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Murcko scaffold

Ring system with 3 rings and 28 atoms

8 chemicals on CompoundList share this ring system.

Rings
3
Scaffold atoms
28
Chemicals
8
With full pages
7
Scaffold SMILES

O=C(NCCN1CCOCC1)C(=Cc1ccccc1)NC(=O)c1ccccc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=C(NCCN1CCOCC1)C(=Cc1ccccc1)NC(=O)c1ccccc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 8 of 8 chemicals

(2Z)-3-(4-Chlorophenyl)-2-[(4-methoxyphenyl)formamido]-N-[2-(morpholin-4-yl)ethyl]prop-2-enamide chemical structure, C23H26ClN3O4
(2Z)-3-(4-Chlorophenyl)-2-[(4-methoxyphenyl)formamido]-N-[2-(morpholin-4-yl)ethyl]prop-2-enamide
C23H26ClN3O4
(Z)-N-(1-(4-Chlorophenyl)-3-((2-morpholinoethyl)amino)-3-oxoprop-1-en-2-yl)-4-methoxybenzamide chemical structure, C23H26ClN3O4, CAS 374099-03-3
(Z)-N-(1-(4-Chlorophenyl)-3-((2-morpholinoethyl)amino)-3-oxoprop-1-en-2-yl)-4-methoxybenzamide
CAS 374099-03-3C23H26ClN3O4
4-ME-N-(1-(((2-(4-Morpholinyl)ET)amino)carbonyl)-2-phenylethenyl)benzamide chemical structure, C23H27N3O3, CAS 324561-91-3
4-ME-N-(1-(((2-(4-Morpholinyl)ET)amino)carbonyl)-2-phenylethenyl)benzamide
CAS 324561-91-3C23H27N3O3
N-[1-(2-Morpholin-4-yl-ethylcarbamoyl)-2-phenyl-vinyl]-benzamide chemical structure, C22H25N3O3, CAS 19380-64-4
N-[1-(2-Morpholin-4-yl-ethylcarbamoyl)-2-phenyl-vinyl]-benzamide
CAS 19380-64-4C22H25N3O3
N-(2-(4-Chlorophenyl)-1-(((2-(4-morpholinyl)ethyl)amino)carbonyl)vinyl)benzamide chemical structure, C22H24ClN3O3, CAS 324561-96-8
N-(2-(4-Chlorophenyl)-1-(((2-(4-morpholinyl)ethyl)amino)carbonyl)vinyl)benzamide
CAS 324561-96-8C22H24ClN3O3
N-[2-(4-Fluoro-phenyl)-1-(2-morpholin-4-yl-ethylcarbamoyl)-vinyl]-benzamide chemical structure, C22H24FN3O3, CAS 406710-84-7
N-[2-(4-Fluoro-phenyl)-1-(2-morpholin-4-yl-ethylcarbamoyl)-vinyl]-benzamide
CAS 406710-84-7C22H24FN3O3
N-[(Z)-1-(4-Methoxyphenyl)-3-(2-morpholin-4-ylethylamino)-3-oxoprop-1-en-2-yl]-4-nitrobenzamide chemical structure, C23H26N4O6, CAS 374551-01-6
N-[(Z)-1-(4-Methoxyphenyl)-3-(2-morpholin-4-ylethylamino)-3-oxoprop-1-en-2-yl]-4-nitrobenzamide
CAS 374551-01-6C23H26N4O6
4-ME-N-(2-(4-Methyl-PH)-1-(((2-(4-morpholinyl)ET)amino)carbonyl)vinyl)benzamide chemical structure, C24H29N3O3, CAS 307973-99-5
4-ME-N-(2-(4-Methyl-PH)-1-(((2-(4-morpholinyl)ET)amino)carbonyl)vinyl)benzamide
CAS 307973-99-5C24H29N3O3