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Murcko scaffold

Ring system with 4 rings and 24 atoms

70 chemicals on CompoundList share this ring system.

Rings
4
Scaffold atoms
24
Chemicals
70
With full pages
18
Scaffold SMILES

O=C(C1=CC(=O)N(c2ccon2)C1c1ccccc1)c1ccco1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=C(C1=CC(=O)N(c2ccon2)C1c1ccccc1)c1ccco1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 49 to 70 of 70 chemicals

5-(2,3-Dimethoxyphenyl)-3-hydroxy-4-(5-methylfuran-2-carbonyl)-1-(5-methylisoxazol-3-yl)-1H-pyrrol-2(5H)-one chemical structure, C22H20N2O7, CAS 618872-72-3
5-(2,3-Dimethoxyphenyl)-3-hydroxy-4-(5-methylfuran-2-carbonyl)-1-(5-methylisoxazol-3-yl)-1H-pyrrol-2(5H)-one
CAS 618872-72-3C22H20N2O7
(4E)-4-[Furan-2-yl(hydroxy)methylidene]-5-(4-hydroxy-3-methoxyphenyl)-1-(5-methyl-1,2-oxazol-3-yl)pyrrolidine-2,3-dione chemical structure, C20H16N2O7, CAS 850156-72-8
(4E)-4-[Furan-2-yl(hydroxy)methylidene]-5-(4-hydroxy-3-methoxyphenyl)-1-(5-methyl-1,2-oxazol-3-yl)pyrrolidine-2,3-dione
CAS 850156-72-8C20H16N2O7
5-(3-Fluorophenyl)-4-(furan-2-carbonyl)-3-hydroxy-1-(5-methylisoxazol-3-yl)-1H-pyrrol-2(5H)-one chemical structure, C19H13FN2O5, CAS 618871-89-9
5-(3-Fluorophenyl)-4-(furan-2-carbonyl)-3-hydroxy-1-(5-methylisoxazol-3-yl)-1H-pyrrol-2(5H)-one
CAS 618871-89-9C19H13FN2O5
(4E)-5-(4-Butoxy-3-methoxyphenyl)-4-[hydroxy(5-methylfuran-2-yl)methylidene]-1-(5-methyl-1,2-oxazol-3-yl)pyrrolidine-2,3-dione chemical structure, C25H26N2O7, CAS 840510-55-6
(4E)-5-(4-Butoxy-3-methoxyphenyl)-4-[hydroxy(5-methylfuran-2-yl)methylidene]-1-(5-methyl-1,2-oxazol-3-yl)pyrrolidine-2,3-dione
CAS 840510-55-6C25H26N2O7
4-(Furan-2-ylcarbonyl)-3-hydroxy-5-(3-hydroxyphenyl)-1-(5-methyl-1,2-oxazol-3-yl)-1,5-dihydro-2H-pyrrol-2-one chemical structure, C19H14N2O6, CAS 850188-61-3
4-(Furan-2-ylcarbonyl)-3-hydroxy-5-(3-hydroxyphenyl)-1-(5-methyl-1,2-oxazol-3-yl)-1,5-dihydro-2H-pyrrol-2-one
CAS 850188-61-3C19H14N2O6
5-(4-(Allyloxy)phenyl)-4-(furan-2-carbonyl)-3-hydroxy-1-(5-methylisoxazol-3-yl)-1H-pyrrol-2(5H)-one chemical structure, C22H18N2O6, CAS 618872-17-6
5-(4-(Allyloxy)phenyl)-4-(furan-2-carbonyl)-3-hydroxy-1-(5-methylisoxazol-3-yl)-1H-pyrrol-2(5H)-one
CAS 618872-17-6C22H18N2O6
