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Murcko scaffold

Ring system with 3 rings and 24 atoms

48 chemicals on CompoundList share this ring system.

Rings
3
Scaffold atoms
24
Chemicals
48
With full pages
11
Scaffold SMILES

O=C(Nc1ccc(S(=O)(=O)Nc2nncs2)cc1)c1ccccc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=C(Nc1ccc(S(=O)(=O)Nc2nncs2)cc1)c1ccccc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 48 of 48 chemicals

N-(4-(N-(5-Ethyl-1,3,4-thiadiazol-2-yl)sulfamoyl)phenyl)-3,5-dinitrobenzamide chemical structure, C17H14N6O7S2, CAS 327038-83-5
N-(4-(N-(5-Ethyl-1,3,4-thiadiazol-2-yl)sulfamoyl)phenyl)-3,5-dinitrobenzamide
CAS 327038-83-5C17H14N6O7S2
N-(4-{[(5-Ethyl-1,3,4-thiadiazol-2-yl)amino]sulfonyl}phenyl)-4-methylbenzamide chemical structure, C18H18N4O3S2, CAS 313660-26-3
N-(4-{[(5-Ethyl-1,3,4-thiadiazol-2-yl)amino]sulfonyl}phenyl)-4-methylbenzamide
CAS 313660-26-3C18H18N4O3S2
N-(4-{[(5-Ethyl-1,3,4-thiadiazol-2-yl)amino]sulfonyl}phenyl)-4-fluorobenzamide chemical structure, C17H15FN4O3S2, CAS 299952-42-4
N-(4-{[(5-Ethyl-1,3,4-thiadiazol-2-yl)amino]sulfonyl}phenyl)-4-fluorobenzamide
CAS 299952-42-4C17H15FN4O3S2
N-[4-[(5-Ethyl-1,3,4-thiadiazol-2-yl)sulfamoyl]phenyl]-3-(1,1,2,2-tetrafluoroethoxy)benzamide chemical structure, C19H16F4N4O4S2, CAS 444927-14-4
N-[4-[(5-Ethyl-1,3,4-thiadiazol-2-yl)sulfamoyl]phenyl]-3-(1,1,2,2-tetrafluoroethoxy)benzamide
CAS 444927-14-4C19H16F4N4O4S2
2-Bromo-N-[4-[(5-ethyl-1,3,4-thiadiazol-2-yl)sulfamoyl]phenyl]benzamide chemical structure, C17H15BrN4O3S2, CAS 313254-85-2
2-Bromo-N-[4-[(5-ethyl-1,3,4-thiadiazol-2-yl)sulfamoyl]phenyl]benzamide
CAS 313254-85-2C17H15BrN4O3S2
2,4-Dichloro-N-{4-[(5-ethyl-1,3,4-thiadiazol-2-yl)sulfamoyl]phenyl}benzamide chemical structure, C17H14Cl2N4O3S2, CAS 314284-92-9
2,4-Dichloro-N-{4-[(5-ethyl-1,3,4-thiadiazol-2-yl)sulfamoyl]phenyl}benzamide
CAS 314284-92-9C17H14Cl2N4O3S2
N-{4-[(5-Ethyl-1,3,4-thiadiazol-2-yl)sulfamoyl]phenyl}-4-methoxybenzamide chemical structure, C18H18N4O4S2, CAS 307524-04-5
N-{4-[(5-Ethyl-1,3,4-thiadiazol-2-yl)sulfamoyl]phenyl}-4-methoxybenzamide
CAS 307524-04-5C18H18N4O4S2
N-{4-[(5-Ethyl-1,3,4-thiadiazol-2-yl)sulfamoyl]phenyl}-3,4-difluorobenzamide chemical structure, C17H14F2N4O3S2, CAS 303797-74-2
N-{4-[(5-Ethyl-1,3,4-thiadiazol-2-yl)sulfamoyl]phenyl}-3,4-difluorobenzamide
CAS 303797-74-2C17H14F2N4O3S2
N-{4-[(5-Ethyl-1,3,4-thiadiazol-2-yl)sulfamoyl]phenyl}benzamide chemical structure, C17H16N4O3S2, CAS 313225-77-3
N-{4-[(5-Ethyl-1,3,4-thiadiazol-2-yl)sulfamoyl]phenyl}benzamide
CAS 313225-77-3C17H16N4O3S2
4-Ethoxy-N-{4-[(5-ethyl-1,3,4-thiadiazol-2-yl)sulfamoyl]phenyl}benzamide chemical structure, C19H20N4O4S2, CAS 307524-02-3
4-Ethoxy-N-{4-[(5-ethyl-1,3,4-thiadiazol-2-yl)sulfamoyl]phenyl}benzamide
CAS 307524-02-3C19H20N4O4S2
4-Bromo-N-{4-[(5-ethyl-1,3,4-thiadiazol-2-yl)sulfamoyl]phenyl}benzamide chemical structure, C17H15BrN4O3S2, CAS 303797-76-4
4-Bromo-N-{4-[(5-ethyl-1,3,4-thiadiazol-2-yl)sulfamoyl]phenyl}benzamide
CAS 303797-76-4C17H15BrN4O3S2
