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Murcko scaffold

1,6-Naphthyridin-5(6H)-one scaffold

64 chemicals on CompoundList share this ring system.

Rings
2
Scaffold atoms
11
Chemicals
64
With full pages
5
Scaffold SMILES

O=c1[nH]ccc2ncccc12

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffoldOpen the 1,6-Naphthyridin-5(6H)-one page
Murcko scaffold O=c1[nH]ccc2ncccc12

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 48 of 64 chemicals

Methyl 8-hydroxy-5-oxo-5,6-dihydro-1,6-naphthyridine-7-carboxylate chemical structure, C10H8N2O4, CAS 67643-24-7
Methyl 8-hydroxy-5-oxo-5,6-dihydro-1,6-naphthyridine-7-carboxylate
CAS 67643-24-7C10H8N2O4
Ethyl 6-(2-hydroxyethyl)-2-methyl-5-oxo-5,6-dihydro[1,6]naphthyridine-3-carboxylate chemical structure, C14H16N2O4, CAS 127749-89-7
Ethyl 6-(2-hydroxyethyl)-2-methyl-5-oxo-5,6-dihydro[1,6]naphthyridine-3-carboxylate
CAS 127749-89-7C14H16N2O4
1,6-Naphthyridin-5(6H)-one chemical structure, C8H6N2O, CAS 23616-31-1
1,6-Naphthyridin-5(6H)-one
CAS 23616-31-1C8H6N2O
Ethyl 2-methyl-5-oxo-5,6-dihydro-1,6-naphthyridine-3-carboxylate chemical structure, C12H12N2O3, CAS 80812-55-1
Ethyl 2-methyl-5-oxo-5,6-dihydro-1,6-naphthyridine-3-carboxylate
CAS 80812-55-1C12H12N2O3
2-(Trifluoromethyl)-1,6-naphthyridin-5(6H)-one chemical structure, C9H5F3N2O, CAS 890301-91-4
2-(Trifluoromethyl)-1,6-naphthyridin-5(6H)-one
CAS 890301-91-4C9H5F3N2O
8-Bromo-2-(trifluoromethyl)-1,6-naphthyridin-5(6H)-one chemical structure, C9H4BrF3N2O, CAS 890301-92-5
8-Bromo-2-(trifluoromethyl)-1,6-naphthyridin-5(6H)-one
CAS 890301-92-5C9H4BrF3N2O
6-Methyl-1,6-naphthyridin-5(6H)-one chemical structure, C9H8N2O, CAS 19693-54-0
6-Methyl-1,6-naphthyridin-5(6H)-one
CAS 19693-54-0C9H8N2O
6-Methyl-5-oxo-5,6-dihydro-1,6-naphthyridine-8-carbaldehyde chemical structure, C10H8N2O2, CAS 88752-77-6
6-Methyl-5-oxo-5,6-dihydro-1,6-naphthyridine-8-carbaldehyde
CAS 88752-77-6C10H8N2O2
6-Methyl-5-oxo-5,6-dihydro-1,6-naphthyridine-8-carboxylic acid chemical structure, C10H8N2O3, CAS 88976-23-2
6-Methyl-5-oxo-5,6-dihydro-1,6-naphthyridine-8-carboxylic acid
CAS 88976-23-2C10H8N2O3
Ethyl 7-methyl-5-oxo-5,6-dihydro-1,6-naphthyridine-8-carboxylate chemical structure, C12H12N2O3, CAS 124259-52-5
Ethyl 7-methyl-5-oxo-5,6-dihydro-1,6-naphthyridine-8-carboxylate
CAS 124259-52-5C12H12N2O3
8-Bromo-1,6-naphthyridin-5(6H)-one chemical structure, C8H5BrN2O, CAS 155057-97-9
8-Bromo-1,6-naphthyridin-5(6H)-one
CAS 155057-97-9C8H5BrN2O
