Murcko scaffold
1-Phenylpiperazine scaffold
6,403 chemicals on CompoundList share this ring system.
- Rings
- 2
- Scaffold atoms
- 12
- Chemicals
- 6,403
- With full pages
- 595
Scaffold SMILES
c1ccc(N2CCNCC2)cc1
A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.
Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.
Chemicals with this scaffold
Open one to see its structure, properties and suppliers.
Showing 1,873 to 1,920 of 6,403 chemicals
![1-(tert-Butoxy)-3-{4-[3-(trifluoromethyl)phenyl]piperazin-1-YL}propan-2-ol hydrochloride chemical structure, C18H28ClF3N2O2, CAS 1185443-98-4](/s/SGKHYEQNMDFPMN-UHFFFAOYSA-N.svg)
1-(tert-Butoxy)-3-{4-[3-(trifluoromethyl)phenyl]piperazin-1-YL}propan-2-ol hydrochloride
CAS 1185443-98-4C18H28ClF3N2O2
1-(4-(4-Methoxyphenyl)piperazin-1-yl)-3-(prop-2-yn-1-yloxy)propan-2-ol dihydrochloride
CAS 1184973-87-2C17H26Cl2N2O3
1-(4-(2-Methoxyphenyl)piperazin-1-yl)-3-(prop-2-yn-1-yloxy)propan-2-ol dihydrochloride
CAS 1185666-05-0C17H26Cl2N2O3
1-(4-(3-Chlorophenyl)piperazin-1-yl)-3-(prop-2-yn-1-yloxy)propan-2-ol hydrochloride
CAS 1185340-07-1C16H22Cl2N2O2
1-(4-(5-Chloro-2-methylphenyl)piperazin-1-yl)-3-(prop-2-yn-1-yloxy)propan-2-ol hydrochloride
CAS 1185104-75-9C17H24Cl2N2O2
1-(Prop-2-yn-1-yloxy)-3-(4-(3-(trifluoromethyl)phenyl)piperazin-1-yl)propan-2-ol hydrochloride
CAS 1185364-15-1C17H22ClF3N2O2
1-(Allyloxy)-3-(4-(4-methoxyphenyl)piperazin-1-yl)propan-2-ol dihydrochloride
CAS 1185175-19-2C17H28Cl2N2O3
1-(Allyloxy)-3-(4-(2-methoxyphenyl)piperazin-1-yl)propan-2-ol dihydrochloride
CAS 1184971-36-5C17H28Cl2N2O3
1-(Allyloxy)-3-(4-(4-fluorophenyl)piperazin-1-yl)propan-2-ol dihydrochloride
CAS 1185168-80-2C16H25Cl2FN2O2
1-(Allyloxy)-3-(4-(3-chlorophenyl)piperazin-1-yl)propan-2-ol hydrochloride
CAS 1185468-78-3C16H24Cl2N2O2
1-(Allyloxy)-3-(4-(5-chloro-2-methylphenyl)piperazin-1-yl)propan-2-ol hydrochloride
CAS 1185128-63-5C17H26Cl2N2O2
1-(Allyloxy)-3-(4-(3-(trifluoromethyl)phenyl)piperazin-1-yl)propan-2-ol hydrochloride
CAS 1185689-13-7C17H24ClF3N2O2
2,2-Dimethyl-1-phenylpiperazine
CAS 223786-43-4C12H18N2
1-(2-Chloro-5-methoxyphenyl)piperazine
CAS 180698-24-2C11H15ClN2O
5-Methyl-2-(piperazin-1-yl)phenol
CAS 180698-30-0C11H16N2O
1-(2-Methoxy-6-methylphenyl)piperazine
CAS 180698-22-0C12H18N2O
2-Methoxy-5-piperazin-1-yl-phenol
CAS 180698-25-3C11H16N2O2
![2-Methyl-4-[4-[(2-methylpropan-2-yl)oxycarbonyl]piperazin-1-yl]benzoic acid chemical structure, C17H24N2O4, CAS 196203-49-3](/s/YXKCZKVQNWMRHZ-UHFFFAOYSA-N.svg)
2-Methyl-4-[4-[(2-methylpropan-2-yl)oxycarbonyl]piperazin-1-yl]benzoic acid
CAS 196203-49-3C17H24N2O4
4-(4-(tert-Butoxycarbonyl)piperazin-1-yl)-3-methylbenzoic acid
CAS 196203-51-7C17H24N2O4
1-(3-Isopropoxyphenyl)piperazine
CAS 201676-87-1C13H20N2O
tert-Butyl 4-(3-hydroxyphenyl)piperazine-1-carboxylate
