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Murcko scaffold

Ring system with 3 rings and 19 atoms

181 chemicals on CompoundList share this ring system.

Rings
3
Scaffold atoms
19
Chemicals
181
With full pages
16
Scaffold SMILES

O=C(Nc1cc2c(s1)CCCCC2)c1ccccc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=C(Nc1cc2c(s1)CCCCC2)c1ccccc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 48 of 181 chemicals

2-(3,4-Dimethylbenzamido)-5,6,7,8-tetrahydro-4H-cyclohepta[b]thiophene-3-carboxamide chemical structure, C19H22N2O2S, CAS 321532-71-2
2-(3,4-Dimethylbenzamido)-5,6,7,8-tetrahydro-4H-cyclohepta[b]thiophene-3-carboxamide
CAS 321532-71-2C19H22N2O2S
Ethyl 2-benzamido-5,6,7,8-tetrahydro-4H-cyclohepta[b]thiophene-3-carboxylate chemical structure, C19H21NO3S, CAS 63274-52-2
Ethyl 2-benzamido-5,6,7,8-tetrahydro-4H-cyclohepta[b]thiophene-3-carboxylate
CAS 63274-52-2C19H21NO3S
2-[(2-Fluorobenzoyl)amino]-N-methyl-5,6,7,8-tetrahydro-4H-cyclohepta[b]thiophene-3-carboxamide chemical structure, C18H19FN2O2S, CAS 297158-82-8
2-[(2-Fluorobenzoyl)amino]-N-methyl-5,6,7,8-tetrahydro-4H-cyclohepta[b]thiophene-3-carboxamide
CAS 297158-82-8C18H19FN2O2S
2-(2-Methylbenzamido)-5,6,7,8-tetrahydro-4H-cyclohepta[b]thiophene-3-carboxamide chemical structure, C18H20N2O2S, CAS 321533-24-8
2-(2-Methylbenzamido)-5,6,7,8-tetrahydro-4H-cyclohepta[b]thiophene-3-carboxamide
CAS 321533-24-8C18H20N2O2S
2-Benzamido-5,6,7,8-tetrahydro-4H-cyclohepta[b]thiophene-3-carboxamide chemical structure, C17H18N2O2S, CAS 300574-38-3
2-Benzamido-5,6,7,8-tetrahydro-4H-cyclohepta[b]thiophene-3-carboxamide
CAS 300574-38-3C17H18N2O2S
Methyl 2-[(4-methylbenzoyl)amino]-5,6,7,8-tetrahydro-4H-cyclohepta[b]thiophene-3-carboxylate chemical structure, C19H21NO3S, CAS 329068-50-0
Methyl 2-[(4-methylbenzoyl)amino]-5,6,7,8-tetrahydro-4H-cyclohepta[b]thiophene-3-carboxylate
CAS 329068-50-0C19H21NO3S
N-(3-Cyano-5,6,7,8-tetrahydro-4H-cyclohepta[b]thiophen-2-yl)benzamide chemical structure, C17H16N2OS, CAS 332373-56-5
N-(3-Cyano-5,6,7,8-tetrahydro-4H-cyclohepta[b]thiophen-2-yl)benzamide
CAS 332373-56-5C17H16N2OS
2-Benzamido-5,6,7,8-tetrahydro-4H-cyclohepta[b]thiophene-3-carboxylic acid chemical structure, C17H17NO3S, CAS 333774-32-6
2-Benzamido-5,6,7,8-tetrahydro-4H-cyclohepta[b]thiophene-3-carboxylic acid
CAS 333774-32-6C17H17NO3S
Methyl 2-[(4-fluorobenzoyl)amino]-5,6,7,8-tetrahydro-4H-cyclohepta[b]thiophene-3-carboxylate chemical structure, C18H18FNO3S, CAS 330465-62-8
Methyl 2-[(4-fluorobenzoyl)amino]-5,6,7,8-tetrahydro-4H-cyclohepta[b]thiophene-3-carboxylate
CAS 330465-62-8C18H18FNO3S
N-(3-Cyano-5,6,7,8-tetrahydro-4H-cyclohepta[b]thiophen-2-yl)-4-methoxybenzamide chemical structure, C18H18N2O2S, CAS 332373-83-8
N-(3-Cyano-5,6,7,8-tetrahydro-4H-cyclohepta[b]thiophen-2-yl)-4-methoxybenzamide
CAS 332373-83-8C18H18N2O2S
2-Chloro-N-(3-cyano-5,6,7,8-tetrahydro-4H-cyclohepta[b]thiophen-2-yl)benzamide chemical structure, C17H15ClN2OS, CAS 331760-57-7
2-Chloro-N-(3-cyano-5,6,7,8-tetrahydro-4H-cyclohepta[b]thiophen-2-yl)benzamide
CAS 331760-57-7C17H15ClN2OS
4-Chloro-N-(3-cyano-5,6,7,8-tetrahydro-4H-cyclohepta[b]thiophen-2-yl)benzamide chemical structure, C17H15ClN2OS, CAS 379256-41-4
