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Murcko scaffold

1-(Thiophen-2-ylmethyl)pyrrolidine scaffold

98 chemicals on CompoundList share this ring system.

Rings
2
Scaffold atoms
11
Chemicals
98
With full pages
3
Scaffold SMILES

c1csc(CN2CCCC2)c1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffoldOpen the 1-(Thiophen-2-ylmethyl)pyrrolidine page
Murcko scaffold c1csc(CN2CCCC2)c1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 48 of 98 chemicals

2-Pyrrolidin-1-yl-2-thiophen-2-yl-ethylamine chemical structure, C10H16N2S, CAS 142919-86-6
2-Pyrrolidin-1-yl-2-thiophen-2-yl-ethylamine
CAS 142919-86-6C10H16N2S
(1-(Thiophen-2-ylmethyl)pyrrolidin-3-yl)methanol chemical structure, C10H15NOS, CAS 170749-89-0
(1-(Thiophen-2-ylmethyl)pyrrolidin-3-yl)methanol
CAS 170749-89-0C10H15NOS
1-(Thiophen-2-ylmethyl)pyrrolidin-3-ol chemical structure, C9H13NOS, CAS 130054-58-9
1-(Thiophen-2-ylmethyl)pyrrolidin-3-ol
CAS 130054-58-9C9H13NOS
Methyl 1-[(3-boronothiophen-2-yl)methyl]-L-prolinate chemical structure, C11H16BNO4S, CAS 878289-34-0
Methyl 1-[(3-boronothiophen-2-yl)methyl]-L-prolinate
CAS 878289-34-0C11H16BNO4S
1-(Thiophen-2-ylmethyl)pyrrolidine chemical structure, C9H13NS, CAS 16087-92-6
1-(Thiophen-2-ylmethyl)pyrrolidine
CAS 16087-92-6C9H13NS
Methyl 5-(1-pyrrolidinylmethyl)-3-thiophenecarboxylate chemical structure, C11H15NO2S, CAS 78908-84-6
Methyl 5-(1-pyrrolidinylmethyl)-3-thiophenecarboxylate
CAS 78908-84-6C11H15NO2S
5-(Pyrrolidin-1-ylmethyl)thiophene-2-carboxylic acid chemical structure, C10H13NO2S, CAS 733784-27-5
5-(Pyrrolidin-1-ylmethyl)thiophene-2-carboxylic acid
CAS 733784-27-5C10H13NO2S
I+/--2-Thienyl-1-pyrrolidineacetonitrile chemical structure, C10H12N2S, CAS 897030-66-9
I+/--2-Thienyl-1-pyrrolidineacetonitrile
CAS 897030-66-9C10H12N2S
1-(Thiophen-2-ylmethyl)pyrrolidin-3-amine chemical structure, C9H14N2S, CAS 933708-04-4
1-(Thiophen-2-ylmethyl)pyrrolidin-3-amine
CAS 933708-04-4C9H14N2S
1-((5-Bromothiophen-2-yl)methyl)pyrrolidin-3-amine chemical structure, C9H13BrN2S, CAS 1044770-07-1
1-((5-Bromothiophen-2-yl)methyl)pyrrolidin-3-amine
CAS 1044770-07-1C9H13BrN2S
1-((5-Bromothiophen-2-yl)methyl)pyrrolidin-3-ol chemical structure, C9H12BrNOS, CAS 1044770-08-2
1-((5-Bromothiophen-2-yl)methyl)pyrrolidin-3-ol
CAS 1044770-08-2C9H12BrNOS
1-[(4-Bromothiophen-2-yl)methyl]pyrrolidin-3-ol chemical structure, C9H12BrNOS, CAS 1044770-11-7
1-[(4-Bromothiophen-2-yl)methyl]pyrrolidin-3-ol
CAS 1044770-11-7C9H12BrNOS
Methyl 1-(thiophen-2-ylmethyl)pyrrolidine-2-carboxylate chemical structure, C11H15NO2S, CAS 1031843-68-1
Methyl 1-(thiophen-2-ylmethyl)pyrrolidine-2-carboxylate
CAS 1031843-68-1C11H15NO2S
(1-((3-Methylthiophen-2-yl)methyl)pyrrolidin-2-yl)methanol chemical structure, C11H17NOS, CAS 864413-74-1
(1-((3-Methylthiophen-2-yl)methyl)pyrrolidin-2-yl)methanol
CAS 864413-74-1C11H17NOS
2-(4-Bromothiophen-2-yl)-2-(pyrrolidin-1-yl)acetic acid hydrochloride chemical structure, C10H13BrClNO2S, CAS 1354949-62-4
2-(4-Bromothiophen-2-yl)-2-(pyrrolidin-1-yl)acetic acid hydrochloride
CAS 1354949-62-4C10H13BrClNO2S
(4-Bromo-2-thienyl)(pyrrolidin-1-yl)acetic acid hydrochloride chemical structure, C10H12BrNO2S, CAS 1249997-23-6
(4-Bromo-2-thienyl)(pyrrolidin-1-yl)acetic acid hydrochloride
CAS 1249997-23-6C10H12BrNO2S
2-(Pyrrolidin-1-yl)-2-(thiophen-2-yl)propanoic acid chemical structure, C11H15NO2S, CAS 898402-48-7
2-(Pyrrolidin-1-yl)-2-(thiophen-2-yl)propanoic acid
CAS 898402-48-7C11H15NO2S
1-[(5-Bromo-2-thienyl)methyl]pyrrolidine chemical structure, C9H12BrNS, CAS 1065184-86-2
1-[(5-Bromo-2-thienyl)methyl]pyrrolidine
CAS 1065184-86-2C9H12BrNS
1-[(4-Bromothiophen-2-yl)methyl]pyrrolidine chemical structure, C9H12BrNS, CAS 1248218-70-3
1-[(4-Bromothiophen-2-yl)methyl]pyrrolidine
CAS 1248218-70-3C9H12BrNS
I(2)-(4-Bromo-2-thienyl)-2-methyl-1-pyrrolidineethanamine chemical structure, C11H17BrN2S, CAS 1216080-23-7
I(2)-(4-Bromo-2-thienyl)-2-methyl-1-pyrrolidineethanamine
CAS 1216080-23-7C11H17BrN2S
I(2)-(5-Chloro-2-thienyl)-I+/-,3-dimethyl-1-pyrrolidineethanamine chemical structure, C12H19ClN2S, CAS 1247658-98-5
I(2)-(5-Chloro-2-thienyl)-I+/-,3-dimethyl-1-pyrrolidineethanamine
CAS 1247658-98-5C12H19ClN2S
(1-((5-Bromothiophen-2-yl)methyl)pyrrolidin-2-yl)methanol chemical structure, C10H14BrNOS, CAS 1250782-42-3
(1-((5-Bromothiophen-2-yl)methyl)pyrrolidin-2-yl)methanol
CAS 1250782-42-3C10H14BrNOS
3-(5-(Pyrrolidin-1-ylmethyl)thiophen-3-yl)prop-2-yn-1-ol chemical structure, C12H15NOS, CAS 1249839-87-9
3-(5-(Pyrrolidin-1-ylmethyl)thiophen-3-yl)prop-2-yn-1-ol
CAS 1249839-87-9C12H15NOS
(1-((4-Bromothiophen-2-yl)methyl)pyrrolidin-2-yl)methanol chemical structure, C10H14BrNOS, CAS 1247988-05-1
(1-((4-Bromothiophen-2-yl)methyl)pyrrolidin-2-yl)methanol
CAS 1247988-05-1C10H14BrNOS