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Murcko scaffold

Ring system with 3 rings and 19 atoms

10 chemicals on CompoundList share this ring system.

Rings
3
Scaffold atoms
19
Chemicals
10
With full pages
1
Scaffold SMILES

O=C(c1ccccc1)N1CCN(c2nccs2)CC1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=C(c1ccccc1)N1CCN(c2nccs2)CC1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 10 of 10 chemicals

Ketone, 4-(2-thiazolyl)piperazinyl 3,4,5-trimethoxyphenyl chemical structure, C17H21N3O4S, CAS 17766-79-9
Ketone, 4-(2-thiazolyl)piperazinyl 3,4,5-trimethoxyphenyl
CAS 17766-79-9C17H21N3O4S
MF-152 chemical structure, C16H15F3N4O2S, CAS 916888-66-9
MF-152
CAS 916888-66-9C16H15F3N4O2S
1-(4-Chlorobenzoyl)-4-(1,3-thiazol-2-yl)piperazine chemical structure, C14H14ClN3OS, CAS 949740-21-0
1-(4-Chlorobenzoyl)-4-(1,3-thiazol-2-yl)piperazine
CAS 949740-21-0C14H14ClN3OS
1-(3-Bromobenzoyl)-4-(1,3-thiazol-2-yl)piperazine chemical structure, C14H14BrN3OS, CAS 1007729-18-1
1-(3-Bromobenzoyl)-4-(1,3-thiazol-2-yl)piperazine
CAS 1007729-18-1C14H14BrN3OS
2-(4-(2-(Trifluoromethyl)benzoyl)piperazin-1-yl)thiazole-5-carboxylic acid chemical structure, C16H14F3N3O3S, CAS 916888-64-7
2-(4-(2-(Trifluoromethyl)benzoyl)piperazin-1-yl)thiazole-5-carboxylic acid
CAS 916888-64-7C16H14F3N3O3S
N-Methyl-2-(4-(2-(trifluoromethyl)benzoyl)piperazin-1-yl)thiazole-5-carboxamide chemical structure, C17H17F3N4O2S, CAS 916888-65-8
N-Methyl-2-(4-(2-(trifluoromethyl)benzoyl)piperazin-1-yl)thiazole-5-carboxamide
CAS 916888-65-8C17H17F3N4O2S
1-(1,3-Thiazol-2-yl)-4-[2-(trifluoromethyl)benzoyl]piperazine chemical structure, C15H14F3N3OS, CAS 916888-69-2
1-(1,3-Thiazol-2-yl)-4-[2-(trifluoromethyl)benzoyl]piperazine
CAS 916888-69-2C15H14F3N3OS
Methyl 2-(4-(2-(trifluoromethyl)benzoyl)piperazin-1-yl)thiazole-5-carboxylate chemical structure, C17H16F3N3O3S, CAS 881384-32-3
Methyl 2-(4-(2-(trifluoromethyl)benzoyl)piperazin-1-yl)thiazole-5-carboxylate
CAS 881384-32-3C17H16F3N3O3S
2-{4-[2-(Trifluoromethyl)benzoyl]piperazin-1-yl}-1,3-thiazole-5-carbonitrile chemical structure, C16H13F3N4OS, CAS 916888-82-9
2-{4-[2-(Trifluoromethyl)benzoyl]piperazin-1-yl}-1,3-thiazole-5-carbonitrile
CAS 916888-82-9C16H13F3N4OS
N-({4-[3-Methyl-4-(4-methyl-1,3-thiazol-2-yl)piperazine-1-carbonyl]phenyl}methyl)prop-2-enamide chemical structure, C20H24N4O2S, CAS 2201046-93-5
N-({4-[3-Methyl-4-(4-methyl-1,3-thiazol-2-yl)piperazine-1-carbonyl]phenyl}methyl)prop-2-enamide
CAS 2201046-93-5C20H24N4O2S