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Murcko scaffold

Ring system with 3 rings and 25 atoms

62 chemicals on CompoundList share this ring system.

Rings: 3
Scaffold atoms: 25
Chemicals: 62
With full pages: 8

Scaffold SMILES

O=C(C=Cc1ccccc1)N(Cc1ccccc1)C1CCS(=O)(=O)C1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold

Murcko scaffold O=C(C=Cc1ccccc1)N(Cc1ccccc1)C1CCS(=O)(=O)C1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 48 of 62 chemicals

N-[(3-Chlorophenyl)methyl]-3-(4-methoxyphenyl)-N-(tetrahydro-1,1-dioxido-3-thienyl)-2-propenamide chemical structure, C21H22ClNO4S, CAS 587006-13-1

N-[(3-Chlorophenyl)methyl]-3-(4-methoxyphenyl)-N-(tetrahydro-1,1-dioxido-3-thienyl)-2-propenamide

CAS 587006-13-1C₂₁H₂₂ClNO₄S

(2E)-N-(4-Chlorobenzyl)-N-(1,1-dioxidotetrahydrothiophen-3-yl)-3-phenylprop-2-enamide chemical structure, C20H20ClNO3S, CAS 620557-16-6

(2E)-N-(4-Chlorobenzyl)-N-(1,1-dioxidotetrahydrothiophen-3-yl)-3-phenylprop-2-enamide

CAS 620557-16-6C₂₀H₂₀ClNO₃S

(2E)-3-(2-Chlorophenyl)-N-[4-(dimethylamino)benzyl]-N-(1,1-dioxidotetrahydrothiophen-3-yl)prop-2-enamide chemical structure, C22H25ClN2O3S, CAS 620561-08-2

(2E)-3-(2-Chlorophenyl)-N-[4-(dimethylamino)benzyl]-N-(1,1-dioxidotetrahydrothiophen-3-yl)prop-2-enamide

CAS 620561-08-2C₂₂H₂₅ClN₂O₃S

(2E)-3-(4-Chlorophenyl)-N-[4-(dimethylamino)benzyl]-N-(1,1-dioxidotetrahydrothiophen-3-yl)prop-2-enamide chemical structure, C22H25ClN2O3S, CAS 577999-87-2

(2E)-3-(4-Chlorophenyl)-N-[4-(dimethylamino)benzyl]-N-(1,1-dioxidotetrahydrothiophen-3-yl)prop-2-enamide

CAS 577999-87-2C₂₂H₂₅ClN₂O₃S

(2E)-N-(1,1-Dioxidotetrahydrothiophen-3-yl)-N-(4-methoxybenzyl)-3-phenylprop-2-enamide chemical structure, C21H23NO4S, CAS 587005-06-9

(2E)-N-(1,1-Dioxidotetrahydrothiophen-3-yl)-N-(4-methoxybenzyl)-3-phenylprop-2-enamide

CAS 587005-06-9C₂₁H₂₃NO₄S

(2E)-N-(4-Chlorobenzyl)-3-(2,4-dichlorophenyl)-N-(1,1-dioxidotetrahydrothiophen-3-yl)prop-2-enamide chemical structure, C20H18Cl3NO3S, CAS 1164464-53-2

(2E)-N-(4-Chlorobenzyl)-3-(2,4-dichlorophenyl)-N-(1,1-dioxidotetrahydrothiophen-3-yl)prop-2-enamide

CAS 1164464-53-2C₂₀H₁₈Cl₃NO₃S

(2E)-3-(2-Chlorophenyl)-N-(3,4-dimethoxybenzyl)-N-(1,1-dioxidotetrahydrothiophen-3-yl)prop-2-enamide chemical structure, C22H24ClNO5S, CAS 620557-25-7

(2E)-3-(2-Chlorophenyl)-N-(3,4-dimethoxybenzyl)-N-(1,1-dioxidotetrahydrothiophen-3-yl)prop-2-enamide

CAS 620557-25-7C₂₂H₂₄ClNO₅S

(2E)-N-(2-Chlorobenzyl)-3-(2,4-dichlorophenyl)-N-(1,1-dioxidotetrahydrothiophen-3-yl)prop-2-enamide chemical structure, C20H18Cl3NO3S, CAS 587009-94-7

