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Murcko scaffold

Ring system with 3 rings and 15 atoms

27 chemicals on CompoundList share this ring system.

Rings
3
Scaffold atoms
15
Chemicals
27
With full pages
3
Scaffold SMILES

c1ccc(-c2cnc(C3CC3)nc2)cc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold c1ccc(-c2cnc(C3CC3)nc2)cc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 27 of 27 chemicals

4-(2-Cyclopropyl-4-ethylpyrimidin-5-yl)benzonitrile chemical structure, C16H15N3, CAS 918422-30-7
4-(2-Cyclopropyl-4-ethylpyrimidin-5-yl)benzonitrile
CAS 918422-30-7C16H15N3
2-Cyclopropyl-4-ethyl-5-(4-iodophenyl)pyrimidine chemical structure, C15H15IN2, CAS 918422-46-5
2-Cyclopropyl-4-ethyl-5-(4-iodophenyl)pyrimidine
CAS 918422-46-5C15H15IN2
4-[4-(1-Bromoethyl)-2-cyclopropylpyrimidin-5-yl]benzonitrile chemical structure, C16H14BrN3, CAS 918422-31-8
4-[4-(1-Bromoethyl)-2-cyclopropylpyrimidin-5-yl]benzonitrile
CAS 918422-31-8C16H14BrN3
4-[4-(1-Azidoethyl)-2-cyclopropylpyrimidin-5-yl]benzonitrile chemical structure, C16H14N6, CAS 918422-32-9
4-[4-(1-Azidoethyl)-2-cyclopropylpyrimidin-5-yl]benzonitrile
CAS 918422-32-9C16H14N6
4-[4-(1-Aminoethyl)-2-cyclopropylpyrimidin-5-yl]benzonitrile chemical structure, C16H16N4, CAS 918422-33-0
4-[4-(1-Aminoethyl)-2-cyclopropylpyrimidin-5-yl]benzonitrile
CAS 918422-33-0C16H16N4
5-(2-Bromophenyl)-2-cyclopropylpyrimidin-4-amine chemical structure, C13H12BrN3, CAS 1484826-61-0
5-(2-Bromophenyl)-2-cyclopropylpyrimidin-4-amine
CAS 1484826-61-0C13H12BrN3
4,6-Dichloro-5-(2-chlorophenyl)-2-(2-methylcyclopropyl)pyrimidine chemical structure, C14H11Cl3N2, CAS 1504525-40-9
4,6-Dichloro-5-(2-chlorophenyl)-2-(2-methylcyclopropyl)pyrimidine
CAS 1504525-40-9C14H11Cl3N2
4,6-Dichloro-5-(2-chlorophenyl)-2-cyclopropylpyrimidine chemical structure, C13H9Cl3N2, CAS 1523025-65-1
4,6-Dichloro-5-(2-chlorophenyl)-2-cyclopropylpyrimidine
CAS 1523025-65-1C13H9Cl3N2
3-(2-Cyclopropyl-5-pyrimidinyl)benzenamine chemical structure, C13H13N3, CAS 1784842-24-5
3-(2-Cyclopropyl-5-pyrimidinyl)benzenamine
CAS 1784842-24-5C13H13N3
5-(4-Bromophenyl)-2-cyclopropyl-4-methylpyrimidine chemical structure, C14H13BrN2, CAS 1779794-82-9
5-(4-Bromophenyl)-2-cyclopropyl-4-methylpyrimidine
CAS 1779794-82-9C14H13BrN2
5-(2-Bromophenyl)-2-cyclopropyl-4-methylPyrimidine chemical structure, C14H13BrN2, CAS 1784490-77-2
5-(2-Bromophenyl)-2-cyclopropyl-4-methylPyrimidine
CAS 1784490-77-2C14H13BrN2
5-(2-Chlorophenyl)-2-cyclopropyl-4-pyrimidinecarboxylic acid chemical structure, C14H11ClN2O2, CAS 1978358-17-6
