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Murcko scaffold

Ring system with 2 rings and 16 atoms

83 chemicals on CompoundList share this ring system.

Rings
2
Scaffold atoms
16
Chemicals
83
With full pages
3
Scaffold SMILES

O=c1[nH]c(=S)[nH]cc1C=Nc1ccccc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=c1[nH]c(=S)[nH]cc1C=Nc1ccccc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 48 of 83 chemicals

5-{[(4-Methoxyphenyl)amino]methylidene}-2-sulfanylidene-1,3-diazinane-4,6-dione chemical structure, C12H11N3O3S, CAS 86327-61-9
5-{[(4-Methoxyphenyl)amino]methylidene}-2-sulfanylidene-1,3-diazinane-4,6-dione
CAS 86327-61-9C12H11N3O3S
5-(((4-Ethylphenyl)amino)methylene)-2-thioxodihydropyrimidine-4,6(1H,5H)-dione chemical structure, C13H13N3O2S, CAS 374769-31-0
5-(((4-Ethylphenyl)amino)methylene)-2-thioxodihydropyrimidine-4,6(1H,5H)-dione
CAS 374769-31-0C13H13N3O2S
2-Thioxo-5-((p-tolylamino)methylene)dihydropyrimidine-4,6(1H,5H)-dione chemical structure, C12H11N3O2S, CAS 200626-85-3
2-Thioxo-5-((p-tolylamino)methylene)dihydropyrimidine-4,6(1H,5H)-dione
CAS 200626-85-3C12H11N3O2S
N-(4-(((4,6-Dioxo-2-thioxotetrahydropyrimidin-5(2H)-ylidene)methyl)amino)phenyl)acetamide chemical structure, C13H12N4O3S, CAS 349486-63-1
N-(4-(((4,6-Dioxo-2-thioxotetrahydropyrimidin-5(2H)-ylidene)methyl)amino)phenyl)acetamide
CAS 349486-63-1C13H12N4O3S
5-{[(2-Bromophenyl)amino]methylidene}-2-sulfanylidene-1,3-diazinane-4,6-dione chemical structure, C11H8BrN3O2S, CAS 349486-67-5
5-{[(2-Bromophenyl)amino]methylidene}-2-sulfanylidene-1,3-diazinane-4,6-dione
CAS 349486-67-5C11H8BrN3O2S
5-{[(3-Chlorophenyl)amino]methylidene}-2-sulfanylidene-1,3-diazinane-4,6-dione chemical structure, C11H8ClN3O2S, CAS 349486-91-5
5-{[(3-Chlorophenyl)amino]methylidene}-2-sulfanylidene-1,3-diazinane-4,6-dione
CAS 349486-91-5C11H8ClN3O2S
5-(((2-Methoxyphenyl)amino)methylene)-2-thioxodihydropyrimidine-4,6(1H,5H)-dione chemical structure, C12H11N3O3S, CAS 349566-84-3
5-(((2-Methoxyphenyl)amino)methylene)-2-thioxodihydropyrimidine-4,6(1H,5H)-dione
CAS 349566-84-3C12H11N3O3S
Ethyl 4-(((4,6-dioxo-2-thioxotetrahydropyrimidin-5(2H)-ylidene)methyl)amino)benzoate chemical structure, C14H13N3O4S, CAS 374602-24-1
Ethyl 4-(((4,6-dioxo-2-thioxotetrahydropyrimidin-5(2H)-ylidene)methyl)amino)benzoate
CAS 374602-24-1C14H13N3O4S
5-[(4-Chloroanilino)methylene]-1,3-dimethyl-2-thioxodihydro-4,6(1H,5H)-pyrimidinedione chemical structure, C13H12ClN3O2S, CAS 69791-22-6
5-[(4-Chloroanilino)methylene]-1,3-dimethyl-2-thioxodihydro-4,6(1H,5H)-pyrimidinedione
CAS 69791-22-6C13H12ClN3O2S
5-(((2,5-Dichlorophenyl)amino)methylene)-2-thioxodihydropyrimidine-4,6(1H,5H)-dione chemical structure, C11H7Cl2N3O2S, CAS 418803-49-3
5-(((2,5-Dichlorophenyl)amino)methylene)-2-thioxodihydropyrimidine-4,6(1H,5H)-dione
CAS 418803-49-3C11H7Cl2N3O2S
5-{[(3-Chloro-4-fluorophenyl)amino]methylidene}-2-sulfanylidene-1,3-diazinane-4,6-dione chemical structure, C11H7ClFN3O2S, CAS 418803-72-2
5-{[(3-Chloro-4-fluorophenyl)amino]methylidene}-2-sulfanylidene-1,3-diazinane-4,6-dione
CAS 418803-72-2C11H7ClFN3O2S