(2E)-N-(2-Chlorobenzyl)-3-(2,4-dichlorophenyl)-N-(1,1-dioxidotetrahydrothiophen-3-yl)prop-2-enamide

CAS 587009-94-7C₂₀H₁₈Cl₃NO₃S

(2E)-N-[4-(Diethylamino)benzyl]-N-(1,1-dioxidotetrahydrothiophen-3-yl)-3-(4-methoxyphenyl)prop-2-enamide chemical structure, C25H32N2O4S, CAS 847247-05-6

(2E)-N-[4-(Diethylamino)benzyl]-N-(1,1-dioxidotetrahydrothiophen-3-yl)-3-(4-methoxyphenyl)prop-2-enamide

CAS 847247-05-6C₂₅H₃₂N₂O₄S

(2E)-3-(4-tert-Butylphenyl)-N-(3-chlorobenzyl)-N-(1,1-dioxidotetrahydrothiophen-3-yl)prop-2-enamide chemical structure, C24H28ClNO3S, CAS 573972-55-1

(2E)-3-(4-tert-Butylphenyl)-N-(3-chlorobenzyl)-N-(1,1-dioxidotetrahydrothiophen-3-yl)prop-2-enamide

CAS 573972-55-1C₂₄H₂₈ClNO₃S

(2E)-N-(2-Chlorobenzyl)-3-(2-chlorophenyl)-N-(1,1-dioxidotetrahydrothiophen-3-yl)prop-2-enamide chemical structure, C20H19Cl2NO3S, CAS 586999-78-2

(2E)-N-(2-Chlorobenzyl)-3-(2-chlorophenyl)-N-(1,1-dioxidotetrahydrothiophen-3-yl)prop-2-enamide

CAS 586999-78-2C₂₀H₁₉Cl₂NO₃S

(2E)-3-(2,4-Dichlorophenyl)-N-(1,1-dioxidotetrahydrothiophen-3-yl)-N-[4-(propan-2-yl)benzyl]prop-2-enamide chemical structure, C23H25Cl2NO3S, CAS 585550-35-2

(2E)-3-(2,4-Dichlorophenyl)-N-(1,1-dioxidotetrahydrothiophen-3-yl)-N-[4-(propan-2-yl)benzyl]prop-2-enamide

CAS 585550-35-2C₂₃H₂₅Cl₂NO₃S

(2E)-N-(3-Bromobenzyl)-N-(1,1-dioxidotetrahydrothiophen-3-yl)-3-(4-methoxyphenyl)prop-2-enamide chemical structure, C21H22BrNO4S, CAS 877783-28-3

(2E)-N-(3-Bromobenzyl)-N-(1,1-dioxidotetrahydrothiophen-3-yl)-3-(4-methoxyphenyl)prop-2-enamide

CAS 877783-28-3C₂₁H₂₂BrNO₄S

(2E)-3-(4-tert-Butylphenyl)-N-[4-(dimethylamino)benzyl]-N-(1,1-dioxidotetrahydrothiophen-3-yl)prop-2-enamide chemical structure, C26H34N2O3S, CAS 620561-25-3

(2E)-3-(4-tert-Butylphenyl)-N-[4-(dimethylamino)benzyl]-N-(1,1-dioxidotetrahydrothiophen-3-yl)prop-2-enamide

CAS 620561-25-3C₂₆H₃₄N₂O₃S

(2E)-N-(1,1-Dioxidotetrahydrothiophen-3-yl)-N-(4-ethylbenzyl)-3-(4-methylphenyl)prop-2-enamide chemical structure, C23H27NO3S, CAS 620562-86-9

(2E)-N-(1,1-Dioxidotetrahydrothiophen-3-yl)-N-(4-ethylbenzyl)-3-(4-methylphenyl)prop-2-enamide

CAS 620562-86-9C₂₃H₂₇NO₃S

(2E)-N-Benzyl-3-(2-chlorophenyl)-N-(1,1-dioxidotetrahydrothiophen-3-yl)prop-2-enamide chemical structure, C20H20ClNO3S, CAS 1164451-72-2

