(1-(4-Fluorobenzyl)piperidin-4-yl)-1H-benzo[d]imidazol-2(3H)-one
CAS 6441-55-0C19H20FN3O
1-{1-[(4-Chlorophenyl)methyl]piperidin-4-yl}-2,3-dihydro-1H-1,3-benzodiazol-2-one chemical structure, C19H20ClN3O, CAS 1027496-63-4
1-{1-[(4-Chlorophenyl)methyl]piperidin-4-yl}-2,3-dihydro-1H-1,3-benzodiazol-2-one
CAS 1027496-63-4C19H20ClN3O
1-(1-(4-Methoxybenzyl)piperidin-4-yl)-1H-benzo[d]imidazol-2(3H)-one chemical structure, C20H23N3O2, CAS 280123-35-5
1-(1-(4-Methoxybenzyl)piperidin-4-yl)-1H-benzo[d]imidazol-2(3H)-one
CAS 280123-35-5C20H23N3O2
1-{1-[1-(2-Chloro-phenyl)-ethyl]-piperidin-4-yl}-1,3-dihydro-benzoimidazol-2-one chemical structure, C20H22ClN3O, CAS 256640-48-9
1-{1-[1-(2-Chloro-phenyl)-ethyl]-piperidin-4-yl}-1,3-dihydro-benzoimidazol-2-one
CAS 256640-48-9C20H22ClN3O
1-[1-(1-Methyl-1-phenylethyl)-4-piperidinyl]-1,3-dihydro-2H-1,3-benzimidazol-2-one chemical structure, C21H25N3O, CAS 231960-65-9
1-[1-(1-Methyl-1-phenylethyl)-4-piperidinyl]-1,3-dihydro-2H-1,3-benzimidazol-2-one
CAS 231960-65-9C21H25N3O
1-(1-(2-(4-Fluorophenyl)propan-2-yl)piperidin-4-yl)-1H-benzo[d]imidazol-2(3H)-one chemical structure, C21H24FN3O, CAS 231960-68-2
1-(1-(2-(4-Fluorophenyl)propan-2-yl)piperidin-4-yl)-1H-benzo[d]imidazol-2(3H)-one
CAS 231960-68-2C21H24FN3O
1-(1-(2-(p-Tolyl)propan-2-yl)piperidin-4-yl)-1H-benzo[d]imidazol-2(3H)-one chemical structure, C22H27N3O, CAS 231960-69-3
1-(1-(2-(p-Tolyl)propan-2-yl)piperidin-4-yl)-1H-benzo[d]imidazol-2(3H)-one
CAS 231960-69-3C22H27N3O
1-(1-(2-(4-Methoxyphenyl)propan-2-yl)piperidin-4-yl)-1H-benzo[d]imidazol-2(3H)-one chemical structure, C22H27N3O2, CAS 231960-71-7
1-(1-(2-(4-Methoxyphenyl)propan-2-yl)piperidin-4-yl)-1H-benzo[d]imidazol-2(3H)-one
CAS 231960-71-7C22H27N3O2
1-{1-[(2-Chloro-4-fluorophenyl)methyl]piperidin-4-yl}-2,3-dihydro-1H-1,3-benzodiazol-2-one chemical structure, C19H19ClFN3O, CAS 909682-49-1
1-{1-[(2-Chloro-4-fluorophenyl)methyl]piperidin-4-yl}-2,3-dihydro-1H-1,3-benzodiazol-2-one
CAS 909682-49-1C19H19ClFN3O
1-(1-Benzylpiperidin-4-yl)-5-chloro-1H-benzo[d]imidazol-2(3H)-one chemical structure, C19H20ClN3O, CAS 185058-65-5
1-(1-Benzylpiperidin-4-yl)-5-chloro-1H-benzo[d]imidazol-2(3H)-one
CAS 185058-65-5C19H20ClN3O