N-(4-(N-(5-Ethyl-1,3,4-thiadiazol-2-yl)sulfamoyl)phenyl)-4-isopropoxybenzamide chemical structure, C20H22N4O4S2, CAS 333747-25-4
N-(4-(N-(5-Ethyl-1,3,4-thiadiazol-2-yl)sulfamoyl)phenyl)-4-isopropoxybenzamide
CAS 333747-25-4C20H22N4O4S2
N-{4-[(5-Ethyl-1,3,4-thiadiazol-2-yl)sulfamoyl]phenyl}-3-fluorobenzamide chemical structure, C17H15FN4O3S2, CAS 441316-12-7
N-{4-[(5-Ethyl-1,3,4-thiadiazol-2-yl)sulfamoyl]phenyl}-3-fluorobenzamide
CAS 441316-12-7C17H15FN4O3S2
N-{4-[(5-Ethyl-1,3,4-thiadiazol-2-yl)sulfamoyl]phenyl}-2,6-difluorobenzamide chemical structure, C17H14F2N4O3S2, CAS 302951-74-2
N-{4-[(5-Ethyl-1,3,4-thiadiazol-2-yl)sulfamoyl]phenyl}-2,6-difluorobenzamide
CAS 302951-74-2C17H14F2N4O3S2
4-Cyano-N-{4-[(5-ethyl-1,3,4-thiadiazol-2-yl)sulfamoyl]phenyl}benzamide chemical structure, C18H15N5O3S2, CAS 307514-13-2
4-Cyano-N-{4-[(5-ethyl-1,3,4-thiadiazol-2-yl)sulfamoyl]phenyl}benzamide
CAS 307514-13-2C18H15N5O3S2
N-[4-[(5-Ethyl-1,3,4-thiadiazol-2-yl)sulfamoyl]phenyl]-3,4-dimethoxybenzamide chemical structure, C19H20N4O5S2, CAS 307505-02-8
N-[4-[(5-Ethyl-1,3,4-thiadiazol-2-yl)sulfamoyl]phenyl]-3,4-dimethoxybenzamide
CAS 307505-02-8C19H20N4O5S2
N-{4-[(5-Ethyl-1,3,4-thiadiazol-2-yl)sulfamoyl]phenyl}-4-nitrobenzamide chemical structure, C17H15N5O5S2, CAS 307524-05-6
N-{4-[(5-Ethyl-1,3,4-thiadiazol-2-yl)sulfamoyl]phenyl}-4-nitrobenzamide
CAS 307524-05-6C17H15N5O5S2
5-Chloro-N-[4-[(5-ethyl-1,3,4-thiadiazol-2-yl)sulfamoyl]phenyl]-2-nitrobenzamide chemical structure, C17H14ClN5O5S2, CAS 428845-82-3
5-Chloro-N-[4-[(5-ethyl-1,3,4-thiadiazol-2-yl)sulfamoyl]phenyl]-2-nitrobenzamide
CAS 428845-82-3C17H14ClN5O5S2
3-Butoxy-N-[4-[(5-ethyl-1,3,4-thiadiazol-2-yl)sulfamoyl]phenyl]benzamide chemical structure, C21H24N4O4S2, CAS 457651-87-5
3-Butoxy-N-[4-[(5-ethyl-1,3,4-thiadiazol-2-yl)sulfamoyl]phenyl]benzamide
CAS 457651-87-5C21H24N4O4S2
4-(Dimethylsulfamoyl)-N-[4-[(5-ethyl-1,3,4-thiadiazol-2-yl)sulfamoyl]phenyl]benzamide chemical structure, C19H21N5O5S3, CAS 303797-77-5
4-(Dimethylsulfamoyl)-N-[4-[(5-ethyl-1,3,4-thiadiazol-2-yl)sulfamoyl]phenyl]benzamide
CAS 303797-77-5C19H21N5O5S3
N-{4-[(5-Ethyl-1,3,4-thiadiazol-2-yl)sulfamoyl]phenyl}-2-nitrobenzamide chemical structure, C17H15N5O5S2, CAS 312914-40-2
N-{4-[(5-Ethyl-1,3,4-thiadiazol-2-yl)sulfamoyl]phenyl}-2-nitrobenzamide
CAS 312914-40-2C17H15N5O5S2
N-[4-[(5-Ethyl-1,3,4-thiadiazol-2-yl)sulfamoyl]phenyl]-3-(trifluoromethyl)benzamide chemical structure, C18H15F3N4O3S2, CAS 867041-40-5
N-[4-[(5-Ethyl-1,3,4-thiadiazol-2-yl)sulfamoyl]phenyl]-3-(trifluoromethyl)benzamide
CAS 867041-40-5C18H15F3N4O3S2
4-Butoxy-N-{4-[(5-ethyl-1,3,4-thiadiazol-2-yl)sulfamoyl]phenyl}benzamide chemical structure, C21H24N4O4S2, CAS 299952-41-3
4-Butoxy-N-{4-[(5-ethyl-1,3,4-thiadiazol-2-yl)sulfamoyl]phenyl}benzamide
CAS 299952-41-3C21H24N4O4S2
4-(Dipropylsulfamoyl)-N-{4-[(5-ethyl-1,3,4-thiadiazol-2-yl)sulfamoyl]phenyl}benzamide chemical structure, C23H29N5O5S3, CAS 307524-07-8
4-(Dipropylsulfamoyl)-N-{4-[(5-ethyl-1,3,4-thiadiazol-2-yl)sulfamoyl]phenyl}benzamide
CAS 307524-07-8C23H29N5O5S3