Murcko scaffold
(4-(Benzo[d]thiazol-2-yl)piperazin-1-yl)(thiophen-2-yl)methanone scaffold
60 chemicals on CompoundList share this ring system.
- Rings
- 4
- Scaffold atoms
- 22
- Chemicals
- 60
- With full pages
- 7
Scaffold SMILES
O=C(c1cccs1)N1CCN(c2nc3ccccc3s2)CC1
A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.
Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.
Chemicals with this scaffold
Open one to see its structure, properties and suppliers.
Showing 1 to 48 of 60 chemicals
![(4-(Benzo[d]thiazol-2-yl)piperazin-1-yl)(5-bromothiophen-2-yl)methanone chemical structure, C16H14BrN3OS2, CAS 681159-84-2](/s/QOARUNAMVBTOSV-UHFFFAOYSA-N.svg)
(4-(Benzo[d]thiazol-2-yl)piperazin-1-yl)(5-bromothiophen-2-yl)methanone
CAS 681159-84-2C16H14BrN3OS2
![(4-(Benzo[d]thiazol-2-yl)piperazin-1-yl)(5-chlorothiophen-2-yl)methanone chemical structure, C16H14ClN3OS2, CAS 681159-90-0](/s/KWSWBTQEYVUUNE-UHFFFAOYSA-N.svg)
(4-(Benzo[d]thiazol-2-yl)piperazin-1-yl)(5-chlorothiophen-2-yl)methanone
CAS 681159-90-0C16H14ClN3OS2
![(4-(Benzo[d]thiazol-2-yl)piperazin-1-yl)(thiophen-2-yl)methanone chemical structure, C16H15N3OS2, CAS 681157-85-7](/s/ZOTKPMMFQUYABS-UHFFFAOYSA-N.svg)
(4-(Benzo[d]thiazol-2-yl)piperazin-1-yl)(thiophen-2-yl)methanone
CAS 681157-85-7C16H15N3OS2
![(4-(6-Ethylbenzo[d]thiazol-2-yl)piperazin-1-yl)(5-nitrothiophen-2-yl)methanone chemical structure, C18H18N4O3S2, CAS 897467-84-4](/s/PKVIMVHXDLNFIT-UHFFFAOYSA-N.svg)
(4-(6-Ethylbenzo[d]thiazol-2-yl)piperazin-1-yl)(5-nitrothiophen-2-yl)methanone
CAS 897467-84-4C18H18N4O3S2
![(4-(6-Methoxybenzo[d]thiazol-2-yl)piperazin-1-yl)(thiophen-2-yl)methanone chemical structure, C17H17N3O2S2, CAS 897468-61-0](/s/GGIHJPQICYCQHM-UHFFFAOYSA-N.svg)
(4-(6-Methoxybenzo[d]thiazol-2-yl)piperazin-1-yl)(thiophen-2-yl)methanone
CAS 897468-61-0C17H17N3O2S2
![(4-(6-Ethoxybenzo[d]thiazol-2-yl)piperazin-1-yl)(thiophen-2-yl)methanone chemical structure, C18H19N3O2S2, CAS 897469-91-9](/s/WOXPFFOYOMJTLD-UHFFFAOYSA-N.svg)
(4-(6-Ethoxybenzo[d]thiazol-2-yl)piperazin-1-yl)(thiophen-2-yl)methanone
CAS 897469-91-9C18H19N3O2S2
![(4-(6-Fluorobenzo[d]thiazol-2-yl)piperazin-1-yl)(thiophen-2-yl)methanone chemical structure, C16H14FN3OS2, CAS 897472-17-2](/s/QEHJDQTYTQIXAC-UHFFFAOYSA-N.svg)
(4-(6-Fluorobenzo[d]thiazol-2-yl)piperazin-1-yl)(thiophen-2-yl)methanone
CAS 897472-17-2C16H14FN3OS2
![(4-(4-Ethoxybenzo[d]thiazol-2-yl)piperazin-1-yl)(thiophen-2-yl)methanone chemical structure, C18H19N3O2S2, CAS 897478-61-4](/s/SRLFCOLJUIRGMS-UHFFFAOYSA-N.svg)