4-Chloro-N-(3-cyano-5,6,7,8-tetrahydro-4H-cyclohepta[b]thiophen-2-yl)benzamide
CAS 379256-41-4C17H15ClN2OS
2-Benzamido-N,N-dimethyl-5,6,7,8-tetrahydro-4H-cyclohepta[b]thiophene-3-carboxamide chemical structure, C19H22N2O2S, CAS 4298-91-3
2-Benzamido-N,N-dimethyl-5,6,7,8-tetrahydro-4H-cyclohepta[b]thiophene-3-carboxamide
CAS 4298-91-3C19H22N2O2S
N-(3-Cyano-5,6,7,8-tetrahydro-4H-cyclohepta[b]thiophen-2-yl)-4-methylbenzamide chemical structure, C18H18N2OS, CAS 362473-18-5
N-(3-Cyano-5,6,7,8-tetrahydro-4H-cyclohepta[b]thiophen-2-yl)-4-methylbenzamide
CAS 362473-18-5C18H18N2OS
Methyl 2-[(3-fluorobenzoyl)amino]-5,6,7,8-tetrahydro-4H-cyclohepta[b]thiophene-3-carboxylate chemical structure, C18H18FNO3S, CAS 352688-48-3
Methyl 2-[(3-fluorobenzoyl)amino]-5,6,7,8-tetrahydro-4H-cyclohepta[b]thiophene-3-carboxylate
CAS 352688-48-3C18H18FNO3S
2-(2,4-Dimethylbenzamido)-5,6,7,8-tetrahydro-4H-cyclohepta[b]thiophene-3-carboxamide chemical structure, C19H22N2O2S, CAS 674362-66-4
2-(2,4-Dimethylbenzamido)-5,6,7,8-tetrahydro-4H-cyclohepta[b]thiophene-3-carboxamide
CAS 674362-66-4C19H22N2O2S
N-(3-Cyano-5,6,7,8-tetrahydro-4H-cyclohepta[b]thiophen-2-yl)-4-ethoxybenzamide chemical structure, C19H20N2O2S, CAS 438034-98-1
N-(3-Cyano-5,6,7,8-tetrahydro-4H-cyclohepta[b]thiophen-2-yl)-4-ethoxybenzamide
CAS 438034-98-1C19H20N2O2S
3-Chloro-N-(3-cyano-5,6,7,8-tetrahydro-4H-cyclohepta[b]thiophen-2-yl)benzamide chemical structure, C17H15ClN2OS, CAS 438034-90-3
3-Chloro-N-(3-cyano-5,6,7,8-tetrahydro-4H-cyclohepta[b]thiophen-2-yl)benzamide
CAS 438034-90-3C17H15ClN2OS
Isopropyl 2-[(2,4-dimethoxybenzoyl)amino]-5,6,7,8-tetrahydro-4H-cyclohepta[b]thiophene-3-carboxylate chemical structure, C22H27NO5S, CAS 6353-37-3
Isopropyl 2-[(2,4-dimethoxybenzoyl)amino]-5,6,7,8-tetrahydro-4H-cyclohepta[b]thiophene-3-carboxylate
CAS 6353-37-3C22H27NO5S
Methyl 2-({2-chloro-5-nitrobenzoyl}amino)-5,6,7,8-tetrahydro-4H-cyclohepta[b]thiophene-3-carboxylate chemical structure, C18H17ClN2O5S, CAS 477571-13-4
Methyl 2-({2-chloro-5-nitrobenzoyl}amino)-5,6,7,8-tetrahydro-4H-cyclohepta[b]thiophene-3-carboxylate
CAS 477571-13-4C18H17ClN2O5S
Methyl 2-({4-nitro-3-methylbenzoyl}amino)-5,6,7,8-tetrahydro-4H-cyclohepta[b]thiophene-3-carboxylate chemical structure, C19H20N2O5S, CAS 544670-82-8
Methyl 2-({4-nitro-3-methylbenzoyl}amino)-5,6,7,8-tetrahydro-4H-cyclohepta[b]thiophene-3-carboxylate
CAS 544670-82-8C19H20N2O5S
Methyl 2-[(3-chlorobenzoyl)amino]-5,6,7,8-tetrahydro-4H-cyclohepta[b]thiophene-3-carboxylate chemical structure, C18H18ClNO3S, CAS 477571-01-0
Methyl 2-[(3-chlorobenzoyl)amino]-5,6,7,8-tetrahydro-4H-cyclohepta[b]thiophene-3-carboxylate
CAS 477571-01-0C18H18ClNO3S
Ethyl 2-(5-chloro-2-nitrobenzamido)-5,6,7,8-tetrahydro-4H-cyclohepta[b]thiophene-3-carboxylate chemical structure, C19H19ClN2O5S, CAS 397290-70-9
Ethyl 2-(5-chloro-2-nitrobenzamido)-5,6,7,8-tetrahydro-4H-cyclohepta[b]thiophene-3-carboxylate
CAS 397290-70-9C19H19ClN2O5S
2-[(5-Chloro-2-methoxybenzoyl)amino]-5,6,7,8-tetrahydro-4H-cyclohepta[b]thiophene-3-carboxamide chemical structure, C18H19ClN2O3S, CAS 353767-26-7
2-[(5-Chloro-2-methoxybenzoyl)amino]-5,6,7,8-tetrahydro-4H-cyclohepta[b]thiophene-3-carboxamide
CAS 353767-26-7C18H19ClN2O3S