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Murcko scaffold

Ring system with 4 rings and 28 atoms

48 chemicals on CompoundList share this ring system.

Rings
4
Scaffold atoms
28
Chemicals
48
With full pages
2
Scaffold SMILES

O=C(Cn1c(=O)n(-c2ccccc2)c(=O)c2ccccc21)Nc1ccccc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=C(Cn1c(=O)n(-c2ccccc2)c(=O)c2ccccc21)Nc1ccccc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 48 of 48 chemicals

2-[3-(3,5-Dimethoxyphenyl)-2,4-dioxoquinazolin-1-yl]-N-(4-ethylphenyl)acetamide chemical structure, C26H25N3O5, CAS 896376-82-2
2-[3-(3,5-Dimethoxyphenyl)-2,4-dioxoquinazolin-1-yl]-N-(4-ethylphenyl)acetamide
CAS 896376-82-2C26H25N3O5
2-(2,4-Dioxo-3-(p-tolyl)-3,4-dihydroquinazolin-1(2H)-yl)-N-(3-methoxyphenyl)acetamide chemical structure, C24H21N3O4, CAS 899782-30-0
2-(2,4-Dioxo-3-(p-tolyl)-3,4-dihydroquinazolin-1(2H)-yl)-N-(3-methoxyphenyl)acetamide
CAS 899782-30-0C24H21N3O4
Methyl 2-(2-(2,4-dioxo-3-(p-tolyl)-3,4-dihydroquinazolin-1(2H)-yl)acetamido)benzoate chemical structure, C25H21N3O5, CAS 899782-49-1
Methyl 2-(2-(2,4-dioxo-3-(p-tolyl)-3,4-dihydroquinazolin-1(2H)-yl)acetamido)benzoate
CAS 899782-49-1C25H21N3O5
2-[3-(3,4-Dimethoxyphenyl)-2,4-dioxo-1,2,3,4-tetrahydroquinazolin-1-yl]-N-(4-methoxyphenyl)acetamide chemical structure, C25H23N3O6, CAS 899922-77-1
2-[3-(3,4-Dimethoxyphenyl)-2,4-dioxo-1,2,3,4-tetrahydroquinazolin-1-yl]-N-(4-methoxyphenyl)acetamide
CAS 899922-77-1C25H23N3O6
N-(3-Methoxyphenyl)-2-[3-(4-methoxyphenyl)-2,4-dioxo-3,4-dihydroquinazolin-1(2H)-yl]acetamide chemical structure, C24H21N3O5, CAS 899923-25-2
N-(3-Methoxyphenyl)-2-[3-(4-methoxyphenyl)-2,4-dioxo-3,4-dihydroquinazolin-1(2H)-yl]acetamide
CAS 899923-25-2C24H21N3O5
N-(4-Fluorophenyl)-2-(3-(4-methoxyphenyl)-2,4-dioxo-3,4-dihydroquinazolin-1(2H)-yl)acetamide chemical structure, C23H18FN3O4, CAS 899923-60-5
N-(4-Fluorophenyl)-2-(3-(4-methoxyphenyl)-2,4-dioxo-3,4-dihydroquinazolin-1(2H)-yl)acetamide
CAS 899923-60-5C23H18FN3O4
Methyl 2-(2-(3-(2,4-dimethoxyphenyl)-2,4-dioxo-3,4-dihydroquinazolin-1(2H)-yl)acetamido)benzoate chemical structure, C26H23N3O7, CAS 892265-87-1
Methyl 2-(2-(3-(2,4-dimethoxyphenyl)-2,4-dioxo-3,4-dihydroquinazolin-1(2H)-yl)acetamido)benzoate
CAS 892265-87-1C26H23N3O7
