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Murcko scaffold

Ring system with 4 rings and 25 atoms

9 chemicals on CompoundList share this ring system.

Rings
4
Scaffold atoms
25
Chemicals
9
With full pages
2
Scaffold SMILES

O=C(CSc1nnc(-c2ccccc2)o1)Nc1cc2c(s1)CCCC2

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=C(CSc1nnc(-c2ccccc2)o1)Nc1cc2c(s1)CCCC2

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 9 of 9 chemicals

N-(3-Cyano-4,5,6,7-tetrahydrobenzo[b]thiophen-2-yl)-2-((5-(p-tolyl)-1,3,4-oxadiazol-2-yl)thio)acetamide chemical structure, C20H18N4O2S2, CAS 337489-25-5
N-(3-Cyano-4,5,6,7-tetrahydrobenzo[b]thiophen-2-yl)-2-((5-(p-tolyl)-1,3,4-oxadiazol-2-yl)thio)acetamide
CAS 337489-25-5C20H18N4O2S2
Ethyl 2-[[2-[(5-phenyl-1,3,4-oxadiazol-2-yl)sulfanyl]acetyl]amino]-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxylate chemical structure, C21H21N3O4S2, CAS 539805-60-2
Ethyl 2-[[2-[(5-phenyl-1,3,4-oxadiazol-2-yl)sulfanyl]acetyl]amino]-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxylate
CAS 539805-60-2C21H21N3O4S2
Ethyl 2-(2-((5-(4-methoxyphenyl)-1,3,4-oxadiazol-2-yl)thio)acetamido)-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylate chemical structure, C22H23N3O5S2, CAS 501111-52-0
Ethyl 2-(2-((5-(4-methoxyphenyl)-1,3,4-oxadiazol-2-yl)thio)acetamido)-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylate
CAS 501111-52-0C22H23N3O5S2
N-(3-Cyano-4,5,6,7-tetrahydro-1-benzothiophen-2-yl)-2-[(5-phenyl-1,3,4-oxadiazol-2-yl)sulfanyl]acetamide chemical structure, C19H16N4O2S2, CAS 485334-61-0
N-(3-Cyano-4,5,6,7-tetrahydro-1-benzothiophen-2-yl)-2-[(5-phenyl-1,3,4-oxadiazol-2-yl)sulfanyl]acetamide
CAS 485334-61-0C19H16N4O2S2
N-(6-tert-Butyl-3-cyano-4,5,6,7-tetrahydro-1-benzothiophen-2-yl)-2-[(5-phenyl-1,3,4-oxadiazol-2-yl)sulfanyl]acetamide chemical structure, C23H24N4O2S2, CAS 679420-62-3
N-(6-tert-Butyl-3-cyano-4,5,6,7-tetrahydro-1-benzothiophen-2-yl)-2-[(5-phenyl-1,3,4-oxadiazol-2-yl)sulfanyl]acetamide
CAS 679420-62-3C23H24N4O2S2
Ethyl 2-(2-((5-(4-bromophenyl)-1,3,4-oxadiazol-2-yl)thio)acetamido)-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylate chemical structure, C21H20BrN3O4S2, CAS 332161-19-0
Ethyl 2-(2-((5-(4-bromophenyl)-1,3,4-oxadiazol-2-yl)thio)acetamido)-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylate
CAS 332161-19-0C21H20BrN3O4S2
Methyl 2-(2-((5-(2-chlorophenyl)-1,3,4-oxadiazol-2-yl)thio)acetamido)-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylate chemical structure, C20H18ClN3O4S2, CAS 941911-32-6
Methyl 2-(2-((5-(2-chlorophenyl)-1,3,4-oxadiazol-2-yl)thio)acetamido)-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylate
CAS 941911-32-6C20H18ClN3O4S2
2-(2-{[5-(4-Methoxyphenyl)-1,3,4-oxadiazol-2-yl]sulfanyl}acetamido)-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxamide chemical structure, C20H20N4O4S2, CAS 875457-43-5
2-(2-{[5-(4-Methoxyphenyl)-1,3,4-oxadiazol-2-yl]sulfanyl}acetamido)-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxamide
CAS 875457-43-5C20H20N4O4S2
2-[[5-(2-Chlorophenyl)-1,3,4-oxadiazol-2-yl]thio]-N-(3-cyano-4,5,6,7-tetrahydrobenzo[b]thien-2-yl)acetamide chemical structure, C19H15ClN4O2S2, CAS 946812-37-9
2-[[5-(2-Chlorophenyl)-1,3,4-oxadiazol-2-yl]thio]-N-(3-cyano-4,5,6,7-tetrahydrobenzo[b]thien-2-yl)acetamide
CAS 946812-37-9C19H15ClN4O2S2