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Murcko scaffold

4-(1H-Benzimidazol-2-yl)-1-benzylpyrrolidin-2-one scaffold

32 chemicals on CompoundList share this ring system.

Rings
4
Scaffold atoms
22
Chemicals
32
With full pages
3
Scaffold SMILES

O=C1CC(c2nc3ccccc3[nH]2)CN1Cc1ccccc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffoldOpen the 4-(1H-Benzimidazol-2-yl)-1-benzylpyrrolidin-2-one page
Murcko scaffold O=C1CC(c2nc3ccccc3[nH]2)CN1Cc1ccccc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 32 of 32 chemicals

1-Benzyl-4-(1-ethyl-1H-1,3-benzodiazol-2-yl)pyrrolidin-2-one chemical structure, C20H21N3O, CAS 847396-34-3
1-Benzyl-4-(1-ethyl-1H-1,3-benzodiazol-2-yl)pyrrolidin-2-one
CAS 847396-34-3C20H21N3O
4-(1H-Benzimidazol-2-yl)-1-benzylpyrrolidin-2-one chemical structure, C18H17N3O, CAS 847396-32-1
4-(1H-Benzimidazol-2-yl)-1-benzylpyrrolidin-2-one
CAS 847396-32-1C18H17N3O
4-[1-(Methylethyl)benzimidazol-2-yl]-1-benzylpyrrolidin-2-one chemical structure, C21H23N3O, CAS 872347-73-4
4-[1-(Methylethyl)benzimidazol-2-yl]-1-benzylpyrrolidin-2-one
CAS 872347-73-4C21H23N3O
1-Benzyl-4-(1-propylbenzimidazol-2-yl)pyrrolidin-2-one chemical structure, C21H23N3O, CAS 847396-35-4
1-Benzyl-4-(1-propylbenzimidazol-2-yl)pyrrolidin-2-one
CAS 847396-35-4C21H23N3O
4-(1-Allyl-1H-benzo[d]imidazol-2-yl)-1-benzylpyrrolidin-2-one chemical structure, C21H21N3O, CAS 847396-36-5
4-(1-Allyl-1H-benzo[d]imidazol-2-yl)-1-benzylpyrrolidin-2-one
CAS 847396-36-5C21H21N3O
1-Benzyl-4-(1-(2-methylallyl)-1H-benzo[d]imidazol-2-yl)pyrrolidin-2-one chemical structure, C22H23N3O, CAS 847396-37-6
1-Benzyl-4-(1-(2-methylallyl)-1H-benzo[d]imidazol-2-yl)pyrrolidin-2-one
CAS 847396-37-6C22H23N3O
1-Benzyl-4-[1-(3-methylbutyl)-1H-1,3-benzodiazol-2-yl]pyrrolidin-2-one chemical structure, C23H27N3O, CAS 847396-39-8
1-Benzyl-4-[1-(3-methylbutyl)-1H-1,3-benzodiazol-2-yl]pyrrolidin-2-one
CAS 847396-39-8C23H27N3O
1-Benzyl-4-(1-prop-2-ynylbenzimidazol-2-yl)pyrrolidin-2-one chemical structure, C21H19N3O, CAS 847396-67-2
1-Benzyl-4-(1-prop-2-ynylbenzimidazol-2-yl)pyrrolidin-2-one
CAS 847396-67-2C21H19N3O
Ethyl 2-{2-[5-oxo-1-benzylpyrrolidin-3-yl]benzimidazolyl}acetate chemical structure, C22H23N3O3, CAS 887347-87-7
Ethyl 2-{2-[5-oxo-1-benzylpyrrolidin-3-yl]benzimidazolyl}acetate
CAS 887347-87-7C22H23N3O3
2-Pyrrolidinone, 1-[(4-fluorophenyl)methyl]-4-[1-(2-propynyl)-1H-1,3-benzimidazol-2-yl]- chemical structure, C21H18FN3O, CAS 887348-02-9
2-Pyrrolidinone, 1-[(4-fluorophenyl)methyl]-4-[1-(2-propynyl)-1H-1,3-benzimidazol-2-yl]-
CAS 887348-02-9C21H18FN3O
4-(1-Ethylbenzimidazol-2-yl)-1-[(4-fluorophenyl)methyl]pyrrolidin-2-one chemical structure, C20H20FN3O, CAS 890642-32-7
4-(1-Ethylbenzimidazol-2-yl)-1-[(4-fluorophenyl)methyl]pyrrolidin-2-one
CAS 890642-32-7C20H20FN3O
1-[(4-Fluorophenyl)methyl]-4-(1-prop-2-enylbenzimidazol-2-yl)pyrrolidin-2-one chemical structure, C21H20FN3O, CAS 890642-35-0
1-[(4-Fluorophenyl)methyl]-4-(1-prop-2-enylbenzimidazol-2-yl)pyrrolidin-2-one