2-(2,4-Dioxo-3-(p-tolyl)-3,4-dihydroquinazolin-1(2H)-yl)-N-(4-ethylphenyl)acetamide chemical structure, C25H23N3O3, CAS 899782-32-2
2-(2,4-Dioxo-3-(p-tolyl)-3,4-dihydroquinazolin-1(2H)-yl)-N-(4-ethylphenyl)acetamide
CAS 899782-32-2C25H23N3O3
2-[3-(3,4-Dimethoxyphenyl)-2,4-dioxo-1,2,3,4-tetrahydroquinazolin-1-yl]-N-ethyl-N-(3-methylphenyl)acetamide chemical structure, C27H27N3O5, CAS 958563-69-4
2-[3-(3,4-Dimethoxyphenyl)-2,4-dioxo-1,2,3,4-tetrahydroquinazolin-1-yl]-N-ethyl-N-(3-methylphenyl)acetamide
CAS 958563-69-4C27H27N3O5
Methyl 2-{2-[3-(4-ethylphenyl)-2,4-dioxo-1,2,3,4-tetrahydroquinazolin-1-yl]acetamido}benzoate chemical structure, C26H23N3O5, CAS 899900-85-7
Methyl 2-{2-[3-(4-ethylphenyl)-2,4-dioxo-1,2,3,4-tetrahydroquinazolin-1-yl]acetamido}benzoate
CAS 899900-85-7C26H23N3O5
2-(3-(3,5-Dimethoxyphenyl)-2,4-dioxo-3,4-dihydroquinazolin-1(2H)-yl)-N-(2-methoxyphenyl)acetamide chemical structure, C25H23N3O6, CAS 892264-53-8
2-(3-(3,5-Dimethoxyphenyl)-2,4-dioxo-3,4-dihydroquinazolin-1(2H)-yl)-N-(2-methoxyphenyl)acetamide
CAS 892264-53-8C25H23N3O6
N-(2,5-Dimethoxyphenyl)-2-(2,4-dioxo-3-(p-tolyl)-3,4-dihydroquinazolin-1(2H)-yl)acetamide chemical structure, C25H23N3O5, CAS 899782-42-4
N-(2,5-Dimethoxyphenyl)-2-(2,4-dioxo-3-(p-tolyl)-3,4-dihydroquinazolin-1(2H)-yl)acetamide
CAS 899782-42-4C25H23N3O5
2-[2,4-Dioxo-3-(3,4,5-trimethoxyphenyl)-1,2,3,4-tetrahydroquinazolin-1-yl]-N-[4-(propan-2-yl)phenyl]acetamide chemical structure, C28H29N3O6, CAS 899900-56-2
2-[2,4-Dioxo-3-(3,4,5-trimethoxyphenyl)-1,2,3,4-tetrahydroquinazolin-1-yl]-N-[4-(propan-2-yl)phenyl]acetamide
CAS 899900-56-2C28H29N3O6
2-(2,4-Dioxo-3-(3,4,5-trimethoxyphenyl)-3,4-dihydroquinazolin-1(2H)-yl)-N-(2-methoxyphenyl)acetamide chemical structure, C26H25N3O7, CAS 892266-99-8
2-(2,4-Dioxo-3-(3,4,5-trimethoxyphenyl)-3,4-dihydroquinazolin-1(2H)-yl)-N-(2-methoxyphenyl)acetamide
CAS 892266-99-8C26H25N3O7
2-(2,4-Dioxo-3-(3,4,5-trimethoxyphenyl)-3,4-dihydroquinazolin-1(2H)-yl)-N-ethyl-N-(m-tolyl)acetamide chemical structure, C28H29N3O6, CAS 899921-85-8
2-(2,4-Dioxo-3-(3,4,5-trimethoxyphenyl)-3,4-dihydroquinazolin-1(2H)-yl)-N-ethyl-N-(m-tolyl)acetamide
CAS 899921-85-8C28H29N3O6
Methyl 2-{2-[2,4-dioxo-3-(3,4,5-trimethoxyphenyl)-1,2,3,4-tetrahydroquinazolin-1-yl]acetamido}benzoate chemical structure, C27H25N3O8, CAS 899922-03-3
