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Murcko scaffold

2-[(2-Benzyl-1-oxo-1,2,3,4-tetrahydroisoquinolin-5-yl)oxy]-N-phenylacetamide scaffold

95 chemicals on CompoundList share this ring system.

Rings: 4
Scaffold atoms: 29
Chemicals: 95
With full pages: 3

Scaffold SMILES

O=C(COc1cccc2c1CCN(Cc1ccccc1)C2=O)Nc1ccccc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold Open the 2-[(2-Benzyl-1-oxo-1,2,3,4-tetrahydroisoquinolin-5-yl)oxy]-N-phenylacetamide page

Murcko scaffold O=C(COc1cccc2c1CCN(Cc1ccccc1)C2=O)Nc1ccccc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 48 of 95 chemicals

2-((2-(4-Bromobenzyl)-1-oxo-1,2,3,4-tetrahydroisoquinolin-5-yl)oxy)-N-phenylacetamide chemical structure, C24H21BrN2O3, CAS 850904-28-8

2-((2-(4-Bromobenzyl)-1-oxo-1,2,3,4-tetrahydroisoquinolin-5-yl)oxy)-N-phenylacetamide

CAS 850904-28-8C₂₄H₂₁BrN₂O₃

2-[[2-[(4-Bromophenyl)methyl]-1-oxo-3,4-dihydroisoquinolin-5-yl]oxy]-N-(3-methylphenyl)acetamide chemical structure, C25H23BrN2O3, CAS 850904-29-9

2-[[2-[(4-Bromophenyl)methyl]-1-oxo-3,4-dihydroisoquinolin-5-yl]oxy]-N-(3-methylphenyl)acetamide

CAS 850904-29-9C₂₅H₂₃BrN₂O₃

2-[[2-[(4-Bromophenyl)methyl]-1-oxo-3,4-dihydroisoquinolin-5-yl]oxy]-N-(4-methylphenyl)acetamide chemical structure, C25H23BrN2O3, CAS 850904-30-2

2-[[2-[(4-Bromophenyl)methyl]-1-oxo-3,4-dihydroisoquinolin-5-yl]oxy]-N-(4-methylphenyl)acetamide

CAS 850904-30-2C₂₅H₂₃BrN₂O₃

2-[[2-[(4-Bromophenyl)methyl]-1-oxo-3,4-dihydroisoquinolin-5-yl]oxy]-N-(4-fluorophenyl)acetamide chemical structure, C24H20BrFN2O3, CAS 850904-31-3

2-[[2-[(4-Bromophenyl)methyl]-1-oxo-3,4-dihydroisoquinolin-5-yl]oxy]-N-(4-fluorophenyl)acetamide

CAS 850904-31-3C₂₄H₂₀BrFN₂O₃

2-[[2-[(4-Bromophenyl)methyl]-1-oxo-3,4-dihydroisoquinolin-5-yl]oxy]-N-(4-methoxyphenyl)acetamide chemical structure, C25H23BrN2O4, CAS 850904-32-4

2-[[2-[(4-Bromophenyl)methyl]-1-oxo-3,4-dihydroisoquinolin-5-yl]oxy]-N-(4-methoxyphenyl)acetamide

CAS 850904-32-4C₂₅H₂₃BrN₂O₄

2-[[2-[(4-Bromophenyl)methyl]-1-oxo-3,4-dihydroisoquinolin-5-yl]oxy]-N-(4-ethoxyphenyl)acetamide chemical structure, C26H25BrN2O4, CAS 850904-33-5

2-[[2-[(4-Bromophenyl)methyl]-1-oxo-3,4-dihydroisoquinolin-5-yl]oxy]-N-(4-ethoxyphenyl)acetamide

CAS 850904-33-5C₂₆H₂₅BrN₂O₄

N-(4-Bromophenyl)-2-[[2-[(4-bromophenyl)methyl]-1-oxo-3,4-dihydroisoquinolin-5-yl]oxy]acetamide chemical structure, C24H20Br2N2O3, CAS 850904-34-6

N-(4-Bromophenyl)-2-[[2-[(4-bromophenyl)methyl]-1-oxo-3,4-dihydroisoquinolin-5-yl]oxy]acetamide

