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Murcko scaffold

Ring system with 3 rings and 25 atoms

232 chemicals on CompoundList share this ring system.

Rings
3
Scaffold atoms
25
Chemicals
232
With full pages
28
Scaffold SMILES

O=C(COc1ccccc1)N(Cc1ccccc1)C1CCS(=O)(=O)C1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=C(COc1ccccc1)N(Cc1ccccc1)C1CCS(=O)(=O)C1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 48 of 232 chemicals

N-[4-(Dimethylamino)benzyl]-N-(1,1-dioxidotetrahydrothiophen-3-yl)-2-(4-methylphenoxy)acetamide chemical structure, C22H28N2O4S, CAS 620560-88-5
N-[4-(Dimethylamino)benzyl]-N-(1,1-dioxidotetrahydrothiophen-3-yl)-2-(4-methylphenoxy)acetamide
CAS 620560-88-5C22H28N2O4S
2-(4-Bromophenoxy)-N-[4-(dimethylamino)benzyl]-N-(1,1-dioxidotetrahydrothiophen-3-yl)acetamide chemical structure, C21H25BrN2O4S, CAS 577765-36-7
2-(4-Bromophenoxy)-N-[4-(dimethylamino)benzyl]-N-(1,1-dioxidotetrahydrothiophen-3-yl)acetamide
CAS 577765-36-7C21H25BrN2O4S
N-[4-(Dimethylamino)benzyl]-N-(1,1-dioxidotetrahydrothiophen-3-yl)-2-phenoxyacetamide chemical structure, C21H26N2O4S, CAS 577962-10-8
N-[4-(Dimethylamino)benzyl]-N-(1,1-dioxidotetrahydrothiophen-3-yl)-2-phenoxyacetamide
CAS 577962-10-8C21H26N2O4S
N-[4-(Dimethylamino)benzyl]-N-(1,1-dioxidotetrahydrothiophen-3-yl)-2-(4-fluorophenoxy)acetamide chemical structure, C21H25FN2O4S, CAS 620560-85-2
N-[4-(Dimethylamino)benzyl]-N-(1,1-dioxidotetrahydrothiophen-3-yl)-2-(4-fluorophenoxy)acetamide
CAS 620560-85-2C21H25FN2O4S
N-(1,1-Dioxidotetrahydrothiophen-3-yl)-2-(4-ethylphenoxy)-N-(4-methoxybenzyl)acetamide chemical structure, C22H27NO5S, CAS 577762-46-0
N-(1,1-Dioxidotetrahydrothiophen-3-yl)-2-(4-ethylphenoxy)-N-(4-methoxybenzyl)acetamide
CAS 577762-46-0C22H27NO5S
N-[(4-Chlorophenyl)methyl]-N-(1,1-dioxothiolan-3-yl)-2-(2-nitrophenoxy)acetamide chemical structure, C19H19ClN2O6S, CAS 585549-15-1
N-[(4-Chlorophenyl)methyl]-N-(1,1-dioxothiolan-3-yl)-2-(2-nitrophenoxy)acetamide
CAS 585549-15-1C19H19ClN2O6S
N-(4-(Dimethylamino)benzyl)-N-(1,1-dioxidotetrahydrothiophen-3-yl)-2-(2-methoxyphenoxy)acetamide chemical structure, C22H28N2O5S, CAS 573970-70-4
N-(4-(Dimethylamino)benzyl)-N-(1,1-dioxidotetrahydrothiophen-3-yl)-2-(2-methoxyphenoxy)acetamide
CAS 573970-70-4C22H28N2O5S
2-(4-Bromophenoxy)-N-(4-chlorobenzyl)-N-(1,1-dioxidotetrahydrothiophen-3-yl)acetamide chemical structure, C19H19BrClNO4S, CAS 578754-08-2
2-(4-Bromophenoxy)-N-(4-chlorobenzyl)-N-(1,1-dioxidotetrahydrothiophen-3-yl)acetamide
CAS 578754-08-2C19H19BrClNO4S
2-(2,4-Dichlorophenoxy)-N-(3,4-dimethoxybenzyl)-N-(1,1-dioxidotetrahydrothiophen-3-yl)acetamide chemical structure, C21H23Cl2NO6S, CAS 575459-49-3
2-(2,4-Dichlorophenoxy)-N-(3,4-dimethoxybenzyl)-N-(1,1-dioxidotetrahydrothiophen-3-yl)acetamide
CAS 575459-49-3C21H23Cl2NO6S
N-(1,1-Dioxidotetrahydrothiophen-3-yl)-2-(2-methoxyphenoxy)-N-(4-methylbenzyl)acetamide chemical structure, C21H25NO5S, CAS 848739-13-9
N-(1,1-Dioxidotetrahydrothiophen-3-yl)-2-(2-methoxyphenoxy)-N-(4-methylbenzyl)acetamide
CAS 848739-13-9C21H25NO5S
2-(2,4-Dichlorophenoxy)-N-(1,1-dioxidotetrahydrothiophen-3-yl)-N-[4-(propan-2-yl)benzyl]acetamide chemical structure, C22H25Cl2NO4S, CAS 577766-36-0
2-(2,4-Dichlorophenoxy)-N-(1,1-dioxidotetrahydrothiophen-3-yl)-N-[4-(propan-2-yl)benzyl]acetamide
CAS 577766-36-0C22H25Cl2NO4S