5-(4-Ethoxy-3-methoxyphenyl)-3-hydroxy-4-(5-methylfuran-2-carbonyl)-1-(5-methylisoxazol-3-yl)-1H-pyrrol-2(5H)-one chemical structure, C23H22N2O7, CAS 618872-78-9
5-(4-Ethoxy-3-methoxyphenyl)-3-hydroxy-4-(5-methylfuran-2-carbonyl)-1-(5-methylisoxazol-3-yl)-1H-pyrrol-2(5H)-one
CAS 618872-78-9C23H22N2O7
5-(4-Fluorophenyl)-4-(furan-2-carbonyl)-3-hydroxy-1-(5-methylisoxazol-3-yl)-1H-pyrrol-2(5H)-one chemical structure, C19H13FN2O5, CAS 618871-91-3
5-(4-Fluorophenyl)-4-(furan-2-carbonyl)-3-hydroxy-1-(5-methylisoxazol-3-yl)-1H-pyrrol-2(5H)-one
CAS 618871-91-3C19H13FN2O5
(4E)-4-[Furan-2-yl(hydroxy)methylidene]-5-[3-methoxy-4-(pentyloxy)phenyl]-1-(5-methyl-1,2-oxazol-3-yl)pyrrolidine-2,3-dione chemical structure, C25H26N2O7, CAS 877808-19-0
(4E)-4-[Furan-2-yl(hydroxy)methylidene]-5-[3-methoxy-4-(pentyloxy)phenyl]-1-(5-methyl-1,2-oxazol-3-yl)pyrrolidine-2,3-dione
CAS 877808-19-0C25H26N2O7
5-(3,4-Dichlorophenyl)-3-hydroxy-4-(5-methylfuran-2-carbonyl)-1-(5-methylisoxazol-3-yl)-1H-pyrrol-2(5H)-one chemical structure, C20H14Cl2N2O5, CAS 618872-47-2
5-(3,4-Dichlorophenyl)-3-hydroxy-4-(5-methylfuran-2-carbonyl)-1-(5-methylisoxazol-3-yl)-1H-pyrrol-2(5H)-one
CAS 618872-47-2C20H14Cl2N2O5
3-Hydroxy-5-(2-methoxyphenyl)-4-(5-methyl-2-furoyl)-1-(5-methyl-3-isoxazolyl)-1,5-dihydro-2H-pyrrol-2-one chemical structure, C21H18N2O6, CAS 618872-60-9
3-Hydroxy-5-(2-methoxyphenyl)-4-(5-methyl-2-furoyl)-1-(5-methyl-3-isoxazolyl)-1,5-dihydro-2H-pyrrol-2-one
CAS 618872-60-9C21H18N2O6
4-(Furan-2-carbonyl)-3-hydroxy-1-(5-methylisoxazol-3-yl)-5-phenyl-1H-pyrrol-2(5H)-one chemical structure, C19H14N2O5, CAS 618871-79-7
4-(Furan-2-carbonyl)-3-hydroxy-1-(5-methylisoxazol-3-yl)-5-phenyl-1H-pyrrol-2(5H)-one
CAS 618871-79-7C19H14N2O5
5-(4-Ethoxyphenyl)-3-hydroxy-4-(5-methylfuran-2-carbonyl)-1-(5-methylisoxazol-3-yl)-1H-pyrrol-2(5H)-one chemical structure, C22H20N2O6, CAS 618872-66-5
5-(4-Ethoxyphenyl)-3-hydroxy-4-(5-methylfuran-2-carbonyl)-1-(5-methylisoxazol-3-yl)-1H-pyrrol-2(5H)-one
CAS 618872-66-5C22H20N2O6
5-(4-(tert-Butyl)phenyl)-3-hydroxy-4-(5-methylfuran-2-carbonyl)-1-(5-methylisoxazol-3-yl)-1H-pyrrol-2(5H)-one chemical structure, C24H24N2O5, CAS 618872-37-0
5-(4-(tert-Butyl)phenyl)-3-hydroxy-4-(5-methylfuran-2-carbonyl)-1-(5-methylisoxazol-3-yl)-1H-pyrrol-2(5H)-one
CAS 618872-37-0C24H24N2O5
