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Murcko scaffold

Ring system with 4 rings and 26 atoms

16 chemicals on CompoundList share this ring system.

Rings
4
Scaffold atoms
26
Chemicals
16
With full pages
7
Scaffold SMILES

O=C(NN1CCCCC1)c1cc(-c2ccccc2)n(-c2ccccc2)n1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=C(NN1CCCCC1)c1cc(-c2ccccc2)n(-c2ccccc2)n1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 16 of 16 chemicals

N-(Piperidin-1-yl)-1-(2,4-dichlorophenyl)-5-(4-iodophenyl)-4-methyl-1H-pyrazole-3-carboxamide chemical structure, C22H21Cl2IN4O, CAS 183232-66-8
N-(Piperidin-1-yl)-1-(2,4-dichlorophenyl)-5-(4-iodophenyl)-4-methyl-1H-pyrazole-3-carboxamide
CAS 183232-66-8C22H21Cl2IN4O
Rimonabant hydrochloride chemical structure, C22H22Cl4N4O, CAS 158681-13-1
Rimonabant hydrochloride
CAS 158681-13-1C22H22Cl4N4O
Rimonabant chemical structure, C22H21Cl3N4O, CAS 168273-06-1
Rimonabant
CAS 168273-06-1C22H21Cl3N4O
Surinabant chemical structure, C23H23BrCl2N4O, CAS 288104-79-0
Surinabant
CAS 288104-79-0C23H23BrCl2N4O
1-(2,4-Dichlorophenyl)-4-methyl-5-(4-methylphenyl)-N-1-piperidinyl-1H-pyrazole-3-carboxamide chemical structure, C23H24Cl2N4O, CAS 680187-10-4
1-(2,4-Dichlorophenyl)-4-methyl-5-(4-methylphenyl)-N-1-piperidinyl-1H-pyrazole-3-carboxamide
CAS 680187-10-4C23H24Cl2N4O
1-(2,4-Dichloro-phenyl)-4-methyl-5-(4-pentyl-phenyl)-1H-pyrazole-3-carboxylic acid piperidin-1-ylamide chemical structure, C27H32Cl2N4O, CAS 336615-76-0
1-(2,4-Dichloro-phenyl)-4-methyl-5-(4-pentyl-phenyl)-1H-pyrazole-3-carboxylic acid piperidin-1-ylamide
CAS 336615-76-0C27H32Cl2N4O
4-Bromo-1-(2,4-dichlorophenyl)-5-(4-pentylphenyl)-N-1-piperidinyl-1H-pyrazole-3-carboxamide chemical structure, C26H29BrCl2N4O, CAS 336615-79-3
4-Bromo-1-(2,4-dichlorophenyl)-5-(4-pentylphenyl)-N-1-piperidinyl-1H-pyrazole-3-carboxamide
CAS 336615-79-3C26H29BrCl2N4O
N-(Piperidin-1-yl)-5-(4-methoxyphenyl)-1-(2,4-dichlorophenyl)-4-methyl-1H-pyrazole-3-carboxamide chemical structure, C23H24Cl2N4O2, CAS 502486-89-7
N-(Piperidin-1-yl)-5-(4-methoxyphenyl)-1-(2,4-dichlorophenyl)-4-methyl-1H-pyrazole-3-carboxamide
CAS 502486-89-7C23H24Cl2N4O2
tert-Butyl [2-(4-{1-(2,4-dichlorophenyl)-4-methyl-3-[(piperidin-1-ylamino)carbonyl]-1H-pyrazol-5-yl}phenoxy)ethyl]ethylcarbamate chemical structure, C31H39Cl2N5O4, CAS 863639-65-0
tert-Butyl [2-(4-{1-(2,4-dichlorophenyl)-4-methyl-3-[(piperidin-1-ylamino)carbonyl]-1H-pyrazol-5-yl}phenoxy)ethyl]ethylcarbamate
CAS 863639-65-0C31H39Cl2N5O4
Azd-1175 chemical structure, C25H25Cl2F3N4O4S, CAS 863639-43-4
Azd-1175
CAS 863639-43-4C25H25Cl2F3N4O4S
Jhu-75528 c-11 chemical structure, C23H21Cl2N5O2, CAS 942063-86-7
Jhu-75528 c-11
CAS 942063-86-7C23H21Cl2N5O2
Jhu-75528 chemical structure, C23H21Cl2N5O2, CAS 947696-17-5
Jhu-75528
CAS 947696-17-5C23H21Cl2N5O2
4-{4-[1-(2,4-Dichlorophenyl)-4-methyl-3-[(piperidin-1-yl)carbamoyl]-1H-pyrazol-5-yl]phenyl}but-3-yn-1-yl nitrate chemical structure, C26H25Cl2N5O4, CAS 1245626-00-9
4-{4-[1-(2,4-Dichlorophenyl)-4-methyl-3-[(piperidin-1-yl)carbamoyl]-1H-pyrazol-5-yl]phenyl}but-3-yn-1-yl nitrate
CAS 1245626-00-9C26H25Cl2N5O4
Rimonabant-d10 hydrochloride chemical structure, C22H22Cl4N4O, CAS 1044909-61-6
Rimonabant-d10 hydrochloride
CAS 1044909-61-6C22H22Cl4N4O
Rimonabant-d10 chemical structure, C22H21Cl3N4O, CAS 929221-88-5
Rimonabant-d10
CAS 929221-88-5C22H21Cl3N4O
1-(2,4-Dichloro-phenyl)-5-(4-hydroxy-phenyl)-4-methyl-1H-pyrazole-3-carboxylic acid piperidin-1-ylamide chemical structure, C22H22Cl2N4O2, CAS 502486-92-2
1-(2,4-Dichloro-phenyl)-5-(4-hydroxy-phenyl)-4-methyl-1H-pyrazole-3-carboxylic acid piperidin-1-ylamide
CAS 502486-92-2C22H22Cl2N4O2