Methyl 2-{2-[2,4-dioxo-3-(3,4,5-trimethoxyphenyl)-1,2,3,4-tetrahydroquinazolin-1-yl]acetamido}benzoate
CAS 899922-03-3C27H25N3O8
2-(6,7-Dimethoxy-2,4-dioxo-3-phenyl-3,4-dihydroquinazolin-1(2H)-yl)-N-(4-methylphenyl)acetamide chemical structure, C25H23N3O5, CAS 925146-75-4
2-(6,7-Dimethoxy-2,4-dioxo-3-phenyl-3,4-dihydroquinazolin-1(2H)-yl)-N-(4-methylphenyl)acetamide
CAS 925146-75-4C25H23N3O5
2-(6,7-Dimethoxy-2,4-dioxo-3-phenyl-3,4-dihydroquinazolin-1(2H)-yl)-N-(2-methylphenyl)acetamide chemical structure, C25H23N3O5, CAS 925194-18-9
2-(6,7-Dimethoxy-2,4-dioxo-3-phenyl-3,4-dihydroquinazolin-1(2H)-yl)-N-(2-methylphenyl)acetamide
CAS 925194-18-9C25H23N3O5
2-[3-(2,4-Dimethoxyphenyl)-2,4-dioxo-1,2,3,4-tetrahydroquinazolin-1-yl]-N-(3-methoxyphenyl)acetamide chemical structure, C25H23N3O6, CAS 892265-33-7
2-[3-(2,4-Dimethoxyphenyl)-2,4-dioxo-1,2,3,4-tetrahydroquinazolin-1-yl]-N-(3-methoxyphenyl)acetamide
CAS 892265-33-7C25H23N3O6
2-(2,4-Dioxo-3-(p-tolyl)-3,4-dihydroquinazolin-1(2H)-yl)-N-(p-tolyl)acetamide chemical structure, C24H21N3O3, CAS 899782-34-4
2-(2,4-Dioxo-3-(p-tolyl)-3,4-dihydroquinazolin-1(2H)-yl)-N-(p-tolyl)acetamide
CAS 899782-34-4C24H21N3O3
2-(2,4-Dioxo-3-(p-tolyl)-3,4-dihydroquinazolin-1(2H)-yl)-N-(2-methoxyphenyl)acetamide chemical structure, C24H21N3O4, CAS 899782-36-6
2-(2,4-Dioxo-3-(p-tolyl)-3,4-dihydroquinazolin-1(2H)-yl)-N-(2-methoxyphenyl)acetamide
CAS 899782-36-6C24H21N3O4
N-(4-Methoxyphenyl)-2-[3-(4-methylphenyl)-2,4-dioxo-1,2,3,4-tetrahydroquinazolin-1-yl]acetamide chemical structure, C24H21N3O4, CAS 899782-56-0
N-(4-Methoxyphenyl)-2-[3-(4-methylphenyl)-2,4-dioxo-1,2,3,4-tetrahydroquinazolin-1-yl]acetamide
CAS 899782-56-0C24H21N3O4
N-(4-Fluorophenyl)-2-[3-(4-methylphenyl)-2,4-dioxo-1,2,3,4-tetrahydroquinazolin-1-yl]acetamide chemical structure, C23H18FN3O3, CAS 899782-58-2
N-(4-Fluorophenyl)-2-[3-(4-methylphenyl)-2,4-dioxo-1,2,3,4-tetrahydroquinazolin-1-yl]acetamide
CAS 899782-58-2C23H18FN3O3
2-(2,4-Dioxo-3-(3,4,5-trimethoxyphenyl)-3,4-dihydroquinazolin-1(2H)-yl)-N-(4-ethoxyphenyl)acetamide chemical structure, C27H27N3O7, CAS 899921-72-3
2-(2,4-Dioxo-3-(3,4,5-trimethoxyphenyl)-3,4-dihydroquinazolin-1(2H)-yl)-N-(4-ethoxyphenyl)acetamide
CAS 899921-72-3C27H27N3O7