(4E)-4-[Hydroxy(5-methylfuran-2-yl)methylidene]-1-(5-methyl-1,2-oxazol-3-yl)-5-[4-(pentyloxy)phenyl]pyrrolidine-2,3-dione chemical structure, C25H26N2O6, CAS 845806-33-9
(4E)-4-[Hydroxy(5-methylfuran-2-yl)methylidene]-1-(5-methyl-1,2-oxazol-3-yl)-5-[4-(pentyloxy)phenyl]pyrrolidine-2,3-dione
CAS 845806-33-9C25H26N2O6
(4E)-4-[Furan-2-yl(hydroxy)methylidene]-5-(4-hydroxyphenyl)-1-(5-methyl-1,2-oxazol-3-yl)pyrrolidine-2,3-dione chemical structure, C19H14N2O6, CAS 877809-32-0
(4E)-4-[Furan-2-yl(hydroxy)methylidene]-5-(4-hydroxyphenyl)-1-(5-methyl-1,2-oxazol-3-yl)pyrrolidine-2,3-dione
CAS 877809-32-0C19H14N2O6
Methyl 4-(3-(furan-2-carbonyl)-4-hydroxy-1-(5-methylisoxazol-3-yl)-5-oxo-2,5-dihydro-1H-pyrrol-2-yl)benzoate chemical structure, C21H16N2O7, CAS 618872-07-4
Methyl 4-(3-(furan-2-carbonyl)-4-hydroxy-1-(5-methylisoxazol-3-yl)-5-oxo-2,5-dihydro-1H-pyrrol-2-yl)benzoate
CAS 618872-07-4C21H16N2O7
3-Hydroxy-4-(5-methylfuran-2-carbonyl)-1-(5-methylisoxazol-3-yl)-5-(p-tolyl)-1H-pyrrol-2(5H)-one chemical structure, C21H18N2O5, CAS 618872-33-6
3-Hydroxy-4-(5-methylfuran-2-carbonyl)-1-(5-methylisoxazol-3-yl)-5-(p-tolyl)-1H-pyrrol-2(5H)-one
CAS 618872-33-6C21H18N2O5
5-(4-Chlorophenyl)-4-(furan-2-carbonyl)-3-hydroxy-1-(5-methylisoxazol-3-yl)-1H-pyrrol-2(5H)-one chemical structure, C19H13ClN2O5, CAS 618871-95-7
5-(4-Chlorophenyl)-4-(furan-2-carbonyl)-3-hydroxy-1-(5-methylisoxazol-3-yl)-1H-pyrrol-2(5H)-one
CAS 618871-95-7C19H13ClN2O5
Methyl 4-(4-hydroxy-3-(5-methylfuran-2-carbonyl)-1-(5-methylisoxazol-3-yl)-5-oxo-2,5-dihydro-1H-pyrrol-2-yl)benzoate chemical structure, C22H18N2O7, CAS 618872-58-5
Methyl 4-(4-hydroxy-3-(5-methylfuran-2-carbonyl)-1-(5-methylisoxazol-3-yl)-5-oxo-2,5-dihydro-1H-pyrrol-2-yl)benzoate
CAS 618872-58-5C22H18N2O7
5-(3-Chlorophenyl)-4-(furan-2-carbonyl)-3-hydroxy-1-(5-methylisoxazol-3-yl)-1H-pyrrol-2(5H)-one chemical structure, C19H13ClN2O5, CAS 618871-93-5
5-(3-Chlorophenyl)-4-(furan-2-carbonyl)-3-hydroxy-1-(5-methylisoxazol-3-yl)-1H-pyrrol-2(5H)-one
CAS 618871-93-5C19H13ClN2O5
4-(Furan-2-carbonyl)-3-hydroxy-1-(5-methyl-1,2-oxazol-3-yl)-5-(3-propoxyphenyl)-2,5-dihydro-1H-pyrrol-2-one chemical structure, C22H20N2O6, CAS 879929-92-7
4-(Furan-2-carbonyl)-3-hydroxy-1-(5-methyl-1,2-oxazol-3-yl)-5-(3-propoxyphenyl)-2,5-dihydro-1H-pyrrol-2-one
CAS 879929-92-7C22H20N2O6