(4-(4-Ethoxybenzo[d]thiazol-2-yl)piperazin-1-yl)(thiophen-2-yl)methanone
CAS 897478-61-4C18H19N3O2S2
![(4-(4-Chlorobenzo[d]thiazol-2-yl)piperazin-1-yl)(thiophen-2-yl)methanone chemical structure, C16H14ClN3OS2, CAS 897479-74-2](/s/IXUISAVVJGBYEV-UHFFFAOYSA-N.svg)
(4-(4-Chlorobenzo[d]thiazol-2-yl)piperazin-1-yl)(thiophen-2-yl)methanone
CAS 897479-74-2C16H14ClN3OS2
![(4-(4-Fluorobenzo[d]thiazol-2-yl)piperazin-1-yl)(thiophen-2-yl)methanone chemical structure, C16H14FN3OS2, CAS 897480-84-1](/s/YDVISZCVKXRUNW-UHFFFAOYSA-N.svg)
(4-(4-Fluorobenzo[d]thiazol-2-yl)piperazin-1-yl)(thiophen-2-yl)methanone
CAS 897480-84-1C16H14FN3OS2
![(4-(4,7-Dimethylbenzo[d]thiazol-2-yl)piperazin-1-yl)(5-nitrothiophen-2-yl)methanone chemical structure, C18H18N4O3S2, CAS 897484-80-9](/s/ZIRMICHOJRMNGU-UHFFFAOYSA-N.svg)
(4-(4,7-Dimethylbenzo[d]thiazol-2-yl)piperazin-1-yl)(5-nitrothiophen-2-yl)methanone
CAS 897484-80-9C18H18N4O3S2
![(4-(4-Methoxy-7-methylbenzo[d]thiazol-2-yl)piperazin-1-yl)(thiophen-2-yl)methanone chemical structure, C18H19N3O2S2, CAS 897486-92-9](/s/JFTAOPJWERFFFT-UHFFFAOYSA-N.svg)
(4-(4-Methoxy-7-methylbenzo[d]thiazol-2-yl)piperazin-1-yl)(thiophen-2-yl)methanone
CAS 897486-92-9C18H19N3O2S2
![(4-(4,5-Dimethylbenzo[d]thiazol-2-yl)piperazin-1-yl)(thiophen-2-yl)methanone chemical structure, C18H19N3OS2, CAS 898351-21-8](/s/QXXWHWORMLYYNX-UHFFFAOYSA-N.svg)
(4-(4,5-Dimethylbenzo[d]thiazol-2-yl)piperazin-1-yl)(thiophen-2-yl)methanone
CAS 898351-21-8C18H19N3OS2
![(4-(4,5-Dimethylbenzo[d]thiazol-2-yl)piperazin-1-yl)(5-nitrothiophen-2-yl)methanone chemical structure, C18H18N4O3S2, CAS 898351-29-6](/s/WVJMDUNOBDCCIW-UHFFFAOYSA-N.svg)
(4-(4,5-Dimethylbenzo[d]thiazol-2-yl)piperazin-1-yl)(5-nitrothiophen-2-yl)methanone
CAS 898351-29-6C18H18N4O3S2
![(5-Chlorothiophen-2-yl)(4-(4,5-dimethylbenzo[d]thiazol-2-yl)piperazin-1-yl)methanone chemical structure, C18H18ClN3OS2, CAS 898351-35-4](/s/DTVOVIVGRFCHLL-UHFFFAOYSA-N.svg)
(5-Chlorothiophen-2-yl)(4-(4,5-dimethylbenzo[d]thiazol-2-yl)piperazin-1-yl)methanone
CAS 898351-35-4C18H18ClN3OS2
![(4-(5-Chloro-4-methylbenzo[d]thiazol-2-yl)piperazin-1-yl)(thiophen-2-yl)methanone chemical structure, C17H16ClN3OS2, CAS 886918-11-2](/s/CPACWCQBJHMNMB-UHFFFAOYSA-N.svg)
(4-(5-Chloro-4-methylbenzo[d]thiazol-2-yl)piperazin-1-yl)(thiophen-2-yl)methanone
CAS 886918-11-2C17H16ClN3OS2
![(5-Chlorothiophen-2-yl)(4-(6-methylbenzo[d]thiazol-2-yl)piperazin-1-yl)methanone chemical structure, C17H16ClN3OS2, CAS 897466-55-6](/s/RIGADFYMYMCMJO-UHFFFAOYSA-N.svg)
