Murcko scaffold
Ring system with 4 rings and 22 atoms
27 chemicals on CompoundList share this ring system.
- Rings
- 4
- Scaffold atoms
- 22
- Chemicals
- 27
- With full pages
- 9
Scaffold SMILES
c1ccc2c(c1)Sc1ccccc1N2CCC1CCCCN1
A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.
Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.
Chemicals with this scaffold
Open one to see its structure, properties and suppliers.
Showing 1 to 27 of 27 chemicals
Mesoridazine
CAS 5588-33-0C21H26N2OS2
Thioridazine
CAS 50-52-2C21H26N2S2
Normesoridazine
CAS 14471-95-5C20H24N2OS2
Sulforidazine
CAS 14759-06-9C21H26N2O2S2
Mesoridazine besylate
CAS 32672-69-8C27H32N2O4S3
Oxyridazine
CAS 14759-04-7C21H26N2OS
Thioridazine hydrochloride
CAS 130-61-0C21H27ClN2S2
Phenothiazine, 2-bromo-10-(2-(1-methyl-2-piperidyl)ethyl)-
CAS 60634-41-5C20H23BrN2S
2-Chloro-10-(2-(1-methyl-2-piperidinyl)ethyl)-10H-phenothiazine
CAS 5060-56-0C20H23ClN2S
Thioridazine N-oxide
CAS 103827-30-1C21H26N2OS2
10H-Phenothiazine, 10-(2-(1-methyl-2-piperidinyl)ethyl)-2-(methylsulfinyl)-, monohydrochloride
CAS 59884-26-3C21H27ClN2OS2
Phenothiazine, 2-isopropoxy-10-(2-(1-methyl-2-piperidyl)ethyl)-
CAS 14759-05-8C23H30N2OS
Phenothiazine, 10-(2-(1-methyl-2-piperidyl)ethyl)-
CAS 32367-75-2C20H24N2S
Northioridazine
CAS 10538-32-6C20H24N2S2
![Hydron, 10-[2-(1-methylpiperidin-2-yl)ethyl]-2-methylsulfanylphenothiazine, chloride chemical structure, C21H27ClN2S2, CAS 1257-76-7](/s/id-657213.svg)
Hydron, 10-[2-(1-methylpiperidin-2-yl)ethyl]-2-methylsulfanylphenothiazine, chloride
CAS 1257-76-7C21H27ClN2S2
![10-{2-[(2s)-1-Methylpiperidin-2-Yl]ethyl}-2-(Methylsulfanyl)-10H-Phenothiazine chemical structure, C21H26N2S2, CAS 114488-10-7](/s/KLBQZWRITKRQQV-INIZCTEOSA-N.svg)
10-{2-[(2s)-1-Methylpiperidin-2-Yl]ethyl}-2-(Methylsulfanyl)-10H-Phenothiazine
CAS 114488-10-7C21H26N2S2
Sulforidazine-d4
CAS 121434-15-9C21H26N2O2S2
Sulforidazine besylate
CAS 23255-94-9C27H32N2O5S3
5-Oxo-L-proline, compound with 10-(2-(1-methyl-2-piperidyl)ethyl)-2-(methylthio)-10H-phenothiazine (1:1)
CAS 93857-20-6C26H33N3O3S2
Thioridazine-d3 hydrochloride
CAS 1189928-36-6C21H27ClN2S2
![2-(Methanesulfonyl)-10-[2-(piperidin-2-yl)ethyl]-10H-phenothiazine chemical structure, C20H24N2O2S2, CAS 58255-92-8](/s/ACEJHVDLZKYZMJ-UHFFFAOYSA-N.svg)
2-(Methanesulfonyl)-10-[2-(piperidin-2-yl)ethyl]-10H-phenothiazine
CAS 58255-92-8C20H24N2O2S2
Thioridazine-d3 2-sulfone
CAS 1329652-09-6C21H26N2O2S2
![10-[2-(1-Methyl-2-piperidyl)ethyl]-10H-phenothiazine Hydrochloride chemical structure, C20H25ClN2S, CAS 112688-25-2](/s/GROPGFYHQTWGRA-UHFFFAOYSA-N.svg)
10-[2-(1-Methyl-2-piperidyl)ethyl]-10H-phenothiazine Hydrochloride
CAS 112688-25-2C20H25ClN2S
Northioridazine hydrochloride
CAS 13002-81-8C20H25ClN2S2
Related scaffolds
Same ring framework with different atoms or bond orders
O=C(Nc1ccccc1)c1c2c(nc3ccccc13)CCCC221 chemicals
C(=Nc1ccccc1)c1c2ccccc2cc2ccccc129 chemicals
O=C(Nc1ccccc1)N1c2ccccc2Sc2ccccc219 chemicals
O=C(Nc1ccccc1)C1c2ccccc2Oc2ccccc214 chemicals
O=C(Oc1ccccc1)c1c2c(nc3ccccc13)CCCC23 chemicals
O=C(CN1CCCCC1)N1c2ccccc2Sc2ccccc213 chemicals
O=C(CN1CCNCC1)N1c2ccccc2Sc2ccccc213 chemicals
O=C(Nc1ncccn1)C1c2ccccc2Oc2ccccc212 chemicals
O=C(Nc1ccccn1)C1c2ccccc2Oc2ccccc212 chemicals
O=S(=O)(NC1c2ccccc2Oc2ccccc21)c1ccccc12 chemicals
O=C(CN1CCOCC1)N1c2ccccc2Sc2ccccc212 chemicals
O=C(NC1c2ccccc2Oc2ccccc21)c1ccccc12 chemicals