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Murcko scaffold

Ring system with 4 rings and 25 atoms

13 chemicals on CompoundList share this ring system.

Rings: 4
Scaffold atoms: 25
Chemicals: 13
With full pages: 2

Scaffold SMILES

O=C1NC(c2ccccc2)C(=Cc2cnn(-c3ccccc3)c2)C1=O

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold

Murcko scaffold O=C1NC(c2ccccc2)C(=Cc2cnn(-c3ccccc3)c2)C1=O

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 13 of 13 chemicals

1-[3-(Dimethylamino)propyl]-5-(3-fluorophenyl)-3-hydroxy-4-(5-methyl-1-phenyl-1H-pyrazole-4-carbonyl)-2,5-dihydro-1H-pyrrol-2-one chemical structure, C26H27FN4O3

1-[3-(Dimethylamino)propyl]-5-(3-fluorophenyl)-3-hydroxy-4-(5-methyl-1-phenyl-1H-pyrazole-4-carbonyl)-2,5-dihydro-1H-pyrrol-2-one

C₂₆H₂₇FN₄O₃

1-[3-(Dimethylamino)propyl]-4-[hydroxy(5-methyl-1-phenyl-1H-pyrazol-4-yl)methylidene]-5-{4-[(prop-2-en-1-yl)oxy]phenyl}pyrrolidine-2,3-dione chemical structure, C29H32N4O4, CAS 7048-75-1

1-[3-(Dimethylamino)propyl]-4-[hydroxy(5-methyl-1-phenyl-1H-pyrazol-4-yl)methylidene]-5-{4-[(prop-2-en-1-yl)oxy]phenyl}pyrrolidine-2,3-dione

CAS 7048-75-1C₂₉H₃₂N₄O₄

1-[3-(Diethylamino)propyl]-5-(2-fluorophenyl)-4-[hydroxy(5-methyl-1-phenyl-1H-pyrazol-4-yl)methylidene]pyrrolidine-2,3-dione chemical structure, C28H31FN4O3, CAS 7048-76-2

1-[3-(Diethylamino)propyl]-5-(2-fluorophenyl)-4-[hydroxy(5-methyl-1-phenyl-1H-pyrazol-4-yl)methylidene]pyrrolidine-2,3-dione

CAS 7048-76-2C₂₈H₃₁FN₄O₃

1-[3-(Diethylamino)propyl]-5-(3-ethoxyphenyl)-4-[hydroxy-(5-methyl-1-phenylpyrazol-4-yl)methylidene]pyrrolidine-2,3-dione chemical structure, C30H36N4O4, CAS 7048-77-3

1-[3-(Diethylamino)propyl]-5-(3-ethoxyphenyl)-4-[hydroxy-(5-methyl-1-phenylpyrazol-4-yl)methylidene]pyrrolidine-2,3-dione

CAS 7048-77-3C₃₀H₃₆N₄O₄

1-[2-(Diethylamino)ethyl]-4-[hydroxy(5-methyl-1-phenyl-1H-pyrazol-4-yl)methylidene]-5-phenylpyrrolidine-2,3-dione chemical structure, C27H30N4O3, CAS 7048-78-4

1-[2-(Diethylamino)ethyl]-4-[hydroxy(5-methyl-1-phenyl-1H-pyrazol-4-yl)methylidene]-5-phenylpyrrolidine-2,3-dione

CAS 7048-78-4C₂₇H₃₀N₄O₃

5-(4-Chlorophenyl)-1-[2-(diethylamino)ethyl]-4-[hydroxy(5-methyl-1-phenyl-1H-pyrazol-4-yl)methylidene]pyrrolidine-2,3-dione chemical structure, C27H29ClN4O3, CAS 7048-79-5

5-(4-Chlorophenyl)-1-[2-(diethylamino)ethyl]-4-[hydroxy(5-methyl-1-phenyl-1H-pyrazol-4-yl)methylidene]pyrrolidine-2,3-dione