5-[(3,4-Dichloroanilino)methylidene]-2-sulfanylidene-1,3-diazinane-4,6-dione chemical structure, C11H7Cl2N3O2S, CAS 5630-14-8
5-[(3,4-Dichloroanilino)methylidene]-2-sulfanylidene-1,3-diazinane-4,6-dione
CAS 5630-14-8C11H7Cl2N3O2S
5-(((3-Chloro-2-methylphenyl)amino)methylene)-2-thioxodihydropyrimidine-4,6(1H,5H)-dione chemical structure, C12H10ClN3O2S, CAS 306753-32-2
5-(((3-Chloro-2-methylphenyl)amino)methylene)-2-thioxodihydropyrimidine-4,6(1H,5H)-dione
CAS 306753-32-2C12H10ClN3O2S
2-Thioxo-5-(((3-(trifluoromethyl)phenyl)amino)methylene)dihydropyrimidine-4,6(1H,5H)-dione chemical structure, C12H8F3N3O2S, CAS 16357-48-5
2-Thioxo-5-(((3-(trifluoromethyl)phenyl)amino)methylene)dihydropyrimidine-4,6(1H,5H)-dione
CAS 16357-48-5C12H8F3N3O2S
5-(((2,4-Dichlorophenyl)amino)methylene)-2-thioxodihydropyrimidine-4,6(1H,5H)-dione chemical structure, C11H7Cl2N3O2S, CAS 349486-66-4
5-(((2,4-Dichlorophenyl)amino)methylene)-2-thioxodihydropyrimidine-4,6(1H,5H)-dione
CAS 349486-66-4C11H7Cl2N3O2S
5-(((3,4-Dimethoxyphenyl)amino)methylene)-2-thioxodihydropyrimidine-4,6(1H,5H)-dione chemical structure, C13H13N3O4S, CAS 351165-33-8
5-(((3,4-Dimethoxyphenyl)amino)methylene)-2-thioxodihydropyrimidine-4,6(1H,5H)-dione
CAS 351165-33-8C13H13N3O4S
5-(((4-Bromophenyl)amino)methylene)-2-thioxodihydropyrimidine-4,6(1H,5H)-dione chemical structure, C11H8BrN3O2S, CAS 200626-86-4
5-(((4-Bromophenyl)amino)methylene)-2-thioxodihydropyrimidine-4,6(1H,5H)-dione
CAS 200626-86-4C11H8BrN3O2S
5-(Anilinomethylene)-2-thioxodihydro-4,6(1H,5H)-pyrimidinedione chemical structure, C11H9N3O2S, CAS 69791-23-7
5-(Anilinomethylene)-2-thioxodihydro-4,6(1H,5H)-pyrimidinedione
CAS 69791-23-7C11H9N3O2S
4,6(1H,5H)-Pyrimidinedione, 1,3-diethyldihydro-5-[(phenylamino)methylene]-2-thioxo- chemical structure, C15H17N3O2S, CAS 41383-01-1
4,6(1H,5H)-Pyrimidinedione, 1,3-diethyldihydro-5-[(phenylamino)methylene]-2-thioxo-
CAS 41383-01-1C15H17N3O2S
5-[(2,4-Dichloroanilino)methylene]-1,3-diethyl-2-thioxodihydro-4,6(1H,5H)-pyrimidinedione chemical structure, C15H15Cl2N3O2S, CAS 353284-26-1
5-[(2,4-Dichloroanilino)methylene]-1,3-diethyl-2-thioxodihydro-4,6(1H,5H)-pyrimidinedione
CAS 353284-26-1C15H15Cl2N3O2S
2-Thioxo-5-((o-tolylamino)methylene)dihydropyrimidine-4,6(1H,5H)-dione chemical structure, C12H11N3O2S, CAS 401634-13-7
2-Thioxo-5-((o-tolylamino)methylene)dihydropyrimidine-4,6(1H,5H)-dione
CAS 401634-13-7C12H11N3O2S
5-{[(2-Chlorophenyl)amino]methylidene}-2-sulfanylidene-1,3-diazinane-4,6-dione chemical structure, C11H8ClN3O2S, CAS 349486-65-3
5-{[(2-Chlorophenyl)amino]methylidene}-2-sulfanylidene-1,3-diazinane-4,6-dione
CAS 349486-65-3C11H8ClN3O2S
5-(((3-Bromophenyl)amino)methylene)-2-thioxodihydropyrimidine-4,6(1H,5H)-dione chemical structure, C11H8BrN3O2S, CAS 349486-87-9
5-(((3-Bromophenyl)amino)methylene)-2-thioxodihydropyrimidine-4,6(1H,5H)-dione
CAS 349486-87-9C11H8BrN3O2S
5-(((4-Iodophenyl)amino)methylene)-2-thioxodihydropyrimidine-4,6(1H,5H)-dione chemical structure, C11H8IN3O2S, CAS 302570-96-3
5-(((4-Iodophenyl)amino)methylene)-2-thioxodihydropyrimidine-4,6(1H,5H)-dione
CAS 302570-96-3C11H8IN3O2S