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Murcko scaffold

Ring system with 4 rings and 28 atoms

25 chemicals on CompoundList share this ring system.

Rings
4
Scaffold atoms
28
Chemicals
25
With full pages
4
Scaffold SMILES

O=C(Nc1ccc(N2CCN(C(=O)c3cccs3)CC2)cc1)c1ccccc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=C(Nc1ccc(N2CCN(C(=O)c3cccs3)CC2)cc1)c1ccccc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 25 of 25 chemicals

3-Chloro-N-[4-[4-(thiophene-2-carbonyl)piperazin-1-yl]phenyl]benzamide chemical structure, C22H20ClN3O2S, CAS 674817-79-9
3-Chloro-N-[4-[4-(thiophene-2-carbonyl)piperazin-1-yl]phenyl]benzamide
CAS 674817-79-9C22H20ClN3O2S
2-Methoxy-3-methyl-N-[4-[4-(thiophene-2-carbonyl)piperazin-1-yl]phenyl]benzamide chemical structure, C24H25N3O3S, CAS 673495-96-0
2-Methoxy-3-methyl-N-[4-[4-(thiophene-2-carbonyl)piperazin-1-yl]phenyl]benzamide
CAS 673495-96-0C24H25N3O3S
2-Fluoro-N-[4-[4-(thiophene-2-carbonyl)piperazin-1-yl]phenyl]benzamide chemical structure, C22H20FN3O2S, CAS 672323-96-5
2-Fluoro-N-[4-[4-(thiophene-2-carbonyl)piperazin-1-yl]phenyl]benzamide
CAS 672323-96-5C22H20FN3O2S
2,5-Dichloro-N-[4-[4-(thiophene-2-carbonyl)piperazin-1-yl]phenyl]benzamide chemical structure, C22H19Cl2N3O2S, CAS 688031-46-1
2,5-Dichloro-N-[4-[4-(thiophene-2-carbonyl)piperazin-1-yl]phenyl]benzamide
CAS 688031-46-1C22H19Cl2N3O2S
2-Bromo-N-[4-[4-(thiophene-2-carbonyl)piperazin-1-yl]phenyl]benzamide chemical structure, C22H20BrN3O2S, CAS 831250-69-2
2-Bromo-N-[4-[4-(thiophene-2-carbonyl)piperazin-1-yl]phenyl]benzamide
CAS 831250-69-2C22H20BrN3O2S
3,5-Dimethoxy-N-[4-[4-(thiophene-2-carbonyl)piperazin-1-yl]phenyl]benzamide chemical structure, C24H25N3O4S, CAS 832108-13-1
3,5-Dimethoxy-N-[4-[4-(thiophene-2-carbonyl)piperazin-1-yl]phenyl]benzamide
CAS 832108-13-1C24H25N3O4S
N-[3-Chloro-4-[4-(thiophene-2-carbonyl)piperazin-1-yl]phenyl]-2-methoxybenzamide chemical structure, C23H22ClN3O3S, CAS 832120-45-3
N-[3-Chloro-4-[4-(thiophene-2-carbonyl)piperazin-1-yl]phenyl]-2-methoxybenzamide
CAS 832120-45-3C23H22ClN3O3S
3,4-Dimethyl-N-[4-[4-(thiophene-2-carbonyl)piperazin-1-yl]phenyl]benzamide chemical structure, C24H25N3O2S, CAS 835896-50-9
3,4-Dimethyl-N-[4-[4-(thiophene-2-carbonyl)piperazin-1-yl]phenyl]benzamide
CAS 835896-50-9C24H25N3O2S
4-Ethoxy-3-nitro-N-[4-[4-(thiophene-2-carbonyl)piperazin-1-yl]phenyl]benzamide chemical structure, C24H24N4O5S, CAS 674361-70-7
4-Ethoxy-3-nitro-N-[4-[4-(thiophene-2-carbonyl)piperazin-1-yl]phenyl]benzamide
CAS 674361-70-7C24H24N4O5S
N-[3-Chloro-4-[4-(thiophene-2-carbonyl)piperazin-1-yl]phenyl]-3,5-dimethylbenzamide chemical structure, C24H24ClN3O2S, CAS 701283-76-3
N-[3-Chloro-4-[4-(thiophene-2-carbonyl)piperazin-1-yl]phenyl]-3,5-dimethylbenzamide
CAS 701283-76-3C24H24ClN3O2S
4-Butoxy-N-[4-[4-(thiophene-2-carbonyl)piperazin-1-yl]phenyl]benzamide chemical structure, C26H29N3O3S, CAS 673490-71-6
4-Butoxy-N-[4-[4-(thiophene-2-carbonyl)piperazin-1-yl]phenyl]benzamide
CAS 673490-71-6C26H29N3O3S