(5-Chlorothiophen-2-yl)(4-(6-methylbenzo[d]thiazol-2-yl)piperazin-1-yl)methanone
CAS 897466-55-6C17H16ClN3OS2
![(5-Chlorothiophen-2-yl)(4-(6-ethylbenzo[d]thiazol-2-yl)piperazin-1-yl)methanone chemical structure, C18H18ClN3OS2, CAS 897467-98-0](/s/BWONALBPALRWBZ-UHFFFAOYSA-N.svg)
(5-Chlorothiophen-2-yl)(4-(6-ethylbenzo[d]thiazol-2-yl)piperazin-1-yl)methanone
CAS 897467-98-0C18H18ClN3OS2
![(5-Chlorothiophen-2-yl)(4-(6-methoxybenzo[d]thiazol-2-yl)piperazin-1-yl)methanone chemical structure, C17H16ClN3O2S2, CAS 897468-93-8](/s/LIMBFBHJVFHIJT-UHFFFAOYSA-N.svg)
(5-Chlorothiophen-2-yl)(4-(6-methoxybenzo[d]thiazol-2-yl)piperazin-1-yl)methanone
CAS 897468-93-8C17H16ClN3O2S2
![(5-Chlorothiophen-2-yl)(4-(6-ethoxybenzo[d]thiazol-2-yl)piperazin-1-yl)methanone chemical structure, C18H18ClN3O2S2, CAS 897470-19-8](/s/RRLLDMWVTDOWNE-UHFFFAOYSA-N.svg)
(5-Chlorothiophen-2-yl)(4-(6-ethoxybenzo[d]thiazol-2-yl)piperazin-1-yl)methanone
CAS 897470-19-8C18H18ClN3O2S2
![(4-(6-Chlorobenzo[d]thiazol-2-yl)piperazin-1-yl)(5-chlorothiophen-2-yl)methanone chemical structure, C16H13Cl2N3OS2, CAS 897471-30-6](/s/BEXQKLBSRPLGCE-UHFFFAOYSA-N.svg)
(4-(6-Chlorobenzo[d]thiazol-2-yl)piperazin-1-yl)(5-chlorothiophen-2-yl)methanone
CAS 897471-30-6C16H13Cl2N3OS2
![(5-Chlorothiophen-2-yl)(4-(6-fluorobenzo[d]thiazol-2-yl)piperazin-1-yl)methanone chemical structure, C16H13ClFN3OS2, CAS 897472-53-6](/s/SWGWKHBOVDDAEH-UHFFFAOYSA-N.svg)
(5-Chlorothiophen-2-yl)(4-(6-fluorobenzo[d]thiazol-2-yl)piperazin-1-yl)methanone
CAS 897472-53-6C16H13ClFN3OS2
![(4-(6-Nitrobenzo[d]thiazol-2-yl)piperazin-1-yl)(thiophen-2-yl)methanone chemical structure, C16H14N4O3S2, CAS 897473-90-4](/s/PCTKJMLHXDBDDW-UHFFFAOYSA-N.svg)
(4-(6-Nitrobenzo[d]thiazol-2-yl)piperazin-1-yl)(thiophen-2-yl)methanone
CAS 897473-90-4C16H14N4O3S2
![(5-Chlorothiophen-2-yl)(4-(6-nitrobenzo[d]thiazol-2-yl)piperazin-1-yl)methanone chemical structure, C16H13ClN4O3S2, CAS 897474-16-7](/s/DCJFVGWEXGIDMP-UHFFFAOYSA-N.svg)
(5-Chlorothiophen-2-yl)(4-(6-nitrobenzo[d]thiazol-2-yl)piperazin-1-yl)methanone
CAS 897474-16-7C16H13ClN4O3S2
- (4-(4-Methylbenzo[d]thiazol-2-yl)piperazin-1-yl)(thiophen-2-yl)methanone897474-89-4C17H17N3OS2
- (5-Chlorothiophen-2-yl)(4-(4-methylbenzo[d]thiazol-2-yl)piperazin-1-yl)methanone897475-23-9C17H16ClN3OS2
- (5-Chlorothiophen-2-yl)(4-(4-ethylbenzo[d]thiazol-2-yl)piperazin-1-yl)methanone897476-58-3C18H18ClN3OS2