N-Benzyl-2-(3,4-dimethylphenoxy)-N-(1,1-dioxidotetrahydrothiophen-3-yl)propanamide chemical structure, C22H27NO4S, CAS 620555-02-4
N-Benzyl-2-(3,4-dimethylphenoxy)-N-(1,1-dioxidotetrahydrothiophen-3-yl)propanamide
CAS 620555-02-4C22H27NO4S
2-(4-Chlorophenoxy)-N-[4-(dimethylamino)benzyl]-N-(1,1-dioxidotetrahydrothiophen-3-yl)acetamide chemical structure, C21H25ClN2O4S, CAS 620560-79-4
2-(4-Chlorophenoxy)-N-[4-(dimethylamino)benzyl]-N-(1,1-dioxidotetrahydrothiophen-3-yl)acetamide
CAS 620560-79-4C21H25ClN2O4S
N-(2-Chlorobenzyl)-N-(1,1-dioxidotetrahydrothiophen-3-yl)-2-[5-methyl-2-(propan-2-yl)phenoxy]acetamide chemical structure, C23H28ClNO4S, CAS 620561-83-3
N-(2-Chlorobenzyl)-N-(1,1-dioxidotetrahydrothiophen-3-yl)-2-[5-methyl-2-(propan-2-yl)phenoxy]acetamide
CAS 620561-83-3C23H28ClNO4S
2-(4-Bromophenoxy)-N-(1,1-dioxidotetrahydrothiophen-3-yl)-N-(4-ethylbenzyl)acetamide chemical structure, C21H24BrNO4S, CAS 620562-54-1
2-(4-Bromophenoxy)-N-(1,1-dioxidotetrahydrothiophen-3-yl)-N-(4-ethylbenzyl)acetamide
CAS 620562-54-1C21H24BrNO4S
N-[4-(Dimethylamino)benzyl]-2-(2,6-dimethylphenoxy)-N-(1,1-dioxidotetrahydrothiophen-3-yl)acetamide chemical structure, C23H30N2O4S, CAS 620561-46-8
N-[4-(Dimethylamino)benzyl]-2-(2,6-dimethylphenoxy)-N-(1,1-dioxidotetrahydrothiophen-3-yl)acetamide
CAS 620561-46-8C23H30N2O4S
2-(4-Chloro-3,5-dimethylphenoxy)-N-[4-(dimethylamino)benzyl]-N-(1,1-dioxidotetrahydrothiophen-3-yl)acetamide chemical structure, C23H29ClN2O4S, CAS 575467-95-7
2-(4-Chloro-3,5-dimethylphenoxy)-N-[4-(dimethylamino)benzyl]-N-(1,1-dioxidotetrahydrothiophen-3-yl)acetamide
CAS 575467-95-7C23H29ClN2O4S
2-(4-Chlorophenoxy)-N-(1,1-dioxidotetrahydrothiophen-3-yl)-N-(4-methoxybenzyl)acetamide chemical structure, C20H22ClNO5S, CAS 573971-01-4
2-(4-Chlorophenoxy)-N-(1,1-dioxidotetrahydrothiophen-3-yl)-N-(4-methoxybenzyl)acetamide
CAS 573971-01-4C20H22ClNO5S
N-Benzyl-2-(4-chloro-2-methylphenoxy)-N-(1,1-dioxidotetrahydrothiophen-3-yl)acetamide chemical structure, C20H22ClNO4S, CAS 575459-21-1
N-Benzyl-2-(4-chloro-2-methylphenoxy)-N-(1,1-dioxidotetrahydrothiophen-3-yl)acetamide
CAS 575459-21-1C20H22ClNO4S
2-(3,4-Dimethylphenoxy)-N-(1,1-dioxothiolan-3-yl)-N-[(4-ethylphenyl)methyl]propanamide chemical structure, C24H31NO4S, CAS 579442-56-1
2-(3,4-Dimethylphenoxy)-N-(1,1-dioxothiolan-3-yl)-N-[(4-ethylphenyl)methyl]propanamide
CAS 579442-56-1C24H31NO4S
N-Benzyl-2-(4-tert-butylphenoxy)-N-(1,1-dioxidotetrahydrothiophen-3-yl)acetamide chemical structure, C23H29NO4S, CAS 573697-23-1
N-Benzyl-2-(4-tert-butylphenoxy)-N-(1,1-dioxidotetrahydrothiophen-3-yl)acetamide
CAS 573697-23-1C23H29NO4S
N-(4-Chlorobenzyl)-2-(4-chloro-2-methylphenoxy)-N-(1,1-dioxidotetrahydrothiophen-3-yl)acetamide chemical structure, C20H21Cl2NO4S, CAS 620557-95-1
N-(4-Chlorobenzyl)-2-(4-chloro-2-methylphenoxy)-N-(1,1-dioxidotetrahydrothiophen-3-yl)acetamide
CAS 620557-95-1C20H21Cl2NO4S
2-(4-Bromophenoxy)-N-(1,1-dioxidotetrahydrothiophen-3-yl)-N-(4-methoxybenzyl)acetamide chemical structure, C20H22BrNO5S, CAS 587003-75-6
2-(4-Bromophenoxy)-N-(1,1-dioxidotetrahydrothiophen-3-yl)-N-(4-methoxybenzyl)acetamide
CAS 587003-75-6C20H22BrNO5S
N-[(3-Bromophenyl)methyl]-N-(1,1-dioxothiolan-3-yl)-2-(4-methylphenoxy)acetamide chemical structure, C20H22BrNO4S, CAS 877786-35-1
N-[(3-Bromophenyl)methyl]-N-(1,1-dioxothiolan-3-yl)-2-(4-methylphenoxy)acetamide
CAS 877786-35-1C20H22BrNO4S