3-Bromo-N-[3-chloro-4-[4-(thiophene-2-carbonyl)piperazin-1-yl]phenyl]-4-ethoxybenzamide chemical structure, C24H23BrClN3O3S, CAS 708283-98-1
3-Bromo-N-[3-chloro-4-[4-(thiophene-2-carbonyl)piperazin-1-yl]phenyl]-4-ethoxybenzamide
CAS 708283-98-1C24H23BrClN3O3S
N-[3-Chloro-4-[4-(thiophene-2-carbonyl)piperazin-1-yl]phenyl]-2-fluorobenzamide chemical structure, C22H19ClFN3O2S, CAS 832679-30-8
N-[3-Chloro-4-[4-(thiophene-2-carbonyl)piperazin-1-yl]phenyl]-2-fluorobenzamide
CAS 832679-30-8C22H19ClFN3O2S
4-Cyano-2-fluoro-N-[4-[4-(thiophene-2-carbonyl)piperazin-1-yl]phenyl]benzamide chemical structure, C23H19FN4O2S, CAS 832688-37-6
4-Cyano-2-fluoro-N-[4-[4-(thiophene-2-carbonyl)piperazin-1-yl]phenyl]benzamide
CAS 832688-37-6C23H19FN4O2S
2-Methoxy-N-[4-[4-(thiophene-2-carbonyl)piperazin-1-yl]phenyl]benzamide chemical structure, C23H23N3O3S, CAS 835891-54-8
2-Methoxy-N-[4-[4-(thiophene-2-carbonyl)piperazin-1-yl]phenyl]benzamide
CAS 835891-54-8C23H23N3O3S
N-[3-Chloro-4-[4-(thiophene-2-carbonyl)piperazin-1-yl]phenyl]-3-methoxybenzamide chemical structure, C23H22ClN3O3S, CAS 708290-29-3
N-[3-Chloro-4-[4-(thiophene-2-carbonyl)piperazin-1-yl]phenyl]-3-methoxybenzamide
CAS 708290-29-3C23H22ClN3O3S
4-(2-Methylpropoxy)-N-[4-[4-(thiophene-2-carbonyl)piperazin-1-yl]phenyl]benzamide chemical structure, C26H29N3O3S, CAS 897112-34-4
4-(2-Methylpropoxy)-N-[4-[4-(thiophene-2-carbonyl)piperazin-1-yl]phenyl]benzamide
CAS 897112-34-4C26H29N3O3S
N-[3-Chloro-4-[4-(thiophene-2-carbonyl)piperazin-1-yl]phenyl]-4-nitrobenzamide chemical structure, C22H19ClN4O4S, CAS 832108-70-0
N-[3-Chloro-4-[4-(thiophene-2-carbonyl)piperazin-1-yl]phenyl]-4-nitrobenzamide
CAS 832108-70-0C22H19ClN4O4S
5-Chloro-2-methoxy-N-[4-[4-(thiophene-2-carbonyl)piperazin-1-yl]phenyl]benzamide chemical structure, C23H22ClN3O3S, CAS 838871-26-4
5-Chloro-2-methoxy-N-[4-[4-(thiophene-2-carbonyl)piperazin-1-yl]phenyl]benzamide
CAS 838871-26-4C23H22ClN3O3S
3-Propoxy-N-[4-[4-(thiophene-2-carbonyl)piperazin-1-yl]phenyl]benzamide chemical structure, C25H27N3O3S, CAS 838884-38-1
3-Propoxy-N-[4-[4-(thiophene-2-carbonyl)piperazin-1-yl]phenyl]benzamide
CAS 838884-38-1C25H27N3O3S
2,6-Dimethoxy-N-[4-[4-(thiophene-2-carbonyl)piperazin-1-yl]phenyl]benzamide chemical structure, C24H25N3O4S, CAS 838900-44-0
2,6-Dimethoxy-N-[4-[4-(thiophene-2-carbonyl)piperazin-1-yl]phenyl]benzamide
CAS 838900-44-0C24H25N3O4S
N-[3-Chloro-4-[4-(thiophene-2-carbonyl)piperazin-1-yl]phenyl]-4-propoxybenzamide chemical structure, C25H26ClN3O3S, CAS 839692-32-9
N-[3-Chloro-4-[4-(thiophene-2-carbonyl)piperazin-1-yl]phenyl]-4-propoxybenzamide
CAS 839692-32-9C25H26ClN3O3S
3,4,5-Trimethoxy-N-[4-[4-(thiophene-2-carbonyl)piperazin-1-yl]phenyl]benzamide chemical structure, C25H27N3O5S, CAS 839695-40-8
3,4,5-Trimethoxy-N-[4-[4-(thiophene-2-carbonyl)piperazin-1-yl]phenyl]benzamide
CAS 839695-40-8C25H27N3O5S
2-Methyl-N-[4-[4-(thiophene-2-carbonyl)piperazin-1-yl]phenyl]benzamide chemical structure, C23H23N3O2S, CAS 688031-41-6
2-Methyl-N-[4-[4-(thiophene-2-carbonyl)piperazin-1-yl]phenyl]benzamide
CAS 688031-41-6C23H23N3O2S