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Murcko scaffold

4-(3,4-Dihydroisoquinolin-2(1H)-ylcarbonyl)-1-phenylpyrrolidin-2-one scaffold

8 chemicals on CompoundList share this ring system.

Rings
4
Scaffold atoms
24
Chemicals
8
With full pages
1
Scaffold SMILES

O=C(C1CC(=O)N(c2ccccc2)C1)N1CCc2ccccc2C1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffoldOpen the 4-(3,4-Dihydroisoquinolin-2(1H)-ylcarbonyl)-1-phenylpyrrolidin-2-one page
Murcko scaffold O=C(C1CC(=O)N(c2ccccc2)C1)N1CCc2ccccc2C1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 8 of 8 chemicals

4-(3,4-Dihydro-2(1H)-isoquinolinylcarbonyl)-1-(4-methylphenyl)-2-pyrrolidinone chemical structure, C21H22N2O2, CAS 825597-71-5
4-(3,4-Dihydro-2(1H)-isoquinolinylcarbonyl)-1-(4-methylphenyl)-2-pyrrolidinone
CAS 825597-71-5C21H22N2O2
4-(3,4-Dihydroisoquinolin-2(1H)-ylcarbonyl)-1-phenylpyrrolidin-2-one chemical structure, C20H20N2O2, CAS 879595-60-5
4-(3,4-Dihydroisoquinolin-2(1H)-ylcarbonyl)-1-phenylpyrrolidin-2-one
CAS 879595-60-5C20H20N2O2
N-{4-[4-(3,4-Dihydroisoquinolin-2(1H)-ylcarbonyl)-2-oxopyrrolidin-1-yl]phenyl}acetamide chemical structure, C22H23N3O3, CAS 905181-91-1
N-{4-[4-(3,4-Dihydroisoquinolin-2(1H)-ylcarbonyl)-2-oxopyrrolidin-1-yl]phenyl}acetamide
CAS 905181-91-1C22H23N3O3
1-(4-Methoxyphenyl)-4-(1,2,3,4-tetrahydroisoquinoline-2-carbonyl)pyrrolidin-2-one chemical structure, C21H22N2O3, CAS 881786-53-4
1-(4-Methoxyphenyl)-4-(1,2,3,4-tetrahydroisoquinoline-2-carbonyl)pyrrolidin-2-one
CAS 881786-53-4C21H22N2O3
4-(3,4-Dihydroisoquinolin-2(1H)-ylcarbonyl)-1-(2-methoxy-5-methylphenyl)pyrrolidin-2-one chemical structure, C22H24N2O3, CAS 925890-80-8
4-(3,4-Dihydroisoquinolin-2(1H)-ylcarbonyl)-1-(2-methoxy-5-methylphenyl)pyrrolidin-2-one
CAS 925890-80-8C22H24N2O3
4-[(6,7-Dimethoxy-3,4-dihydroisoquinolin-2(1H)-yl)carbonyl]-1-(4-methoxyphenyl)pyrrolidin-2-one chemical structure, C23H26N2O5, CAS 1010924-35-2
4-[(6,7-Dimethoxy-3,4-dihydroisoquinolin-2(1H)-yl)carbonyl]-1-(4-methoxyphenyl)pyrrolidin-2-one
CAS 1010924-35-2C23H26N2O5
4-[(6,7-Dimethoxy-3,4-dihydroisoquinolin-2(1H)-yl)carbonyl]-1-(3-methoxyphenyl)pyrrolidin-2-one chemical structure, C23H26N2O5, CAS 1010872-45-3
4-[(6,7-Dimethoxy-3,4-dihydroisoquinolin-2(1H)-yl)carbonyl]-1-(3-methoxyphenyl)pyrrolidin-2-one
CAS 1010872-45-3C23H26N2O5
1-(4-Chlorophenyl)-4-[(6,7-dimethoxy-3,4-dihydroisoquinolin-2(1H)-yl)carbonyl]pyrrolidin-2-one chemical structure, C22H23ClN2O4, CAS 1010929-52-8
1-(4-Chlorophenyl)-4-[(6,7-dimethoxy-3,4-dihydroisoquinolin-2(1H)-yl)carbonyl]pyrrolidin-2-one
CAS 1010929-52-8C22H23ClN2O4