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Murcko scaffold

Ring system with 4 rings and 25 atoms

18 chemicals on CompoundList share this ring system.

Rings: 4
Scaffold atoms: 25
Chemicals: 18
With full pages: 2

Scaffold SMILES

C(=Cc1ccccc1)C1=NN(c2ccccc2)C(c2ccccc2)C1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold

Murcko scaffold C(=Cc1ccccc1)C1=NN(c2ccccc2)C(c2ccccc2)C1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 18 of 18 chemicals

Benzenamine, 4-(2-(5-(4-(diethylamino)phenyl)-4,5-dihydro-1-phenyl-1H-pyrazol-3-yl)ethenyl)-N,N-diethyl- chemical structure, C31H38N4, CAS 57609-72-0

Benzenamine, 4-(2-(5-(4-(diethylamino)phenyl)-4,5-dihydro-1-phenyl-1H-pyrazol-3-yl)ethenyl)-N,N-diethyl-

CAS 57609-72-0C₃₁H₃₈N₄

4,5-Dihydro-5-(4-methoxyphenyl)-3-[2-(4-methoxyphenyl)ethenyl]-1-phenyl-1H-pyrazole chemical structure, C25H24N2O2, CAS 2256-18-0

4,5-Dihydro-5-(4-methoxyphenyl)-3-[2-(4-methoxyphenyl)ethenyl]-1-phenyl-1H-pyrazole

CAS 2256-18-0C₂₅H₂₄N₂O₂

5-(4-Bromophenyl)-3-(4-bromostyryl)-1-(3-chlorophenyl)-4,5-dihydro-1H-pyrazole chemical structure, C23H17Br2ClN2, CAS 303194-74-3

5-(4-Bromophenyl)-3-(4-bromostyryl)-1-(3-chlorophenyl)-4,5-dihydro-1H-pyrazole

CAS 303194-74-3C₂₃H₁₇Br₂ClN₂

5-(3,4-Dimethoxyphenyl)-3-(3,4-dimethoxystyryl)-1-phenyl-4,5-dihydro-1H-pyrazole chemical structure, C27H28N2O4, CAS 92683-10-8

5-(3,4-Dimethoxyphenyl)-3-(3,4-dimethoxystyryl)-1-phenyl-4,5-dihydro-1H-pyrazole

CAS 92683-10-8C₂₇H₂₈N₂O₄

3-(4-Chlorophenyl)-5-[(E)-2-(4-chlorophenyl)ethenyl]-2-(4-fluorophenyl)-3,4-dihydropyrazole chemical structure, C23H17Cl2FN2, CAS 312617-41-7

3-(4-Chlorophenyl)-5-[(E)-2-(4-chlorophenyl)ethenyl]-2-(4-fluorophenyl)-3,4-dihydropyrazole

CAS 312617-41-7C₂₃H₁₇Cl₂FN₂

2-(4-Nitrophenyl)-3-phenyl-5-[(E)-2-phenylethenyl]-3,4-dihydropyrazole chemical structure, C23H19N3O2, CAS 2256-19-1

2-(4-Nitrophenyl)-3-phenyl-5-[(E)-2-phenylethenyl]-3,4-dihydropyrazole

CAS 2256-19-1C₂₃H₁₉N₃O₂

1,5-Diphenyl-3-styryl-2-pyrazoline chemical structure, C23H20N2, CAS 325150-61-6

1,5-Diphenyl-3-styryl-2-pyrazoline

CAS 325150-61-6C₂₃H₂₀N₂

2-(4-Chlorophenyl)-3-(2-methoxyphenyl)-5-[(E)-2-(2-methoxyphenyl)ethenyl]-3,4-dihydropyrazole chemical structure, C25H23ClN2O2, CAS 299969-56-5

2-(4-Chlorophenyl)-3-(2-methoxyphenyl)-5-[(E)-2-(2-methoxyphenyl)ethenyl]-3,4-dihydropyrazole

CAS 299969-56-5C₂₅H₂₃ClN₂O₂

5-(4-Methoxyphenyl)-3-[2-(4-methoxyphenyl)vinyl]-1-phenyl-4,5-dihydro-1H-pyrazole chemical structure, C25H24N2O2, CAS 904927-15-7

5-(4-Methoxyphenyl)-3-[2-(4-methoxyphenyl)vinyl]-1-phenyl-4,5-dihydro-1H-pyrazole