CAS 890642-35-0C21H20FN3O
Ethyl 2-(2-{1-[(4-fluorophenyl)methyl]-5-oxopyrrolidin-3-yl}-1H-1,3-benzodiazol-1-yl)acetate chemical structure, C22H22FN3O3, CAS 890642-38-3
Ethyl 2-(2-{1-[(4-fluorophenyl)methyl]-5-oxopyrrolidin-3-yl}-1H-1,3-benzodiazol-1-yl)acetate
CAS 890642-38-3C22H22FN3O3
1-Benzyl-4-(1-(2-ethoxyethyl)-1H-benzo[d]imidazol-2-yl)pyrrolidin-2-one chemical structure, C22H25N3O2, CAS 912889-86-2
1-Benzyl-4-(1-(2-ethoxyethyl)-1H-benzo[d]imidazol-2-yl)pyrrolidin-2-one
CAS 912889-86-2C22H25N3O2
Isopropyl 2-(2-(1-(4-fluorobenzyl)-5-oxopyrrolidin-3-yl)-1H-benzo[d]imidazol-1-yl)acetate chemical structure, C23H24FN3O3, CAS 912890-40-5
Isopropyl 2-(2-(1-(4-fluorobenzyl)-5-oxopyrrolidin-3-yl)-1H-benzo[d]imidazol-1-yl)acetate
CAS 912890-40-5C23H24FN3O3
1-(4-Fluorobenzyl)-4-(1-(2-methylallyl)-1H-benzo[d]imidazol-2-yl)pyrrolidin-2-one chemical structure, C22H22FN3O, CAS 915189-37-6
1-(4-Fluorobenzyl)-4-(1-(2-methylallyl)-1H-benzo[d]imidazol-2-yl)pyrrolidin-2-one
CAS 915189-37-6C22H22FN3O
N,N-Bis(methylethyl)-2-{2-[5-oxo-1-benzylpyrrolidin-3-yl]benzimidazolyl}acetam ide chemical structure, C26H32N4O2, CAS 942863-64-1
N,N-Bis(methylethyl)-2-{2-[5-oxo-1-benzylpyrrolidin-3-yl]benzimidazolyl}acetam ide
CAS 942863-64-1C26H32N4O2
2-[2-(1-Benzyl-5-oxopyrrolidin-3-yl)-1H-benzimidazol-1-yl]-N,N-dipropylacetamide chemical structure, C26H32N4O2, CAS 955453-35-7
2-[2-(1-Benzyl-5-oxopyrrolidin-3-yl)-1H-benzimidazol-1-yl]-N,N-dipropylacetamide
CAS 955453-35-7C26H32N4O2
2-{2-[5-Oxo-1-benzylpyrrolidin-3-yl]benzimidazolyl}-N,N-diprop-2-enylacetamide chemical structure, C26H28N4O2, CAS 955485-87-7
2-{2-[5-Oxo-1-benzylpyrrolidin-3-yl]benzimidazolyl}-N,N-diprop-2-enylacetamide
CAS 955485-87-7C26H28N4O2
Methylethyl 2-{2-[5-oxo-1-benzylpyrrolidin-3-yl]benzimidazolyl}acetate chemical structure, C23H25N3O3, CAS 955453-64-2
Methylethyl 2-{2-[5-oxo-1-benzylpyrrolidin-3-yl]benzimidazolyl}acetate
CAS 955453-64-2C23H25N3O3
4-(1-(2-Bromoallyl)-1H-benzo[d]imidazol-2-yl)-1-(4-fluorobenzyl)pyrrolidin-2-one chemical structure, C21H19BrFN3O, CAS 942863-72-1
4-(1-(2-Bromoallyl)-1H-benzo[d]imidazol-2-yl)-1-(4-fluorobenzyl)pyrrolidin-2-one
CAS 942863-72-1C21H19BrFN3O
1-(4-Fluorobenzyl)-4-(1-isopentyl-1H-benzo[d]imidazol-2-yl)pyrrolidin-2-one chemical structure, C23H26FN3O, CAS 942863-68-5
1-(4-Fluorobenzyl)-4-(1-isopentyl-1H-benzo[d]imidazol-2-yl)pyrrolidin-2-one
CAS 942863-68-5C23H26FN3O
N,N-Diethyl-2-(2-{1-[(4-fluorophenyl)methyl]-5-oxopyrrolidin-3-yl}-1H-1,3-benzodiazol-1-yl)acetamide chemical structure, C24H27FN4O2, CAS 942863-83-4
N,N-Diethyl-2-(2-{1-[(4-fluorophenyl)methyl]-5-oxopyrrolidin-3-yl}-1H-1,3-benzodiazol-1-yl)acetamide
CAS 942863-83-4C24H27FN4O2
2-(2-{1-[(4-Fluorophenyl)methyl]-5-oxopyrrolidin-3-yl}benzimidazolyl)-N,N-bis(methylethyl)acetamide chemical structure, C26H31FN4O2, CAS 943100-89-8
2-(2-{1-[(4-Fluorophenyl)methyl]-5-oxopyrrolidin-3-yl}benzimidazolyl)-N,N-bis(methylethyl)acetamide
CAS 943100-89-8C26H31FN4O2