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Murcko scaffold

1-((Pyridin-4-yl)methyl)piperazine scaffold

74 chemicals on CompoundList share this ring system.

Rings
2
Scaffold atoms
13
Chemicals
74
With full pages
3
Scaffold SMILES

c1cc(CN2CCNCC2)ccn1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffoldOpen the 1-((Pyridin-4-yl)methyl)piperazine page
Murcko scaffold c1cc(CN2CCNCC2)ccn1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 48 of 74 chemicals

1-(Propylsulfonyl)-4-(4-pyridylmethyl)piperazine chemical structure, C13H21N3O2S, CAS 441745-82-0
1-(Propylsulfonyl)-4-(4-pyridylmethyl)piperazine
CAS 441745-82-0C13H21N3O2S
1-Ethylsulfonyl-4-(pyridin-4-ylmethyl)piperazine chemical structure, C12H19N3O2S, CAS 429624-76-0
1-Ethylsulfonyl-4-(pyridin-4-ylmethyl)piperazine
CAS 429624-76-0C12H19N3O2S
3-Methyl-1-[4-(pyridin-4-ylmethyl)piperazin-1-yl]butan-1-one chemical structure, C15H23N3O, CAS 423734-09-2
3-Methyl-1-[4-(pyridin-4-ylmethyl)piperazin-1-yl]butan-1-one
CAS 423734-09-2C15H23N3O
1-Methylsulfonyl-4-(pyridin-4-ylmethyl)piperazine chemical structure, C11H17N3O2S, CAS 441743-29-9
1-Methylsulfonyl-4-(pyridin-4-ylmethyl)piperazine
CAS 441743-29-9C11H17N3O2S
1-((Pyridin-4-yl)methyl)piperazine chemical structure, C10H15N3, CAS 62089-74-1
1-((Pyridin-4-yl)methyl)piperazine
CAS 62089-74-1C10H15N3
1-Boc-4-(carboxy-pyridin-4-yl-methyl)-piperazine chemical structure, C16H23N3O4, CAS 885274-54-4
1-Boc-4-(carboxy-pyridin-4-yl-methyl)-piperazine
CAS 885274-54-4C16H23N3O4
1-[(3-Methylpyridin-4-yl)methyl]piperazine chemical structure, C11H17N3, CAS 524673-88-9
1-[(3-Methylpyridin-4-yl)methyl]piperazine
CAS 524673-88-9C11H17N3
2-(Piperazin-1-yl)-2-(pyridin-4-yl)acetonitrile chemical structure, C11H14N4, CAS 137675-15-1
2-(Piperazin-1-yl)-2-(pyridin-4-yl)acetonitrile
CAS 137675-15-1C11H14N4
1-Methyl-4-[(pyridin-4-yl)methyl]piperazine chemical structure, C11H17N3, CAS 1821678-02-7
1-Methyl-4-[(pyridin-4-yl)methyl]piperazine
CAS 1821678-02-7C11H17N3
4-Pyridin-4-ylmethyl-piperazine-1-carboxylic acid tert-butyl ester chemical structure, C15H23N3O2, CAS 150812-38-7
4-Pyridin-4-ylmethyl-piperazine-1-carboxylic acid tert-butyl ester
CAS 150812-38-7C15H23N3O2
tert-Butyl 4-[(4-acetylpiperazin-1-yl)methyl]-6-methylpyridin-2-ylcarbamate chemical structure, C18H28N4O3, CAS 479613-21-3
tert-Butyl 4-[(4-acetylpiperazin-1-yl)methyl]-6-methylpyridin-2-ylcarbamate
CAS 479613-21-3C18H28N4O3
1-{4-[(Pyridin-4-yl)methyl]piperazin-1-yl}ethan-1-one chemical structure, C12H17N3O, CAS 942486-74-0
1-{4-[(Pyridin-4-yl)methyl]piperazin-1-yl}ethan-1-one
CAS 942486-74-0C12H17N3O
2-(4-Methylpiperazin-1-yl)-2-(pyridin-4-yl)acetonitrile chemical structure, C12H16N4, CAS 1017450-53-1
2-(4-Methylpiperazin-1-yl)-2-(pyridin-4-yl)acetonitrile
CAS 1017450-53-1C12H16N4
(4-Ethylpiperazin-1-yl)(pyridin-4-yl)acetonitrile chemical structure, C13H18N4, CAS 1017485-43-6
(4-Ethylpiperazin-1-yl)(pyridin-4-yl)acetonitrile
CAS 1017485-43-6C13H18N4
1-(1-Pyridin-4-yl-ethyl)-piperazine trihydrochloride chemical structure, C11H20Cl3N3, CAS 521914-40-9
1-(1-Pyridin-4-yl-ethyl)-piperazine trihydrochloride
CAS 521914-40-9C11H20Cl3N3
1-(Pyridin-4-ylmethyl)piperazine hydrochloride chemical structure, C10H16ClN3, CAS 416852-29-4
1-(Pyridin-4-ylmethyl)piperazine hydrochloride
CAS 416852-29-4C10H16ClN3
1-Pyridin-4-ylmethyl-piperazine trihydrochloride chemical structure, C10H18Cl3N3, CAS 333992-80-6
1-Pyridin-4-ylmethyl-piperazine trihydrochloride
CAS 333992-80-6C10H18Cl3N3
1-(Pyridin-4-ylmethyl)piperazine dihydrochloride chemical structure, C10H17Cl2N3, CAS 1185314-04-8
1-(Pyridin-4-ylmethyl)piperazine dihydrochloride
CAS 1185314-04-8C10H17Cl2N3
3-Amino-1-[4-(pyridin-4-ylmethyl)piperazin-1-yl]propan-1-one chemical structure, C13H20N4O, CAS 1179651-20-7
3-Amino-1-[4-(pyridin-4-ylmethyl)piperazin-1-yl]propan-1-one
CAS 1179651-20-7C13H20N4O
Methyl 2-(4-Boc-piperazino)-2-(4-pyridyl)acetate chemical structure, C17H25N3O4, CAS 957761-38-5
Methyl 2-(4-Boc-piperazino)-2-(4-pyridyl)acetate
CAS 957761-38-5C17H25N3O4
1-[(2-Chloropyridin-4-yl)methyl]piperazine chemical structure, C10H14ClN3, CAS 1204701-53-0
1-[(2-Chloropyridin-4-yl)methyl]piperazine
CAS 1204701-53-0C10H14ClN3
tert-Butyl 4-((2,6-dichloropyridin-4-yl)methyl)piperazine-1-carboxylate chemical structure, C15H21Cl2N3O2, CAS 1276110-20-3
tert-Butyl 4-((2,6-dichloropyridin-4-yl)methyl)piperazine-1-carboxylate
CAS 1276110-20-3C15H21Cl2N3O2
5-Chloro-1-[4-(4-pyridinylmethyl)-1-piperazinyl]-1-pentanone chemical structure, C15H22ClN3O, CAS 1179932-49-0
5-Chloro-1-[4-(4-pyridinylmethyl)-1-piperazinyl]-1-pentanone
CAS 1179932-49-0C15H22ClN3O
1-[(2-Methoxypyridin-4-yl)methyl]piperazine chemical structure, C11H17N3O, CAS 1211520-04-5
1-[(2-Methoxypyridin-4-yl)methyl]piperazine
CAS 1211520-04-5C11H17N3O