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Murcko scaffold

1-Phenylpiperazine scaffold

6,403 chemicals on CompoundList share this ring system.

Rings
2
Scaffold atoms
12
Chemicals
6,403
With full pages
595
Scaffold SMILES

c1ccc(N2CCNCC2)cc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffoldOpen the 1-Phenylpiperazine page
Murcko scaffold c1ccc(N2CCNCC2)cc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 385 to 432 of 6,403 chemicals

2-[4-(4-Bromo-phenyl)-piperazin-1-yl]-ethylamine chemical structure, C12H18BrN3, CAS 199616-96-1
2-[4-(4-Bromo-phenyl)-piperazin-1-yl]-ethylamine
CAS 199616-96-1C12H18BrN3
Ethyl (4-phenyl-1-piperazinyl)carbothioylcarbamate chemical structure, C14H19N3O2S, CAS 325770-57-8
Ethyl (4-phenyl-1-piperazinyl)carbothioylcarbamate
CAS 325770-57-8C14H19N3O2S
1-[4-(Ethylsulfonyl)phenyl]piperazine chemical structure, C12H18N2O2S, CAS 725700-04-9
1-[4-(Ethylsulfonyl)phenyl]piperazine
CAS 725700-04-9C12H18N2O2S
Methyl 4-(4-fluorophenyl)piperazine-1-carboxylate chemical structure, C12H15FN2O2, CAS 329042-42-4
Methyl 4-(4-fluorophenyl)piperazine-1-carboxylate
CAS 329042-42-4C12H15FN2O2
Benzenemethanol, 2-chloro-4-(4-methyl-1-piperazinyl)-, N-oxide chemical structure, C12H17ClN2O2, CAS 76239-56-0
Benzenemethanol, 2-chloro-4-(4-methyl-1-piperazinyl)-, N-oxide
CAS 76239-56-0C12H17ClN2O2
Benzenemethanol, 2-chloro-4-(4-ethyl-1-piperazinyl)-, N-oxide chemical structure, C13H19ClN2O2, CAS 76239-58-2
Benzenemethanol, 2-chloro-4-(4-ethyl-1-piperazinyl)-, N-oxide
CAS 76239-58-2C13H19ClN2O2
Benzenemethanol, 2-chloro-4-(4-(1-methylethyl)-1-piperazinyl)- chemical structure, C14H21ClN2O, CAS 76239-59-3
Benzenemethanol, 2-chloro-4-(4-(1-methylethyl)-1-piperazinyl)-
CAS 76239-59-3C14H21ClN2O
Benzenemethanol, 2-chloro-4-(4-(1-methylethyl)-1-piperazinyl)-, N-oxide chemical structure, C14H21ClN2O2, CAS 76239-60-6
Benzenemethanol, 2-chloro-4-(4-(1-methylethyl)-1-piperazinyl)-, N-oxide
CAS 76239-60-6C14H21ClN2O2
Oxalic acid--1-(3-ethyl-4-phenylpiperazin-1-yl)propan-2-amine (2/1) chemical structure, C19H29N3O8, CAS 77562-84-6
Oxalic acid--1-(3-ethyl-4-phenylpiperazin-1-yl)propan-2-amine (2/1)
CAS 77562-84-6C19H29N3O8
1-Piperazineethanamine, alpha-methyl-4-(1-methylethyl)-N-phenyl-, ethanedioate (1:2) chemical structure, C20H31N3O8, CAS 77562-86-8
1-Piperazineethanamine, alpha-methyl-4-(1-methylethyl)-N-phenyl-, ethanedioate (1:2)
CAS 77562-86-8C20H31N3O8
1-Piperazineethanamine, 4-butyl-alpha-methyl-N-phenyl-, ethanedioate, hydrate (2:4:1) chemical structure, C21H33N3O8, CAS 77562-88-0
1-Piperazineethanamine, 4-butyl-alpha-methyl-N-phenyl-, ethanedioate, hydrate (2:4:1)
CAS 77562-88-0C21H33N3O8
Piperazine, 1-(3-chloropropyl)-4-(3-(trifluoromethyl)phenyl)- chemical structure, C14H18ClF3N2, CAS 78056-40-3