CAS 7048-79-5C₂₇H₂₉ClN₄O₃

1-[2-(Diethylamino)ethyl]-5-(2,3-dimethoxyphenyl)-4-[hydroxy-(5-methyl-1-phenylpyrazol-4-yl)methylidene]pyrrolidine-2,3-dione chemical structure, C29H34N4O5, CAS 7048-80-8

1-[2-(Diethylamino)ethyl]-5-(2,3-dimethoxyphenyl)-4-[hydroxy-(5-methyl-1-phenylpyrazol-4-yl)methylidene]pyrrolidine-2,3-dione

CAS 7048-80-8C₂₉H₃₄N₄O₅

1-(3-(Dimethylamino)propyl)-3-hydroxy-4-(5-methyl-1-phenyl-1H-pyrazole-4-carbonyl)-5-phenyl-1H-pyrrol-2(5H)-one chemical structure, C26H28N4O3, CAS 908229-11-8

1-(3-(Dimethylamino)propyl)-3-hydroxy-4-(5-methyl-1-phenyl-1H-pyrazole-4-carbonyl)-5-phenyl-1H-pyrrol-2(5H)-one

CAS 908229-11-8C₂₆H₂₈N₄O₃

1-[3-(Dimethylamino)propyl]-5-(3-fluorophenyl)-3-hydroxy-4-[(5-methyl-1-phenyl pyrazol-4-yl)carbonyl]-3-pyrrolin-2-one chemical structure, C26H27FN4O3, CAS 955870-17-4

1-[3-(Dimethylamino)propyl]-5-(3-fluorophenyl)-3-hydroxy-4-[(5-methyl-1-phenyl pyrazol-4-yl)carbonyl]-3-pyrrolin-2-one

CAS 955870-17-4C₂₆H₂₇FN₄O₃

1-(2-(Dimethylamino)ethyl)-5-(4-fluorophenyl)-3-hydroxy-4-(5-methyl-1-phenyl-1H-pyrazole-4-carbonyl)-1H-pyrrol-2(5H)-one chemical structure, C25H25FN4O3, CAS 1010863-51-0

1-(2-(Dimethylamino)ethyl)-5-(4-fluorophenyl)-3-hydroxy-4-(5-methyl-1-phenyl-1H-pyrazole-4-carbonyl)-1H-pyrrol-2(5H)-one

CAS 1010863-51-0C₂₅H₂₅FN₄O₃

1-(2-(Dimethylamino)ethyl)-5-(2-fluorophenyl)-3-hydroxy-4-(5-methyl-1-phenyl-1H-pyrazole-4-carbonyl)-1H-pyrrol-2(5H)-one chemical structure, C25H25FN4O3, CAS 1010863-12-3

1-(2-(Dimethylamino)ethyl)-5-(2-fluorophenyl)-3-hydroxy-4-(5-methyl-1-phenyl-1H-pyrazole-4-carbonyl)-1H-pyrrol-2(5H)-one

CAS 1010863-12-3C₂₅H₂₅FN₄O₃

1-(2-(Dimethylamino)ethyl)-3-hydroxy-4-(5-methyl-1-phenyl-1H-pyrazole-4-carbonyl)-5-phenyl-1H-pyrrol-2(5H)-one chemical structure, C25H26N4O3, CAS 955869-55-3

1-(2-(Dimethylamino)ethyl)-3-hydroxy-4-(5-methyl-1-phenyl-1H-pyrazole-4-carbonyl)-5-phenyl-1H-pyrrol-2(5H)-one

CAS 955869-55-3C₂₅H₂₆N₄O₃

1-(2-(Dimethylamino)ethyl)-3-hydroxy-4-(5-methyl-1-phenyl-1H-pyrazole-4-carbonyl)-5-(p-tolyl)-1H-pyrrol-2(5H)-one chemical structure, C26H28N4O3, CAS 955895-98-4

1-(2-(Dimethylamino)ethyl)-3-hydroxy-4-(5-methyl-1-phenyl-1H-pyrazole-4-carbonyl)-5-(p-tolyl)-1H-pyrrol-2(5H)-one

CAS 955895-98-4C₂₆H₂₈N₄O₃