5-(2-Chlorophenyl)-2-cyclopropyl-4-pyrimidinecarboxylic acid
CAS 1978358-17-6C14H11ClN2O2
Methyl 5-(2-chlorophenyl)-2-cyclopropylpyrimidine-4-carboxylate chemical structure, C15H13ClN2O2, CAS 1978358-76-7
Methyl 5-(2-chlorophenyl)-2-cyclopropylpyrimidine-4-carboxylate
CAS 1978358-76-7C15H13ClN2O2
5-(2-Chlorophenyl)-2-cyclopropyl-4-pyrimidinecarboxaldehyde chemical structure, C14H11ClN2O, CAS 2174192-68-6
5-(2-Chlorophenyl)-2-cyclopropyl-4-pyrimidinecarboxaldehyde
CAS 2174192-68-6C14H11ClN2O
5-(2-Chlorophenyl)-2-cyclopropyl-4-pyrimidinecarboxamide chemical structure, C14H12ClN3O, CAS 1978359-61-3
5-(2-Chlorophenyl)-2-cyclopropyl-4-pyrimidinecarboxamide
CAS 1978359-61-3C14H12ClN3O
5-(2-Chlorophenyl)-2-cyclopropyl-4-methylPyrimidine chemical structure, C14H13ClN2, CAS 2174189-57-0
5-(2-Chlorophenyl)-2-cyclopropyl-4-methylPyrimidine
CAS 2174189-57-0C14H13ClN2
5-(2-Chlorophenyl)-2-cyclopropyl-4-ethynylpyrimidine chemical structure, C15H11ClN2, CAS 2174189-63-8
5-(2-Chlorophenyl)-2-cyclopropyl-4-ethynylpyrimidine
CAS 2174189-63-8C15H11ClN2
5-(2-Chloro-4-fluorophenyl)-2-cyclopropyl-4-pyrimidinecarboxylic acid chemical structure, C14H10ClFN2O2, CAS 1978358-22-3
5-(2-Chloro-4-fluorophenyl)-2-cyclopropyl-4-pyrimidinecarboxylic acid
CAS 1978358-22-3C14H10ClFN2O2
Methyl 5-(2-chloro-6-methoxyphenyl)-2-cyclopropylpyrimidine-4-carboxylate chemical structure, C16H15ClN2O3, CAS 1978358-77-8
Methyl 5-(2-chloro-6-methoxyphenyl)-2-cyclopropylpyrimidine-4-carboxylate
CAS 1978358-77-8C16H15ClN2O3
tert-Butyl N-[5-(2-bromophenyl)-2-cyclopropylpyrimidin-4-yl]carbamate chemical structure, C18H20BrN3O2, CAS 2680691-15-8
tert-Butyl N-[5-(2-bromophenyl)-2-cyclopropylpyrimidin-4-yl]carbamate
CAS 2680691-15-8C18H20BrN3O2
5-(2-Chloro-6-methoxyphenyl)-2-cyclopropyl-4-pyrimidinecarboxylic acid chemical structure, C15H13ClN2O3, CAS 1978358-53-0
5-(2-Chloro-6-methoxyphenyl)-2-cyclopropyl-4-pyrimidinecarboxylic acid
CAS 1978358-53-0C15H13ClN2O3
Methyl 2-cyclopropyl-5-(2,3-dichlorophenyl)pyrimidine-4-carboxylate chemical structure, C15H12Cl2N2O2, CAS 1978358-86-9
Methyl 2-cyclopropyl-5-(2,3-dichlorophenyl)pyrimidine-4-carboxylate
CAS 1978358-86-9C15H12Cl2N2O2
Methyl 2-cyclopropyl-5-(2,5-dichlorophenyl)pyrimidine-4-carboxylate chemical structure, C15H12Cl2N2O2, CAS 1978358-79-0
Methyl 2-cyclopropyl-5-(2,5-dichlorophenyl)pyrimidine-4-carboxylate
CAS 1978358-79-0C15H12Cl2N2O2
Methyl 2-cyclopropyl-5-(2,6-dimethylphenyl)pyrimidine-4-carboxylate chemical structure, C17H18N2O2, CAS 1978359-00-0
Methyl 2-cyclopropyl-5-(2,6-dimethylphenyl)pyrimidine-4-carboxylate
CAS 1978359-00-0C17H18N2O2