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Murcko scaffold

1-(Thien-2-ylmethyl)piperazine scaffold

103 chemicals on CompoundList share this ring system.

Rings
2
Scaffold atoms
12
Chemicals
103
With full pages
11
Scaffold SMILES

c1csc(CN2CCNCC2)c1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffoldOpen the 1-(Thien-2-ylmethyl)piperazine page
Murcko scaffold c1csc(CN2CCNCC2)c1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 48 of 103 chemicals

1-(Thien-2-ylmethyl)piperazine chemical structure, C9H14N2S, CAS 39244-79-6
1-(Thien-2-ylmethyl)piperazine
CAS 39244-79-6C9H14N2S
1-[(5-Bromothiophen-2-yl)methyl]-4-methylpiperazine chemical structure, C10H15BrN2S, CAS 414883-01-5
1-[(5-Bromothiophen-2-yl)methyl]-4-methylpiperazine
CAS 414883-01-5C10H15BrN2S
1-((4-Bromothiophen-2-yl)methyl)-4-methylpiperazine chemical structure, C10H15BrN2S, CAS 364794-30-9
1-((4-Bromothiophen-2-yl)methyl)-4-methylpiperazine
CAS 364794-30-9C10H15BrN2S
1-Methyl-4-(thiophen-2-ylmethyl)piperazine chemical structure, C10H16N2S, CAS 261715-49-5
1-Methyl-4-(thiophen-2-ylmethyl)piperazine
CAS 261715-49-5C10H16N2S
2-[4-(Thiophen-2-ylmethyl)piperazin-1-yl]ethanol chemical structure, C11H18N2OS, CAS 415701-90-5
2-[4-(Thiophen-2-ylmethyl)piperazin-1-yl]ethanol
CAS 415701-90-5C11H18N2OS
1-[(5-Bromothiophen-2-yl)methyl]-4-ethylpiperazine chemical structure, C11H17BrN2S, CAS 414876-29-2
1-[(5-Bromothiophen-2-yl)methyl]-4-ethylpiperazine
CAS 414876-29-2C11H17BrN2S
Piperazine, 1-ethyl-4-(2-thienylmethyl)-(9CI) chemical structure, C11H18N2S, CAS 414879-47-3
Piperazine, 1-ethyl-4-(2-thienylmethyl)-(9CI)
CAS 414879-47-3C11H18N2S
1-[(5-Bromothiophen-2-yl)methyl]piperazine chemical structure, C9H13BrN2S, CAS 523981-55-7
1-[(5-Bromothiophen-2-yl)methyl]piperazine
CAS 523981-55-7C9H13BrN2S
1-[(5-Chlorothiophen-2-yl)methyl]piperazine chemical structure, C9H13ClN2S, CAS 55513-18-3
1-[(5-Chlorothiophen-2-yl)methyl]piperazine
CAS 55513-18-3C9H13ClN2S
2-(4-Boc-piperazinyl)-2-(2-thienyl)acetic acid chemical structure, C15H22N2O4S, CAS 763109-79-1
2-(4-Boc-piperazinyl)-2-(2-thienyl)acetic acid
CAS 763109-79-1C15H22N2O4S
Piperazinium, 4-carboxy-1-methyl-1-(2-thenyl)-, chloride, ethyl ester chemical structure, C13H21ClN2O2S, CAS 109187-85-1
Piperazinium, 4-carboxy-1-methyl-1-(2-thenyl)-, chloride, ethyl ester
CAS 109187-85-1C13H21ClN2O2S
2-(4-Methylpiperazin-1-yl)-2-(thiophen-2-yl)ethan-1-amine chemical structure, C11H19N3S, CAS 857041-65-7
2-(4-Methylpiperazin-1-yl)-2-(thiophen-2-yl)ethan-1-amine
CAS 857041-65-7C11H19N3S
1-[(3-Methylthiophen-2-yl)methyl]piperazine chemical structure, C10H16N2S, CAS 523981-56-8
1-[(3-Methylthiophen-2-yl)methyl]piperazine
CAS 523981-56-8C10H16N2S
1-[(5-Ethylthien-2-yl)methyl]piperazine chemical structure, C11H18N2S, CAS 523981-54-6
1-[(5-Ethylthien-2-yl)methyl]piperazine
CAS 523981-54-6C11H18N2S
1-[1-(5-Bromothiophen-2-yl)ethyl]piperazine chemical structure, C10H15BrN2S, CAS 521265-05-4
1-[1-(5-Bromothiophen-2-yl)ethyl]piperazine
CAS 521265-05-4C10H15BrN2S
N-[1-(4-Ethylpiperazin-1-yl)-1-thiophen-2-ylpropan-2-yl]methanesulfonamide chemical structure, C14H25N3O2S2, CAS 847381-10-6
N-[1-(4-Ethylpiperazin-1-yl)-1-thiophen-2-ylpropan-2-yl]methanesulfonamide
CAS 847381-10-6C14H25N3O2S2
1-[(5-Methylthien-2-yl)methyl]piperazine chemical structure, C10H16N2S, CAS 523981-53-5
1-[(5-Methylthien-2-yl)methyl]piperazine
CAS 523981-53-5C10H16N2S
1-[1-(Thiophen-2-yl)ethyl]piperazine chemical structure, C10H16N2S, CAS 521263-96-7
1-[1-(Thiophen-2-yl)ethyl]piperazine
CAS 521263-96-7C10H16N2S
2-(Piperazin-1-yl)-2-(thiophen-2-yl)acetonitrile chemical structure, C10H13N3S, CAS 875159-96-9
2-(Piperazin-1-yl)-2-(thiophen-2-yl)acetonitrile
CAS 875159-96-9C10H13N3S
2-[4-(2-Chloroacetyl)piperazin-1-yl]-2-(thiophen-2-yl)acetonitrile chemical structure, C12H14ClN3OS, CAS 923242-15-3
2-[4-(2-Chloroacetyl)piperazin-1-yl]-2-(thiophen-2-yl)acetonitrile
CAS 923242-15-3C12H14ClN3OS
2-Chloro-1-(4-((thiophen-2-yl)methyl)piperazin-1-yl)ethan-1-one hydrochloride chemical structure, C11H16Cl2N2OS, CAS 1049766-99-5
2-Chloro-1-(4-((thiophen-2-yl)methyl)piperazin-1-yl)ethan-1-one hydrochloride
CAS 1049766-99-5C11H16Cl2N2OS
1-(Chloroacetyl)-4-[(5-chlorothien-2-yl)methyl]piperazine hydrochloride chemical structure, C11H15Cl3N2OS, CAS 1051366-60-9
1-(Chloroacetyl)-4-[(5-chlorothien-2-yl)methyl]piperazine hydrochloride
CAS 1051366-60-9C11H15Cl3N2OS
1-(4-((5-Bromothiophen-2-yl)methyl)piperazin-1-yl)-2-chloroethan-1-one hydrochloride chemical structure, C11H15BrCl2N2OS, CAS 1052544-19-0
1-(4-((5-Bromothiophen-2-yl)methyl)piperazin-1-yl)-2-chloroethan-1-one hydrochloride
CAS 1052544-19-0C11H15BrCl2N2OS
5-[(Piperazin-1-yl)methyl]thiophene-3-carbonitrile chemical structure, C10H13N3S, CAS 2229573-90-2
5-[(Piperazin-1-yl)methyl]thiophene-3-carbonitrile
CAS 2229573-90-2C10H13N3S