CAS 850904-34-6C₂₄H₂₀Br₂N₂O₃

Ethyl 4-(2-((2-(4-bromobenzyl)-1-oxo-1,2,3,4-tetrahydroisoquinolin-5-yl)oxy)acetamido)benzoate chemical structure, C27H25BrN2O5, CAS 850904-35-7

Ethyl 4-(2-((2-(4-bromobenzyl)-1-oxo-1,2,3,4-tetrahydroisoquinolin-5-yl)oxy)acetamido)benzoate

CAS 850904-35-7C₂₇H₂₅BrN₂O₅

2-((2-(4-Bromobenzyl)-1-oxo-1,2,3,4-tetrahydroisoquinolin-5-yl)oxy)-N-(2,3-dimethylphenyl)acetamide chemical structure, C26H25BrN2O3, CAS 850904-36-8

2-((2-(4-Bromobenzyl)-1-oxo-1,2,3,4-tetrahydroisoquinolin-5-yl)oxy)-N-(2,3-dimethylphenyl)acetamide

CAS 850904-36-8C₂₆H₂₅BrN₂O₃

2-[[2-[(4-Bromophenyl)methyl]-1-oxo-3,4-dihydroisoquinolin-5-yl]oxy]-N-(2,5-dimethylphenyl)acetamide chemical structure, C26H25BrN2O3, CAS 850904-37-9

2-[[2-[(4-Bromophenyl)methyl]-1-oxo-3,4-dihydroisoquinolin-5-yl]oxy]-N-(2,5-dimethylphenyl)acetamide

CAS 850904-37-9C₂₆H₂₅BrN₂O₃

2-((2-(4-Bromobenzyl)-1-oxo-1,2,3,4-tetrahydroisoquinolin-5-yl)oxy)-N-(2,4-dimethylphenyl)acetamide chemical structure, C26H25BrN2O3, CAS 850904-38-0

2-((2-(4-Bromobenzyl)-1-oxo-1,2,3,4-tetrahydroisoquinolin-5-yl)oxy)-N-(2,4-dimethylphenyl)acetamide

CAS 850904-38-0C₂₆H₂₅BrN₂O₃

2-((2-(4-Bromobenzyl)-1-oxo-1,2,3,4-tetrahydroisoquinolin-5-yl)oxy)-N-(3,5-dimethylphenyl)acetamide chemical structure, C26H25BrN2O3, CAS 850904-43-7

2-((2-(4-Bromobenzyl)-1-oxo-1,2,3,4-tetrahydroisoquinolin-5-yl)oxy)-N-(3,5-dimethylphenyl)acetamide

CAS 850904-43-7C₂₆H₂₅BrN₂O₃

2-((2-(4-Bromobenzyl)-1-oxo-1,2,3,4-tetrahydroisoquinolin-5-yl)oxy)-N-(2-chloro-5-(trifluoromethyl)phenyl)acetamide chemical structure, C25H19BrClF3N2O3, CAS 850904-44-8

2-((2-(4-Bromobenzyl)-1-oxo-1,2,3,4-tetrahydroisoquinolin-5-yl)oxy)-N-(2-chloro-5-(trifluoromethyl)phenyl)acetamide

CAS 850904-44-8C₂₅H₁₉BrClF₃N₂O₃

2-((2-(4-Bromobenzyl)-1-oxo-1,2,3,4-tetrahydroisoquinolin-5-yl)oxy)-N-(2,4-dimethoxyphenyl)acetamide chemical structure, C26H25BrN2O5, CAS 850904-45-9

2-((2-(4-Bromobenzyl)-1-oxo-1,2,3,4-tetrahydroisoquinolin-5-yl)oxy)-N-(2,4-dimethoxyphenyl)acetamide

CAS 850904-45-9C₂₆H₂₅BrN₂O₅

2-[(2-Benzyl-1-oxo-1,2,3,4-tetrahydroisoquinolin-5-yl)oxy]-N-phenylacetamide chemical structure, C24H22N2O3, CAS 850905-49-6