CAS 198627-86-0C15H22N2O3
1-(2,3-Dimethoxyphenyl)piperazine
CAS 103027-44-7C12H18N2O2
![Dimethyl[(2-piperazinylphenyl)methyl]amine chemical structure, C13H21N3, CAS 494783-13-0](/s/ATTCCASKRFESFD-UHFFFAOYSA-N.svg)
Dimethyl[(2-piperazinylphenyl)methyl]amine
CAS 494783-13-0C13H21N3
![N-[4-(Piperazin-1-yl)phenyl]methanesulfonamide hydrochloride chemical structure, C11H18ClN3O2S, CAS 112940-54-2](/s/XTCHLADGBZLOCT-UHFFFAOYSA-N.svg)
N-[4-(Piperazin-1-yl)phenyl]methanesulfonamide hydrochloride
CAS 112940-54-2C11H18ClN3O2S
- 2-Fluoro-4-(piperazin-1-yl)benzonitrile204192-45-0C11H12FN3
- tert-Butyl 4-(4-amino-2-chlorophenyl)piperazine-1-carboxylate193902-81-7C15H22ClN3O2
- tert-Butyl 4-(3,4-diaminophenyl)piperazine-1-carboxylate193902-99-7C15H24N4O2
- tert-Butyl 4-(2-chloro-4-nitrophenyl)piperazine-1-carboxylate193902-80-6C15H20ClN3O4
- tert-Butyl 4-(4-amino-3-(trifluoromethyl)phenyl)piperazine-1-carboxylate193902-90-8C16H22F3N3O2
- tert-Butyl 4-(4-nitro-2-(trifluoromethyl)phenyl)piperazine-1-carboxylate193902-86-2C16H20F3N3O4
- tert-Butyl 4-(4-aminophenyl)piperazine-1-carboxylate hydrochlorideC15H24ClN3O2
- Methyl 3-(piperazin-1-yl)benzoate179003-08-8C12H16N2O2
- 2-[4-(2-Chlorophenyl)piperazin-1-yl]acetic acid119357-76-5C12H15ClN2O2
- 4-Fluoro-3-(4-methylpiperazin-1-yl)aniline105377-06-8C11H16FN3
- Methyl 3,4-dimethoxy-5-(4-methyl-1-piperazinyl)benzoate148546-86-5C15H22N2O4
- 1-(But-3-yn-1-yl)-4-phenylpiperazine174266-44-5C14H18N2
- 1-(4-Methoxy-3,5-dimethylphenyl)piperazine204634-63-9C13H20N2O
- 1-Chlorocarbonyl-4-(o-fluorophenyl)piperazine177489-04-2C11H12ClFN2O
- 2-Bromo-1-[4-(2,3-dimethylphenyl)piperazin-1-yl]ethanone177489-05-3C14H19BrN2O
- 1-Chlorocarbonyl-4-(o-methoxyphenyl)piperazine177489-02-0C12H15ClN2O2
- 2-Methoxy-3-(4-methylpiperazin-1-yl)aniline148547-05-1C12H19N3O
- 1-(3-Acetoxyphenyl)piperazine180698-20-8C12H16N2O2
- 1-(2-Methoxy-5-methylphenyl)piperazine105105-33-7C12H18N2O
- 1-(5-Methoxy-2-methylphenyl)piperazine180698-23-1C12H18N2O
- 4-Fluoro-2-(piperazin-1-yl)benzonitrile182181-40-4C11H12FN3
- 3-Chloro-4-(piperazin-1-yl)benzonitrile182181-32-4C11H12ClN3
- 5-Fluoro-2-(piperazin-1-yl)benzonitrile182181-30-2C11H12FN3
- 5-Chloro-2-(piperazin-1-yl)benzonitrile182181-36-8C11H12ClN3
Only the first 1,920 are listed here. Use the substructure search to filter further.
Related scaffolds
Same ring framework with different atoms or bond orders
c1ccc(-c2ccccc2)cc11,627 chemicals
c1ccc(C2CCNCC2)cc1277 chemicals
c1ccc(C2CCCCC2)cc1274 chemicals
c1ccc(N2CCCCC2)cc1235 chemicals
c1ccc(-c2ccccn2)cc1219 chemicals
c1ccc(N2CCOCC2)cc1202 chemicals
C1=CC(c2ccccc2)C=CN1155 chemicals
c1ccc(-c2ccncc2)cc1124 chemicals
c1ccc(-c2ccccn2)nc1118 chemicals
c1ccc(N2CCNCC2)nc1112 chemicals
c1ccc(-c2ncccn2)cc1107 chemicals
c1ccc(-c2ccncn2)cc1106 chemicals