- (4-(4-Methoxybenzo[d]thiazol-2-yl)piperazin-1-yl)(thiophen-2-yl)methanone897477-21-3C17H17N3O2S2
- (5-Chlorothiophen-2-yl)(4-(4-methoxybenzo[d]thiazol-2-yl)piperazin-1-yl)methanone897477-53-1C17H16ClN3O2S2
- (5-Chlorothiophen-2-yl)(4-(4-ethoxybenzo[d]thiazol-2-yl)piperazin-1-yl)methanone897478-91-0C18H18ClN3O2S2
- (4-(4-Chlorobenzo[d]thiazol-2-yl)piperazin-1-yl)(5-chlorothiophen-2-yl)methanone897479-02-6C16H13Cl2N3OS2
- (5-Chlorothiophen-2-yl)(4-(4-fluorobenzo[d]thiazol-2-yl)piperazin-1-yl)methanone897480-27-2C16H13ClFN3OS2
- (4-(4,6-Difluorobenzo[d]thiazol-2-yl)piperazin-1-yl)(thiophen-2-yl)methanone897481-24-2C16H13F2N3OS2
- (5-Chlorothiophen-2-yl)(4-(4,6-difluorobenzo[d]thiazol-2-yl)piperazin-1-yl)methanone897481-56-0C16H12ClF2N3OS2
- (5-Chlorothiophen-2-yl)(4-(5,7-dimethylbenzo[d]thiazol-2-yl)piperazin-1-yl)methanone897482-75-6C18H18ClN3OS2
- (4-(4,6-Dimethylbenzo[d]thiazol-2-yl)piperazin-1-yl)(thiophen-2-yl)methanone897483-44-2C18H19N3OS2
- (5-Chlorothiophen-2-yl)(4-(4,6-dimethylbenzo[d]thiazol-2-yl)piperazin-1-yl)methanone897483-74-8C18H18ClN3OS2
- (5-Chlorothiophen-2-yl)(4-(4,7-dimethylbenzo[d]thiazol-2-yl)piperazin-1-yl)methanone897484-94-5C18H18ClN3OS2
- (4-(7-Chloro-4-methylbenzo[d]thiazol-2-yl)piperazin-1-yl)(5-chlorothiophen-2-yl)methanone897488-31-2C17H15Cl2N3OS2
- (4-(7-Chloro-4-methoxybenzo[d]thiazol-2-yl)piperazin-1-yl)(thiophen-2-yl)methanone886952-77-8C17H16ClN3O2S2
- (4-(5,6-Dimethylbenzo[d]thiazol-2-yl)piperazin-1-yl)(thiophen-2-yl)methanone899748-82-4C18H19N3OS2
- (4-(4-(Methylsulfonyl)benzo[d]thiazol-2-yl)piperazin-1-yl)(thiophen-2-yl)methanone941918-63-4C17H17N3O3S3
- (4-(6-(Methylsulfonyl)benzo[d]thiazol-2-yl)piperazin-1-yl)(thiophen-2-yl)methanone941962-08-9C17H17N3O3S3
- (5-Chlorothiophen-2-yl)(4-(4-(methylsulfonyl)benzo[d]thiazol-2-yl)piperazin-1-yl)methanone941918-65-6C17H16ClN3O3S3
- (5-Chlorothiophen-2-yl)(4-(6-(methylsulfonyl)benzo[d]thiazol-2-yl)piperazin-1-yl)methanone941981-63-1C17H16ClN3O3S3
- (5-Bromothiophen-2-yl)(4-(6-methylbenzo[d]thiazol-2-yl)piperazin-1-yl)methanone897466-53-4C17H16BrN3OS2
- (5-Bromothiophen-2-yl)(4-(6-fluorobenzo[d]thiazol-2-yl)piperazin-1-yl)methanone897472-51-4C16H13BrFN3OS2
- (4-(6-Bromobenzo[d]thiazol-2-yl)piperazin-1-yl)(5-chlorothiophen-2-yl)methanone897473-63-1C16H13BrClN3OS2
Related scaffolds
Same ring framework with different atoms or bond orders
![Scaffold O=C(c1ccco1)N1CCC(c2nc3ccccc3[nH]2)CC1](/scaffold/QUYWRZIARFYNPV-UHFFFAOYSA-N/structure.svg)