2-[(2-Benzyl-1-oxo-1,2,3,4-tetrahydroisoquinolin-5-yl)oxy]-N-phenylacetamide

CAS 850905-49-6C₂₄H₂₂N₂O₃

2-((2-Benzyl-1-oxo-1,2,3,4-tetrahydroisoquinolin-5-yl)oxy)-N-(m-tolyl)acetamide chemical structure, C25H24N2O3, CAS 850905-50-9

2-((2-Benzyl-1-oxo-1,2,3,4-tetrahydroisoquinolin-5-yl)oxy)-N-(m-tolyl)acetamide

CAS 850905-50-9C₂₅H₂₄N₂O₃

2-((2-Benzyl-1-oxo-1,2,3,4-tetrahydroisoquinolin-5-yl)oxy)-N-(p-tolyl)acetamide chemical structure, C25H24N2O3, CAS 850905-51-0

2-((2-Benzyl-1-oxo-1,2,3,4-tetrahydroisoquinolin-5-yl)oxy)-N-(p-tolyl)acetamide

CAS 850905-51-0C₂₅H₂₄N₂O₃

2-[(2-Benzyl-1-oxo-3,4-dihydroisoquinolin-5-yl)oxy]-N-(4-fluorophenyl)acetamide chemical structure, C24H21FN2O3, CAS 850905-52-1

2-[(2-Benzyl-1-oxo-3,4-dihydroisoquinolin-5-yl)oxy]-N-(4-fluorophenyl)acetamide

CAS 850905-52-1C₂₄H₂₁FN₂O₃

2-[(2-Benzyl-1-oxo-1,2,3,4-tetrahydroisoquinolin-5-yl)oxy]-N-(4-methoxyphenyl)acetamide chemical structure, C25H24N2O4, CAS 850905-53-2

2-[(2-Benzyl-1-oxo-1,2,3,4-tetrahydroisoquinolin-5-yl)oxy]-N-(4-methoxyphenyl)acetamide

CAS 850905-53-2C₂₅H₂₄N₂O₄

2-[(2-Benzyl-1-oxo-3,4-dihydroisoquinolin-5-yl)oxy]-N-(4-ethoxyphenyl)acetamide chemical structure, C26H26N2O4, CAS 850905-54-3

2-[(2-Benzyl-1-oxo-3,4-dihydroisoquinolin-5-yl)oxy]-N-(4-ethoxyphenyl)acetamide

CAS 850905-54-3C₂₆H₂₆N₂O₄

2-[(2-Benzyl-1-oxo-3,4-dihydroisoquinolin-5-yl)oxy]-N-(4-bromophenyl)acetamide chemical structure, C24H21BrN2O3, CAS 850905-55-4

2-[(2-Benzyl-1-oxo-3,4-dihydroisoquinolin-5-yl)oxy]-N-(4-bromophenyl)acetamide

CAS 850905-55-4C₂₄H₂₁BrN₂O₃

Ethyl 4-[[2-[(2-benzyl-1-oxo-3,4-dihydroisoquinolin-5-yl)oxy]acetyl]amino]benzoate chemical structure, C27H26N2O5, CAS 850905-56-5

Ethyl 4-[[2-[(2-benzyl-1-oxo-3,4-dihydroisoquinolin-5-yl)oxy]acetyl]amino]benzoate

CAS 850905-56-5C₂₇H₂₆N₂O₅

2-((2-Benzyl-1-oxo-1,2,3,4-tetrahydroisoquinolin-5-yl)oxy)-N-(2,3-dimethylphenyl)acetamide chemical structure, C26H26N2O3, CAS 850905-57-6

2-((2-Benzyl-1-oxo-1,2,3,4-tetrahydroisoquinolin-5-yl)oxy)-N-(2,3-dimethylphenyl)acetamide

CAS 850905-57-6C₂₆H₂₆N₂O₃

2-((2-Benzyl-1-oxo-1,2,3,4-tetrahydroisoquinolin-5-yl)oxy)-N-(2,5-dimethylphenyl)acetamide chemical structure, C26H26N2O3, CAS 850905-58-7

2-((2-Benzyl-1-oxo-1,2,3,4-tetrahydroisoquinolin-5-yl)oxy)-N-(2,5-dimethylphenyl)acetamide

CAS 850905-58-7C₂₆H₂₆N₂O₃