CAS 904927-15-7C₂₅H₂₄N₂O₂

2-(4-Chlorophenyl)-3-phenyl-5-[(E)-2-phenylethenyl]-3,4-dihydropyrazole chemical structure, C23H19ClN2, CAS 299969-54-3

2-(4-Chlorophenyl)-3-phenyl-5-[(E)-2-phenylethenyl]-3,4-dihydropyrazole

CAS 299969-54-3C₂₃H₁₉ClN₂

2-(3,4-Dichlorophenyl)-3-phenyl-5-[(E)-2-phenylethenyl]-3,4-dihydropyrazole chemical structure, C23H18Cl2N2, CAS 301326-35-2

2-(3,4-Dichlorophenyl)-3-phenyl-5-[(E)-2-phenylethenyl]-3,4-dihydropyrazole

CAS 301326-35-2C₂₃H₁₈Cl₂N₂

3-(2,3-Dimethoxyphenyl)-5-[(E)-2-(2,3-dimethoxyphenyl)ethenyl]-2-(3-fluorophenyl)-3,4-dihydropyrazole chemical structure, C27H27FN2O4, CAS 376617-36-6

3-(2,3-Dimethoxyphenyl)-5-[(E)-2-(2,3-dimethoxyphenyl)ethenyl]-2-(3-fluorophenyl)-3,4-dihydropyrazole

CAS 376617-36-6C₂₇H₂₇FN₂O₄

2-(3-Bromophenyl)-3-(2,3-dimethoxyphenyl)-5-[(E)-2-(2,3-dimethoxyphenyl)ethenyl]-3,4-dihydropyrazole chemical structure, C27H27BrN2O4, CAS 303194-70-9

2-(3-Bromophenyl)-3-(2,3-dimethoxyphenyl)-5-[(E)-2-(2,3-dimethoxyphenyl)ethenyl]-3,4-dihydropyrazole

CAS 303194-70-9C₂₇H₂₇BrN₂O₄

2-(3-Fluorophenyl)-3-(4-methoxyphenyl)-5-[(E)-2-(4-methoxyphenyl)ethenyl]-3,4-dihydropyrazole chemical structure, C25H23FN2O2, CAS 303194-76-5

2-(3-Fluorophenyl)-3-(4-methoxyphenyl)-5-[(E)-2-(4-methoxyphenyl)ethenyl]-3,4-dihydropyrazole

CAS 303194-76-5C₂₅H₂₃FN₂O₂

2-[2-Chloro-5-(trifluoromethyl)phenyl]-3-phenyl-5-[(E)-2-phenylethenyl]-3,4-dihydropyrazole chemical structure, C24H18ClF3N2, CAS 303194-84-5

2-[2-Chloro-5-(trifluoromethyl)phenyl]-3-phenyl-5-[(E)-2-phenylethenyl]-3,4-dihydropyrazole

CAS 303194-84-5C₂₄H₁₈ClF₃N₂

3-(4-Chlorophenyl)-5-[(E)-2-(4-chlorophenyl)ethenyl]-2-phenyl-3,4-dihydropyrazole chemical structure, C23H18Cl2N2, CAS 904927-14-6

3-(4-Chlorophenyl)-5-[(E)-2-(4-chlorophenyl)ethenyl]-2-phenyl-3,4-dihydropyrazole

CAS 904927-14-6C₂₃H₁₈Cl₂N₂

(2E)-2-Cyano-3-(4-{5-phenyl-3-[(E)-2-phenylethenyl]-4,5-dihydro-1H-pyrazol-1-yl}phenyl)prop-2-enamide chemical structure, C27H22N4O, CAS 327103-56-0

(2E)-2-Cyano-3-(4-{5-phenyl-3-[(E)-2-phenylethenyl]-4,5-dihydro-1H-pyrazol-1-yl}phenyl)prop-2-enamide

CAS 327103-56-0C₂₇H₂₂N₄O

1H-Pyrazole,5-(4-(1,1-dimethylethyl)phenyl)-3-(2-(4-(1,1-dimethylethyl)phenyl)ethenyl)-4,5-dihydro-1-phenyl- chemical structure, C31H36N2, CAS 152015-94-6

1H-Pyrazole,5-(4-(1,1-dimethylethyl)phenyl)-3-(2-(4-(1,1-dimethylethyl)phenyl)ethenyl)-4,5-dihydro-1-phenyl-

CAS 152015-94-6C₃₁H₃₆N₂