3-Bromo-1,6-naphthyridin-5(6H)-one chemical structure, C8H5BrN2O, CAS 1260665-60-8
3-Bromo-1,6-naphthyridin-5(6H)-one
CAS 1260665-60-8C8H5BrN2O
7-Chloro-1,6-naphthyridin-5-ol chemical structure, C8H5ClN2O, CAS 1378337-51-9
7-Chloro-1,6-naphthyridin-5-ol
CAS 1378337-51-9C8H5ClN2O
Methyl 6-amino-2-methyl-5-oxo-5,6-dihydro-1,6-naphthyridine-3-carboxylate chemical structure, C11H11N3O3, CAS 1030419-97-6
Methyl 6-amino-2-methyl-5-oxo-5,6-dihydro-1,6-naphthyridine-3-carboxylate
CAS 1030419-97-6C11H11N3O3
Methyl 2,6-dimethyl-5-oxo-5,6-dihydro-1,6-naphthyridine-3-carboxylate chemical structure, C12H12N2O3, CAS 1158602-47-1
Methyl 2,6-dimethyl-5-oxo-5,6-dihydro-1,6-naphthyridine-3-carboxylate
CAS 1158602-47-1C12H12N2O3
1,6-Naphthyridine-3-carboxylic acid, 6-ethyl-5,6-dihydro-2-methyl-5-oxo-, methyl ester chemical structure, C13H14N2O3, CAS 80812-57-3
1,6-Naphthyridine-3-carboxylic acid, 6-ethyl-5,6-dihydro-2-methyl-5-oxo-, methyl ester
CAS 80812-57-3C13H14N2O3
Methyl 6-isopropyl-2-methyl-5-oxo-5,6-dihydro[1,6]naphthyridine-3-carboxylate chemical structure, C14H16N2O3, CAS 1158361-61-5
Methyl 6-isopropyl-2-methyl-5-oxo-5,6-dihydro[1,6]naphthyridine-3-carboxylate
CAS 1158361-61-5C14H16N2O3
8-Iodo-1,6-naphthyridin-5(6H)-one chemical structure, C8H5IN2O, CAS 107484-68-4
8-Iodo-1,6-naphthyridin-5(6H)-one
CAS 107484-68-4C8H5IN2O
6-Isopropyl-2-methyl-5-oxo-5,6-dihydro-1,6-naphthyridine-3-carboxylic acid chemical structure, C13H14N2O3, CAS 1232782-60-3
6-Isopropyl-2-methyl-5-oxo-5,6-dihydro-1,6-naphthyridine-3-carboxylic acid
CAS 1232782-60-3C13H14N2O3
8-Hydroxy-6H-1,6-naphthyridin-5-one chemical structure, C8H6N2O2, CAS 679797-45-6
8-Hydroxy-6H-1,6-naphthyridin-5-one
CAS 679797-45-6C8H6N2O2
(5-Oxo-1,6-naphthyridin-6(5H)-YL)acetic acid chemical structure, C10H8N2O3, CAS 1190392-11-0
(5-Oxo-1,6-naphthyridin-6(5H)-YL)acetic acid
CAS 1190392-11-0C10H8N2O3
3-(2-Methoxyethoxy)-1,6-naphthyridin-5(6H)-one chemical structure, C11H12N2O3, CAS 1173699-59-6
3-(2-Methoxyethoxy)-1,6-naphthyridin-5(6H)-one
CAS 1173699-59-6C11H12N2O3
Ethyl 2-(3-methoxy-5-oxo-1,6-naphthyridin-6(5H)-yl)propanoate chemical structure, C14H16N2O4, CAS 1173699-71-2
Ethyl 2-(3-methoxy-5-oxo-1,6-naphthyridin-6(5H)-yl)propanoate
CAS 1173699-71-2C14H16N2O4
2-(3-(2-Methoxyethoxy)-5-oxo-1,6-naphthyridin-6(5H)-yl)propanoic acid chemical structure, C14H16N2O5, CAS 1173880-09-5
2-(3-(2-Methoxyethoxy)-5-oxo-1,6-naphthyridin-6(5H)-yl)propanoic acid
CAS 1173880-09-5C14H16N2O5