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Murcko scaffold

Phenylthiohydantoin scaffold

133 chemicals on CompoundList share this ring system.

Rings
2
Scaffold atoms
13
Chemicals
133
With full pages
20
Scaffold SMILES

O=C1CNC(=S)N1c1ccccc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffoldOpen the Phenylthiohydantoin page
Murcko scaffold O=C1CNC(=S)N1c1ccccc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 48 of 133 chemicals

1-Imidazolidineacetic acid, 4-oxo-3-phenyl-2-thioxo- chemical structure, C11H10N2O3S, CAS 62609-86-3
1-Imidazolidineacetic acid, 4-oxo-3-phenyl-2-thioxo-
CAS 62609-86-3C11H10N2O3S
4-(3,4,4-Trimethyl-5-oxo-2-thioxo-1-imidazolidinyl)-2-(trifluoromethyl)benzonitrile chemical structure, C14H12F3N3OS, CAS 143782-25-6
4-(3,4,4-Trimethyl-5-oxo-2-thioxo-1-imidazolidinyl)-2-(trifluoromethyl)benzonitrile
CAS 143782-25-6C14H12F3N3OS
RU 59063 chemical structure, C17H18F3N3O2S, CAS 155180-53-3
RU 59063
CAS 155180-53-3C17H18F3N3O2S
(S)-3-(5-Oxo-1-phenyl-2-thioxoimidazolidin-4-yl)propanoic acid chemical structure, C12H12N2O3S, CAS 7390-22-9
(S)-3-(5-Oxo-1-phenyl-2-thioxoimidazolidin-4-yl)propanoic acid
CAS 7390-22-9C12H12N2O3S
4-Imidazolidinepropanamide, 5-oxo-1-phenyl-2-thioxo-, (S)- chemical structure, C12H13N3O2S, CAS 29588-05-4
4-Imidazolidinepropanamide, 5-oxo-1-phenyl-2-thioxo-, (S)-
CAS 29588-05-4C12H13N3O2S
(S)-5-(2-(Methylsulfonyl)ethyl)-3-phenyl-2-thioxoimidazolidin-4-one chemical structure, C12H14N2O3S2, CAS 65319-62-2
(S)-5-(2-(Methylsulfonyl)ethyl)-3-phenyl-2-thioxoimidazolidin-4-one
CAS 65319-62-2C12H14N2O3S2
2-[[(4R)-5-Oxo-1-phenyl-2-sulfanylideneimidazolidin-4-yl]methylsulfanyl]acetic acid chemical structure, C12H12N2O3S2, CAS 29635-91-4
2-[[(4R)-5-Oxo-1-phenyl-2-sulfanylideneimidazolidin-4-yl]methylsulfanyl]acetic acid
CAS 29635-91-4C12H12N2O3S2
(R)-5-Isobutyl-3-phenyl-2-thioxoimidazolidin-4-one chemical structure, C13H16N2OS, CAS 92419-07-3
(R)-5-Isobutyl-3-phenyl-2-thioxoimidazolidin-4-one
CAS 92419-07-3C13H16N2OS
Phenylthiohydantoin chemical structure, C9H8N2OS, CAS 2010-15-3
Phenylthiohydantoin
CAS 2010-15-3C9H8N2OS
3-(4-Ethoxyphenyl)-2-sulfanyl-3,5-dihydro-4H-imidazol-4-one chemical structure, C11H12N2O2S, CAS 32261-88-4
3-(4-Ethoxyphenyl)-2-sulfanyl-3,5-dihydro-4H-imidazol-4-one
CAS 32261-88-4C11H12N2O2S
(4S)-5-Oxo-1-phenyl-2-thioxoimidazolidine-4-acetic acid chemical structure, C11H10N2O3S, CAS 29588-04-3
(4S)-5-Oxo-1-phenyl-2-thioxoimidazolidine-4-acetic acid
CAS 29588-04-3C11H10N2O3S
Hydantoin, 3-(p-methoxyphenyl)-2-thio- chemical structure, C10H10N2O2S, CAS 39123-62-1
Hydantoin, 3-(p-methoxyphenyl)-2-thio-
CAS 39123-62-1C10H10N2O2S
3-(2,5-Dichlorophenyl)-2-thioxo-4-imidazolidinone chemical structure, C9H6Cl2N2OS, CAS 675827-59-5
3-(2,5-Dichlorophenyl)-2-thioxo-4-imidazolidinone
CAS 675827-59-5C9H6Cl2N2OS
RefChem:313943 chemical structure, C10H10N2OS, CAS 7390-20-7
RefChem:313943
CAS 7390-20-7C10H10N2OS
Sbb023539 chemical structure, C10H10N2OS, CAS 18391-77-0
Sbb023539
CAS 18391-77-0C10H10N2OS
2-Mercapto-3-(3-methylphenyl)-3,5-dihydro-4H-imidazol-4-one chemical structure, C10H10N2OS, CAS 61388-77-0
2-Mercapto-3-(3-methylphenyl)-3,5-dihydro-4H-imidazol-4-one
CAS 61388-77-0C10H10N2OS
(5R)-5-[(1S)-1-Hydroxyethyl]-3-phenyl-2-sulfanylideneimidazolidin-4-one chemical structure, C11H12N2O2S, CAS 29583-08-2
(5R)-5-[(1S)-1-Hydroxyethyl]-3-phenyl-2-sulfanylideneimidazolidin-4-one
CAS 29583-08-2C11H12N2O2S
3-(4-Methylphenyl)-2-thioxo-4-imidazolidinone chemical structure, C10H10N2OS, CAS 32607-35-5
3-(4-Methylphenyl)-2-thioxo-4-imidazolidinone
CAS 32607-35-5C10H10N2OS
Methyl [3-(4-ethylphenyl)-4-oxo-2-thioxo-1-imidazolidinyl]acetate chemical structure, C14H16N2O3S, CAS 592477-74-2
Methyl [3-(4-ethylphenyl)-4-oxo-2-thioxo-1-imidazolidinyl]acetate
CAS 592477-74-2C14H16N2O3S
Methyl [3-(4-ethoxyphenyl)-4-oxo-2-thioxo-1-imidazolidinyl]acetate chemical structure, C14H16N2O4S, CAS 592477-75-3
Methyl [3-(4-ethoxyphenyl)-4-oxo-2-thioxo-1-imidazolidinyl]acetate
CAS 592477-75-3C14H16N2O4S
2-Sulfanylidene-3-[4-(trifluoromethyl)phenyl]imidazolidin-4-one chemical structure, C10H7F3N2OS, CAS 338773-10-7
2-Sulfanylidene-3-[4-(trifluoromethyl)phenyl]imidazolidin-4-one
CAS 338773-10-7C10H7F3N2OS
3-(4-Fluorophenyl)-2-thioxoimidazolidin-4-one chemical structure, C9H7FN2OS, CAS 55407-30-2
3-(4-Fluorophenyl)-2-thioxoimidazolidin-4-one
CAS 55407-30-2C9H7FN2OS
1-(4-Chlorophenyl)-2-sulfanyl-4,5-dihydro-1H-imidazol-5-one chemical structure, C9H7ClN2OS, CAS 55327-43-0
1-(4-Chlorophenyl)-2-sulfanyl-4,5-dihydro-1H-imidazol-5-one
CAS 55327-43-0C9H7ClN2OS
3-(2-Methylphenyl)-2-thioxoimidazolidin-4-one chemical structure, C10H10N2OS, CAS 32607-34-4
3-(2-Methylphenyl)-2-thioxoimidazolidin-4-one
CAS 32607-34-4C10H10N2OS