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Murcko scaffold

Ring system with 4 rings and 23 atoms

8 chemicals on CompoundList share this ring system.

Rings
4
Scaffold atoms
23
Chemicals
8
With full pages
3
Scaffold SMILES

O=C(CN1CCNCC1)N1c2ccccc2Sc2ccccc21

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=C(CN1CCNCC1)N1c2ccccc2Sc2ccccc21

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 8 of 8 chemicals

Ketone, (4-(2-hydroxyethyl)piperazinyl)methyl phenothiazin-10-yl, dihydrochloride chemical structure, C20H25Cl2N3O2S, CAS 29573-89-5
Ketone, (4-(2-hydroxyethyl)piperazinyl)methyl phenothiazin-10-yl, dihydrochloride
CAS 29573-89-5C20H25Cl2N3O2S
Ketone, 2-chlorophenothiazin-10-yl (4-(2-hydroxyethyl)-1-piperazinyl)methyl, dihydrochloride chemical structure, C20H24Cl3N3O2S, CAS 29573-90-8
Ketone, 2-chlorophenothiazin-10-yl (4-(2-hydroxyethyl)-1-piperazinyl)methyl, dihydrochloride
CAS 29573-90-8C20H24Cl3N3O2S
2-(4-Methylpiperazin-1-yl)-1-(10H-phenothiazin-10-yl)ethanone chemical structure, C19H21N3OS, CAS 102178-64-3
2-(4-Methylpiperazin-1-yl)-1-(10H-phenothiazin-10-yl)ethanone
CAS 102178-64-3C19H21N3OS
1-(2-Chlorophenothiazin-10-yl)-2-(4-methylpiperazin-1-yl)ethanone chemical structure, C19H20ClN3OS, CAS 59260-84-3
1-(2-Chlorophenothiazin-10-yl)-2-(4-methylpiperazin-1-yl)ethanone
CAS 59260-84-3C19H20ClN3OS
2-(4-Ethylpiperazino)-1-(10H-phenothiazin-10-yl)-1-ethanone chemical structure, C20H23N3OS, CAS 102157-54-0
2-(4-Ethylpiperazino)-1-(10H-phenothiazin-10-yl)-1-ethanone
CAS 102157-54-0C20H23N3OS
2-Chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine chemical structure, C20H22ClN3O2S, CAS 61524-32-1
2-Chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine
CAS 61524-32-1C20H22ClN3O2S
2-[4-(2-Hydroxyethyl)piperazin-1-yl]-1-[2-(trifluoromethyl)phenothiazin-10-yl]ethanone chemical structure, C21H23ClF3N3O2S, CAS 74317-41-2
2-[4-(2-Hydroxyethyl)piperazin-1-yl]-1-[2-(trifluoromethyl)phenothiazin-10-yl]ethanone
CAS 74317-41-2C21H23ClF3N3O2S
1-(2-Methoxy-10H-phenothiazin-10-yl)-2-(4-methylpiperazin-1-yl)ethan-1-one--hydrogen chloride (1/1) chemical structure, C20H24ClN3O2S, CAS 57628-50-9
1-(2-Methoxy-10H-phenothiazin-10-yl)-2-(4-methylpiperazin-1-yl)ethan-1-one--hydrogen chloride (1/1)
CAS 57628-50-9C20H24ClN3O2S