Piperazine, 1-(3-chloropropyl)-4-(3-(trifluoromethyl)phenyl)-
CAS 78056-40-3C14H18ClF3N2
1-Piperazinecarboxamide, N-((methylamino)carbonyl)-4-phenyl- chemical structure, C13H18N4O2, CAS 80712-07-8
1-Piperazinecarboxamide, N-((methylamino)carbonyl)-4-phenyl-
CAS 80712-07-8C13H18N4O2
1-Piperazinecarboxamide, N-((methylamino)carbonyl)-4-(2-methylphenyl)- chemical structure, C14H20N4O2, CAS 80712-08-9
1-Piperazinecarboxamide, N-((methylamino)carbonyl)-4-(2-methylphenyl)-
CAS 80712-08-9C14H20N4O2
1-Piperazinecarboxamide, N-((methylamino)carbonyl)-4-(3-methylphenyl)- chemical structure, C14H20N4O2, CAS 80712-09-0
1-Piperazinecarboxamide, N-((methylamino)carbonyl)-4-(3-methylphenyl)-
CAS 80712-09-0C14H20N4O2
1-Piperazinecarboxamide, N-((methylamino)carbonyl)-4-(4-methylphenyl)- chemical structure, C14H20N4O2, CAS 80712-10-3
1-Piperazinecarboxamide, N-((methylamino)carbonyl)-4-(4-methylphenyl)-
CAS 80712-10-3C14H20N4O2
1-Piperazinecarboxamide, N-((methylamino)carbonyl)-4-(3-(trifluoromethyl)phenyl)- chemical structure, C14H17F3N4O2, CAS 80712-11-4
1-Piperazinecarboxamide, N-((methylamino)carbonyl)-4-(3-(trifluoromethyl)phenyl)-
CAS 80712-11-4C14H17F3N4O2
1-Piperazinecarboxamide, N-methyl-N-((methylamino)carbonyl)-4-phenyl- chemical structure, C14H20N4O2, CAS 80712-12-5
1-Piperazinecarboxamide, N-methyl-N-((methylamino)carbonyl)-4-phenyl-
CAS 80712-12-5C14H20N4O2
1-Piperazinecarboxamide, 4-(2-chlorophenyl)-N-methyl-N-((methylamino)carbonyl)- chemical structure, C14H19ClN4O2, CAS 80712-13-6
1-Piperazinecarboxamide, 4-(2-chlorophenyl)-N-methyl-N-((methylamino)carbonyl)-
CAS 80712-13-6C14H19ClN4O2
1-Piperazinecarboxamide, 4-(3-chlorophenyl)-N-methyl-N-((methylamino)carbonyl)- chemical structure, C14H19ClN4O2, CAS 80712-14-7
1-Piperazinecarboxamide, 4-(3-chlorophenyl)-N-methyl-N-((methylamino)carbonyl)-
CAS 80712-14-7C14H19ClN4O2
1-Piperazinecarboxamide, 4-(4-chlorophenyl)-N-methyl-N-((methylamino)carbonyl)- chemical structure, C14H19ClN4O2, CAS 80712-15-8
1-Piperazinecarboxamide, 4-(4-chlorophenyl)-N-methyl-N-((methylamino)carbonyl)-
CAS 80712-15-8C14H19ClN4O2
1-Piperazinecarboxamide, N-methyl-N-((methylamino)carbonyl)-4-(4-methylphenyl)- chemical structure, C15H22N4O2, CAS 80712-16-9
1-Piperazinecarboxamide, N-methyl-N-((methylamino)carbonyl)-4-(4-methylphenyl)-
CAS 80712-16-9C15H22N4O2
1-Piperazinecarboxamide, 4-(4-methoxyphenyl)-N-methyl-N-((methylamino)carbonyl)- chemical structure, C15H22N4O3, CAS 80712-17-0
1-Piperazinecarboxamide, 4-(4-methoxyphenyl)-N-methyl-N-((methylamino)carbonyl)-
CAS 80712-17-0C15H22N4O3
1-Piperazinecarboxamide, N-methyl-N-((methylamino)carbonyl)-4-(3-(trifluoromethyl)phenyl)- chemical structure, C15H19F3N4O2, CAS 80712-18-1
1-Piperazinecarboxamide, N-methyl-N-((methylamino)carbonyl)-4-(3-(trifluoromethyl)phenyl)-
CAS 80712-18-1C15H19F3N4O2