1-(1-(4-(tert-Butyl)benzyl)piperidin-4-yl)-1H-benzo[d]imidazol-2(3H)-one chemical structure, C23H29N3O, CAS 198969-78-7
1-(1-(4-(tert-Butyl)benzyl)piperidin-4-yl)-1H-benzo[d]imidazol-2(3H)-one
CAS 198969-78-7C23H29N3O
Orphine chemical structure, C20H23N3O, CAS 59708-49-5
Orphine
CAS 59708-49-5C20H23N3O
1-(1-Benzylpiperidin-4-yl)-5-methyl-1H-benzo[d]imidazol-2(3H)-one chemical structure, C20H23N3O, CAS 334649-88-6
1-(1-Benzylpiperidin-4-yl)-5-methyl-1H-benzo[d]imidazol-2(3H)-one
CAS 334649-88-6C20H23N3O
3-(1-Benzylpiperid-4-yl)-5-chloro-1,3-dihydro-2H-benzimidazol-2-one chemical structure, C19H20ClN3O, CAS 162140-03-6
3-(1-Benzylpiperid-4-yl)-5-chloro-1,3-dihydro-2H-benzimidazol-2-one
CAS 162140-03-6C19H20ClN3O
1-(1-(3,5-Difluorobenzyl)piperidin-4-yl)-1H-benzo[d]imidazol-2(3H)-one chemical structure, C19H19F2N3O, CAS 909681-36-3
1-(1-(3,5-Difluorobenzyl)piperidin-4-yl)-1H-benzo[d]imidazol-2(3H)-one
CAS 909681-36-3C19H19F2N3O
1-(1-(2-Methoxybenzyl)piperidin-4-yl)-1H-benzo[d]imidazol-2(3H)-one chemical structure, C20H23N3O2, CAS 909681-48-7
1-(1-(2-Methoxybenzyl)piperidin-4-yl)-1H-benzo[d]imidazol-2(3H)-one
CAS 909681-48-7C20H23N3O2
2-((4-(2-Oxo-2,3-dihydro-1H-benzo[d]imidazol-1-yl)piperidin-1-yl)methyl)benzonitrile chemical structure, C20H20N4O, CAS 909681-85-2
2-((4-(2-Oxo-2,3-dihydro-1H-benzo[d]imidazol-1-yl)piperidin-1-yl)methyl)benzonitrile
CAS 909681-85-2C20H20N4O
3-((4-(2-Oxo-2,3-dihydro-1H-benzo[d]imidazol-1-yl)piperidin-1-yl)methyl)benzonitrile chemical structure, C20H20N4O, CAS 909682-07-1
3-((4-(2-Oxo-2,3-dihydro-1H-benzo[d]imidazol-1-yl)piperidin-1-yl)methyl)benzonitrile
CAS 909682-07-1C20H20N4O
1-(1-(2,4-Difluorobenzyl)piperidin-4-yl)-1H-benzo[d]imidazol-2(3H)-one chemical structure, C19H19F2N3O, CAS 909682-98-0
1-(1-(2,4-Difluorobenzyl)piperidin-4-yl)-1H-benzo[d]imidazol-2(3H)-one
CAS 909682-98-0C19H19F2N3O
1-(1-(3-Fluorobenzyl)piperidin-4-yl)-1H-benzo[d]imidazol-2(3H)-one chemical structure, C19H20FN3O, CAS 909683-37-0
1-(1-(3-Fluorobenzyl)piperidin-4-yl)-1H-benzo[d]imidazol-2(3H)-one
CAS 909683-37-0C19H20FN3O
1-(1-(3-Methoxybenzyl)piperidin-4-yl)-1H-benzo[d]imidazol-2(3H)-one chemical structure, C20H23N3O2, CAS 374730-78-6
1-(1-(3-Methoxybenzyl)piperidin-4-yl)-1H-benzo[d]imidazol-2(3H)-one
CAS 374730-78-6C20H23N3O2