(2E)-N-Benzyl-3-(2-chlorophenyl)-N-(1,1-dioxidotetrahydrothiophen-3-yl)prop-2-enamide

CAS 1164451-72-2C₂₀H₂₀ClNO₃S

(2E)-N-(4-Chlorobenzyl)-N-(1,1-dioxidotetrahydrothiophen-3-yl)-3-(4-methylphenyl)prop-2-enamide chemical structure, C21H22ClNO3S, CAS 620557-12-2

(2E)-N-(4-Chlorobenzyl)-N-(1,1-dioxidotetrahydrothiophen-3-yl)-3-(4-methylphenyl)prop-2-enamide

CAS 620557-12-2C₂₁H₂₂ClNO₃S

(2E)-N-(1,1-Dioxidotetrahydrothiophen-3-yl)-3-(4-methylphenyl)-N-[4-(propan-2-yl)benzyl]prop-2-enamide chemical structure, C24H29NO3S, CAS 577790-91-1

(2E)-N-(1,1-Dioxidotetrahydrothiophen-3-yl)-3-(4-methylphenyl)-N-[4-(propan-2-yl)benzyl]prop-2-enamide

CAS 577790-91-1C₂₄H₂₉NO₃S

(2E)-N-(3-Bromobenzyl)-N-(1,1-dioxidotetrahydrothiophen-3-yl)-3-(4-methylphenyl)prop-2-enamide chemical structure, C21H22BrNO3S, CAS 850744-60-4

(2E)-N-(3-Bromobenzyl)-N-(1,1-dioxidotetrahydrothiophen-3-yl)-3-(4-methylphenyl)prop-2-enamide

CAS 850744-60-4C₂₁H₂₂BrNO₃S

(2E)-3-(4-tert-Butylphenyl)-N-(1,1-dioxidotetrahydrothiophen-3-yl)-N-[4-(propan-2-yl)benzyl]prop-2-enamide chemical structure, C27H35NO3S, CAS 620558-90-9

(2E)-3-(4-tert-Butylphenyl)-N-(1,1-dioxidotetrahydrothiophen-3-yl)-N-[4-(propan-2-yl)benzyl]prop-2-enamide

CAS 620558-90-9C₂₇H₃₅NO₃S

(2E)-N-(3-Chlorobenzyl)-N-(1,1-dioxidotetrahydrothiophen-3-yl)-3-phenylprop-2-enamide chemical structure, C20H20ClNO3S, CAS 620558-81-8

(2E)-N-(3-Chlorobenzyl)-N-(1,1-dioxidotetrahydrothiophen-3-yl)-3-phenylprop-2-enamide

CAS 620558-81-8C₂₀H₂₀ClNO₃S

(2E)-N-(1,1-Dioxidotetrahydrothiophen-3-yl)-N-(4-methoxybenzyl)-3-(4-methylphenyl)prop-2-enamide chemical structure, C22H25NO4S, CAS 573948-78-4

(2E)-N-(1,1-Dioxidotetrahydrothiophen-3-yl)-N-(4-methoxybenzyl)-3-(4-methylphenyl)prop-2-enamide

CAS 573948-78-4C₂₂H₂₅NO₄S

(2E)-3-(4-Chlorophenyl)-N-(1,1-dioxidotetrahydrothiophen-3-yl)-N-(4-ethylbenzyl)prop-2-enamide chemical structure, C22H24ClNO3S, CAS 620562-82-5

(2E)-3-(4-Chlorophenyl)-N-(1,1-dioxidotetrahydrothiophen-3-yl)-N-(4-ethylbenzyl)prop-2-enamide

CAS 620562-82-5C₂₂H₂₄ClNO₃S

(2E)-N-(1,1-Dioxidotetrahydrothiophen-3-yl)-N-(4-ethylbenzyl)-3-(4-methoxyphenyl)prop-2-enamide chemical structure, C23H27NO4S, CAS 620563-25-9

(2E)-N-(1,1-Dioxidotetrahydrothiophen-3-yl)-N-(4-ethylbenzyl)-3-(4-methoxyphenyl)prop-2-enamide

CAS 620563-25-9C₂₃H₂₇NO₄S